PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33088695-0 2020 Functional nano-vector boost anti-atherosclerosis efficacy of berberine in Apoe (-/-) mice. Berberine 62-71 apolipoprotein E Mus musculus 75-79 33088695-3 2020 The aim of this study was to develop an effective BBR-entrapped nano-system for treating AS in high-fat diet (HFD)-fed Apoe (-/-) mice, and also explore the possible underlying mechanisms involved. Berberine 50-53 apolipoprotein E Mus musculus 119-123 32566106-6 2020 Here, we demonstrated that berberine reduced serum lipid levels, antagonized hepatic lipid accumulation, improved intima-media thickening, and alleviated atherosclerotic lesions in ApoE-/- mice fed a western-type diet for 12 weeks. Berberine 27-36 apolipoprotein E Mus musculus 181-185 32231564-0 2020 Effect of Berberine on Atherosclerosis and Gut Microbiota Modulation and Their Correlation in High-Fat Diet-Fed ApoE-/- Mice. Berberine 10-19 apolipoprotein E Mus musculus 112-116 30257374-0 2018 Berberine treatment reduces atherosclerosis by mediating gut microbiota in apoE-/- mice. Berberine 0-9 apolipoprotein E Mus musculus 75-79 31895879-6 2020 Here, we demonstrated that berberine could inhibit atherosclerosis in apolipoprotein E-deficient mice and induce cholesterol reduction as well as decrease the content of macrophages. Berberine 27-36 apolipoprotein E Mus musculus 70-86 27181586-0 2016 Berberine activates peroxisome proliferator-activated receptor gamma to increase atherosclerotic plaque stability in Apoe-/- mice with hyperhomocysteinemia. Berberine 0-9 apolipoprotein E Mus musculus 117-121 29393413-6 2018 In vivo experiments showed that BBR treatment (5 mg/kg/day) significantly reduced the serum levels of visfatin, lipid, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), the protein expression of visfatin, p-p38 MAPK and p-c-Jun N-terminal kinase (JNK) in mice aorta and the distribution of visfatin in the atherosclerotic lesions in ApoE-/- mice fed with a Western diet. Berberine 32-35 apolipoprotein E Mus musculus 349-353 29202334-0 2018 Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe-/- mice. Berberine 0-9 apolipoprotein E Mus musculus 107-111 29075339-0 2017 Berberine ameliorates non-alcoholic steatohepatitis in ApoE-/- mice. Berberine 0-9 apolipoprotein E Mus musculus 55-59 27181586-6 2016 RESULTS: Homocysteine thiolactone (50 mg/kg/day, 8 weeks) reduced the atherosclerotic plaque stability in the carotid artery of Apoe-/- mice, which was reversed by BBR administration (1.0 g/kg/day). Berberine 164-167 apolipoprotein E Mus musculus 128-132 25425200-0 2014 Berberine derivatives reduce atherosclerotic plaque size and vulnerability in apoE(-/-) mice. Berberine 0-9 apolipoprotein E Mus musculus 78-82 26177349-8 2015 Furthermore, long-term administration of berberine decreased mean BP and pulse BP, increased artery response to vasodilator and reduced vascular collagen content in aged mice deficient in apolipoprotein E (Apoe-KO), but not in Apoe-KO old mice with lentivirus-mediated overexpression of TRPV4 channel. Berberine 41-50 apolipoprotein E Mus musculus 188-204 26177349-8 2015 Furthermore, long-term administration of berberine decreased mean BP and pulse BP, increased artery response to vasodilator and reduced vascular collagen content in aged mice deficient in apolipoprotein E (Apoe-KO), but not in Apoe-KO old mice with lentivirus-mediated overexpression of TRPV4 channel. Berberine 41-50 apolipoprotein E Mus musculus 206-210 34592881-8 2021 Here, we proved that in ApoE -/- mice receiving high-fat diet for 12 weeks, BBR can reduce serum lipid levels, improve intimal hyperplasia, and antagonize carotid lipid accumulation, which may be achieved through regulating the PI3K/AKT/mTOR signaling pathway, regulating autophagy, promoting cell proliferation and inhibiting cell apoptosis. Berberine 76-79 apolipoprotein E Mus musculus 24-28 19014947-10 2009 Administration of BBR (100 mg/kg/d) increased TF activity and impaired TFPI expression in carotid artery of ApoE(-/-) mice. Berberine 18-21 apolipoprotein E Mus musculus 108-112 21980456-6 2011 RESULTS: In ApoE-/- mice, chronic administration of berberine significantly reduced aortic lesions, markedly reduced oxidative stress and expression of adhesion molecules in aorta, and significantly increased UCP2 levels. Berberine 52-61 apolipoprotein E Mus musculus 12-16 33863898-3 2021 Here, we show that BBR attenuated TMA/TMAO production in the C57BL/6J and ApoE KO mice fed with choline-supplemented chow diet, and mitigated atherosclerotic lesion areas in ApoE KO mice. Berberine 19-22 apolipoprotein E Mus musculus 74-78 34790723-0 2021 Berberine attenuates atherosclerotic lesions and hepatic steatosis in ApoE-/- mice by down-regulating PCSK9 via ERK1/2 pathway. Berberine 0-9 apolipoprotein E Mus musculus 70-74 34790723-12 2021 Conclusions: Data indicated that BBR significantly attenuated lipid disorder, reduced aortic plaque formation, and alleviated hepatic lipid accumulation in ApoE-/- mice fed with HFD, which was associated with down-regulation of PCSK9 through ERK1/2 pathway. Berberine 33-36 apolipoprotein E Mus musculus 156-160 33863898-3 2021 Here, we show that BBR attenuated TMA/TMAO production in the C57BL/6J and ApoE KO mice fed with choline-supplemented chow diet, and mitigated atherosclerotic lesion areas in ApoE KO mice. Berberine 19-22 apolipoprotein E Mus musculus 174-178