PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10411684-7 1999 "Flip flop" was gauged by preferential decrements in phosphatidylserine (PS) versus phosphatidylcholine (PC; PS/PC ratios) in response to extracellular (Naja) PLA2 exposure. Phosphatidylcholines 84-103 phospholipase A2, group IB, pancreas Mus musculus 159-163 10230818-9 1999 The chemically related (and precursor molecule of LPC in PLA2 reaction) phosphatidylcholine (PC) had no effect on any of the above studied parameters. Phosphatidylcholines 72-91 phospholipase A2, group IB, pancreas Mus musculus 57-61 10230818-9 1999 The chemically related (and precursor molecule of LPC in PLA2 reaction) phosphatidylcholine (PC) had no effect on any of the above studied parameters. Phosphatidylcholines 51-53 phospholipase A2, group IB, pancreas Mus musculus 57-61 6806255-1 1982 Mouse peritoneal macrophages have a phospholipase A2 activity which is optimally active at pH 8.5 (PLA8.5), requires 2 mM Ca2+ and is capable of hydrolyzing arachidonic acid from phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 179-198 phospholipase A2, group IB, pancreas Mus musculus 36-52 9924985-4 1998 The results showed that of all tested phospholipids only phosphatidylcholine (PC) increased PLA2 activity in the control cells, whereas in their transformed counterparts both PC and phosphatidic acid (PA) induced such effect. Phosphatidylcholines 57-76 phospholipase A2, group IB, pancreas Mus musculus 92-96 9924985-4 1998 The results showed that of all tested phospholipids only phosphatidylcholine (PC) increased PLA2 activity in the control cells, whereas in their transformed counterparts both PC and phosphatidic acid (PA) induced such effect. Phosphatidylcholines 78-80 phospholipase A2, group IB, pancreas Mus musculus 92-96 9924985-6 1998 The results demonstrated that the arachidonic acid-containing PC and PA molecules induced a more pronounced increase of membrane-associated PLA2 activity in ras-transformed cells compared to the corresponding palmitate-stearate- or oleate- containing molecular species. Phosphatidylcholines 62-64 phospholipase A2, group IB, pancreas Mus musculus 140-144 1910288-3 1991 Tumor-derived cells exhibited significant PLA2 activity(ies) with arachidonoyl containing phosphatidylcholine and phosphatidylethanolamine as substrates in cell-free assays. Phosphatidylcholines 90-109 phospholipase A2, group IB, pancreas Mus musculus 42-46 1910288-6 1991 The pH profiles for hydrolysis of phosphatidylcholine and phosphatidylethanolamine differed; all other aspects of PLA2-mediated hydrolysis of these two substrates were similar including a Ca2+ requirement for activity. Phosphatidylcholines 34-53 phospholipase A2, group IB, pancreas Mus musculus 114-118 2971218-2 1988 We have measured phosphatidylinositol-specific phospholipase C and phosphatidylcholine-specific phospholipase A2 in the reproductive tract of male and female mouse (CD-I) fetuses at the 18th day of gestation. Phosphatidylcholines 67-86 phospholipase A2, group IB, pancreas Mus musculus 96-112 3396665-3 1988 Therefore, we have examined the effect of TCE on the intra- and extracellular surfactant pools and the activity of phospholipase A2, an enzyme which controls the remodeling of phosphatidylcholine to dipalmitoylphosphatidylcholine, the primary constituent of the pulmonary surfactant. Phosphatidylcholines 176-195 phospholipase A2, group IB, pancreas Mus musculus 115-131 3131322-1 1988 The kinetics of the Ca2+-dependent, alkaline pH optimum, membrane-bound phospholipase A2 from the P388D1 macrophage-like cell line were studied using various phosphatidylcholine (PC) and phosphatidylethanolamine (PE) substrates. Phosphatidylcholines 158-177 phospholipase A2, group IB, pancreas Mus musculus 72-88 3930615-6 1985 Therefore, TPA probably is not involved in the turnover of PI in these cells but is involved in the activation of PC hydrolyzing phospholipase A2 and PI hydrolyzing phospholipase C in these keratinocytes releasing arachidonic acid which then undergoes oxygenation reactions to provide biologically active eicosanoids. Phosphatidylcholines 114-116 phospholipase A2, group IB, pancreas Mus musculus 129-145 9788614-2 1998 After phorbol ester treatment, AA is hydrolyzed from keratinocytes primarily by the cytosolic form of phospholipase A2 (cPLA2), which exhibited a strong substrate preference for phosphatidylcholine over phosphatidylethanolamine and AA over other fatty acids. Phosphatidylcholines 178-197 phospholipase A2, group IB, pancreas Mus musculus 102-118 7657619-6 1995 This was verified by demonstrating that the phospholipids, phosphatidylcholine and phosphatidylinositol, were hydrolyzed to glycerophosphocholine and glycerophosphoinositol by incubation with recombinant 85-kDa PLA2. Phosphatidylcholines 59-78 phospholipase A2, group IB, pancreas Mus musculus 211-215 8177371-4 1994 With choline phosphoglyceride as a substrate, phospholipase A2 activity was predominantly Ca(2+)-dependent, although a small, but measurable Ca(2+)-independent component was present. Phosphatidylcholines 5-29 phospholipase A2, group IB, pancreas Mus musculus 46-62 8177371-6 1994 These findings indicate that activity of a phospholipase A2, which utilizes choline phosphoglyceride as a substrate, is affected by the aging process. Phosphatidylcholines 76-100 phospholipase A2, group IB, pancreas Mus musculus 43-59 1532578-0 1992 Bombesin stimulates the rapid activation of phospholipase A2-catalyzed phosphatidylcholine hydrolysis in Swiss 3T3 cells. Phosphatidylcholines 71-90 phospholipase A2, group IB, pancreas Mus musculus 44-60 1532578-4 1992 The corresponding production of lysophosphatidylcholine suggested the involvement of a phosphatidylcholine-specific phospholipase A2. Phosphatidylcholines 36-55 phospholipase A2, group IB, pancreas Mus musculus 116-132 1532578-6 1992 These data strongly suggest that occupation of the bombesin receptor is closely coupled to activation of phospholipase A2 which results in the rapid release of arachidonic acid from phosphatidylcholine. Phosphatidylcholines 182-201 phospholipase A2, group IB, pancreas Mus musculus 105-121 1636497-1 1992 Phospholipase A2 activity in lysates of mast cells and their related cells [mouse bone marrow-derived IL-3 dependent mast cells (BMMC), rat connective tissue mast cells (CTMC), and rat mastocytoma RBL-2H3 cells] was measured using phosphatidylethanolamine (PE), phosphatidylserine (PS), and phosphatidylcholine (PC) as exogenous substrates. Phosphatidylcholines 291-310 phospholipase A2, group IB, pancreas Mus musculus 0-16 1636497-1 1992 Phospholipase A2 activity in lysates of mast cells and their related cells [mouse bone marrow-derived IL-3 dependent mast cells (BMMC), rat connective tissue mast cells (CTMC), and rat mastocytoma RBL-2H3 cells] was measured using phosphatidylethanolamine (PE), phosphatidylserine (PS), and phosphatidylcholine (PC) as exogenous substrates. Phosphatidylcholines 312-314 phospholipase A2, group IB, pancreas Mus musculus 0-16 1662619-4 1991 Three lines of evidence indicate phospholipase A2 activity to be involved in arachidonic acid release: (a) its inhibition by mepacrine, (b) the concomitant generation of lysophosphatidylcholine from [3H]choline-labeled cells and (c) an increase in arachidonic acid release from 14C-labeled phosphatidylcholine in particulate fractions from PMA-treated and bradykinin-treated keratinocytes. Phosphatidylcholines 174-193 phospholipase A2, group IB, pancreas Mus musculus 33-49 3733728-3 1986 Leukotriene D4 treatment resulted in a dose-dependent, stereospecific increase in phospholipase A2 activity with phosphatidylcholine as a substrate. Phosphatidylcholines 113-132 phospholipase A2, group IB, pancreas Mus musculus 82-98 4024704-2 1985 Phosphatidylcholine with arachidonoyl at position 2 was cleaved preferentially by an alkaline phospholipase A2 (pH-optimum 9.0) leading to selective liberation of arachidonic acid. Phosphatidylcholines 0-19 phospholipase A2, group IB, pancreas Mus musculus 94-110 6237161-7 1984 The PC-binding proteins possessed a typical phospholipase A2 activity, which was maximal at pH 9.5, depended on Ca++, and was specific for cleavage of fatty acid from the sn-2 position of phosphatidylcholine. Phosphatidylcholines 188-207 phospholipase A2, group IB, pancreas Mus musculus 44-60 6804944-4 1982 Phosphatidylcholine-binding proteins possessed a typical phospholipase A2 activity (phosphatide 2-acylhydrolase, EC 3.1.1.4), which was maximal (10 mumol/min per mg of protein) at pH 9.5, depended on Ca2+, and was specific for cleavage of fatty acid from the C-2 position of the glycerol backbone of phosphatidylcholine. Phosphatidylcholines 0-19 phospholipase A2, group IB, pancreas Mus musculus 57-73 6804944-4 1982 Phosphatidylcholine-binding proteins possessed a typical phospholipase A2 activity (phosphatide 2-acylhydrolase, EC 3.1.1.4), which was maximal (10 mumol/min per mg of protein) at pH 9.5, depended on Ca2+, and was specific for cleavage of fatty acid from the C-2 position of the glycerol backbone of phosphatidylcholine. Phosphatidylcholines 300-319 phospholipase A2, group IB, pancreas Mus musculus 57-73 14664823-1 2003 Phospholipase A(2) (PLA(2)) hydrolyzes phosphatidylcholine to lysophosphatidylcholine and arachidonic acid. Phosphatidylcholines 39-58 phospholipase A2, group IB, pancreas Mus musculus 0-18 27282246-1 2016 Phospholipase A2 (sPLA2), pivotal for allergic and inflammatory response, hydrolyses phosphatidylcholine (PC) to lysophosphatidylcholine (LPC). Phosphatidylcholines 85-104 phospholipase A2, group IB, pancreas Mus musculus 0-16 27282246-1 2016 Phospholipase A2 (sPLA2), pivotal for allergic and inflammatory response, hydrolyses phosphatidylcholine (PC) to lysophosphatidylcholine (LPC). Phosphatidylcholines 106-108 phospholipase A2, group IB, pancreas Mus musculus 0-16 26708397-1 2015 BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1). Phosphatidylcholines 81-101 phospholipase A2, group IB, pancreas Mus musculus 110-126 26708397-1 2015 BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1). Phosphatidylcholines 38-40 phospholipase A2, group IB, pancreas Mus musculus 110-126 26708397-1 2015 BACKGROUND: Lysophosphatidylcholine (LPC) is generated through the hydrolysis of phospha-tidylcholine (PC) by phospholipase A2 and is converted back to PC by lysophosphatidylcholine acyltransferase 1 (LPCAT1). Phosphatidylcholines 103-105 phospholipase A2, group IB, pancreas Mus musculus 110-126 19016452-11 2009 In addition, this study presents evidence suggesting a specific role for phospholipase A2-mediated PtdCho catabolism. Phosphatidylcholines 99-105 phospholipase A2, group IB, pancreas Mus musculus 73-89 19159281-8 2009 Phospholipase A2, which hydrolyses phosphatidylcholine to Acyl-GPC, is a known modifier gene of the model phenotype (Mom1), and altered expression of choline phospholipid enzymes has been reported in gut tissue from Apc(Min/+) mice. Phosphatidylcholines 35-54 phospholipase A2, group IB, pancreas Mus musculus 0-16 14664823-1 2003 Phospholipase A(2) (PLA(2)) hydrolyzes phosphatidylcholine to lysophosphatidylcholine and arachidonic acid. Phosphatidylcholines 39-58 phospholipase A2, group IB, pancreas Mus musculus 20-26