PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7593548-3	1995	While adrenalectomy did not prevent the effect of CH-38083, the block of the sympathetic transmission by chlorisondamine fully abolished the inhibitory effect of CH-38083 on LPS-induced TNF-alpha production, suggesting that the effect of the alpha 2-adrenoceptor blocking agent is corticosteroid-independent, but it requires intact sympathetic activity.	7,8-(methylenedioxy)-14-hydroxyberbane	162-170	toll-like receptor 4	Mus musculus	174-177	
7593548-1	1995	In a previous study we demonstrated that mice pretreated with the highly selective alpha 2-adrenoceptor antagonist CH-38083 showed blunting of the tumor necrosis factor-alpha (TNF-alpha) response induced by bacterial lipopolysaccharide (LPS).	7,8-(methylenedioxy)-14-hydroxyberbane	115-123	toll-like receptor 4	Mus musculus	237-240