PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1361312-3	1992	DMED, a 4(5)substituted imidazole, has been shown to inhibit adrenal steroidogenesis and human liver microsomal alfentanil metabolism, reactions mediated by cytochrome P-450.	Alfentanil	112-122	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	157-173	
1519785-3	1992	It has been shown previously that alfentanil clearance is independent of the polymorphic debrisoquine hydroxylase (P-450 2D6), and it is therefore of interest to identify the human cytochrome P-450 enzymes involved in noralfentanil formation, the primary reaction involved in the oxidative N-dealkylation at the piperidine nitrogen.	Alfentanil	34-44	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	181-197	
3140691-3	1988	The role of a specific cytochrome P-450 form, debrisoquine 4-hydroxylase, in the metabolism of alfentanil was investigated by competitive inhibition experiments over the concentration range 4-100 microM.	Alfentanil	95-105	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	23-39