PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3126051-1 1987 The administration of alfentanil by infusion appears to present advantages for the induction and maintenance of anaesthesia during general surgery lasting over 1 h. The following dosage scheme is proposed: a loading dose of 100 micrograms kg-1, given either in one or two doses, or as a fast infusion administered over 10 min, followed by a maintenance infusion at a rate of 1 microgram kg-1 min-1. Alfentanil 22-32 CD59 molecule (CD59 blood group) Homo sapiens 392-397 2503375-6 1989 Values for pharmacokinetic parameters of alfentanil were as follows: clearance, 5.2 +/- 2.0 ml kg-1 min-1; volume of distribution, 0.63 +/- 0.20 1 kg-1; and elimination half-life, 96.9 +/- 52.5 min. Alfentanil 41-51 CD59 molecule (CD59 blood group) Homo sapiens 100-105 2495860-5 1989 Plasma clearance of alfentanil in young healthy subjects, 9.3 +/- 6.3 ml.kg-1.min-1, also showed an inverse relationship with age (r = -0.54, P less than 0.001), and was not affected by surgical stress in subjects older than 60 years. Alfentanil 20-30 CD59 molecule (CD59 blood group) Homo sapiens 78-83 3126053-10 1987 This study supports the view that after an appropriate loading dose a fixed-rate infusion of alfentanil at 1 microgram kg-1 min-1 can be given for up to 7 h to provide satisfactory stable analgesia without undue post-operative ventilatory depression or prolonged recovery in the majority of cases. Alfentanil 93-103 CD59 molecule (CD59 blood group) Homo sapiens 124-129 3126054-5 1987 After 10 min the maintenance infusion rate of alfentanil of 1 microgram kg-1 min-1 was begun. Alfentanil 46-56 CD59 molecule (CD59 blood group) Homo sapiens 77-82 3126054-14 1987 The use of a 10-min, 10 micrograms kg-1 min-1 loading infusion, then a maintenance infusion of 1 microgram kg-1 min-1 delivered by a modified Fresenius-injectomat infusion pump may be the first step in simplifying the continuous infusion of alfentanil. Alfentanil 241-251 CD59 molecule (CD59 blood group) Homo sapiens 112-117 2875678-2 1986 Alfentanil was administered as a loading infusion (25-130 micrograms/kg) followed by a maintenance infusion (0.25-1.3 micrograms X kg-1 X min-1) as part of a nitrous oxide-narcotic-muscle relaxant technique. Alfentanil 0-10 CD59 molecule (CD59 blood group) Homo sapiens 138-143 2875678-4 1986 The alfentanil clearance rate was significantly lower in patients with liver dysfunction (2.3 +/- 1.3 vs 4.2 +/- 2.0 ml X kg-1 X min-1, mean +/- SD). Alfentanil 4-14 CD59 molecule (CD59 blood group) Homo sapiens 129-134 2875679-1 1986 In a group of seven patients undergoing intracranial surgery under neurolept anesthesia, an alfentanil infusion was initiated with a loading dose of 235 micrograms/kg over 5 min, followed by a maintenance infusion rate of 1.8 microgram X kg-1 X min-1 in order to obtain a steady state plasma concentration (Css) of 400 ng/ml-1 according to an infusion model. Alfentanil 92-102 CD59 molecule (CD59 blood group) Homo sapiens 245-250 2876719-6 1986 The required infusion rate for alfentanil was between 0.4 and 0.5 micrograms kg-1 min-1. Alfentanil 31-41 CD59 molecule (CD59 blood group) Homo sapiens 82-87 2937338-5 1986 The pulse rate following intubation showed a smaller rise (P less than 0.001) with alfentanil of 26 (SD 14.6) beats min-1, than the normal saline group of 46 (SD 13.3) beats min-1. Alfentanil 83-93 CD59 molecule (CD59 blood group) Homo sapiens 116-121 3090845-3 1986 Alfentanil was given before intubation (1 mg), as a loading dose before starting surgery (50 micrograms kg-1) and by a continuous infusion at a rate of 1 microgram kg-1 min-1. Alfentanil 0-10 CD59 molecule (CD59 blood group) Homo sapiens 169-174 6797453-2 1981 Alfentanil was infused at a rate of 3.0mg min-1 until the patients (breathing pure oxygen) became unconscious. Alfentanil 0-10 CD59 molecule (CD59 blood group) Homo sapiens 42-47 8873540-7 1996 RESULTS: Alfentanil decreased the slope of the carbon dioxide response curve from 2.14 +/- 0.40 to 1.43 +/- 0.19 l.min-1.mmHg-1 (x +/- SE, P < 0.05), and decreased the minute ventilation at P(ET)CO2 = 50 mmHg (VE50) from 19.7 +/- 1.2 to 14.8 +/- 0.9l.min-1 (P < 0.05). Alfentanil 9-19 CD59 molecule (CD59 blood group) Homo sapiens 115-120 15595588-6 2004 Patients who received alfentanil had significantly lower heart rates than those who received nerve blockade only (96.0+/-15.6 vs. 115.9+/-23.2 beats min(-1), P < 0.001). Alfentanil 22-32 CD59 molecule (CD59 blood group) Homo sapiens 149-155 9743396-7 1998 Alfentanil decreased both the initial and second acute hypoxic responses (from 1.27+/-0.73 to 0.99+/-0.39 l x min(-1) x %(-1), P < 0.05; and from 0.99+/-0.70 to 0.41+/-0.29 l x min(-1) x %(-1), P < 0.05, respectively). Alfentanil 0-10 CD59 molecule (CD59 blood group) Homo sapiens 110-116 9743396-7 1998 Alfentanil decreased both the initial and second acute hypoxic responses (from 1.27+/-0.73 to 0.99+/-0.39 l x min(-1) x %(-1), P < 0.05; and from 0.99+/-0.70 to 0.41+/-0.29 l x min(-1) x %(-1), P < 0.05, respectively). Alfentanil 0-10 CD59 molecule (CD59 blood group) Homo sapiens 180-186 9847642-15 1998 The simulated constant infusion rate for remifentanil of 15 micrograms.min1 (8 micrograms.min-1 for fentanyl and 75 micrograms.min-1 for alfentanil) allowed the therapeutic threshold to be reached in 10 min with remifentanil, in 22 min with fentanyl and in 17 min with alfentanil. Alfentanil 137-147 CD59 molecule (CD59 blood group) Homo sapiens 127-132 9847642-15 1998 The simulated constant infusion rate for remifentanil of 15 micrograms.min1 (8 micrograms.min-1 for fentanyl and 75 micrograms.min-1 for alfentanil) allowed the therapeutic threshold to be reached in 10 min with remifentanil, in 22 min with fentanyl and in 17 min with alfentanil. Alfentanil 269-279 CD59 molecule (CD59 blood group) Homo sapiens 90-95 8873540-7 1996 RESULTS: Alfentanil decreased the slope of the carbon dioxide response curve from 2.14 +/- 0.40 to 1.43 +/- 0.19 l.min-1.mmHg-1 (x +/- SE, P < 0.05), and decreased the minute ventilation at P(ET)CO2 = 50 mmHg (VE50) from 19.7 +/- 1.2 to 14.8 +/- 0.9l.min-1 (P < 0.05). Alfentanil 9-19 CD59 molecule (CD59 blood group) Homo sapiens 254-259 8638836-10 1996 Corresponding NONMEM parameters for alfentanil are 0.36 l x min(-1), 34.11, and 94.5 min. Alfentanil 36-46 CD59 molecule (CD59 blood group) Homo sapiens 60-66 8280548-7 1993 Mean intraoperative alfentanil requirement was greater in patients with Crohn"s disease (2.48 micrograms kg-1 min-1) than in control patients (1.35 micrograms kg-1 min-1) (P < 0.01). Alfentanil 20-30 CD59 molecule (CD59 blood group) Homo sapiens 110-115 7588662-4 1995 Anaesthesia was maintained in the intravenous group by infusion of alfentanil 1-1.5 micrograms kg-1 min-1 and injections of midazolam 2.5-5 mg h-1, and in the inhalational group by isoflurane up to 2%. Alfentanil 67-77 CD59 molecule (CD59 blood group) Homo sapiens 100-105 8499195-5 1993 The average effective therapeutic infusion of alfentanil was 0.140 (0.032) mg min-1. Alfentanil 46-56 CD59 molecule (CD59 blood group) Homo sapiens 78-83 1616160-4 1992 The average alfentanil dosage requirements were 1.49 +/- 0.50 and 1.46 +/- 0.55 micrograms.kg-1.min-1 (mean +/- SD) in the physician- and patient-controlled groups, respectively. Alfentanil 12-22 CD59 molecule (CD59 blood group) Homo sapiens 96-101