PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34803500-0 2021 Berberine improves insulin-induced diabetic retinopathy through exclusively suppressing Akt/mTOR-mediated HIF-1alpha/VEGF activation in retina endothelial cells. Berberine 0-9 thymoma viral proto-oncogene 1 Mus musculus 88-91 34592881-8 2021 Here, we proved that in ApoE -/- mice receiving high-fat diet for 12 weeks, BBR can reduce serum lipid levels, improve intimal hyperplasia, and antagonize carotid lipid accumulation, which may be achieved through regulating the PI3K/AKT/mTOR signaling pathway, regulating autophagy, promoting cell proliferation and inhibiting cell apoptosis. Berberine 76-79 thymoma viral proto-oncogene 1 Mus musculus 233-236 34803500-5 2021 Methods: To better understand the therapeutic potential of berberine in the presence of insulin, we elaborated the action of mechanism whether berberine inhibited retinal expression of HIF-1alpha and VEGF through regulating AKT/mTOR pathway. Berberine 59-68 thymoma viral proto-oncogene 1 Mus musculus 224-227 34803500-5 2021 Methods: To better understand the therapeutic potential of berberine in the presence of insulin, we elaborated the action of mechanism whether berberine inhibited retinal expression of HIF-1alpha and VEGF through regulating AKT/mTOR pathway. Berberine 143-152 thymoma viral proto-oncogene 1 Mus musculus 224-227 34803500-9 2021 Berberine suppressed Akt/mTOR activity in these cells, and restoration of Akt/mTOR signalling attenuated berberine"s inhibition on HIF-1alpha and VEGF expression. Berberine 0-9 thymoma viral proto-oncogene 1 Mus musculus 21-24 34803500-9 2021 Berberine suppressed Akt/mTOR activity in these cells, and restoration of Akt/mTOR signalling attenuated berberine"s inhibition on HIF-1alpha and VEGF expression. Berberine 105-114 thymoma viral proto-oncogene 1 Mus musculus 74-77 34803500-11 2021 Conclusion: Berberine improves insulin-induced diabetic retinopathy in type I and II diabetes through inhibiting insulin-induced activation of retinal endotheliocytes via Akt/mTOR/ HIF-1alpha/VEGF pathway. Berberine 12-21 thymoma viral proto-oncogene 1 Mus musculus 171-174 35254584-0 2022 Berberis lycium fruit extract and its phytoconstituents berberine and rutin mitigate collagen-CFA-induced arthritis (CIA) via improving GSK3beta/STAT/Akt/MAPKs/NF-kappaB signaling axis mediated oxi-inflammation and joint articular damage in murine model. Berberine 56-65 thymoma viral proto-oncogene 1 Mus musculus 150-153 35495613-0 2022 Berberine attenuates sepsis-induced cardiac dysfunction by upregulating the Akt/eNOS pathway in mice. Berberine 0-9 thymoma viral proto-oncogene 1 Mus musculus 76-79 35495613-9 2022 In addition, it increased the heart total nitric oxide synthase (NOS) activity and upregulated the protein expressions of p-Akt and phosphorylated endothelial (e)NOS, which indicated that the Akt/eNOS pathway was activated by berberine. Berberine 226-235 thymoma viral proto-oncogene 1 Mus musculus 124-127 35495613-9 2022 In addition, it increased the heart total nitric oxide synthase (NOS) activity and upregulated the protein expressions of p-Akt and phosphorylated endothelial (e)NOS, which indicated that the Akt/eNOS pathway was activated by berberine. Berberine 226-235 thymoma viral proto-oncogene 1 Mus musculus 192-195 35495613-11 2022 In conclusion, berberine attenuated sepsis-induced cardiac dysfunction by upregulating the Akt/eNOS pathway in mice. Berberine 15-24 thymoma viral proto-oncogene 1 Mus musculus 91-94 34690771-10 2021 After oral administration, BBR significantly inhibited the PI3K/Akt pathway and Rap1 activation and suppressed ADP-induced platelet activation and carrageenan-induced thrombosis in mice without prolonging bleeding time. Berberine 27-30 thymoma viral proto-oncogene 1 Mus musculus 64-67 35571083-0 2022 Co-Crystal of Rosiglitazone With Berberine Ameliorates Hyperglycemia and Insulin Resistance Through the PI3K/AKT/TXNIP Pathway In Vivo and In Vitro. Berberine 33-42 thymoma viral proto-oncogene 1 Mus musculus 109-112 35001506-0 2022 Berberine regulates mesangial cell proliferation and cell cycle to attenuate diabetic nephropathy through the PI3K/Akt/AS160/GLUT1 signalling pathway. Berberine 0-9 thymoma viral proto-oncogene 1 Mus musculus 115-118 29403554-13 2018 In conclusion, the results of the present study indicate that berberine inhibits inflammatory responses through the NF-kappaB signaling pathway and suppresses the apoptosis of myocardial cells via the PI3K/AKT signaling pathway in a mouse model of ischemia-reperfusion injury. Berberine 62-71 thymoma viral proto-oncogene 1 Mus musculus 206-209 33390968-5 2020 The BBR-induced activation of the AMPK pathway and AKT phosphorylation in adipocytes and adipose tissue were also attenuated by inhibition or knockout of Sirt1. Berberine 4-7 thymoma viral proto-oncogene 1 Mus musculus 51-54 32393087-7 2020 Moreover, berberine enhanced the phosphorylation levels of protein kinase B (PKB/AKT; 2.27-fold) and glycogen synthase kinase-3beta (GSK3beta; 2.56-fold), and increased hepatic glycogen content (from 0.19 to 1.65). Berberine 10-19 thymoma viral proto-oncogene 1 Mus musculus 77-80 32393087-7 2020 Moreover, berberine enhanced the phosphorylation levels of protein kinase B (PKB/AKT; 2.27-fold) and glycogen synthase kinase-3beta (GSK3beta; 2.56-fold), and increased hepatic glycogen content (from 0.19 to 1.65). Berberine 10-19 thymoma viral proto-oncogene 1 Mus musculus 81-84 29545879-14 2018 In addition, the expression and phosphorylation levels of PI3K and AKT were downregulated in epithelial cells following treatment with berberine. Berberine 135-144 thymoma viral proto-oncogene 1 Mus musculus 67-70 29545879-18 2018 Therefore, the results of the present study demonstrate that berberine inhibits inflammation and apoptosis via the PI3K/AKT signaling pathway and may therefore attenuate the progression of NEC. Berberine 61-70 thymoma viral proto-oncogene 1 Mus musculus 120-123 29482156-0 2018 Berberine inhibits macrophage M1 polarization via AKT1/SOCS1/NF-kappaB signaling pathway to protect against DSS-induced colitis. Berberine 0-9 thymoma viral proto-oncogene 1 Mus musculus 50-54 29482156-8 2018 Further investigation showed that berberine promoted AKT1 expression in mRNA and protein level. Berberine 34-43 thymoma viral proto-oncogene 1 Mus musculus 53-57 29482156-9 2018 Silence of AKT1 abolished the inhibitory effect of berberine on macrophages M1 polarization. Berberine 51-60 thymoma viral proto-oncogene 1 Mus musculus 11-15 29482156-10 2018 The berberine-induced AKT1 expression promoted suppressers of cytokine signaling (SOCS1) activation, which inhibited nuclear factor-kappa B (NF-kappaB) phosphorylation. Berberine 4-13 thymoma viral proto-oncogene 1 Mus musculus 22-26 29482156-11 2018 In addition, we also found that berberine activated AKT1/SOCS1 signaling pathway but inhibited p65 phosphorylation in macrophages in vivo. Berberine 32-41 thymoma viral proto-oncogene 1 Mus musculus 52-56 29482156-12 2018 Therefore, we concluded that berberine played a regulatory role in macrophages M1 polarization in DSS-induced colitis via AKT1/SOCS1/NF-kappaB signaling pathway. Berberine 29-38 thymoma viral proto-oncogene 1 Mus musculus 122-126 32454290-11 2020 In xenografts, the berberine induced autophagy leads to suppression of tumor proliferation with no side-effect, and western blotting displayed an apparent attenuation of p-mTOR, p-p70S6K, p-Akt, p-ERK, p-JNK and p-p38 in tumors from berberine treated mice. Berberine 19-28 thymoma viral proto-oncogene 1 Mus musculus 190-193 32494123-0 2020 Berberine Induces Autophagic Cell Death in Acute Lymphoblastic Leukemia by Inactivating AKT/mTORC1 Signaling. Berberine 0-9 thymoma viral proto-oncogene 1 Mus musculus 88-91 32494123-9 2020 Mechanistic studies exhibit that berberine induces autophagic death in ALL cells by inactivating AKT/mTORC1 signaling. Berberine 33-42 thymoma viral proto-oncogene 1 Mus musculus 97-100 32494123-10 2020 Chemically targeting AKT/mTORC1 signaling controls berberine-induced cell autophagy in vitro, and blockade of autophagic process blunts berberine-alleviated pathological condition in vivo. Berberine 51-60 thymoma viral proto-oncogene 1 Mus musculus 21-24 32494123-11 2020 Discussion: In conclusion, our study reveals that berberine could induce ALL cell autophagic death by inactivating AKT/mTORC1 signaling that could be used to develop small molecule drug for ALL treatment. Berberine 50-59 thymoma viral proto-oncogene 1 Mus musculus 115-118 27462872-5 2017 Furthermore, both berberine and nandinine inhibited serine phosphorylation of insulin receptor substrate-1 induced by IkappaB kinase beta and increased tyrosine phosphorylation of insulin receptor substrate-1 to activate the PI3K/Akt pathway, which finally led to insulin-mediated glucose uptake. Berberine 18-27 thymoma viral proto-oncogene 1 Mus musculus 230-233 27702567-11 2016 The phosphorylation of AKT (Ser473) was increased in berberine-treated adipose tissue. Berberine 53-62 thymoma viral proto-oncogene 1 Mus musculus 23-26 27235712-14 2016 Molecular insights revealed that berberine regulates EMT via downregulation of PI3/Akt and Ras-Raf-ERK signalling and subsequent upregulation of p38-MAPK. Berberine 33-42 thymoma viral proto-oncogene 1 Mus musculus 83-86 25048007-0 2015 Berberine protects homocysteic acid-induced HT-22 cell death: involvement of Akt pathway. Berberine 0-9 thymoma viral proto-oncogene 1 Mus musculus 77-80 25837881-5 2015 Meanwhile, berberine significantly inhibited the activation of Akt and suppressed tumor growth in xenograft nude mice injected with human gastric cancer cells. Berberine 11-20 thymoma viral proto-oncogene 1 Mus musculus 63-66 22469516-0 2012 Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells. Berberine 0-9 thymoma viral proto-oncogene 1 Mus musculus 121-124 19546885-7 2009 Analysis in RAW264.7 cells indicated that berberine induced SR-A expression by suppressing PTEN expression, which led to sustained Akt activation. Berberine 42-51 thymoma viral proto-oncogene 1 Mus musculus 131-134 27639645-0 2016 Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARalpha/RARbeta in melanoma cells. Berberine 0-9 thymoma viral proto-oncogene 1 Mus musculus 93-96 27639645-4 2016 We found that berberine also downregulation the expression level of p-PI3K, p-AKT and retinoic acid receptor alpha (RARalpha) and upregulation the expression level of retinoic acid receptor beta and gamma (RARbeta and RARgamma). Berberine 14-23 thymoma viral proto-oncogene 1 Mus musculus 78-81 27639645-7 2016 In conclusion, Our study reveal that berberine can reverse the epithelial to mesenchymal transition of mouse melanoma B16 cells and may be a useful adjuvant therapeutic agent in the treatment of melanoma through the PI3K/Akt pathway and inactivation PI3K/AKT could regulate RARalpha/RARbeta expression. Berberine 37-46 thymoma viral proto-oncogene 1 Mus musculus 221-224 27639645-7 2016 In conclusion, Our study reveal that berberine can reverse the epithelial to mesenchymal transition of mouse melanoma B16 cells and may be a useful adjuvant therapeutic agent in the treatment of melanoma through the PI3K/Akt pathway and inactivation PI3K/AKT could regulate RARalpha/RARbeta expression. Berberine 37-46 thymoma viral proto-oncogene 1 Mus musculus 255-258 25716948-0 2015 Berberine regulates melanin synthesis by activating PI3K/AKT, ERK and GSK3beta in B16F10 melanoma cells. Berberine 0-9 thymoma viral proto-oncogene 1 Mus musculus 57-60 25716948-6 2015 The results showed that treatment with berberine resulted in a reduction in the phosphorylation of PI3K/AKT, ERK, and GSK3beta. Berberine 39-48 thymoma viral proto-oncogene 1 Mus musculus 104-107 22459600-7 2012 We also found that BBR significantly decreased the levels of C-terminal fragments of APP and the hyperphosphorylation of APP and tau via the Akt/glycogen synthase kinase 3 signaling pathway in N2a mouse neuroblastoma cells stably expressing human Swedish mutant APP695 (N2a-SwedAPP). Berberine 19-22 thymoma viral proto-oncogene 1 Mus musculus 141-144 21705841-0 2011 Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activation of Akt signaling pathway. Berberine 0-9 thymoma viral proto-oncogene 1 Mus musculus 99-102 21705841-8 2011 Collectively, Berberine upregulates the activity of Akt possibly via insulin signaling pathway, eventually lowering high blood glucose in alloxan-induced diabetic mice. Berberine 14-23 thymoma viral proto-oncogene 1 Mus musculus 52-55