PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9175129-1 1997 The role of phosphatidylcholine (PC) and phosphatidylinositol (PI) specific phospholipase C (PLC) enzymes in the release of immunoreactive arginine vasopressin (ir-AVP) from rat hypothalami in vitro was examined. Phosphatidylcholines 12-31 arginine vasopressin Rattus norvegicus 148-159 9915331-8 1999 Propofol inhibited vasopressin-induced activation of phosphoinositide-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D, but this effect of propofol was significant only at supraclinical concentration (0.1 mM). Phosphatidylcholines 102-121 arginine vasopressin Rattus norvegicus 19-30 9578155-7 1998 In AVP-stimulated cells, an increase of [3H-methyl] labeled phosphatidylcholine and lysophosphatidylcholine was observed after stimulation with AVP, followed by an apparent increase of [3H-methyl] labeled lysophosphatidylcholine. Phosphatidylcholines 60-79 arginine vasopressin Rattus norvegicus 3-6 9578155-7 1998 In AVP-stimulated cells, an increase of [3H-methyl] labeled phosphatidylcholine and lysophosphatidylcholine was observed after stimulation with AVP, followed by an apparent increase of [3H-methyl] labeled lysophosphatidylcholine. Phosphatidylcholines 60-79 arginine vasopressin Rattus norvegicus 144-147 8584016-5 1995 When the cells were pulse labelled with [3H]-choline, vasopressin stimulation caused a decrease in the labelled phosphatidylcholine with a corresponding increase in the labelled choline. Phosphatidylcholines 112-131 arginine vasopressin Rattus norvegicus 54-65 8584016-7 1995 Alternatively, the labelled choline produced by vasopressin stimulation was released into the medium, thus reducing the recycling of label precursor back into the phospholipid and making the decrease in the labelling of phosphatidylcholine readily detectable. Phosphatidylcholines 220-239 arginine vasopressin Rattus norvegicus 48-59 2170380-4 1990 Here we demonstrate that VP-induced PIP2 hydrolysis is closely accompanied by phosphatidylcholine (PC) degradation by phospholipase D. Cells prelabeled with [3H]arachidonic acid showed rapid formation and diminution of [3H]diacylglycerol (DG) (5-15s) when treated with VP; this was accompanied by a reduction in polyphosphoinositide radioactivity. Phosphatidylcholines 99-101 arginine vasopressin Rattus norvegicus 25-27 7576493-1 1995 In the present study, we examined the effect of vasopressin (AVP) on phosphatidylcholine-hydrolyzing phospholipase D activity in primary cultured rat aortic smooth muscle cells. Phosphatidylcholines 69-88 arginine vasopressin Rattus norvegicus 48-59 1539683-0 1992 Vasopressin and phorbol ester-stimulated phosphatidylcholine metabolism in mesangial cells. Phosphatidylcholines 41-60 arginine vasopressin Rattus norvegicus 0-11 1539683-1 1992 We have studied the effects of the vasoactive agents phorbol 12-myristate 13-acetate (PMA) and vasopressin (VP) on phosphatidylcholine metabolism in cultured rat glomerular mesangial cells. Phosphatidylcholines 115-134 arginine vasopressin Rattus norvegicus 95-106 1539683-1 1992 We have studied the effects of the vasoactive agents phorbol 12-myristate 13-acetate (PMA) and vasopressin (VP) on phosphatidylcholine metabolism in cultured rat glomerular mesangial cells. Phosphatidylcholines 115-134 arginine vasopressin Rattus norvegicus 108-110 1539683-2 1992 PMA and VP stimulate the incorporation of [3H]choline into phosphatidylcholine and the release of [3H]choline into the culture medium. Phosphatidylcholines 59-78 arginine vasopressin Rattus norvegicus 8-10 1539683-6 1992 A dual labeling study ([3H]myristic acid and [14C]arachidonic acid) suggests that phosphatidylcholine is an important source of diacylglycerol in cells treated with VP and PMA. Phosphatidylcholines 82-101 arginine vasopressin Rattus norvegicus 165-167 2280671-2 1990 We have investigated the production of diacylglycerol from nonphosphoinositide sources, and we demonstrated that vasopressin and other vasoactive agents stimulate hydrolysis of phosphatidylcholine in a variety of cultured vascular smooth muscle cells of rat and human origin. Phosphatidylcholines 177-196 arginine vasopressin Rattus norvegicus 113-124 2170380-0 1990 Vasopressin-induced polyphosphoinositide and phosphatidylcholine degradation in fibroblasts. Phosphatidylcholines 45-64 arginine vasopressin Rattus norvegicus 0-11 2170380-4 1990 Here we demonstrate that VP-induced PIP2 hydrolysis is closely accompanied by phosphatidylcholine (PC) degradation by phospholipase D. Cells prelabeled with [3H]arachidonic acid showed rapid formation and diminution of [3H]diacylglycerol (DG) (5-15s) when treated with VP; this was accompanied by a reduction in polyphosphoinositide radioactivity. Phosphatidylcholines 78-97 arginine vasopressin Rattus norvegicus 25-27 8139391-0 1994 Biphasic modulation of choline uptake and phosphatidylcholine biosynthesis by vasopressin in rat cardiac myocytes. Phosphatidylcholines 42-61 arginine vasopressin Rattus norvegicus 78-89 8139391-4 1994 The biosynthesis of phosphatidylcholine was also affected by vasopressin in a biphasic manner. Phosphatidylcholines 20-39 arginine vasopressin Rattus norvegicus 61-72 8139391-5 1994 At low concentrations of vasopressin, a general increase in cytosine triphosphate:phosphocholine cytidylyltransferase activity was observed that caused an enhanced conversion of phosphocholine to phosphatidylcholine via the cytidine diphosphocholine pathway. Phosphatidylcholines 196-215 arginine vasopressin Rattus norvegicus 25-36 2170380-6 1990 In cells prelabeled with [3H]myristic acid, which is predominantly incorporated into cellular PC, VP elicited the generation of [3H]myristoyl phosphatidate (PA) as early as 15 s, in the absence of an increase in labeled DG. Phosphatidylcholines 94-96 arginine vasopressin Rattus norvegicus 98-100 2912496-1 1989 The current study examined the effect of vasopressin on the secretion of phosphatidylcholine, the principal component of pulmonary surfactant, from adult rat alveolar type II pneumocytes in primary culture. Phosphatidylcholines 73-92 arginine vasopressin Rattus norvegicus 41-52 2912496-5 1989 The stimulation of phosphatidylcholine release by vasopressin was duplicated by the vasopressin fragment, amino acids 4 through 9. Phosphatidylcholines 19-38 arginine vasopressin Rattus norvegicus 50-61 2912496-5 1989 The stimulation of phosphatidylcholine release by vasopressin was duplicated by the vasopressin fragment, amino acids 4 through 9. Phosphatidylcholines 19-38 arginine vasopressin Rattus norvegicus 84-95 2912496-9 1989 When vasopressin and isoproterenol were added concomitantly, the effects on phosphatidylcholine secretion were additive. Phosphatidylcholines 76-95 arginine vasopressin Rattus norvegicus 5-16 3117799-9 1987 Only phosphatidylcholine, among the major phospholipids, decreased in the membranes in response to GTP gamma S. The fatty acid composition of the phosphatidate produced in response to vasopressin in hepatocytes also suggests that phosphatidylcholine may be the source of hormonally elicited phosphatidate. Phosphatidylcholines 5-24 arginine vasopressin Rattus norvegicus 184-195 3365241-0 1988 Vasopressin is the only component of serum-free medium that stimulates phosphatidylcholine hydrolysis and accumulation of diacylglycerol in cultured REF52 cells. Phosphatidylcholines 71-90 arginine vasopressin Rattus norvegicus 0-11 3365241-1 1988 Vasopressin stimulates phosphatidylcholine hydrolysis in REF52 cells, and this phosphatidylcholine hydrolysis results in increases in choline containing metabolites in the culture medium (2.3 x control levels) and accumulation of cellular diacylglycerol (6.5 x control levels). Phosphatidylcholines 23-42 arginine vasopressin Rattus norvegicus 0-11 3365241-1 1988 Vasopressin stimulates phosphatidylcholine hydrolysis in REF52 cells, and this phosphatidylcholine hydrolysis results in increases in choline containing metabolites in the culture medium (2.3 x control levels) and accumulation of cellular diacylglycerol (6.5 x control levels). Phosphatidylcholines 79-98 arginine vasopressin Rattus norvegicus 0-11 3365241-2 1988 Vasopressin is the only component of a 6-component mixture of the serum-free medium for REF52 cells that induces the phosphatidylcholine hydrolysis response. Phosphatidylcholines 117-136 arginine vasopressin Rattus norvegicus 0-11 3365241-4 1988 Maximal levels of both phosphatidyl-choline hydrolysis and accumulation of diacylglycerol are observed between 10 and 20 min after treatment with vasopressin. Phosphatidylcholines 23-43 arginine vasopressin Rattus norvegicus 146-157 3365241-5 1988 Effects are maximal at vasopressin concentrations of 100 ng/ml; the ED50 for vasopressin-stimulated phosphatidyl-choline hydrolysis is approximately 0.7 ng/ml. Phosphatidylcholines 100-120 arginine vasopressin Rattus norvegicus 77-88 2830903-0 1988 Vasopressin, phorbol diesters and serum elicit choline glycerophospholipid hydrolysis and diacylglycerol formation in nontransformed cells: transformed derivatives do not respond. Phosphatidylcholines 47-74 arginine vasopressin Rattus norvegicus 0-11 2830903-6 1988 Experiments employing REF52 cells prelabeled with [3H]choline demonstrated that both TPA and vasopressin induce the hydrolysis of cellular choline-containing glycerophospholipids; this was measured by both a decrease in cell-associated phosphatidylcholine radioactivity and an increase in the production of water-soluble [3H]choline-containing metabolites in the culture medium. Phosphatidylcholines 236-255 arginine vasopressin Rattus norvegicus 93-104 2830903-11 1988 Further, collateral with vasopressin-induced phosphatidylcholine hydrolysis, the cellular release of arachidonic acid occurs. Phosphatidylcholines 45-64 arginine vasopressin Rattus norvegicus 25-36 3117799-9 1987 Only phosphatidylcholine, among the major phospholipids, decreased in the membranes in response to GTP gamma S. The fatty acid composition of the phosphatidate produced in response to vasopressin in hepatocytes also suggests that phosphatidylcholine may be the source of hormonally elicited phosphatidate. Phosphatidylcholines 230-249 arginine vasopressin Rattus norvegicus 184-195 6818955-0 1982 Inhibition of phosphatidylcholine synthesis by vasopressin and angiotensin in rat hepatocytes. Phosphatidylcholines 14-33 arginine vasopressin Rattus norvegicus 47-58 3032270-0 1987 Effects of vasopressin on the synthesis of phosphatidylethanolamines and phosphatidylcholines by isolated rat hepatocytes. Phosphatidylcholines 73-93 arginine vasopressin Rattus norvegicus 11-22 3032270-1 1987 The effect of vasopressin on the biosynthesis of phosphatidylcholines and phosphatidylethanolamines was investigated in freshly isolated rat hepatocytes in suspension. Phosphatidylcholines 49-69 arginine vasopressin Rattus norvegicus 14-25 3032270-2 1987 Treatment of hepatocytes with vasopressin inhibits the incorporation of [Me-14C]choline into phosphatidylcholines in a dose-dependent manner. Phosphatidylcholines 93-113 arginine vasopressin Rattus norvegicus 30-41 3032270-5 1987 In contrast with the inhibitory effect of vasopressin on the synthesis of phosphatidylcholines, this hormone stimulates the incorporation of [1,2-14C]ethanolamine into phosphatidylethanolamines in a dose-dependent manner. Phosphatidylcholines 74-94 arginine vasopressin Rattus norvegicus 42-53 6818955-1 1982 The addition of 1 microM-vasopressin or -angiotensin to isolated rat hepatocytes induced a fast transient inhibition of the rate of incorporation of [Me-3H]choline into phosphatidylcholine. Phosphatidylcholines 169-188 arginine vasopressin Rattus norvegicus 25-36 598786-1 1977 The incorporation of 32P-orthophosphate into phosphatidylethanolamine and phosphatidylcholine in vas deferens was increased by incubation with cocaine and denervation enhanced the action of cocaine on phospholipid metabolism in vas deferens. Phosphatidylcholines 74-93 arginine vasopressin Rattus norvegicus 97-100 598786-1 1977 The incorporation of 32P-orthophosphate into phosphatidylethanolamine and phosphatidylcholine in vas deferens was increased by incubation with cocaine and denervation enhanced the action of cocaine on phospholipid metabolism in vas deferens. Phosphatidylcholines 74-93 arginine vasopressin Rattus norvegicus 228-231