PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18030306-4 2008 In brain regions associated with the processing of the sensory intensity of pain (primary and secondary somatosensory cortices, posterior insular cortex), activation decreased linearly in relation to alfentanil concentrations, which was significantly less pronounced in OPRM1 118G carriers. Alfentanil 200-210 opioid receptor mu 1 Homo sapiens 270-275 15044556-5 2004 administration of mu opioid receptor (MOR) agonists (fentanyl, alfentanil, remifentanil, and morphine) evoked scratching in a dose- and time-dependent manner. Alfentanil 63-73 opioid receptor mu 1 Homo sapiens 18-36 15044556-5 2004 administration of mu opioid receptor (MOR) agonists (fentanyl, alfentanil, remifentanil, and morphine) evoked scratching in a dose- and time-dependent manner. Alfentanil 63-73 opioid receptor mu 1 Homo sapiens 38-41 11240593-1 2001 PURPOSE: Alfentanil is a high potency mu opiate receptor agonist commonly used during presurgical induction of anesthesia. Alfentanil 9-19 opioid receptor mu 1 Homo sapiens 38-56 9121816-7 1996 In contrast, addition of a mu-opiate receptor agonist (alfentanil 2.4 mM) to the strychnine perfusate selectively reduced responsiveness to high intensity stimulation, while having no effect on the exaggerated response to hair deflection. Alfentanil 55-65 opioid receptor mu 1 Homo sapiens 27-45 16906017-1 2006 AIM: To investigate whether OPRM1 118A>G polymorphism affects analgesic and respiratory depressive effects of alfentanil and assess its role for the therapeutic range of alfentanil. Alfentanil 113-123 opioid receptor mu 1 Homo sapiens 28-33 16906017-2 2006 METHODS: In an open-label, single-occasion design, 10 non-carriers, four heterozygous and six homozygous carriers of the variant OPRM1 118G allele received a computerized infusion of alfentanil to achieve target effect-site concentrations of 0, 33.33, 66.67 and 100 ng/ml. Alfentanil 183-193 opioid receptor mu 1 Homo sapiens 129-134 16906017-8 2006 CONCLUSION: OPRM1 118A>G polymorphism affects both analgesic and respiratory depressive effects of alfentanil. Alfentanil 102-112 opioid receptor mu 1 Homo sapiens 12-17