PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12208559-4 2002 Tianeptine was shown to inhibit the ion currents induced by the inhibitory neurotransmitters GABA and glycine as well as the inwardly rectifying K(+) current induced by 5-HT and 8-hydroxy-2 (di-n-propylamino) tetraline hydrobromide (8-OH-DPAT), a 5-HT(1A) agonist. tianeptine 0-10 5-hydroxytryptamine receptor 1A Rattus norvegicus 247-254 8364729-6 1993 Whereas the actions of imipramine and tianeptine on 5-HT2 and 5-HT1A receptors are specific to each drug, the surprising finding of a similar effect of both drugs to reduce serotonin transporter sites labelled by [3H]paroxetine suggest the possibility of a common action for these two drugs in spite of their opposite effects on serotonin re-uptake. tianeptine 38-48 5-hydroxytryptamine receptor 1A Rattus norvegicus 62-68 7531300-6 1994 The hypothermic response to the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT, 0.15 mg/kg, s.c.) was significantly attenuated after chronic setraline treatment, whereas tianeptine was inactive at the 2 doses tested. tianeptine 198-208 5-hydroxytryptamine receptor 1A Rattus norvegicus 32-38