PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22256788-5 2013 We propose that cyclin D1 may be a central molecule in the pathogenesis of CCSK, driven mainly by the sonic hedgehog and the nuclear factor-kappa B pathways and secondarily by the mammalian target of rapamycin complex mTORC2/PI3K/Akt pathway, heat shock protein 90, and possibly phospholipase D1. ccsk 75-79 AKT serine/threonine kinase 1 Homo sapiens 230-233 16299227-4 2005 RESULTS: Using unsupervised methods, the gene expression profile of CCSK was distinctive: differentially expressed genes could largely be grouped into four categories: (a) a wide variety of neural markers, (b) members of the Sonic hedgehog pathway, (c) members of the phosphoinositide-3-kinase/Akt cell proliferation pathway, and (d) known therapeutic targets. ccsk 68-72 AKT serine/threonine kinase 1 Homo sapiens 294-297