PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25751590-9 2015 Cyclin D1 immunohistochemistry helps distinguish CCSK from blastemal WT and metanephric adenoma and rhabdoid tumors, but not from neuroblastomas and mesoblastic nephromas. ccsk 49-53 cyclin D1 Homo sapiens 0-9 22256788-5 2013 We propose that cyclin D1 may be a central molecule in the pathogenesis of CCSK, driven mainly by the sonic hedgehog and the nuclear factor-kappa B pathways and secondarily by the mammalian target of rapamycin complex mTORC2/PI3K/Akt pathway, heat shock protein 90, and possibly phospholipase D1. ccsk 75-79 cyclin D1 Homo sapiens 16-25 34673711-4 2021 We aimed to evaluate the utility of cyclin D1 and BCOR immunohistochemistry in differentiating CCSK from its morphologic mimics. ccsk 95-99 cyclin D1 Homo sapiens 36-45 34673711-8 2021 Strong, diffuse nuclear immunoreactivity for cyclin D1 and BCOR was noted in 61% (n=11/18) and 83% (n=15/18) of CCSK, respectively, while it was significantly less in WT (n=3/10 for cyclin D1) (n=2/10 for BCOR). ccsk 112-116 cyclin D1 Homo sapiens 45-54 34673711-11 2021 CONCLUSION: Our results provide evidence that concurrent immunopositivity with cyclin D1 and BCOR is helpful in distinguishing CCSK from its morphologic mimics. ccsk 127-131 cyclin D1 Homo sapiens 79-88 30736802-5 2019 In this study, we aim to determine the usefulness of Cyclin D1 in differentiating between CCSK and other pediatric renal neoplasms and to compare our results with those of recently published studies. ccsk 90-94 cyclin D1 Homo sapiens 53-62 30736802-10 2019 RESULTS: Most or all cases of CCSK, neuroblastoma and renal Ewing sarcoma demonstrated diffuse and strong positivity for Cyclin D1. ccsk 30-34 cyclin D1 Homo sapiens 121-130 30736802-13 2019 CONCLUSIONS: Cyclin D1 is a sensitive but not specific immunohistochemical marker for CCSK and many other pediatric renal malignant neoplasms as well as for neuroblastoma. ccsk 86-90 cyclin D1 Homo sapiens 13-22 30736802-15 2019 However, Cyclin D1 is very helpful in distinguishing between blastema-rich WT and CCSK. ccsk 82-86 cyclin D1 Homo sapiens 9-18 25556515-4 2015 As this fusion results in overexpression of cyclin D1 in ESS, we postulated that overexpression would also occur in CCSK; cyclin D1 immunohistochemistry could then be used to differentiate CCSK from other tumours. ccsk 116-120 cyclin D1 Homo sapiens 44-53 25556515-4 2015 As this fusion results in overexpression of cyclin D1 in ESS, we postulated that overexpression would also occur in CCSK; cyclin D1 immunohistochemistry could then be used to differentiate CCSK from other tumours. ccsk 189-193 cyclin D1 Homo sapiens 44-53 25556515-4 2015 As this fusion results in overexpression of cyclin D1 in ESS, we postulated that overexpression would also occur in CCSK; cyclin D1 immunohistochemistry could then be used to differentiate CCSK from other tumours. ccsk 189-193 cyclin D1 Homo sapiens 122-131 25556515-10 2015 CONCLUSIONS: Cyclin D1 is most helpful in distinguishing CCSK from WT, rhabdoid tumour, and some CMNs, but not from neuroblastoma or Ewing sarcomas. ccsk 57-61 cyclin D1 Homo sapiens 13-22 25751590-10 2015 Cyclin D1 overexpression in CCSK is not contingent on YWHAE-FAM22 translocation, and cyclin D1 inhibition may potentially be explored as a targeted therapeutic strategy in CCSK. ccsk 28-32 cyclin D1 Homo sapiens 0-9