PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19846952-4 2009 Berberine-induced apoptosis was associated with a reduction of the mitochondrial membrane potential associated with changes in the Bax/Bcl-2 ratio, release of cytochrome c from mitochondria and activation of down stream caspase-3. Berberine 0-9 cytochrome c, somatic Homo sapiens 159-171 21527846-6 2011 Treatment of SK-MEL-2 melanoma cells with berberine induced disruption of the mitochondrial transmembrane potential, release of cytochrome c and apoptosis-inducing factor from the mitochondria to the cytosol, generation of reactive oxygen species (ROS), and a decreased ATP/ADP ratio. Berberine 42-51 cytochrome c, somatic Homo sapiens 128-140 20830746-5 2010 Mechanistic studies showed that berberine may activate mitochondrial apoptosis in HepG2 and MHCC97-L cells by increasing Bax expression, the formation of permeable transition pores, cytochrome C release to cytosol, and subsequent activation of the caspases 3 and 9 execution pathway. Berberine 32-41 cytochrome c, somatic Homo sapiens 182-194 20656010-4 2010 We found that Bcl-2/Bax ratio was significantly decreased and cytochrome c was released from mitochondrion to cytosol, which indicated that the mitochondrial pathway was activated by berberine. Berberine 183-192 cytochrome c, somatic Homo sapiens 62-74 20691179-8 2010 Western blotting with treated cells revealed that berberine induces apoptosis in MCF-7 cells through a mitochondria-dependent pathway by increasing levels of cytoplasmic cytochrome c, caspase-9 activity and cleavage of PARP while decreasing levels of Bcl-2. Berberine 50-59 cytochrome c, somatic Homo sapiens 170-182 18451495-4 2008 Combined treatment with berberine and cisplatin acted in concert to induce loss of mitochondrial membrane potential (Delta Psi m), release of cytochrome-c from mitochondria, and decreased expression of antiapoptotic Bcl-2, Bcl-x/L, resulting in activation of caspases and apoptosis. Berberine 24-33 cytochrome c, somatic Homo sapiens 142-154 19652370-7 2009 Further study revealed that berberine could scavenger the reactive oxygen species (ROS), inhibit the c-jun NH(2)-terminal kinase (JNK), the loss of mitochondrial membrane potential and the release of cytochrome c (Cyt C) and caspase-3. Berberine 28-37 cytochrome c, somatic Homo sapiens 200-212 19652370-7 2009 Further study revealed that berberine could scavenger the reactive oxygen species (ROS), inhibit the c-jun NH(2)-terminal kinase (JNK), the loss of mitochondrial membrane potential and the release of cytochrome c (Cyt C) and caspase-3. Berberine 28-37 cytochrome c, somatic Homo sapiens 214-219 18275980-4 2008 Berberine-induced apoptosis was associated with the disruption of the mitochondrial membrane potential, release of apoptogenic molecules (cytochrome c and Smac/DIABLO) from mitochondria and cleavage of caspase-9,-3 and PARP proteins. Berberine 0-9 cytochrome c, somatic Homo sapiens 138-150 18275980-7 2008 Berberine-induced apoptosis was blocked in the presence of antioxidant, N-acetylcysteine, through the prevention of disruption of mitochondrial membrane potential and subsequently release of cytochrome c and Smac/DIABLO. Berberine 0-9 cytochrome c, somatic Homo sapiens 191-203 17673978-4 2007 Treatment of SW620 cells with 50 microM berberine resulted in activation of the caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c; whereas, the expression of BID and anti-apoptosis factor c-IAP1, Bcl-2, and Bcl-(XL) were decreased markedly. Berberine 40-49 cytochrome c, somatic Homo sapiens 170-182 18001034-6 2007 Berberine also inhibited the generation of ROS and the subsequent mitochondrial membrane potential collapse, chromosome condensation, cytochrome C release, and caspase-3 activation induced by oxLDL in HUVECs. Berberine 0-9 cytochrome c, somatic Homo sapiens 134-146 17970083-10 2007 Prolonged exposure of the HSC-3 cells to berberine causes increased apoptosis through reduced levels of MMP, release of cytochrome c and activation of caspase-3. Berberine 41-50 cytochrome c, somatic Homo sapiens 120-132 11302188-0 2001 Inhibitory activity of berberine on DNA strand cleavage induced by hydrogen peroxide and cytochrome c. Berberine 23-32 cytochrome c, somatic Homo sapiens 89-101 16440412-10 2006 CONCLUSION: Berberine induces p53 expression and leads to the decrease of the mitochondrial membrane potential, Cytochrome C release and activation of caspase-3 for the induction of apoptosis. Berberine 12-21 cytochrome c, somatic Homo sapiens 112-124 16189662-7 2006 Moreover, berberine induced the activation of caspase-8 and -3, and caused the cleavage of poly ADP-ribose polymerase (PARP) and the cytochrome c release, whereas the expression of Bid and anti-apoptosis factor Bcl-XL were decreased markedly. Berberine 10-19 cytochrome c, somatic Homo sapiens 133-145 11302188-1 2001 The inhibitory activity of berberine on the DNA single-strand cleavage induced by hydrogen peroxide and cytochrome c was measured. Berberine 27-36 cytochrome c, somatic Homo sapiens 104-116 26672764-0 2016 Melatonin inhibits AP-2beta/hTERT, NF-kappaB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells. Berberine 139-148 cytochrome c, somatic Homo sapiens 85-91 35571453-10 2022 BBR induced apoptosis in NSCLC cells as evidenced by caspase-3 cleavage, cytochrome c release, and mitochondrial membrane depolarization. Berberine 0-3 cytochrome c, somatic Homo sapiens 73-85 28826092-0 2017 Berberine activates caspase-9/cytochrome c-mediated apoptosis to suppress triple-negative breast cancer cells in vitro and in vivo. Berberine 0-9 cytochrome c, somatic Homo sapiens 30-42 26672764-5 2016 Further mechanism study showed that melatonin promoted the cleavage of caspse-9 and PARP, enhanced the inhibition of Bcl2, and triggered the releasing of cytochrome C (Cyto C), thereby increasing the berberine-induced apoptosis. Berberine 200-209 cytochrome c, somatic Homo sapiens 154-166 26672764-5 2016 Further mechanism study showed that melatonin promoted the cleavage of caspse-9 and PARP, enhanced the inhibition of Bcl2, and triggered the releasing of cytochrome C (Cyto C), thereby increasing the berberine-induced apoptosis. Berberine 200-209 cytochrome c, somatic Homo sapiens 168-174 26672764-9 2016 Collectively, our results demonstrated that melatonin enhanced the antitumor activity of berberine by activating caspase/Cyto C and inhibiting AP-2beta/hTERT, NF-kappaB/COX-2 and Akt/ERK signaling pathways. Berberine 89-98 cytochrome c, somatic Homo sapiens 121-127 23869238-0 2013 Berberine Targets AP-2/hTERT, NF-kappaB/COX-2, HIF-1alpha/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth. Berberine 0-9 cytochrome c, somatic Homo sapiens 67-79