PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26226164-4 2015 Oral administration of BBR was able to significantly reduce this alcohol-induced damage, inhibit increases of alcohol-induced TNFalpha and IL-1beta expression in gastrointestinal mucosa as well as their upstream signals TLR2 and TLR4, and regulate cytokines that modulate tight junctions. Berberine 23-26 interleukin 1 beta Homo sapiens 139-147 29891588-4 2018 Berberine treatment improved DSS-induced colitis symptoms, attenuated inflammatory markers (myeloperoxidase, tumor necrosis factor-alpha, and interleukin-1beta and -6), and enhanced P-gp expression in a dose-dependent manner. Berberine 0-9 interleukin 1 beta Homo sapiens 142-166 29263046-0 2017 Berberine Attenuates NLRP3 Inflammasome Activation in Macrophages to Reduce the Secretion of Interleukin-1beta. Berberine 0-9 interleukin 1 beta Homo sapiens 93-110 29263046-7 2017 RESULTS: In this study we observed that berberine suppressed IL-1beta secretion that was induced by the activation of the NLRP3 inflammasome in macrophages. Berberine 40-49 interleukin 1 beta Homo sapiens 61-69 29263046-9 2017 Moreover, Berberine inhibited the expression of pro-IL-1beta through inhibition of the nuclear factor kappab (NF-kappaB) pathway, which prevented the priming IL-1beta secretion. Berberine 10-19 interleukin 1 beta Homo sapiens 48-60 29263046-9 2017 Moreover, Berberine inhibited the expression of pro-IL-1beta through inhibition of the nuclear factor kappab (NF-kappaB) pathway, which prevented the priming IL-1beta secretion. Berberine 10-19 interleukin 1 beta Homo sapiens 52-60 29263046-10 2017 CONCLUSION: Our results suggest that berberine alleviates NLRP3 inflammation activation by reducing IL-1beta secretion from macrophages, which could be an important therapeutic target in atherosclerosis. Berberine 37-46 interleukin 1 beta Homo sapiens 100-108 28000894-0 2017 Berberine affects osteosarcoma via downregulating the caspase-1/IL-1beta signaling axis. Berberine 0-9 interleukin 1 beta Homo sapiens 64-72 28000894-8 2017 Furthermore, administration of berberine is capable of reducing the expression of caspase-1 and IL-1beta in osteosarcoma cells and inhibiting the growth of tumor cells. Berberine 31-40 interleukin 1 beta Homo sapiens 96-104 28000894-9 2017 Based on the above, for the first time, we propose the hyposis that berberine could gengerate an anti-osteosarcoma property through downregulating caspase-1/IL-1beta inflammatory signaling axis. Berberine 68-77 interleukin 1 beta Homo sapiens 157-165 27689075-11 2016 Meanwhile, there was significant reduction in the expressions of NLRP3 and IL-1beta mRNA in groups 6.25 muM berberine and 25 muM berberine when compared with model group (P < 0.05). Berberine 108-117 interleukin 1 beta Homo sapiens 75-83 27689075-11 2016 Meanwhile, there was significant reduction in the expressions of NLRP3 and IL-1beta mRNA in groups 6.25 muM berberine and 25 muM berberine when compared with model group (P < 0.05). Berberine 129-138 interleukin 1 beta Homo sapiens 75-83 27689075-13 2016 Therefore, berberine alleviates monosodium urate crystals-induced inflammation by downregulating NLRP3 and IL-1beta expressions. Berberine 11-20 interleukin 1 beta Homo sapiens 107-115 17681786-0 2007 Berberine suppresses inflammatory agents-induced interleukin-1beta and tumor necrosis factor-alpha productions via the inhibition of IkappaB degradation in human lung cells. Berberine 0-9 interleukin 1 beta Homo sapiens 49-66 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. Berberine 122-131 interleukin 1 beta Homo sapiens 267-271 17295145-1 2007 PURPOSE: To examine the effects of berberine, an alkaloid isolated from some medicinal herbs, on the disruption of the barrier function in a human retinal pigment epithelial cell line (ARPE-19) stimulated with interleukin-1beta (IL-1beta). Berberine 35-44 interleukin 1 beta Homo sapiens 210-227 17295145-5 2007 RESULTS: Berberine dose-dependently inhibited decreased TER and increased the permeability to HRP and SF in the cells stimulated with IL-1beta. Berberine 9-18 interleukin 1 beta Homo sapiens 134-142 17295145-6 2007 CONCLUSIONS: Berberine dose-dependently inhibited the disruption of the barrier function in the ARPE-19 cell line induced by IL-1beta. Berberine 13-22 interleukin 1 beta Homo sapiens 125-133 16391493-1 2006 PURPOSE: The aims of this study were to examine the effects of berberine, an alkaloid isolated from some medicinal herbs, on interleukin 8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) expression in a human retinal pigment epithelial cell line (ARPE-19) stimulated with interleukin 1beta (IL-1beta) or tumor necrosis factor alpha (TNF-alpha). Berberine 63-72 interleukin 1 beta Homo sapiens 274-291 16391493-1 2006 PURPOSE: The aims of this study were to examine the effects of berberine, an alkaloid isolated from some medicinal herbs, on interleukin 8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) expression in a human retinal pigment epithelial cell line (ARPE-19) stimulated with interleukin 1beta (IL-1beta) or tumor necrosis factor alpha (TNF-alpha). Berberine 63-72 interleukin 1 beta Homo sapiens 293-301 16391493-7 2006 CONCLUSION: These findings indicate that berberine dose-dependently inhibited the expression of IL-8 and MCP-1 induced by IL-1beta or TNF-alpha. Berberine 41-50 interleukin 1 beta Homo sapiens 122-130 16132116-0 2005 Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells. Berberine 98-107 interleukin 1 beta Homo sapiens 21-38 31412862-6 2019 BBR also caused a marked reduction in the secretion of proinflammatory cytokines, Interleukin-1alpha (IL-1alpha), Interleukin-1beta (IL-1beta), Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha). Berberine 0-3 interleukin 1 beta Homo sapiens 114-131 35085532-5 2022 Berberine had an antagonistic effect for the majority of genes mutual for AD and toxic metal mixture: ACHE, APP, BAX, BCL2, CASP3, HMOX1, IL1B, MAPT, SOD2, TNF. Berberine 0-9 interleukin 1 beta Homo sapiens 138-142 31139563-0 2019 Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1beta and IL-18 Release. Berberine 21-30 interleukin 1 beta Homo sapiens 81-89 31139563-6 2019 In this study, we demonstrate that berberine significantly inhibits inflammatory cytokine Caspase-1 activation via ERK1/2 signaling and subsequent production of IL-1beta and IL-18 by glioma cells. Berberine 35-44 interleukin 1 beta Homo sapiens 161-169 31264347-8 2019 Dietary berberine significantly mitigated the LPS-induced decreases in the mRNA expression of nuclear factor-kappa B (NF-kappaB), TNF-alpha, IL-1beta, inducible nitrite synthase and cyclooxygenase-2 (p < 0.05) in the liver. Berberine 8-17 interleukin 1 beta Homo sapiens 141-149 30816449-0 2019 Berberine prevents human nucleus pulposus cells from IL-1beta-induced extracellular matrix degradation and apoptosis by inhibiting the NF-kappaB pathway. Berberine 0-9 interleukin 1 beta Homo sapiens 53-61