PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18190795-1 2008 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 18190795-1 2008 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 18423386-1 2008 Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of phosphatidic acid (PA), which is itself a source of diacylglycerol (DAG). Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-52 18423386-1 2008 Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of phosphatidic acid (PA), which is itself a source of diacylglycerol (DAG). Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-57 18432522-1 2008 Phospholipase D (PLD), which hydrolyzes phosphatidylcholine to phosphatidic acid (PA) and choline, is present in human platelets. Phosphatidylcholines 40-59 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 18432522-1 2008 Phospholipase D (PLD), which hydrolyzes phosphatidylcholine to phosphatidic acid (PA) and choline, is present in human platelets. Phosphatidylcholines 40-59 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 17233594-1 2007 Generation of PA (phosphatidic acid) by PLD (phospholipase D)-catalysed hydrolysis of phosphatidylcholine plays a pivotal role in cellular signalling pathways that regulate organization of the actin cytoskeleton, vesicular transport and exocytosis and stimulation of cell growth and survival. Phosphatidylcholines 86-105 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-43 17914593-1 2007 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 17914593-1 2007 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 17914593-1 2007 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline. Phosphatidylcholines 71-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 17914593-1 2007 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline. Phosphatidylcholines 71-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 17465727-1 2007 Mammalian phospholipase D (PLD), a signal transduction-activated enzyme, hydrolyzes phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Phosphatidylcholines 84-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 17465727-1 2007 Mammalian phospholipase D (PLD), a signal transduction-activated enzyme, hydrolyzes phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Phosphatidylcholines 84-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 17245604-1 2007 Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of the versatile lipid second messenger, phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-52 17245604-1 2007 Hydrolysis of phosphatidylcholine by phospholipase D (PLD) leads to the generation of the versatile lipid second messenger, phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-57 17627030-2 2007 Among signal transducers used by chemoattractant receptors, the phosphatidylcholine-specific phospholipase D (PLD) produces large amounts of second messengers in most cell types. Phosphatidylcholines 64-83 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-108 17627030-2 2007 Among signal transducers used by chemoattractant receptors, the phosphatidylcholine-specific phospholipase D (PLD) produces large amounts of second messengers in most cell types. Phosphatidylcholines 64-83 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 110-113 17405772-5 2007 Increased PTEN expression in unstimulated MCF-7 breast cancer cells results in a 51% increase in phosphatidic acid, with a decrease in phosphatidylcholine, suggesting that PTEN may regulate phospholipase D (PLD). Phosphatidylcholines 135-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 190-205 17405772-5 2007 Increased PTEN expression in unstimulated MCF-7 breast cancer cells results in a 51% increase in phosphatidic acid, with a decrease in phosphatidylcholine, suggesting that PTEN may regulate phospholipase D (PLD). Phosphatidylcholines 135-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 207-210 17233594-1 2007 Generation of PA (phosphatidic acid) by PLD (phospholipase D)-catalysed hydrolysis of phosphatidylcholine plays a pivotal role in cellular signalling pathways that regulate organization of the actin cytoskeleton, vesicular transport and exocytosis and stimulation of cell growth and survival. Phosphatidylcholines 86-105 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 45-60 16380371-3 2006 PtdCho is hydrolyzed by phospholipase A2 (PLA2), PtdChospecific phospholipase C (PtdCho-PLC), and phospholipase D (PLD). Phosphatidylcholines 0-6 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 98-113 16843818-5 2006 PLD catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA). Phosphatidylcholines 32-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 16916782-1 2006 Phospholipase D (PLD) hydrolyzes the phosphodiester bond of the predominant membrane phospholipid, phosphatidylcholine producing phosphatidic acid and free choline. Phosphatidylcholines 99-118 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 16916782-1 2006 Phospholipase D (PLD) hydrolyzes the phosphodiester bond of the predominant membrane phospholipid, phosphatidylcholine producing phosphatidic acid and free choline. Phosphatidylcholines 99-118 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 16737317-0 2006 Synthesis and evaluation of fluorogenic substrates for phospholipase D and phospholipase C. Fluorogenic analogues of phosphatidylcholine and lysophosphatidylcholine, DDPB and lysoDDPB, were synthesized by an enzyme-assisted strategy. Phosphatidylcholines 117-136 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 55-70 16380371-3 2006 PtdCho is hydrolyzed by phospholipase A2 (PLA2), PtdChospecific phospholipase C (PtdCho-PLC), and phospholipase D (PLD). Phosphatidylcholines 0-6 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 115-118 15665518-5 2005 PLD-catalyzed conversion of phosphatidylcholine to phosphatydilethanol (PetOH), in the presence of ethanol, was monitored by thin layer chromatography. Phosphatidylcholines 28-47 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 16878701-1 2006 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to produce the membrane-associated second messenger, phosphatidic acid (PA) and choline. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 16878701-1 2006 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to produce the membrane-associated second messenger, phosphatidic acid (PA) and choline. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 16179605-1 2005 Phospholipase D (PLD), which catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline, plays key roles in cellular signal transduction by mediating extracellular stimuli including hormones, growth factors, neurotransmitters, cytokines and extracellular matrix molecules. Phosphatidylcholines 57-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 16179605-1 2005 Phospholipase D (PLD), which catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline, plays key roles in cellular signal transduction by mediating extracellular stimuli including hormones, growth factors, neurotransmitters, cytokines and extracellular matrix molecules. Phosphatidylcholines 57-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 15294123-4 2004 Elastase and myeloperoxidase (MPO) release was measured for the parameters of neutrophil activation, neutrophil PLD activity was determined by quantitation of choline produced from the stable product of phosphatidylcholine catalyzed by PLD. Phosphatidylcholines 203-222 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 236-239 15475361-1 2004 Mammalian phospholipases D (PLD), which catalyze the hydrolysis of phosphatidylcholine to phosphatidic acid (PA), have been implicated in various cell signaling and vesicle trafficking processes. Phosphatidylcholines 67-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-26 15475361-1 2004 Mammalian phospholipases D (PLD), which catalyze the hydrolysis of phosphatidylcholine to phosphatidic acid (PA), have been implicated in various cell signaling and vesicle trafficking processes. Phosphatidylcholines 67-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 28-31 15249196-0 2004 p44/42(ERK1/2) MAPK and PLD activation by PGD2 preserves papillary phosphatidylcholine homeostasis. Phosphatidylcholines 67-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 24-27 14517341-2 2003 PLD, which catalyzes the hydrolysis of phosphatidylcholine (PC) to phosphatidic acid (PA) and choline, is activated in response to stimulators of vesicle transport, endocytosis, exocytosis, cell migration, and mitosis. Phosphatidylcholines 39-58 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 14501041-1 2004 Mammalian phospholipase D (PLD) activity hydrolyzes phosphatidylcholine (PC) into phosphatidic acid (PA) and free choline. Phosphatidylcholines 52-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 14501041-1 2004 Mammalian phospholipase D (PLD) activity hydrolyzes phosphatidylcholine (PC) into phosphatidic acid (PA) and free choline. Phosphatidylcholines 52-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 14501041-1 2004 Mammalian phospholipase D (PLD) activity hydrolyzes phosphatidylcholine (PC) into phosphatidic acid (PA) and free choline. Phosphatidylcholines 73-75 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 14501041-1 2004 Mammalian phospholipase D (PLD) activity hydrolyzes phosphatidylcholine (PC) into phosphatidic acid (PA) and free choline. Phosphatidylcholines 73-75 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 14646617-4 2003 Melanoma cell lines showed phosphatidylcholine-hydrolysing, phosphatidylinositol 4,5-bisphosphate-dependent PLD activity, which was activated by phorbol ester and a non-hydrolysable guanosine triphosphate (GTP) analogue in a dose-dependent and synergistic manner, whereas primary melanocytes exhibited only low PLD activity compared with the melanoma cell lines. Phosphatidylcholines 27-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 108-111 14646617-4 2003 Melanoma cell lines showed phosphatidylcholine-hydrolysing, phosphatidylinositol 4,5-bisphosphate-dependent PLD activity, which was activated by phorbol ester and a non-hydrolysable guanosine triphosphate (GTP) analogue in a dose-dependent and synergistic manner, whereas primary melanocytes exhibited only low PLD activity compared with the melanoma cell lines. Phosphatidylcholines 27-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 311-314 14517341-2 2003 PLD, which catalyzes the hydrolysis of phosphatidylcholine (PC) to phosphatidic acid (PA) and choline, is activated in response to stimulators of vesicle transport, endocytosis, exocytosis, cell migration, and mitosis. Phosphatidylcholines 60-62 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 12546662-1 2003 Phospholipase D (PLD) hydrolyses phosphatidylcholine into phosphatidic acid (PA) and choline. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 12546662-1 2003 Phospholipase D (PLD) hydrolyses phosphatidylcholine into phosphatidic acid (PA) and choline. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 12429836-1 2002 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid, a molecule known to have multiple physiological roles, including release of nascent secretory vesicles from the trans-Golgi network. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 12429836-1 2002 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid, a molecule known to have multiple physiological roles, including release of nascent secretory vesicles from the trans-Golgi network. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 12162465-1 2002 Phospholipase D (PLD), a phospholipid phosphohydrolase, catalyzes the hydrolysis of phosphatidylcholine and other membrane phospholipids to phosphatidic acid (PA) and choline. Phosphatidylcholines 84-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 12217395-1 2002 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidate (PA). Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 12217395-1 2002 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidate (PA). Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 12162465-1 2002 Phospholipase D (PLD), a phospholipid phosphohydrolase, catalyzes the hydrolysis of phosphatidylcholine and other membrane phospholipids to phosphatidic acid (PA) and choline. Phosphatidylcholines 84-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 12191592-2 2002 PLD metabolizes phosphatidylcholine to generate phosphatidic acid (PA). Phosphatidylcholines 16-35 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 11000525-2 2000 To date, two types of mammalian phosphatidylcholine-specific PLD cDNAs, designated as PLD-1 and PLD-2, have been cloned. Phosphatidylcholines 32-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 61-64 11530878-2 2001 One critical aspect of intracellular signaling is regulation of key cell functions by lipid mediators, in particular the generation of a key mediator, phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine by phospholipase D (PLD). Phosphatidylcholines 196-215 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 219-234 11530878-2 2001 One critical aspect of intracellular signaling is regulation of key cell functions by lipid mediators, in particular the generation of a key mediator, phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine by phospholipase D (PLD). Phosphatidylcholines 196-215 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 236-239 11734063-1 2001 BACKGROUND: In cholinergic neurons, the hydrolysis of phosphatidylcholine (PC) by a phospholipase D (PLD)-type enzyme generates some of the precursor choline used for the synthesis of the neurotransmitter acetylcholine (ACh). Phosphatidylcholines 54-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 101-104 11734063-1 2001 BACKGROUND: In cholinergic neurons, the hydrolysis of phosphatidylcholine (PC) by a phospholipase D (PLD)-type enzyme generates some of the precursor choline used for the synthesis of the neurotransmitter acetylcholine (ACh). Phosphatidylcholines 75-77 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 101-104 21331729-1 2001 Phospholipase D (PLD), which hydrolyzes phospholipids (primarily phos-phatidylcholine) to generate phosphatidic acid, is an essential component in cellular signal transduction (1,2). Phosphatidylcholines 65-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 21331729-1 2001 Phospholipase D (PLD), which hydrolyzes phospholipids (primarily phos-phatidylcholine) to generate phosphatidic acid, is an essential component in cellular signal transduction (1,2). Phosphatidylcholines 65-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 11090971-1 2000 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 11090971-1 2000 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 11090971-1 2000 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline. Phosphatidylcholines 71-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 11090971-1 2000 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline. Phosphatidylcholines 71-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 11152958-4 2000 When phosphatidylcholine-specific phospholipase C (PC-PLC) was inhibited by D609, the Fas-induced changes in PLD activity, DAG content, and PKC translocation were inhibited. Phosphatidylcholines 5-24 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 109-112 11706993-1 2001 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidate (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 11706993-1 2001 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidate (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 11294898-1 2001 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 11294898-1 2001 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to generate phosphatidic acid. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 10660303-1 2000 The signalling pathway leading, for example, to actin cytoskeletal reorganisation, secretion or superoxide generation involves phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine to generate phosphatidic acid, which appears to mediate the messenger functions of this pathway. Phosphatidylcholines 173-192 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 127-142 10642495-1 2000 Interaction of extracellular-signal molecules with cell-surface receptors often activates a phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine and other phospholipids, generating phosphatidic acid. Phosphatidylcholines 137-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 92-107 10642495-1 2000 Interaction of extracellular-signal molecules with cell-surface receptors often activates a phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine and other phospholipids, generating phosphatidic acid. Phosphatidylcholines 137-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 109-112 10777500-9 2000 Likewise, PLDbeta C2 bound phosphatidylcholine (PC), the substrate of PLD, in the presence of submillimolar Ca(2+) concentrations, whereas PLDalpha C2 did so only in the presence of millimolar levels of the metal ion. Phosphatidylcholines 27-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-13 10777500-9 2000 Likewise, PLDbeta C2 bound phosphatidylcholine (PC), the substrate of PLD, in the presence of submillimolar Ca(2+) concentrations, whereas PLDalpha C2 did so only in the presence of millimolar levels of the metal ion. Phosphatidylcholines 48-50 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-13 10873602-5 2000 Finally, basal- and agonist-stimulated PLD activity was inhibited in phosphatidylcholine-specific anti-PLD immunoprecipitates (IC(50) = 75 microM). Phosphatidylcholines 69-88 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 39-42 10873602-5 2000 Finally, basal- and agonist-stimulated PLD activity was inhibited in phosphatidylcholine-specific anti-PLD immunoprecipitates (IC(50) = 75 microM). Phosphatidylcholines 69-88 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 103-106 10873862-4 2000 PLD also catalyses a transphosphatidylation reaction in the presence of phosphatidylcholine and a short-chained primary or secondary alcohol. Phosphatidylcholines 72-91 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 10660303-1 2000 The signalling pathway leading, for example, to actin cytoskeletal reorganisation, secretion or superoxide generation involves phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine to generate phosphatidic acid, which appears to mediate the messenger functions of this pathway. Phosphatidylcholines 173-192 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 144-147 10562546-0 1999 Loss of receptor regulation by a phospholipase D1 mutant unresponsive to protein kinase C. Activation of phosphatidylcholine-specific phospholipase D (PLD) constitutes an important part of the cellular response to agonist signaling. Phosphatidylcholines 105-124 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 151-154 10529371-1 1999 Phospholipase D (PLD) plays an important role in signaling through phosphatidylcholine (PC) and in the production of superoxide (respiratory burst) by polymorphonuclear leukocytes (PMN) stimulated by the chemoattractant fMet-Leu-Phe (fMLP). Phosphatidylcholines 67-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 10529371-1 1999 Phospholipase D (PLD) plays an important role in signaling through phosphatidylcholine (PC) and in the production of superoxide (respiratory burst) by polymorphonuclear leukocytes (PMN) stimulated by the chemoattractant fMet-Leu-Phe (fMLP). Phosphatidylcholines 67-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 10529371-1 1999 Phospholipase D (PLD) plays an important role in signaling through phosphatidylcholine (PC) and in the production of superoxide (respiratory burst) by polymorphonuclear leukocytes (PMN) stimulated by the chemoattractant fMet-Leu-Phe (fMLP). Phosphatidylcholines 88-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 10529371-1 1999 Phospholipase D (PLD) plays an important role in signaling through phosphatidylcholine (PC) and in the production of superoxide (respiratory burst) by polymorphonuclear leukocytes (PMN) stimulated by the chemoattractant fMet-Leu-Phe (fMLP). Phosphatidylcholines 88-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 10529371-4 1999 Using a range of concentrations (3-20 microM) which inhibit ERK activity, PD 98059 inhibited PLD activity induced by fMLP in cytochalasin B-primed PMN, as assessed by production-tritiated phosphatidylethanol (PEt), phosphatidic acid (PA), and hydrolysis of PC. Phosphatidylcholines 257-259 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 10207000-5 1999 Dimeric Ymt was shown to have PLD-like activity as demonstrated by the hydrolysis of phosphatidylcholine. Phosphatidylcholines 85-104 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 30-33 10425391-2 1999 Virtually every cell uses phosphatidylcholine as substrate to produce phosphatidic acid in a controlled reaction catalyzed by specific PLD isoforms. Phosphatidylcholines 26-45 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 135-138 10375402-2 1999 Purified human liver microsomal cytochromes P450 (P450)-P450 1A2 and P450 2E1-were shown to have appreciable PLD activity, hydrolyzing phosphatidylcholine but not other phospholipids, generating PA and choline. Phosphatidylcholines 135-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 109-112 9873061-1 1999 The primary known function of phospholipase D (PLD) is to generate phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine. Phosphatidylcholines 112-131 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 30-45 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. Phosphatidylcholines 152-171 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. Phosphatidylcholines 152-171 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. Phosphatidylcholines 173-179 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. Phosphatidylcholines 173-179 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 9989927-2 1999 This ATP-stimulated influx of divalent cations has been shown to activate an intracellular phospholipase D (PLD) which hydrolyzes membrane phosphatidylcholine. Phosphatidylcholines 139-158 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 91-106 9989927-2 1999 This ATP-stimulated influx of divalent cations has been shown to activate an intracellular phospholipase D (PLD) which hydrolyzes membrane phosphatidylcholine. Phosphatidylcholines 139-158 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 108-111 9920915-1 1999 Activation of phosphatidylcholine-specific phospholipase D (PLD) has been proposed to play roles in numerous cellular pathways including signal transduction and membrane vesicular trafficking. Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 60-63 10087440-1 1999 Phospholipase D (PLD) is a phosphodiesterase that catalyses hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidylcholines 74-93 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 10087440-1 1999 Phospholipase D (PLD) is a phosphodiesterase that catalyses hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidylcholines 74-93 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9873061-1 1999 The primary known function of phospholipase D (PLD) is to generate phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine. Phosphatidylcholines 112-131 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 47-50 9867870-1 1999 The mammalian phosphatidylcholine-specific phospholipase D (PLD) enzymes PLD1 and PLD2 have been proposed to play roles in signal transduction and membrane vesicular trafficking in distinct subcellular compartments. Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 60-63 10216475-1 1999 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating phosphatidic acid which may act as a second messenger during cell proliferation, therefore PLD is believed to play an important role in tumorigenesis. Phosphatidylcholines 75-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 25-40 10216475-1 1999 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating phosphatidic acid which may act as a second messenger during cell proliferation, therefore PLD is believed to play an important role in tumorigenesis. Phosphatidylcholines 75-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 42-45 10216475-1 1999 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating phosphatidic acid which may act as a second messenger during cell proliferation, therefore PLD is believed to play an important role in tumorigenesis. Phosphatidylcholines 75-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 198-201 9639664-3 1998 Hydrolysis of PtdCho by phospholipase D (PLD) and resynthesis of PtdCho from labeled choline were stimulated 2- to 4-fold by PKC activation with the phorbol ester, 4beta-12-O-tetradecanoylphorbol-13-acetate (beta-TPA), in all cells except those from heterozygous X-ALD individuals. Phosphatidylcholines 14-20 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 24-39 12114973-1 1999 The effects of some inhibitors of protein kinase C(PKC) and tyrosine protein kinase(TPK)as well as the antibodies to PKC isotypes on the activity of phosphatidylcholine-specific phospholipase D(PLD)in 7721 human hepatocarcinoma cells were determined in order to study the regulation of PKC and TPK on PLD in these cells. Phosphatidylcholines 149-168 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 194-197 12114973-1 1999 The effects of some inhibitors of protein kinase C(PKC) and tyrosine protein kinase(TPK)as well as the antibodies to PKC isotypes on the activity of phosphatidylcholine-specific phospholipase D(PLD)in 7721 human hepatocarcinoma cells were determined in order to study the regulation of PKC and TPK on PLD in these cells. Phosphatidylcholines 149-168 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 301-304 9813240-1 1998 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate phosphatidic acid and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9761774-1 1998 Phospholipase D (PLD) cleaves phosphatidylcholine in response to a variety of cell stimuli to release phosphatidic acid, which is associated with a number of cellular responses including regulated secretion, mitogenesis, and cytoskeletal changes. Phosphatidylcholines 30-49 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 9761774-1 1998 Phospholipase D (PLD) cleaves phosphatidylcholine in response to a variety of cell stimuli to release phosphatidic acid, which is associated with a number of cellular responses including regulated secretion, mitogenesis, and cytoskeletal changes. Phosphatidylcholines 30-49 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9639664-3 1998 Hydrolysis of PtdCho by phospholipase D (PLD) and resynthesis of PtdCho from labeled choline were stimulated 2- to 4-fold by PKC activation with the phorbol ester, 4beta-12-O-tetradecanoylphorbol-13-acetate (beta-TPA), in all cells except those from heterozygous X-ALD individuals. Phosphatidylcholines 14-20 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 41-44 9601059-7 1998 The formation of phosphatidylbutanol by PLD was greatest when PtdCho was the predominantly labelled phospholipid, indicating that PtdCho was the preferred, but not the only, phospholipid substrate for PLD. Phosphatidylcholines 62-68 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-43 9601059-7 1998 The formation of phosphatidylbutanol by PLD was greatest when PtdCho was the predominantly labelled phospholipid, indicating that PtdCho was the preferred, but not the only, phospholipid substrate for PLD. Phosphatidylcholines 130-136 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-43 9601059-7 1998 The formation of phosphatidylbutanol by PLD was greatest when PtdCho was the predominantly labelled phospholipid, indicating that PtdCho was the preferred, but not the only, phospholipid substrate for PLD. Phosphatidylcholines 130-136 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 201-204 9601059-10 1998 Our results show that MARCKS is an essential link in the PKC-mediated activation of PtdCho-specific PLD in these cells and that the stimulation of PtdCho synthesis by PMA is a secondary response. Phosphatidylcholines 84-90 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 100-103 9516439-7 1998 In membranes of HEK-293 cells pretreated with TcdB-1470 or TcsL, basal and stable GTP analog-stimulated PLD activities measured with exogenous phosphatidylcholine, in the presence or absence of phosphatidylinositol 4,5-bisphosphate, were not altered. Phosphatidylcholines 143-162 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 104-107 9593849-4 1998 In multidrug resistant MCF-7/MDR1 cells, which highly express PKC-alpha but lack the PtdCho-specific PLD activity, 100-nM PMA had relatively small stimulatory effects on the uptake of [14C]choline (approximately 1.5-fold) and [14C]PtdCho synthesis (1.5- to 2-fold). Phosphatidylcholines 85-91 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 101-104 9575167-2 1998 The activity of bacterial phospholipase D (PLD), a Ca2+-dependent enzyme, toward phosphatidylcholine bilayers was enhanced 7-fold by incorporation of 10 mol % phosphatidic acid (PA) in the vesicle bilayer. Phosphatidylcholines 81-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 26-41 9575167-2 1998 The activity of bacterial phospholipase D (PLD), a Ca2+-dependent enzyme, toward phosphatidylcholine bilayers was enhanced 7-fold by incorporation of 10 mol % phosphatidic acid (PA) in the vesicle bilayer. Phosphatidylcholines 81-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 43-46 9559647-1 1998 The generation of lipid second messengers via phosphatidylcholine (PC)-specific phospholipase D (PLD) has emerged as an important step leading to transduction of extracellular signals. Phosphatidylcholines 46-65 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 80-95 9559647-1 1998 The generation of lipid second messengers via phosphatidylcholine (PC)-specific phospholipase D (PLD) has emerged as an important step leading to transduction of extracellular signals. Phosphatidylcholines 46-65 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 97-100 9559647-1 1998 The generation of lipid second messengers via phosphatidylcholine (PC)-specific phospholipase D (PLD) has emerged as an important step leading to transduction of extracellular signals. Phosphatidylcholines 67-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 80-95 9559647-1 1998 The generation of lipid second messengers via phosphatidylcholine (PC)-specific phospholipase D (PLD) has emerged as an important step leading to transduction of extracellular signals. Phosphatidylcholines 67-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 97-100 9593849-0 1998 Phorbol ester stimulation of phosphatidylcholine synthesis requires expression of both protein kinase C-alpha and phospholipase D. Phosphatidylcholines 29-48 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 114-129 9593849-1 1998 The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho). Phosphatidylcholines 154-173 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 109-124 9593849-1 1998 The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho). Phosphatidylcholines 154-173 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-129 9593849-1 1998 The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho). Phosphatidylcholines 175-181 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 109-124 9593849-1 1998 The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho). Phosphatidylcholines 175-181 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-129 9593849-2 1998 Here, attached and suspended NIH 3T3 fibroblasts as well as variants of the MCF-7 human breast carcinoma cell line expressing PKC-alpha and a PtdCho-specific PLD activity at widely different levels were used to determine the possible role of PKC-alpha, PtdCho hydrolysis, and choline uptake in the mediation of PMA effect on PtdCho synthesis. Phosphatidylcholines 142-148 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 158-161 9560313-1 1998 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine, generating phosphatidic acid and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9535751-2 1998 The PLD activity was measured by phosphatidylethanol produced from radiolabeled phosphatidylcholine or myristic acid in the presence of ethanol. Phosphatidylcholines 80-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-7 9580032-1 1998 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine, a major substrate, to phosphatidic acid and choline, and its activity is regulated by a variety of hormones, growth factors, and other extracellular signals in mammalian cells. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 9487144-3 1998 We examined involvement of PLD and PKC in the hydrolysis and resynthesis of PtdCho and phosphatidylethanolamine stimulated by beta-TPA, bryostatin (a non-phorbol PKC activator) and oleic acid (18:1n-9) in the four cell lines. Phosphatidylcholines 76-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 9487144-10 1998 Thus, activation of PLD hydrolysis preceding resynthesis is involved in the stimulatory effects of beta-TPA on PtdCho synthesis in some but not all of these neural derived cells. Phosphatidylcholines 111-117 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 20-23 9580032-1 1998 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine, a major substrate, to phosphatidic acid and choline, and its activity is regulated by a variety of hormones, growth factors, and other extracellular signals in mammalian cells. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9405162-1 1997 Phosphatidic acid (PA) is mainly formed by the hydrolysis of phosphatidylcholine due to the activation of phospholipase D (PLD). Phosphatidylcholines 61-80 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 106-121 9405162-1 1997 Phosphatidic acid (PA) is mainly formed by the hydrolysis of phosphatidylcholine due to the activation of phospholipase D (PLD). Phosphatidylcholines 61-80 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 123-126 9307024-1 1997 Activation of phosphatidylcholine-specific phospholipase D(PLD) occurs as part of the complex signal-transduction cascade initiated by agonist stimulation of tyrosine kinase and G-protein-coupled receptors. Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 59-62 9366248-2 1997 When stimulated by polyamines, mitochondrial PLD utilized endogenous phosphatidylethanolamine (PE) as substrate whereas stimulated by monoamines, both PE and phosphatidylcholine (PC) were hydrolysed. Phosphatidylcholines 158-177 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 45-48 9366248-2 1997 When stimulated by polyamines, mitochondrial PLD utilized endogenous phosphatidylethanolamine (PE) as substrate whereas stimulated by monoamines, both PE and phosphatidylcholine (PC) were hydrolysed. Phosphatidylcholines 179-181 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 45-48 9163343-2 1997 As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line. Phosphatidylcholines 171-190 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-141 9305796-6 1997 We next examined the effect of calyculin A on products of the phosphatidylcholine-specific phospholipase D (PLD) pathway by assaying the mass levels of phosphatidic acid (PA), choline and diacylglycerol (DAG). Phosphatidylcholines 62-81 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 91-106 9305796-6 1997 We next examined the effect of calyculin A on products of the phosphatidylcholine-specific phospholipase D (PLD) pathway by assaying the mass levels of phosphatidic acid (PA), choline and diacylglycerol (DAG). Phosphatidylcholines 62-81 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 108-111 9271075-1 1997 Phospholipase D (PLD) is responsible for the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidylcholines 59-78 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 9271075-1 1997 Phospholipase D (PLD) is responsible for the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidylcholines 59-78 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 9218127-7 1997 The sustained phase is mediated by a Ca(2+)-independent isoform of PKC, PKC-epsilon DAG for this process is generated by PLC- and PLD-mediated hydrolysis of PC. Phosphatidylcholines 157-159 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 130-133 9163343-2 1997 As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line. Phosphatidylcholines 171-190 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 143-146 9163343-2 1997 As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line. Phosphatidylcholines 192-198 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-141 9163343-2 1997 As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line. Phosphatidylcholines 192-198 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 143-146 8855796-9 1996 The increase of 3H-choline in slices" supernatant and the decrease of 3H-choline-labeled PtdCho induced by PDBu, ATP, thapsigargin, and STSP indicate that the activated PLD hydrolyzed PtdCho. Phosphatidylcholines 89-95 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 169-172 9003363-5 1996 Analysis of the fractions using exogenous phosphatidylcholine as substrate confirmed the presence of ARF1-dependent PLD activity in endomembranes and plasma membrane, and also identified an additional activity in the cytosol. Phosphatidylcholines 42-61 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 116-119 8910539-1 1996 Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC). Phosphatidylcholines 60-79 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 15-30 8910539-1 1996 Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC). Phosphatidylcholines 60-79 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 32-35 8910539-1 1996 Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC). Phosphatidylcholines 81-87 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 15-30 8910539-1 1996 Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC). Phosphatidylcholines 81-87 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 32-35 8798752-2 1996 In intact HL-60 cells, phorbol myristate acetate (PMA) activated PLD as measured by [3H]palmitate-labeled phosphatidylcholine conversion to phosphatidylethanol in the presence of 2% ethanol. Phosphatidylcholines 106-125 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 65-68 8855796-9 1996 The increase of 3H-choline in slices" supernatant and the decrease of 3H-choline-labeled PtdCho induced by PDBu, ATP, thapsigargin, and STSP indicate that the activated PLD hydrolyzed PtdCho. Phosphatidylcholines 184-190 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 169-172 8856074-7 1996 In membranes of toxin-B-treated cells, basal and GTP[S]-stimulated PLD activities were reduced, when measured with exogenous phosphatidylcholine as enzyme substrate. Phosphatidylcholines 125-144 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-70 8856074-8 1996 Inclusion of PtdIns(4,5)P2 with phosphatidylcholine in the substrate vesicles or addition of PtdIns(4,5)P2 fully restored basal and GTP[S]-stimulated PLD activities in membranes of toxin-B-treated cells. Phosphatidylcholines 32-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 150-153 8906581-5 1996 12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells. Phosphatidylcholines 102-121 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-82 8906581-5 1996 12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells. Phosphatidylcholines 102-121 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 84-87 8906581-5 1996 12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells. Phosphatidylcholines 123-129 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-82 8906581-5 1996 12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells. Phosphatidylcholines 123-129 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 84-87 8770926-0 1996 Insulin stimulates phospholipase D-dependent phosphatidylcholine hydrolysis, Rho translocation, de novo phospholipid synthesis, and diacylglycerol/protein kinase C signaling in L6 myotubes. Phosphatidylcholines 45-64 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 19-34 8770926-4 1996 We found that insulin provoked rapid increases in phospholipase D (PLD)-dependent hydrolysis of PC, as evidenced by increases in choline release and phosphatidylethanol production in cells incubated in the presence of ethanol. Phosphatidylcholines 96-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 50-65 8770926-4 1996 We found that insulin provoked rapid increases in phospholipase D (PLD)-dependent hydrolysis of PC, as evidenced by increases in choline release and phosphatidylethanol production in cells incubated in the presence of ethanol. Phosphatidylcholines 96-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-70 8805276-1 1996 BACKGROUND: Agonist-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating the putative messenger phosphatidate (PA). Phosphatidylcholines 81-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-46 8681425-2 1996 Phosphatidylcholine is the major substrate for PLD. Phosphatidylcholines 0-19 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 47-50 8681431-3 1996 A phosphatidylcholine-specific PLD activity was recently purified from pig lung, but its possible regulation by PKC has not been reported yet. Phosphatidylcholines 2-21 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 8805276-1 1996 BACKGROUND: Agonist-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine, generating the putative messenger phosphatidate (PA). Phosphatidylcholines 81-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 48-51 8633059-1 1996 Bovine kidney phospholipase D (PLD) was assayed by measuring the formation of phosphatidylethanol from added radioactive phosphatidylcholine (PtdCho) in the presence of ethanol, guanosine 5"-[gamma-thio]triphosphate, ammonium sulfate, and cytosol factor that contained small GTP-binding regulatory proteins. Phosphatidylcholines 121-140 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-29 8633059-1 1996 Bovine kidney phospholipase D (PLD) was assayed by measuring the formation of phosphatidylethanol from added radioactive phosphatidylcholine (PtdCho) in the presence of ethanol, guanosine 5"-[gamma-thio]triphosphate, ammonium sulfate, and cytosol factor that contained small GTP-binding regulatory proteins. Phosphatidylcholines 121-140 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 8633059-1 1996 Bovine kidney phospholipase D (PLD) was assayed by measuring the formation of phosphatidylethanol from added radioactive phosphatidylcholine (PtdCho) in the presence of ethanol, guanosine 5"-[gamma-thio]triphosphate, ammonium sulfate, and cytosol factor that contained small GTP-binding regulatory proteins. Phosphatidylcholines 142-148 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-29 8633059-1 1996 Bovine kidney phospholipase D (PLD) was assayed by measuring the formation of phosphatidylethanol from added radioactive phosphatidylcholine (PtdCho) in the presence of ethanol, guanosine 5"-[gamma-thio]triphosphate, ammonium sulfate, and cytosol factor that contained small GTP-binding regulatory proteins. Phosphatidylcholines 142-148 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 8633059-3 1996 This PLD preferentially used PtdCho as substrate. Phosphatidylcholines 29-35 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 5-8 8633059-8 1996 The results suggest that mammalian PLD reacts nearly selectively with PtdCho in the form of mixed micelles or membranes with other phospholipids, especially PtdEtn. Phosphatidylcholines 70-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 35-38 8699936-4 1996 Phosphatidic acid, a phospholipase D (PLD) -mediated product of membrane phosphatidylcholine is decreased in response to FMLP. Phosphatidylcholines 73-92 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 21-36 8699936-4 1996 Phosphatidic acid, a phospholipase D (PLD) -mediated product of membrane phosphatidylcholine is decreased in response to FMLP. Phosphatidylcholines 73-92 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 38-41 8618893-2 1995 When assayed by measuring the phosphatidyl transfer reaction to ethanol with exogenously added radioactive phosphatidylcholine as substrate, the PLD required a high concentration (1.6 M) of ammonium sulfate to exhibit high enzymatic activity. Phosphatidylcholines 107-126 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 145-148 7583579-3 1995 In [14C]lyso-PC-labeled or [14C]choline (Cho)-labeled cells, a biphasic activation of PC-specific phospholipase D (PLD) with peak maxima 30 to 60 seconds and 5 to 7 minutes after stimulation with 20 micrograms/mL HDL3 was shown by (1) a 1.5- to 3-fold increase in Cho release, and (3) transphosphatidylation of PC to phosphatidylbutanol in the presence of 0.3% butanol. Phosphatidylcholines 13-15 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 115-118 8530346-1 1995 Activation of phosphatidylcholine-specific phospholipase D (PLD) has been implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 43-58 8530346-1 1995 Activation of phosphatidylcholine-specific phospholipase D (PLD) has been implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. Phosphatidylcholines 14-33 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 60-63 7758577-2 1995 Comparison with phospholipid compositions confirmed that PLD acted primarily on phosphatidylcholine (PtdCho). Phosphatidylcholines 80-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 8564710-3 1995 Appropriate conditions were developed to test the PLD transphosphatidylation activity against exogenous phosphatidylcholine (PCho) in an in vitro system. Phosphatidylcholines 104-123 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 50-53 8564710-3 1995 Appropriate conditions were developed to test the PLD transphosphatidylation activity against exogenous phosphatidylcholine (PCho) in an in vitro system. Phosphatidylcholines 125-129 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 50-53 7672124-1 1995 The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types. Phosphatidylcholines 193-212 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-141 7672124-1 1995 The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types. Phosphatidylcholines 193-212 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 143-146 7672124-1 1995 The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types. Phosphatidylcholines 214-220 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-141 7672124-1 1995 The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types. Phosphatidylcholines 214-220 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 143-146 8640350-0 1995 Mastoparan-induced phosphatidylcholine hydrolysis by phospholipase D activation in human astrocytoma cells. Phosphatidylcholines 19-38 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-68 8640350-17 1995 These results suggest that mastoparan induces phosphatidylcholine (PC) hydrolysis by activation of PLD, not by activation of phosphatidylcholine-specific phospholipase C (PC-PLC); mastoparan-induced PLD activation is not mediated by G proteins. Phosphatidylcholines 46-65 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 99-102 8640350-17 1995 These results suggest that mastoparan induces phosphatidylcholine (PC) hydrolysis by activation of PLD, not by activation of phosphatidylcholine-specific phospholipase C (PC-PLC); mastoparan-induced PLD activation is not mediated by G proteins. Phosphatidylcholines 67-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 99-102 7758577-2 1995 Comparison with phospholipid compositions confirmed that PLD acted primarily on phosphatidylcholine (PtdCho). Phosphatidylcholines 101-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 7721742-3 1995 GTP gamma S-stimulated PLD activity was detected in the membranes when exogenous labeled phosphatidylcholine was used in the presence of phosphatidylethanolamine and phosphatidylinositol 4,5-bisphosphate, but not when [3H]myristic acid-labeled endogenous substrate was used. Phosphatidylcholines 89-108 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 23-26 7945188-1 1994 The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) were examined in drug-sensitive and multidrug-resistant lines of MCF-7 human breast carcinoma cells. Phosphatidylcholines 138-157 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-19 7998998-1 1994 Bradykinin activates adenylate cyclase via a pathway that involves the "up-stream" regulation of phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine and activation of protein kinase C (PKC) in airway smooth muscle [Stevens, Pyne, Grady and Pyne (1994) Biochem. Phosphatidylcholines 143-162 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 97-112 7998998-1 1994 Bradykinin activates adenylate cyclase via a pathway that involves the "up-stream" regulation of phospholipase D (PLD)-catalysed hydrolysis of phosphatidylcholine and activation of protein kinase C (PKC) in airway smooth muscle [Stevens, Pyne, Grady and Pyne (1994) Biochem. Phosphatidylcholines 143-162 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 114-117 7944397-4 1994 Of the two major substrates of PLD, phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), vitamin K3 (10-100 microM) preferentially inhibited PtdEtn hydrolysis when stimulated by PMA or platelet-derived growth factor, the latter being a hormonal activator of PKC. Phosphatidylcholines 36-55 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 7944397-4 1994 Of the two major substrates of PLD, phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), vitamin K3 (10-100 microM) preferentially inhibited PtdEtn hydrolysis when stimulated by PMA or platelet-derived growth factor, the latter being a hormonal activator of PKC. Phosphatidylcholines 57-63 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 7945188-1 1994 The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) were examined in drug-sensitive and multidrug-resistant lines of MCF-7 human breast carcinoma cells. Phosphatidylcholines 138-157 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 21-24 7945188-1 1994 The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) were examined in drug-sensitive and multidrug-resistant lines of MCF-7 human breast carcinoma cells. Phosphatidylcholines 159-165 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-19 7945188-1 1994 The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) were examined in drug-sensitive and multidrug-resistant lines of MCF-7 human breast carcinoma cells. Phosphatidylcholines 159-165 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 21-24 7945188-4 1994 The PLD activators sphingosine and H2O2 were found to elicit only a slight (1.28-1.4-fold) stimulatory effect on PtdCho hydrolysis in both the MCF-7/WT and MCF-7/MDR cell types, and had only a small effect on PtdEtn hydrolysis in the MCF-7/WT cells as well. Phosphatidylcholines 113-119 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-7 8176221-6 1994 BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells. Phosphatidylcholines 52-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 20-35 7935319-1 1994 Activation of the M3 muscarinic receptor in 1321N1 human astrocytoma cells leads to increased phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine, which is maximal within 1 min of exposure to agonist. Phosphatidylcholines 140-159 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 94-109 7935319-1 1994 Activation of the M3 muscarinic receptor in 1321N1 human astrocytoma cells leads to increased phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine, which is maximal within 1 min of exposure to agonist. Phosphatidylcholines 140-159 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 111-114 8207217-3 1994 These compounds also inhibited phospholipase D (PLD)-catalyzed breakdown of phosphatidyl choline, suggesting a possible link between tyrosine kinase and PLD. Phosphatidylcholines 76-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-46 8207217-3 1994 These compounds also inhibited phospholipase D (PLD)-catalyzed breakdown of phosphatidyl choline, suggesting a possible link between tyrosine kinase and PLD. Phosphatidylcholines 76-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 48-51 8207217-3 1994 These compounds also inhibited phospholipase D (PLD)-catalyzed breakdown of phosphatidyl choline, suggesting a possible link between tyrosine kinase and PLD. Phosphatidylcholines 76-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 153-156 8039770-7 1994 In this paper, involvement of G proteins in the regulation of phospholipase A2 and phosphatidylcholine-specific PLC and PLD is also discussed. Phosphatidylcholines 83-102 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 120-123 8176221-6 1994 BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells. Phosphatidylcholines 52-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-40 8176221-6 1994 BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells. Phosphatidylcholines 73-75 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 20-35 8176221-6 1994 BK also activated a phospholipase D (PLD) to cleave phosphatidylcholine (PC), because it caused an increase in phosphatidic acid (PA) content and a sustained DAG formation, which both were inhibited by ethanol in [3H]myristic acid-labeled cells. Phosphatidylcholines 73-75 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 37-40 8185671-2 1994 In NIH 3T3 fibroblasts, sphingosine has also been shown to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (Kiss Z and Anderson WB, J Biol Chem 265: 7345-7350, 1990). Phosphatidylcholines 119-138 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 69-84 8185671-2 1994 In NIH 3T3 fibroblasts, sphingosine has also been shown to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (Kiss Z and Anderson WB, J Biol Chem 265: 7345-7350, 1990). Phosphatidylcholines 119-138 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 86-89 8185671-2 1994 In NIH 3T3 fibroblasts, sphingosine has also been shown to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (Kiss Z and Anderson WB, J Biol Chem 265: 7345-7350, 1990). Phosphatidylcholines 140-146 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 69-84 8185671-2 1994 In NIH 3T3 fibroblasts, sphingosine has also been shown to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (Kiss Z and Anderson WB, J Biol Chem 265: 7345-7350, 1990). Phosphatidylcholines 140-146 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 86-89 8053546-9 1994 These results show that a fluorescent assay can be used to rapidly assess the activity of PLD and other phosphatidylcholine-utilizing phospholipases in cell and tissue extracts. Phosphatidylcholines 104-123 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 90-93 8053546-2 1994 A rapid assay for agonist-activated PLD activity in cell extracts was developed, utilizing a fluorescent derivative of phosphatidylcholine as substrate. Phosphatidylcholines 119-138 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 36-39 8261513-1 1993 The hydrolysis of phosphatidylcholine by phospholipase D (PLD) results in the production of phosphatidic acid and choline. Phosphatidylcholines 18-37 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 41-56 8261513-1 1993 The hydrolysis of phosphatidylcholine by phospholipase D (PLD) results in the production of phosphatidic acid and choline. Phosphatidylcholines 18-37 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 58-61 8392931-4 1993 In the presence of an alcohol, PLD converts phosphatidylcholine (PC) into a phosphatidylalcohol (by transphosphatidylation) rather than into PA. Phosphatidylcholines 44-63 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 8268464-0 1993 Phospholipase D-mediated hydrolysis of phosphatidylcholine: role in cell signalling. Phosphatidylcholines 39-58 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 8268464-2 1993 The signal-dependent formation of phosphatidic acid (PA), by PLD-catalyzed hydrolysis of phosphatidylcholine (PC), may represent a novel and ubiquitous signal transduction pathway in mammalian cells. Phosphatidylcholines 89-108 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 61-64 8268464-2 1993 The signal-dependent formation of phosphatidic acid (PA), by PLD-catalyzed hydrolysis of phosphatidylcholine (PC), may represent a novel and ubiquitous signal transduction pathway in mammalian cells. Phosphatidylcholines 110-112 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 61-64 8263781-6 1993 Conversely, propranolol and p-chloromercuribenzoic acid (pCMB), which inhibit a phosphatidylcholine-specific phospholipase D (PLD)-dependent pathway, reduced contraction of esophageal but not of LES muscle cells. Phosphatidylcholines 80-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 109-124 8263781-6 1993 Conversely, propranolol and p-chloromercuribenzoic acid (pCMB), which inhibit a phosphatidylcholine-specific phospholipase D (PLD)-dependent pathway, reduced contraction of esophageal but not of LES muscle cells. Phosphatidylcholines 80-99 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-129 8263781-9 1993 It was concluded that ACh-induced esophageal contraction depends preferentially on M2 receptors, a PTX-sensitive G13 protein, phosphatidylcholine-specific PLD and production of diacylglycerol (DAG) and is independent of IP3 formation and the release of intracellular Ca++. Phosphatidylcholines 126-145 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 155-158 8392931-4 1993 In the presence of an alcohol, PLD converts phosphatidylcholine (PC) into a phosphatidylalcohol (by transphosphatidylation) rather than into PA. Phosphatidylcholines 65-67 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 8392931-5 1993 We found in bradykinin-stimulated human fibroblasts that PLD mediates transphosphatidylation from PC (donor) to the endogenous "alcohol" DG (acceptor), yielding bis(1,2-diacylglycero)-3-sn-phosphate (bisphosphatidic acid; bisPA). Phosphatidylcholines 98-100 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 8383432-9 1993 generation is associated with marked inhibition of phospholipase D (PLD) activity, with limited hydrolysis of phosphatidylcholine and formation of phosphatidic acid. Phosphatidylcholines 110-129 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 68-71 8504157-8 1993 The PA synthesis caused by the two stimulators was similarly inhibited by staurosporine and by a chronic treatment with PMA (100 nM for 24 h), suggesting that the activation of PLD is linked to the action of protein kinase C. With the cells labeled with radioactive choline and ethanolamine, we found that the amniotic PLD hydrolyzed almost equally phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 349-368 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 177-180 8503884-3 1993 Our experiments suggest that phospholipase D (PLD)-mediated phosphatidylcholine (PtdCho) hydrolysis is the major source of both DG and PtdOH during the late signalling phase. Phosphatidylcholines 60-79 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-44 8503884-3 1993 Our experiments suggest that phospholipase D (PLD)-mediated phosphatidylcholine (PtdCho) hydrolysis is the major source of both DG and PtdOH during the late signalling phase. Phosphatidylcholines 60-79 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 8503884-3 1993 Our experiments suggest that phospholipase D (PLD)-mediated phosphatidylcholine (PtdCho) hydrolysis is the major source of both DG and PtdOH during the late signalling phase. Phosphatidylcholines 81-87 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-44 8503884-3 1993 Our experiments suggest that phospholipase D (PLD)-mediated phosphatidylcholine (PtdCho) hydrolysis is the major source of both DG and PtdOH during the late signalling phase. Phosphatidylcholines 81-87 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 8503884-10 1993 Thus, in angiotensin II-stimulated cultured vascular smooth-muscle cells, PLD-mediated PtdCho hydrolysis is the major source of sustained DG and PtdOH, whereas phosphoinositide breakdown is a minor contributor. Phosphatidylcholines 87-93 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 74-77 8380986-5 1993 PtdCho-specific phospholipase D (PLD) activation was documented by the accumulation of [3H]phosphatidylethanol in cells prelabelled with [3H]myristic acid and stimulated in the presence of 1% (v/v) ethanol; this metabolic pathway, however, proved to be a minor one leading to generation of phosphatidic acid (PtdOH) during cell stimulation, whereas DG production by the sequential action of PtdCho-specific PLD and PtdOH phosphohydrolase was not observed. Phosphatidylcholines 0-6 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 16-31 8380986-5 1993 PtdCho-specific phospholipase D (PLD) activation was documented by the accumulation of [3H]phosphatidylethanol in cells prelabelled with [3H]myristic acid and stimulated in the presence of 1% (v/v) ethanol; this metabolic pathway, however, proved to be a minor one leading to generation of phosphatidic acid (PtdOH) during cell stimulation, whereas DG production by the sequential action of PtdCho-specific PLD and PtdOH phosphohydrolase was not observed. Phosphatidylcholines 0-6 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 33-36 8380986-5 1993 PtdCho-specific phospholipase D (PLD) activation was documented by the accumulation of [3H]phosphatidylethanol in cells prelabelled with [3H]myristic acid and stimulated in the presence of 1% (v/v) ethanol; this metabolic pathway, however, proved to be a minor one leading to generation of phosphatidic acid (PtdOH) during cell stimulation, whereas DG production by the sequential action of PtdCho-specific PLD and PtdOH phosphohydrolase was not observed. Phosphatidylcholines 0-6 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 407-410 1431912-2 1992 Because various G protein-coupled receptors stimulate the hydrolysis of phosphatidylcholine by phospholipase D (PLD), we examined the possibility that metabotropic EAA receptors exist that are coupled to the activation of PLD. Phosphatidylcholines 72-91 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 95-110 1472000-1 1992 Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss & Anderson (1990) J. Biol. Phosphatidylcholines 172-191 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 84-99 1472000-1 1992 Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss & Anderson (1990) J. Biol. Phosphatidylcholines 172-191 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 101-104 1472000-1 1992 Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss & Anderson (1990) J. Biol. Phosphatidylcholines 193-199 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 84-99 1472000-1 1992 Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss & Anderson (1990) J. Biol. Phosphatidylcholines 193-199 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 101-104 1431912-2 1992 Because various G protein-coupled receptors stimulate the hydrolysis of phosphatidylcholine by phospholipase D (PLD), we examined the possibility that metabotropic EAA receptors exist that are coupled to the activation of PLD. Phosphatidylcholines 72-91 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 112-115 1446736-3 1992 Results have shown a combined modulation of PIP2-specific phospholipase C and phospholipase D. In particular, a decreased activity of PIP2-specific PLC has been found, concomitant to a PLD-mediated phosphatidylcholine hydrolysis, suggesting that the intracellular signalling activated by interferon in Daudi cells involves a phospholipase D/phosphohydrolase pathway. Phosphatidylcholines 198-217 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 185-188 1417792-0 1992 Human neutrophil phospholipase D activation by N-formylmethionyl-leucylphenylalanine reveals a two-step process for the control of phosphatidylcholine breakdown and oxidative burst. Phosphatidylcholines 131-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-32 1623116-7 1992 The data clearly indicate that LPS stimulates phosphatidylcholine breakdown, implying that the liberation of phosphatidic acid or diacylglycerol via PLC/PLD reaction may be relevant to the initiation of LPS-induced monocytic activation. Phosphatidylcholines 46-65 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 153-156 1323272-7 1992 Vasopressin stimulated an increase in formation of choline, but not of phosphocholine, suggesting that PLD was the major catalytic route of PtdCho hydrolysis in this cell line. Phosphatidylcholines 140-146 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 103-106 1543719-5 1992 This change in Cdl was sensitive enough to monitor the course of enzymatic hydrolysis of the PC monolayer by PLD. Phosphatidylcholines 93-95 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 109-112 1727727-1 1992 Our recent studies have demonstrated the presence in neonatal islet cells and intact adult islets of a phosphatidylcholine-directed phospholipase D (PLD) which is activated after phorbol ester stimulation. Phosphatidylcholines 103-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 132-147 1727727-1 1992 Our recent studies have demonstrated the presence in neonatal islet cells and intact adult islets of a phosphatidylcholine-directed phospholipase D (PLD) which is activated after phorbol ester stimulation. Phosphatidylcholines 103-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 149-152 1727727-8 1992 These findings demonstrate for the first time that a physiological nutrient activates a phospholipase directed against endogenous phosphatidylcholine in intact islet cells; furthermore, they indicate a role for PLD in a delayed formation of phosphatidic acid in the islet cell. Phosphatidylcholines 130-149 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 211-214 1659906-1 1991 Recent evidence suggests that the hydrolysis of phosphatidylcholine (PC) by phospholipase D (PLD) may mediate superoxide anion (O2-) production in human neutrophils. Phosphatidylcholines 48-67 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-91 1659906-7 1991 These data are consistent with the hypothesis that PA produced through the hydrolysis of PC by PLD is an important mediator of O2- production in response to receptor-dependent agonists. Phosphatidylcholines 89-91 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 95-98 1659906-1 1991 Recent evidence suggests that the hydrolysis of phosphatidylcholine (PC) by phospholipase D (PLD) may mediate superoxide anion (O2-) production in human neutrophils. Phosphatidylcholines 48-67 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 1659906-1 1991 Recent evidence suggests that the hydrolysis of phosphatidylcholine (PC) by phospholipase D (PLD) may mediate superoxide anion (O2-) production in human neutrophils. Phosphatidylcholines 69-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-91 1659906-1 1991 Recent evidence suggests that the hydrolysis of phosphatidylcholine (PC) by phospholipase D (PLD) may mediate superoxide anion (O2-) production in human neutrophils. Phosphatidylcholines 69-71 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 1659382-4 1991 PDGF-stimulated phosphatidylcholine (PtdCho) hydrolysis in Swiss 3T3 fibroblasts, as measured by the formation of water-soluble choline metabolites and phosphatidylbutanol (PtdBut) accumulation, was by a phospholipase D (PLD)-catalysed pathway which was kinetically downstream of initial PtdIns(4,5)P2 hydrolysis. Phosphatidylcholines 37-43 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 204-219 1659382-4 1991 PDGF-stimulated phosphatidylcholine (PtdCho) hydrolysis in Swiss 3T3 fibroblasts, as measured by the formation of water-soluble choline metabolites and phosphatidylbutanol (PtdBut) accumulation, was by a phospholipase D (PLD)-catalysed pathway which was kinetically downstream of initial PtdIns(4,5)P2 hydrolysis. Phosphatidylcholines 37-43 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 221-224 1659382-8 1991 Down-regulation of protein kinase C (PKC), by pre-treatment with phorbol 12-myristate 13-acetate, abolished both [3H]choline and [3H]PtdBut formation, suggesting that PLD-catalysed PtdCho hydrolysis may be dependent on PKC activation, supporting its dependence on prior PtdIns(4,5)P2 hydrolysis. Phosphatidylcholines 181-187 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 167-170 2037586-6 1991 Stimulation with BK resulted in the rapid and synchronous formation of [3H]choline and [3H]myristoyl-PA from the correspondingly prelabeled PC, indicative of phospholipase D (PLD) activity. Phosphatidylcholines 140-142 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 158-173 1665301-0 1991 Granulocyte-macrophage colony-stimulating factor (GM-CSF) primes human neutrophils for enhanced phosphatidylcholine breakdown by phospholipase D. Phosphatidylcholines 96-115 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 129-144 1665301-4 1991 The data indicate GM-CSF up-regulates phosphatidylcholine hydrolysis by a PLD by interfering with the excitation-response coupling sequence at a site distal to the fMLP receptor. Phosphatidylcholines 38-57 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 74-77 1654804-0 1991 Sequential degradation of choline phosphoglycerides by phospholipase D and phosphatidate phosphohydrolase in dibutyryl cAMP-differentiated U937 cells. Phosphatidylcholines 26-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 55-70 2201747-9 1990 The formation of PEt associated with a concomitant decrease in PdtOH directly demonstrated that the mechanism by which GM-CSF enhances PdtOH production is activation of a PLD active on phosphatidylcholine. Phosphatidylcholines 185-204 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 171-174 1829383-0 1991 Assessment of receptor-dependent activation of phosphatidylcholine hydrolysis by both phospholipase D and phospholipase C. Enhancement of cellular phospholipase D (PLD)-1 and phospholipase C (PLC)-mediated hydrolysis of endogenous phosphatidylcholine (PC) during receptor-mediated cell activation has received increasing attention inasmuch as both enzymes can result in the formation of 1,2-diacylglycerol (DAG). Phosphatidylcholines 47-66 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 86-101 1997787-4 1991 Depending on the system, activation of PLD has been suggested to be either dependent on, or independent of, Ca2+ and protein kinase C. PLD primarily hydrolyses phosphatidylcholine (PC) but phosphatidylinositol and phosphatidylethanolamine have also been reported as substrates. Phosphatidylcholines 160-179 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 39-42 1997787-4 1991 Depending on the system, activation of PLD has been suggested to be either dependent on, or independent of, Ca2+ and protein kinase C. PLD primarily hydrolyses phosphatidylcholine (PC) but phosphatidylinositol and phosphatidylethanolamine have also been reported as substrates. Phosphatidylcholines 160-179 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 135-138 1997787-4 1991 Depending on the system, activation of PLD has been suggested to be either dependent on, or independent of, Ca2+ and protein kinase C. PLD primarily hydrolyses phosphatidylcholine (PC) but phosphatidylinositol and phosphatidylethanolamine have also been reported as substrates. Phosphatidylcholines 181-183 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 39-42 1997787-4 1991 Depending on the system, activation of PLD has been suggested to be either dependent on, or independent of, Ca2+ and protein kinase C. PLD primarily hydrolyses phosphatidylcholine (PC) but phosphatidylinositol and phosphatidylethanolamine have also been reported as substrates. Phosphatidylcholines 181-183 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 135-138 2753160-4 1989 These results indicate the presence of a phospholipase D (PLD) acting on phosphatidylcholine in human PMN. Phosphatidylcholines 73-92 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 41-56 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidylcholines 84-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidylcholines 84-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidylcholines 105-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 35134390-1 2022 Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Phosphatidylcholines 105-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 35450377-1 2022 Phospholipase D (PLD) is a phospholipase enzyme responsible for hydrolyzing phosphatidylcholine into the lipid signaling molecule, phosphatidic acid, and choline. Phosphatidylcholines 76-95 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 35450377-1 2022 Phospholipase D (PLD) is a phospholipase enzyme responsible for hydrolyzing phosphatidylcholine into the lipid signaling molecule, phosphatidic acid, and choline. Phosphatidylcholines 76-95 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 2793844-0 1989 Phosphatidylcholine hydrolysis by phospholipase D determines phosphatidate and diglyceride levels in chemotactic peptide-stimulated human neutrophils. Phosphatidylcholines 0-19 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 34-49 2753160-4 1989 These results indicate the presence of a phospholipase D (PLD) acting on phosphatidylcholine in human PMN. Phosphatidylcholines 73-92 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 58-61 32800947-5 2020 Phospholipase D (PLD) isoforms PLD1/2 catalyze the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA), regulating tumor progression and metastasis. Phosphatidylcholines 65-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 33740632-5 2021 Using the HMSC-NH2-PLD, a high-efficient method for the conversion of phosphatidylserine (PS) from phosphatidylcholine (PC) and L-serine was proposed. Phosphatidylcholines 99-118 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-22 33740632-5 2021 Using the HMSC-NH2-PLD, a high-efficient method for the conversion of phosphatidylserine (PS) from phosphatidylcholine (PC) and L-serine was proposed. Phosphatidylcholines 120-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-22 32800947-5 2020 Phospholipase D (PLD) isoforms PLD1/2 catalyze the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA), regulating tumor progression and metastasis. Phosphatidylcholines 65-84 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 30625315-4 2019 Phospholipase D (PLD) cleaves phosphatidylcholine to choline and phosphatidic acid (PA), with PA assumed to mediate all downstream signaling. Phosphatidylcholines 30-49 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 32121031-2 2020 To perform the assay, an aliquot of a PLD standard solution is typically added to borate buffer containing phosphatidylcholine at a certain concentration and the oxidation current of hydrogen peroxide is then measured at the rotating modified electrode by applying a detection potential of + 0.7 V vs. SCE. Phosphatidylcholines 107-126 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 38-41 32661773-4 2020 Phospholipase D (PLD), an enzyme that hydrolyzes phosphatidylcholine to yield phosphatidic acid, regulates several cellular functions as proliferation, survival, migration or vesicular trafficking. Phosphatidylcholines 49-68 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 32661773-4 2020 Phospholipase D (PLD), an enzyme that hydrolyzes phosphatidylcholine to yield phosphatidic acid, regulates several cellular functions as proliferation, survival, migration or vesicular trafficking. Phosphatidylcholines 49-68 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 31541319-3 2020 One such important enzyme is phospholipase D (PLD), which cleaves phosphatidylcholine to yield phosphatidic acid and choline. Phosphatidylcholines 66-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-44 31541319-3 2020 One such important enzyme is phospholipase D (PLD), which cleaves phosphatidylcholine to yield phosphatidic acid and choline. Phosphatidylcholines 66-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 31311871-6 2019 Our method capitalizes on the remarkable discovery that bulky, hydrophilic trans-cyclooctene-containing primary alcohols can supplant water as the nucleophile in the PLD active site in a transphosphatidylation reaction of PLD"s lipid substrate, phosphatidylcholine. Phosphatidylcholines 245-264 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 166-169 31311871-6 2019 Our method capitalizes on the remarkable discovery that bulky, hydrophilic trans-cyclooctene-containing primary alcohols can supplant water as the nucleophile in the PLD active site in a transphosphatidylation reaction of PLD"s lipid substrate, phosphatidylcholine. Phosphatidylcholines 245-264 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 222-225 30877512-2 2019 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 30877512-2 2019 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 30320913-1 2019 Mammalian phospholipase D (PLD) mostly hydrolyzes phosphatidylcholine producing phosphatidic acid. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 30299003-1 2019 The synthesis of nonnatural phospholipid, phosphatidylhydroxybutyrate (PB), was firstly introduced by phospholipase D (PLD)-mediated transphosphatidylation of phosphatidylcholine (PC) with sodium gamma-hydroxybutyrate (NaGHB) in the aqueous-solid system. Phosphatidylcholines 159-178 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 30299003-1 2019 The synthesis of nonnatural phospholipid, phosphatidylhydroxybutyrate (PB), was firstly introduced by phospholipase D (PLD)-mediated transphosphatidylation of phosphatidylcholine (PC) with sodium gamma-hydroxybutyrate (NaGHB) in the aqueous-solid system. Phosphatidylcholines 159-178 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 30299003-1 2019 The synthesis of nonnatural phospholipid, phosphatidylhydroxybutyrate (PB), was firstly introduced by phospholipase D (PLD)-mediated transphosphatidylation of phosphatidylcholine (PC) with sodium gamma-hydroxybutyrate (NaGHB) in the aqueous-solid system. Phosphatidylcholines 180-182 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 30299003-1 2019 The synthesis of nonnatural phospholipid, phosphatidylhydroxybutyrate (PB), was firstly introduced by phospholipase D (PLD)-mediated transphosphatidylation of phosphatidylcholine (PC) with sodium gamma-hydroxybutyrate (NaGHB) in the aqueous-solid system. Phosphatidylcholines 180-182 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 30455469-4 2019 Genetic and in vitro characterization of the PLD from Escherichia coli MS 200-1 showed this enzyme is essential for bacterial hydrolysis of PC and prefers this substrate. Phosphatidylcholines 140-142 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 45-48 30369483-1 2018 Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions. Phosphatidylcholines 0-19 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 34-49 30369483-1 2018 Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions. Phosphatidylcholines 0-19 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 51-54 30369483-1 2018 Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions. Phosphatidylcholines 21-23 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 34-49 30369483-1 2018 Phosphatidylcholine (PC)-specific phospholipase D (PLD) hydrolyzes the phosphodiester bond of the PC to generate phosphatidic acid (PA) and regulates several subcellular functions. Phosphatidylcholines 21-23 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 51-54 30103144-1 2018 Phosphatidylethanol (PEth) is an alcohol biomarker formed from phosphatidylcholine (PC) by the enzyme phospholipase D (PLD) in the presence of ethanol. Phosphatidylcholines 63-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 30103144-1 2018 Phosphatidylethanol (PEth) is an alcohol biomarker formed from phosphatidylcholine (PC) by the enzyme phospholipase D (PLD) in the presence of ethanol. Phosphatidylcholines 63-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 30625315-4 2019 Phospholipase D (PLD) cleaves phosphatidylcholine to choline and phosphatidic acid (PA), with PA assumed to mediate all downstream signaling. Phosphatidylcholines 30-49 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 29894783-4 2018 The immobilized PLD showed high activity and stability in catalyzing the conversion of phosphatidylcholine (PC) to phosphatidylserine (PS). Phosphatidylcholines 87-106 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 16-19 29894783-4 2018 The immobilized PLD showed high activity and stability in catalyzing the conversion of phosphatidylcholine (PC) to phosphatidylserine (PS). Phosphatidylcholines 108-110 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 16-19 29560412-2 2018 Abnormally elevated levels of PLD activity are well-established in Alzheimer"s disease (AD), implicating the two isoforms of mammalian phosphatidylcholine cleaving PLD (PC-PLD1 and PC-PLD2). Phosphatidylcholines 135-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 30-33 30159399-2 2018 The enzymes phospholipase C and D (PLC and PLD) both cleave the phosphorus-oxygen bonds of phosphate esters in phosphatidylcholine (PC) lipids. Phosphatidylcholines 111-130 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 43-46 30159399-2 2018 The enzymes phospholipase C and D (PLC and PLD) both cleave the phosphorus-oxygen bonds of phosphate esters in phosphatidylcholine (PC) lipids. Phosphatidylcholines 132-134 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 43-46 30159399-4 2018 While PLC converts PC to diacylglycerol (DAG), the interaction of PC with PLD produces phosphatidic acid (PA). Phosphatidylcholines 66-68 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 74-77 30159399-11 2018 Conversely, PLD-treated PC liposomes remain stable up to extremely high conversions to PA. Phosphatidylcholines 24-26 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 12-15 29032301-5 2018 Here, we succeeded in obtaining asymmetric vesicles by means of transphosphatidylation reactions with phospholipase D (PLD), which acts exclusively on phosphatidylcholine (PC) present in the outer leaflet of vesicles. Phosphatidylcholines 151-170 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 29032301-5 2018 Here, we succeeded in obtaining asymmetric vesicles by means of transphosphatidylation reactions with phospholipase D (PLD), which acts exclusively on phosphatidylcholine (PC) present in the outer leaflet of vesicles. Phosphatidylcholines 151-170 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 29032301-5 2018 Here, we succeeded in obtaining asymmetric vesicles by means of transphosphatidylation reactions with phospholipase D (PLD), which acts exclusively on phosphatidylcholine (PC) present in the outer leaflet of vesicles. Phosphatidylcholines 172-174 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 29032301-5 2018 Here, we succeeded in obtaining asymmetric vesicles by means of transphosphatidylation reactions with phospholipase D (PLD), which acts exclusively on phosphatidylcholine (PC) present in the outer leaflet of vesicles. Phosphatidylcholines 172-174 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 29560412-2 2018 Abnormally elevated levels of PLD activity are well-established in Alzheimer"s disease (AD), implicating the two isoforms of mammalian phosphatidylcholine cleaving PLD (PC-PLD1 and PC-PLD2). Phosphatidylcholines 135-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 164-167 29560412-2 2018 Abnormally elevated levels of PLD activity are well-established in Alzheimer"s disease (AD), implicating the two isoforms of mammalian phosphatidylcholine cleaving PLD (PC-PLD1 and PC-PLD2). Phosphatidylcholines 135-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 181-188 30109649-3 2018 However, most PLD assays developed so far are either discontinuous or based on the indirect determination of choline released upon phosphatidylcholine (PC) hydrolysis. Phosphatidylcholines 131-150 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-17 30109649-3 2018 However, most PLD assays developed so far are either discontinuous or based on the indirect determination of choline released upon phosphatidylcholine (PC) hydrolysis. Phosphatidylcholines 152-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 14-17 30109649-5 2018 This assay exhibits a strong fluorescence signal upon Ca2+ complexation with the PLD-generated PA and is not limited to PC as the substrate but allows the use of natural phospholipids with various headgroups. Phosphatidylcholines 120-122 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 81-84 28780751-1 2018 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA) which in some cell types play a pivotal role in agonist-induced increase in NADPH oxidase-derived [Formula: see text]production. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 28780751-1 2018 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA) which in some cell types play a pivotal role in agonist-induced increase in NADPH oxidase-derived [Formula: see text]production. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 27009527-1 2016 The purpose of this study was to improve the efficiency of enzymatic synthesis of phosphatidylinositol (PI) from phosphatidylcholine (PC) and myo-inositol in a phospholipase D (PLD)-mediated transphosphatidylation. Phosphatidylcholines 113-132 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 160-175 29104923-2 2017 Phospholipase D (PLD) enzymes affect cell signaling by producing the pleiotropic lipid second messenger phosphatidic acid via hydrolysis of phosphatidylcholine. Phosphatidylcholines 140-159 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 29104923-2 2017 Phospholipase D (PLD) enzymes affect cell signaling by producing the pleiotropic lipid second messenger phosphatidic acid via hydrolysis of phosphatidylcholine. Phosphatidylcholines 140-159 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 27666314-1 2016 The purely aqueous system of phospholipase D (PLD)-mediated transphosphatidylation using pre-existing carriers for the adsorption of phosphatidylcholine (PC) to act as an "artificial interface" was introduced to replace the liquid-liquid system. Phosphatidylcholines 133-152 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-44 27666314-1 2016 The purely aqueous system of phospholipase D (PLD)-mediated transphosphatidylation using pre-existing carriers for the adsorption of phosphatidylcholine (PC) to act as an "artificial interface" was introduced to replace the liquid-liquid system. Phosphatidylcholines 133-152 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 27666314-1 2016 The purely aqueous system of phospholipase D (PLD)-mediated transphosphatidylation using pre-existing carriers for the adsorption of phosphatidylcholine (PC) to act as an "artificial interface" was introduced to replace the liquid-liquid system. Phosphatidylcholines 154-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-44 27666314-1 2016 The purely aqueous system of phospholipase D (PLD)-mediated transphosphatidylation using pre-existing carriers for the adsorption of phosphatidylcholine (PC) to act as an "artificial interface" was introduced to replace the liquid-liquid system. Phosphatidylcholines 154-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 46-49 27009527-1 2016 The purpose of this study was to improve the efficiency of enzymatic synthesis of phosphatidylinositol (PI) from phosphatidylcholine (PC) and myo-inositol in a phospholipase D (PLD)-mediated transphosphatidylation. Phosphatidylcholines 113-132 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 177-180 27009527-1 2016 The purpose of this study was to improve the efficiency of enzymatic synthesis of phosphatidylinositol (PI) from phosphatidylcholine (PC) and myo-inositol in a phospholipase D (PLD)-mediated transphosphatidylation. Phosphatidylcholines 134-136 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 160-175 27009527-1 2016 The purpose of this study was to improve the efficiency of enzymatic synthesis of phosphatidylinositol (PI) from phosphatidylcholine (PC) and myo-inositol in a phospholipase D (PLD)-mediated transphosphatidylation. Phosphatidylcholines 134-136 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 177-180 27009527-7 2016 Binding assays revealed that PLD re-localized from the aqueous phase to the solvent-buffer interface, where the enzymatic reaction takes place, in the presence of both, the salt and PC. Phosphatidylcholines 182-184 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-32 27403735-3 2016 Many phospholipids have signalling capacity, however, this review will focus on phosphatidic acid (PA) and the enzymes implicated in its production from diacylglycerol (DAG) and phosphatidylcholine (PC): DGK and PLD respectively. Phosphatidylcholines 178-197 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 212-215 27403735-3 2016 Many phospholipids have signalling capacity, however, this review will focus on phosphatidic acid (PA) and the enzymes implicated in its production from diacylglycerol (DAG) and phosphatidylcholine (PC): DGK and PLD respectively. Phosphatidylcholines 199-201 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 212-215 25926691-1 2015 Individual members of the mammalian phospholipase D (PLD) superfamily undertake roles that extend from generating the second messenger signaling lipid, phosphatidic acid, through hydrolysis of the membrane phospholipid, phosphatidylcholine, to functioning as an endonuclease to generate small RNAs and facilitating membrane vesicle trafficking through seemingly nonenzymatic mechanisms. Phosphatidylcholines 220-239 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 36-51 27058440-3 2016 PLD enzymes specifically cleave phosphatidyl choline (PC) producing phosphatidic acid (PA) and choline. Phosphatidylcholines 32-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 27058440-3 2016 PLD enzymes specifically cleave phosphatidyl choline (PC) producing phosphatidic acid (PA) and choline. Phosphatidylcholines 54-56 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 25926691-1 2015 Individual members of the mammalian phospholipase D (PLD) superfamily undertake roles that extend from generating the second messenger signaling lipid, phosphatidic acid, through hydrolysis of the membrane phospholipid, phosphatidylcholine, to functioning as an endonuclease to generate small RNAs and facilitating membrane vesicle trafficking through seemingly nonenzymatic mechanisms. Phosphatidylcholines 220-239 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-56 24995811-4 2014 The PLD hydrolyzes the headgroup of a phospholipid, generally phosphatidylcholine (PC), to phosphatidic acid (PA) and choline and is assumed to play an important function in cell regulation and receptor trafficking. Phosphatidylcholines 62-81 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-7 25632961-4 2015 A critical factor regulating mTOR is phosphatidic acid (PA), a central metabolite of membrane lipid biosynthesis and the product of the phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine. Phosphatidylcholines 182-201 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 136-151 25632961-4 2015 A critical factor regulating mTOR is phosphatidic acid (PA), a central metabolite of membrane lipid biosynthesis and the product of the phospholipase D (PLD)-catalyzed hydrolysis of phosphatidylcholine. Phosphatidylcholines 182-201 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 153-156 25523098-1 2014 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Phosphatidylcholines 75-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 25-40 25523098-1 2014 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Phosphatidylcholines 75-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 42-45 25523098-1 2014 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Phosphatidylcholines 96-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 25-40 25523098-1 2014 Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Phosphatidylcholines 96-98 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 42-45 25197053-4 2014 We investigated the regulation of TREK channels by phosphatidic acid (PA), which is generated by phospholipase D (PLD) via hydrolysis of phosphatidylcholine. Phosphatidylcholines 137-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 97-112 25197053-4 2014 We investigated the regulation of TREK channels by phosphatidic acid (PA), which is generated by phospholipase D (PLD) via hydrolysis of phosphatidylcholine. Phosphatidylcholines 137-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 114-117 26020241-3 2015 Phospholipase D (PLD) is a phosphatidylcholine- and phosphatidylethanolamine-hydrolyzing enzyme that catalyzes the production of phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling in various organisms. Phosphatidylcholines 27-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 26020241-3 2015 Phospholipase D (PLD) is a phosphatidylcholine- and phosphatidylethanolamine-hydrolyzing enzyme that catalyzes the production of phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling in various organisms. Phosphatidylcholines 27-46 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 24995811-4 2014 The PLD hydrolyzes the headgroup of a phospholipid, generally phosphatidylcholine (PC), to phosphatidic acid (PA) and choline and is assumed to play an important function in cell regulation and receptor trafficking. Phosphatidylcholines 83-85 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-7 23723068-3 2013 PLD catalyzes the hydrolysis of phosphatidylcholine into PA. Phosphatidylcholines 32-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 24456402-0 2014 Monitoring phosphatidic acid formation in intact phosphatidylcholine bilayers upon phospholipase D catalysis. Phosphatidylcholines 49-68 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 83-98 25036123-1 2014 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA). Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 25036123-1 2014 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA). Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 25036123-1 2014 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA). Phosphatidylcholines 71-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 25036123-1 2014 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), the most abundant phospholipids of plasma membrane, resulting in the production of choline and phosphatidic acid (PA). Phosphatidylcholines 71-73 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 23639419-2 2013 Many reports exist on PLD-mediated synthesis of natural and tailor-made PLs with functional head groups, from easily available lecithin or phosphatidylcholine. Phosphatidylcholines 139-158 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 22-25 23644991-4 2013 On the outer layer of the vesicle, the phospholipase D (PLD) reacted to convert PC to phosphatidic acid. Phosphatidylcholines 80-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 39-54 23644991-4 2013 On the outer layer of the vesicle, the phospholipase D (PLD) reacted to convert PC to phosphatidic acid. Phosphatidylcholines 80-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 56-59 23681537-1 2013 Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine. Phosphatidylcholines 63-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 23681537-1 2013 Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine. Phosphatidylcholines 63-82 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 23681537-1 2013 Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine. Phosphatidylcholines 84-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 23681537-1 2013 Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine. Phosphatidylcholines 84-86 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 22824913-1 2012 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidic acid. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 22622287-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) catalyzed for the conversion of PC to phosphatidic acid. Phosphatidylcholines 94-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-55 22622287-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) catalyzed for the conversion of PC to phosphatidic acid. Phosphatidylcholines 94-96 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 22824913-1 2012 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidic acid. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 20601268-2 2011 After a 24-hour reaction of phosphatidylcholine (PC) and tyrosol with PLD, a new product was detected by TLC and identified to phosphatidyl-tyrosol by high-resolution MS and NMR analyses. Phosphatidylcholines 28-47 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-73 22609605-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) reacted on the layer to convert phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidylcholines 94-113 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-55 22609605-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) reacted on the layer to convert phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidylcholines 94-113 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 22609605-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) reacted on the layer to convert phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidylcholines 115-117 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 40-55 22609605-2 2012 At the outer layer of the vesicles, the phospholipase D (PLD) reacted on the layer to convert phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidylcholines 115-117 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 57-60 22212660-1 2012 Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling. Phosphatidylcholines 27-47 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 22212660-1 2012 Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling. Phosphatidylcholines 27-47 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 22212660-1 2012 Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling. Phosphatidylcholines 49-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 22212660-1 2012 Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling. Phosphatidylcholines 49-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 21984187-2 2011 At the outer layer of the vesicles, phospholipase D catalyzed for the conversion of phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidylcholines 84-103 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 36-51 21984187-2 2011 At the outer layer of the vesicles, phospholipase D catalyzed for the conversion of phosphatidylcholine (PC) to phosphatidic acid (PA). Phosphatidylcholines 105-107 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 36-51 20735042-1 2010 Phospholipase D (PLD) catalyzes the conversion of phosphatidylcholine to the lipid second messenger phosphatidic acid. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 20735042-1 2010 Phospholipase D (PLD) catalyzes the conversion of phosphatidylcholine to the lipid second messenger phosphatidic acid. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 20623096-1 2010 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 20623096-1 2010 Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19497293-5 2009 Based on these results, an assay for determining the activity of phospholipase D (PLD) toward natural phospholipids such as PC, PE, and PG was developed. Phosphatidylcholines 124-126 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 65-80 19497293-5 2009 Based on these results, an assay for determining the activity of phospholipase D (PLD) toward natural phospholipids such as PC, PE, and PG was developed. Phosphatidylcholines 124-126 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 82-85 19345277-1 2009 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate phosphatidic acid and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 19345277-1 2009 Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to generate phosphatidic acid and choline. Phosphatidylcholines 50-69 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19540356-2 2009 PA production at the plasma membrane and on trafficking membrane organelles by classical Phospholipase D (PLD) through the hydrolysis of phosphatidylcholine (PC) has been studied widely. Phosphatidylcholines 137-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 89-104 19540356-2 2009 PA production at the plasma membrane and on trafficking membrane organelles by classical Phospholipase D (PLD) through the hydrolysis of phosphatidylcholine (PC) has been studied widely. Phosphatidylcholines 137-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 106-109 19540356-2 2009 PA production at the plasma membrane and on trafficking membrane organelles by classical Phospholipase D (PLD) through the hydrolysis of phosphatidylcholine (PC) has been studied widely. Phosphatidylcholines 158-160 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 89-104 19540356-2 2009 PA production at the plasma membrane and on trafficking membrane organelles by classical Phospholipase D (PLD) through the hydrolysis of phosphatidylcholine (PC) has been studied widely. Phosphatidylcholines 158-160 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 106-109 19146388-4 2009 Several studies have reported evidence that alphaSyn can inhibit phospholipase D (PLD), which hydrolyzes phosphatidylcholine to form phosphatidic acid and choline. Phosphatidylcholines 105-124 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 65-80 19146388-4 2009 Several studies have reported evidence that alphaSyn can inhibit phospholipase D (PLD), which hydrolyzes phosphatidylcholine to form phosphatidic acid and choline. Phosphatidylcholines 105-124 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 82-85 19160674-1 2009 Phospholipase D (PLD) is an enzyme producing phosphatidic acid and choline through hydrolysis of phosphatidylcholine. Phosphatidylcholines 97-116 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 19160674-1 2009 Phospholipase D (PLD) is an enzyme producing phosphatidic acid and choline through hydrolysis of phosphatidylcholine. Phosphatidylcholines 97-116 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19012176-1 2008 Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 19012176-1 2008 Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 19012176-1 2008 Phospholipase D (PLD) hydrolyses phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLD"s functions in cells. Phosphatidylcholines 33-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 142-145 18523140-1 2008 The phosphatidylcholine-using phospholipase D (PLD) isoform PLD2 is widely expressed in mammalian cells and is activated in response to a variety of promitogenic agonists. Phosphatidylcholines 4-23 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 47-50 18422860-1 2008 The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). Phosphatidylcholines 18-37 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-68 18422860-1 2008 The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). Phosphatidylcholines 18-37 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-73 18422860-1 2008 The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). Phosphatidylcholines 39-41 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-68 18422860-1 2008 The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). Phosphatidylcholines 39-41 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-73 20438709-1 2010 Phosphatidic acid (PA), the primary metabolite of the phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine, has been shown to act as a tumor promoting second messenger in many cancer cell lines. Phosphatidylcholines 99-118 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-69 20438709-1 2010 Phosphatidic acid (PA), the primary metabolite of the phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine, has been shown to act as a tumor promoting second messenger in many cancer cell lines. Phosphatidylcholines 99-118 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 71-74 19931432-3 2010 PLD incubation of EY mainly converts phosphatidylcholine into phosphatidic acid (PA). Phosphatidylcholines 37-56 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 19264150-2 2009 PLD catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA). Phosphatidylcholines 32-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 19540357-2 2009 PLD hydrolyzes phosphatidylcholine to generate phosphatidic acid (PA), a lipid that favors membranes with negative curvature and thus can facilitate both membrane fission and fusion. Phosphatidylcholines 15-34 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 18523140-1 2008 The phosphatidylcholine-using phospholipase D (PLD) isoform PLD2 is widely expressed in mammalian cells and is activated in response to a variety of promitogenic agonists. Phosphatidylcholines 4-23 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 30-45 18422860-1 2008 The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). Phosphatidylcholines 118-120 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 53-68 18422860-1 2008 The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). Phosphatidylcholines 118-120 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 70-73