PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7593548-1	1995	In a previous study we demonstrated that mice pretreated with the highly selective alpha 2-adrenoceptor antagonist CH-38083 showed blunting of the tumor necrosis factor-alpha (TNF-alpha) response induced by bacterial lipopolysaccharide (LPS).	7,8-(methylenedioxy)-14-hydroxyberbane	115-123	tumor necrosis factor	Mus musculus	147-174	
7593548-1	1995	In a previous study we demonstrated that mice pretreated with the highly selective alpha 2-adrenoceptor antagonist CH-38083 showed blunting of the tumor necrosis factor-alpha (TNF-alpha) response induced by bacterial lipopolysaccharide (LPS).	7,8-(methylenedioxy)-14-hydroxyberbane	115-123	tumor necrosis factor	Mus musculus	176-185	
7738470-2	1995	It was found that the LPS-induced TNF-alpha response was significantly blunted in mice pretreated with CH-38083, a novel and highly selective alpha 2-adrenoreceptor antagonist (the alpha 2/alpha 1 ratio is > 2000).	7,8-(methylenedioxy)-14-hydroxyberbane	103-111	tumor necrosis factor	Mus musculus	34-43	
7593548-3	1995	While adrenalectomy did not prevent the effect of CH-38083, the block of the sympathetic transmission by chlorisondamine fully abolished the inhibitory effect of CH-38083 on LPS-induced TNF-alpha production, suggesting that the effect of the alpha 2-adrenoceptor blocking agent is corticosteroid-independent, but it requires intact sympathetic activity.	7,8-(methylenedioxy)-14-hydroxyberbane	162-170	tumor necrosis factor	Mus musculus	186-195