PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24277991-2 2013 The limitation of berberine seems to be its poor oral bioavailability, which is affected by the presence, in enterocytes, of P-glycoprotein - an active adenosine triphosphate (ATP)-consuming efflux protein that extrudes berberine into the intestinal lumen, thus limiting its absorption. Berberine 18-27 ATP binding cassette subfamily B member 1 Homo sapiens 125-139 29891588-0 2018 Berberine Upregulates P-Glycoprotein in Human Caco-2 Cells and in an Experimental Model of Colitis in the Rat via Activation of Nrf2-Dependent Mechanisms. Berberine 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 22-36 29891588-4 2018 Berberine treatment improved DSS-induced colitis symptoms, attenuated inflammatory markers (myeloperoxidase, tumor necrosis factor-alpha, and interleukin-1beta and -6), and enhanced P-gp expression in a dose-dependent manner. Berberine 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 182-186 29891588-5 2018 Although colonic expression of the P-gp-related nuclear receptor pregnane X receptor and transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) were downregulated in the colitis model, gene and protein expression analysis revealed that berberine treatment reversed only the downregulation of Nrf2. Berberine 253-262 ATP binding cassette subfamily B member 1 Homo sapiens 35-39 29891588-6 2018 In vitro studies using Caco-2 cells showed that the multidrug resistance 1 (MDR1) gene and P-gp protein were upregulated by berberine in a dose- and time-dependent manner. Berberine 124-133 ATP binding cassette subfamily B member 1 Homo sapiens 52-74 29891588-6 2018 In vitro studies using Caco-2 cells showed that the multidrug resistance 1 (MDR1) gene and P-gp protein were upregulated by berberine in a dose- and time-dependent manner. Berberine 124-133 ATP binding cassette subfamily B member 1 Homo sapiens 76-80 29891588-6 2018 In vitro studies using Caco-2 cells showed that the multidrug resistance 1 (MDR1) gene and P-gp protein were upregulated by berberine in a dose- and time-dependent manner. Berberine 124-133 ATP binding cassette subfamily B member 1 Homo sapiens 91-95 29891588-7 2018 Significant upregulation of the MDR1 gene by berberine was abrogated by Nrf2 silencing, indicating that the Nrf2-mediated pathway was responsible for this activation. Berberine 45-54 ATP binding cassette subfamily B member 1 Homo sapiens 32-36 29891588-9 2018 These results indicate the possible involvement of Nrf2-mediated upregulation of P-gp in the therapeutic effect of berberine on colitis and highlight the potential of P-gp and/or Nrf2 as new therapeutic targets for IBD. Berberine 115-124 ATP binding cassette subfamily B member 1 Homo sapiens 81-85 24277991-2 2013 The limitation of berberine seems to be its poor oral bioavailability, which is affected by the presence, in enterocytes, of P-glycoprotein - an active adenosine triphosphate (ATP)-consuming efflux protein that extrudes berberine into the intestinal lumen, thus limiting its absorption. Berberine 220-229 ATP binding cassette subfamily B member 1 Homo sapiens 125-139 12530470-6 2002 In Caco-2 cells, berberine uptake was significantly increased by P-glycoprotein inhibitors and by monoclonal antibody C219. Berberine 17-26 ATP binding cassette subfamily B member 1 Homo sapiens 65-79 23372711-0 2013 Inhibition of P-glycoprotein by HIV protease inhibitors increases intracellular accumulation of berberine in murine and human macrophages. Berberine 96-105 ATP binding cassette subfamily B member 1 Homo sapiens 14-28 23372711-10 2013 The results indicate that P-gp contributed to the efflux of BBR in macrophages. Berberine 60-63 ATP binding cassette subfamily B member 1 Homo sapiens 26-30 18157518-0 2008 Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Berberine 42-51 ATP binding cassette subfamily B member 1 Homo sapiens 166-170 18157518-0 2008 Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Berberine 42-51 ATP binding cassette subfamily B member 1 Homo sapiens 187-192 12610223-4 2003 The benzyladenine-induced band in T. minus showed properties similar to those of human MDR1, including the recognition of berberine, which suggests that the ABC protein detected in T. minus takes this endogenous alkaloid as a putative substrate for transport. Berberine 122-131 ATP binding cassette subfamily B member 1 Homo sapiens 87-91 21319959-8 2011 Berberine, palmatine, jateorhizine, and coptisine were all P-gp substrates; and at the range of 1-100 muM, berberine, palmatine, jateorhizine, and coptisine had no inhibitory effects on P-gp. Berberine 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 59-63 18157518-7 2008 When transfected cells were grown polarized on permeable filter supports, berberine was transferred from the basolateral to the apical compartments many times faster by MDCK-OCT1/MDR1 P-gp double transfectants than by MDCK-OCT1 or MDCK-MDR1 P-gp single transfectants. Berberine 74-83 ATP binding cassette subfamily B member 1 Homo sapiens 179-183 18157518-7 2008 When transfected cells were grown polarized on permeable filter supports, berberine was transferred from the basolateral to the apical compartments many times faster by MDCK-OCT1/MDR1 P-gp double transfectants than by MDCK-OCT1 or MDCK-MDR1 P-gp single transfectants. Berberine 74-83 ATP binding cassette subfamily B member 1 Homo sapiens 236-240 18157518-8 2008 The specific MDR1 P-gp inhibitor, zosuquidar trihydrochloride (LY335979), strongly inhibited berberine efflux into the apical compartment. Berberine 93-102 ATP binding cassette subfamily B member 1 Homo sapiens 13-17 17213652-0 2007 Human MDR1 and MRP1 recognize berberine as their transport substrate. Berberine 30-39 ATP binding cassette subfamily B member 1 Homo sapiens 6-10 17213652-2 2007 Cells expressing MDR1 or MRP1 accumulated less berberine. Berberine 47-56 ATP binding cassette subfamily B member 1 Homo sapiens 17-21 17213652-3 2007 Berberine accumulation depended on the cellular ATP level, and was reversed by typical inhibitors of MDR1, suggesting that human MDR1 and MRP1 directly efflux berberine as their substrate. Berberine 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 101-105 17213652-3 2007 Berberine accumulation depended on the cellular ATP level, and was reversed by typical inhibitors of MDR1, suggesting that human MDR1 and MRP1 directly efflux berberine as their substrate. Berberine 0-9 ATP binding cassette subfamily B member 1 Homo sapiens 129-133 17213652-3 2007 Berberine accumulation depended on the cellular ATP level, and was reversed by typical inhibitors of MDR1, suggesting that human MDR1 and MRP1 directly efflux berberine as their substrate. Berberine 159-168 ATP binding cassette subfamily B member 1 Homo sapiens 101-105 17213652-3 2007 Berberine accumulation depended on the cellular ATP level, and was reversed by typical inhibitors of MDR1, suggesting that human MDR1 and MRP1 directly efflux berberine as their substrate. Berberine 159-168 ATP binding cassette subfamily B member 1 Homo sapiens 129-133 12434406-0 2002 P-glycoprotein-mediated transport of berberine across Caco-2 cell monolayers. Berberine 37-46 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 12434406-8 2002 These results suggest that the repeated administration of berberine may up-regulate P-gp functions in Caco-2 cells. Berberine 58-67 ATP binding cassette subfamily B member 1 Homo sapiens 84-88 12434406-9 2002 If this occurs in the gastrointestinal epithelial cells, the repeated administration of berberine may reduce the gastrointestinal absorption of P-gp substrates including chemotherapeutic agents such as daunomycin. Berberine 88-97 ATP binding cassette subfamily B member 1 Homo sapiens 144-148 32748032-1 2020 Possible role of P-glycoprotein in the neuroprotective mechanism of berberine in intracerebroventricular streptozotocin-induced cognitive dysfunction. Berberine 68-77 ATP binding cassette subfamily B member 1 Homo sapiens 17-31 33362566-7 2020 Furthermore, berberine treatment concentration-dependently down-regulated the multidrug resistance-associated protein 1 and multi-drug resistance-1 protein levels in the BGC-823/DDP and SGC7901/DDP cells. Berberine 13-22 ATP binding cassette subfamily B member 1 Homo sapiens 124-147 30944202-10 2019 More importantly, MMP not only significantly enhanced berberine uptake driven by cell membrane potential (P<0.01) but also inhibited p-glycoprotein (P-gp)-mediated berberine efflux (P<0.01). Berberine 167-176 ATP binding cassette subfamily B member 1 Homo sapiens 136-150 30944202-10 2019 More importantly, MMP not only significantly enhanced berberine uptake driven by cell membrane potential (P<0.01) but also inhibited p-glycoprotein (P-gp)-mediated berberine efflux (P<0.01). Berberine 167-176 ATP binding cassette subfamily B member 1 Homo sapiens 152-156 30558158-7 2018 In the in vitro experiments, OPCs significantly inhibited the efflux and increased the uptake of the P-glycoprotein (P-gp) substrate rhodamine-123 (R123) and BB in Caco-2 intestinal cells. Berberine 158-160 ATP binding cassette subfamily B member 1 Homo sapiens 117-121 32109457-7 2020 We found that the combination of berberine and evodiamine showed synergistic anticancer activity in P-glycoprotein (P-gp)-positive colorectal cancer cells through attenuating the overexpression of P-gp mRNA independent of cell cycle arrest and cell apoptosis. Berberine 33-42 ATP binding cassette subfamily B member 1 Homo sapiens 100-114 32109457-7 2020 We found that the combination of berberine and evodiamine showed synergistic anticancer activity in P-glycoprotein (P-gp)-positive colorectal cancer cells through attenuating the overexpression of P-gp mRNA independent of cell cycle arrest and cell apoptosis. Berberine 33-42 ATP binding cassette subfamily B member 1 Homo sapiens 116-120 32109457-7 2020 We found that the combination of berberine and evodiamine showed synergistic anticancer activity in P-glycoprotein (P-gp)-positive colorectal cancer cells through attenuating the overexpression of P-gp mRNA independent of cell cycle arrest and cell apoptosis. Berberine 33-42 ATP binding cassette subfamily B member 1 Homo sapiens 197-201