PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11101306-5 2000 By examination of the binding affinities and potencies of substituted NDP-MSH peptides at receptor mutants, evidence was found that core melanocortin peptide residue Arg8 interacts at a molecular level with hMC4R TM3 residue D122. d122 225-229 tropomyosin 3 Homo sapiens 213-216 11101306-8 2000 In addition, mutation of TM3 residue D122 or D126 decreased the binding affinity of hMC4R antagonist SHU 9119. d122 37-41 tropomyosin 3 Homo sapiens 25-28