PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35189055-11 2022 CONCLUSION: Our findings demonstrated that a possible strategy for combating disease severity with berberine treatment in Staphylococcus aureus induced septic arthritis in mice, which targets the Th17 and Treg cells have driven the NF-kappaB/JNK-RANKL axis. Berberine 99-108 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 232-241 34427876-15 2021 Additionally, berberine inhibited NF-kappaB pathway by regulating LINC00943/miR-142-5p/KPNA4 axis. Berberine 14-23 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 34-43 35254584-0 2022 Berberis lycium fruit extract and its phytoconstituents berberine and rutin mitigate collagen-CFA-induced arthritis (CIA) via improving GSK3beta/STAT/Akt/MAPKs/NF-kappaB signaling axis mediated oxi-inflammation and joint articular damage in murine model. Berberine 56-65 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 160-169 35284463-5 2022 We demonstrated that BBR could suppress the expression of phosphorylated nuclear factor-kappa B (NF-kappaB) and further restrain the downstream gene nucleotide-binding domain and leucine-rich repeat protein-3 (Nlrp3). Berberine 21-24 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 73-95 35284463-5 2022 We demonstrated that BBR could suppress the expression of phosphorylated nuclear factor-kappa B (NF-kappaB) and further restrain the downstream gene nucleotide-binding domain and leucine-rich repeat protein-3 (Nlrp3). Berberine 21-24 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 97-106 34523052-0 2021 Berberine Attenuates Neonatal Sepsis in Mice By Inhibiting FOXA1 and NF-kappaB Signal Transduction Via the Induction of MiR-132-3p. Berberine 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 69-78 34523052-9 2021 The effects of berberine on NS-induced impairments were blocked by the injection of the miR-132-3p antagomir, which exacerbated intestinal injuries, induced systemic inflammation, and reactivated the FOXA1 and NF-kappaB pathways. Berberine 15-24 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 210-219 35596224-13 2022 In addition, the NF-kappaB expression was greatly suppressed in mice fed with stool from BBR treated AOM/DSS mice. Berberine 89-92 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 17-26 35596224-15 2022 CONCLUSIONS: Stool obtained from BBR treated AOM/DSS mice was able to increase colon length while simultaneously decreasing the density of macroscopic polyps, cell proliferation, inflammatory modulators and the expression of NF-kappaB. Berberine 33-36 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 225-234 32194416-4 2020 In the current study, we found that BBR significantly decreased lipid accumulation, ameliorated reactive oxygen species (ROS) and lipid peroxides, Tumor necrosis factor alpha (TNF-alpha) expression, and phosphorylation of Nuclear factor kappa B (NF-kappaB) p65 both in vivo and in vitro. Berberine 36-39 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 222-244 33849702-0 2021 Berberine prevents diabetic retinopathy through inhibiting HIF-1alpha /VEGF/ NF-kappa B pathway in db/db mice. Berberine 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 77-87 33849702-5 2021 Berberine prevent DR development through modulating the glucolipid metabolism and inhibiting the HIF-1alpha /VEGF/NF-kappa B pathway, suggesting that berberine maybe a potential agent for the treatment of DR. Berberine 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 114-124 33849702-5 2021 Berberine prevent DR development through modulating the glucolipid metabolism and inhibiting the HIF-1alpha /VEGF/NF-kappa B pathway, suggesting that berberine maybe a potential agent for the treatment of DR. Berberine 150-159 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 114-124 32581538-8 2020 Oral administration of BBR-NLCs significantly alleviated colitis symptoms (DAI, colon length, spleen swelling, MPO activity) through inhibition of NF-kappaB nuclear translocation, decreased expression of pro-inflammatory cytokines (IL-1beta, IL-6, MMP-9, CX3CR1, COX-2, TERT), and increased expression of the tight junction protein ZO-1. Berberine 23-26 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 147-156 35153744-5 2021 We confirmed that berberine mediated the neuroinflammatory reaction induced by cisplatin by inhibiting the overexpression of TRPV1 and NF-kappaB and activating the JNK/p38 MAPK pathways in early injury, which inhibited the expression of p-JNK and mediated the expression of p38 MAPK/ERK in late injury in vivo. Berberine 18-27 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 135-144 35153744-7 2021 In TRPV1 knockout mice, the expression of NF-kappaB increased in late stage, and berberine inhibited the overexpression of NF-kappaB and p-ERK in late injury. Berberine 81-90 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 42-51 35153744-7 2021 In TRPV1 knockout mice, the expression of NF-kappaB increased in late stage, and berberine inhibited the overexpression of NF-kappaB and p-ERK in late injury. Berberine 81-90 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 123-132 32050154-9 2020 The results showed that BBR reduced GVHD-induced weight loss and GVHD index scores, attenuated liver and intestinal injury, and inhibited ALT and AST activities, inflammation, oxidative stress and NF-kappaB activation in liver and intestine. Berberine 24-27 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 197-206 32194416-4 2020 In the current study, we found that BBR significantly decreased lipid accumulation, ameliorated reactive oxygen species (ROS) and lipid peroxides, Tumor necrosis factor alpha (TNF-alpha) expression, and phosphorylation of Nuclear factor kappa B (NF-kappaB) p65 both in vivo and in vitro. Berberine 36-39 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 246-255 31863867-0 2020 Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: Impact on intestinal epithelial barrier, gut microbiota profile and TLR4-MyD88-NF-kappaB pathway. Berberine 3-12 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 190-199 30306659-5 2018 Berberine suppressed the viral infection-induced up-regulation of TLR7 signaling pathway, such as TLR7, MyD88, and NF-kappaB (p65), at both the mRNA and protein levels. Berberine 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 115-124 31746359-11 2020 In addition, BBR inhibited translocation of nuclear factor (NF)-kappaB p65 from the cytosol to the nucleus, and degradation of inhibitory kappa-Balpha in LPS-exposed mIMCD-3 cells. Berberine 13-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 44-70 31744490-16 2019 BBR might interact with TLR4 and disturb TLR4/MyD88/NFkappaB signalling pathway, and it might be the mechanism by which BBR attenuated inflammation in the early phase. Berberine 0-3 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 52-60 31744490-16 2019 BBR might interact with TLR4 and disturb TLR4/MyD88/NFkappaB signalling pathway, and it might be the mechanism by which BBR attenuated inflammation in the early phase. Berberine 120-123 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 52-60 30651787-9 2019 The expression of p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappaB expression was downregulated in myocardial cells from in mice with anoxia-reoxygenation injury following berberine treatment compared with untreated mice. Berberine 198-207 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 66-92 29132092-0 2017 Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-kappaB signaling, oxidative stress and neuroinflammation. Berberine 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 142-151 29482156-0 2018 Berberine inhibits macrophage M1 polarization via AKT1/SOCS1/NF-kappaB signaling pathway to protect against DSS-induced colitis. Berberine 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 61-70 29482156-10 2018 The berberine-induced AKT1 expression promoted suppressers of cytokine signaling (SOCS1) activation, which inhibited nuclear factor-kappa B (NF-kappaB) phosphorylation. Berberine 4-13 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 117-139 29482156-10 2018 The berberine-induced AKT1 expression promoted suppressers of cytokine signaling (SOCS1) activation, which inhibited nuclear factor-kappa B (NF-kappaB) phosphorylation. Berberine 4-13 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 141-150 29482156-12 2018 Therefore, we concluded that berberine played a regulatory role in macrophages M1 polarization in DSS-induced colitis via AKT1/SOCS1/NF-kappaB signaling pathway. Berberine 29-38 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 133-142 29403554-13 2018 In conclusion, the results of the present study indicate that berberine inhibits inflammatory responses through the NF-kappaB signaling pathway and suppresses the apoptosis of myocardial cells via the PI3K/AKT signaling pathway in a mouse model of ischemia-reperfusion injury. Berberine 62-71 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 116-125 30266998-0 2018 Berberine attenuates ischemia-reperfusion injury through inhibiting HMGB1 release and NF-kappaB nuclear translocation. Berberine 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 86-95 30266998-10 2018 Furthermore, pretreatment with berberine dose-dependently suppressed the nuclear-to cytosolic translocation of high-mobility group box1 (HMGB1) protein, the cytosolic-to nuclear translocation of nuclear factor kappa B (NF-kappaB) and decreased the expression of TLR4 in ischemic cortical tissue. Berberine 31-40 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 195-217 30266998-10 2018 Furthermore, pretreatment with berberine dose-dependently suppressed the nuclear-to cytosolic translocation of high-mobility group box1 (HMGB1) protein, the cytosolic-to nuclear translocation of nuclear factor kappa B (NF-kappaB) and decreased the expression of TLR4 in ischemic cortical tissue. Berberine 31-40 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 219-228 30266998-11 2018 Moreover, co-administration of glycyrrhizin and berberine exerted more potent suppression on the HMGB1/TLR4/NF-kappaB pathway than berberine or glycyrrhizin administered alone. Berberine 48-57 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 108-117 30266998-12 2018 These results demonstrate that berberine protects the brain from ischemia-reperfusion injury and the mechanism may rely on its anti-inflammatory effects mediated by suppressing the activation of HMGB1/TLR4/NF-kappaB signaling. Berberine 31-40 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 206-215 29132092-9 2017 BBR lowered the activity of NF-kappaB signaling in the hippocampus of AD mice. Berberine 0-3 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 28-37 29132092-11 2017 CONCLUSION: BBR attenuated cognitive deficits and limited hyperphosphorylation of tau via inhibiting the activation of NF-kappaB signaling pathway, and by retarding oxidative stress and neuro-inflammation. Berberine 12-15 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 119-128 28888780-8 2017 Further mechanistic studies revealed that BBR-induced inhibition of NF-kappaB is Sirt1-dependent, as either pharmacologically or genetically inactivating Sirt1 enhanced the IkappaBetaalpha degradation, IKK phosphorylation, NF-kappaB p65 acetylation and DNA-binding activity. Berberine 42-45 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 68-77 28888780-0 2017 Berberine suppresses LPS-induced inflammation through modulating Sirt1/NF-kappaB signaling pathway in RAW264.7 cells. Berberine 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 71-80 28888780-8 2017 Further mechanistic studies revealed that BBR-induced inhibition of NF-kappaB is Sirt1-dependent, as either pharmacologically or genetically inactivating Sirt1 enhanced the IkappaBetaalpha degradation, IKK phosphorylation, NF-kappaB p65 acetylation and DNA-binding activity. Berberine 42-45 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 223-232 24602493-9 2014 Furthermore, berberine could significantly suppressed the increasing expression of NF-kappaB, IL-6, TNFalpha, and IFNbeta in the RAW264.7 challenged with LPS. Berberine 13-22 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 83-92 28842306-7 2017 In addition, chronic berberine treatment inhibited nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) signaling pathway as the phosphorylated proteins of NF-kappaB, IkappaB kinase (IKK)alpha and IKKbeta in the hippocampus were suppressed after berberine administration. Berberine 21-30 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 115-124 28842306-7 2017 In addition, chronic berberine treatment inhibited nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) signaling pathway as the phosphorylated proteins of NF-kappaB, IkappaB kinase (IKK)alpha and IKKbeta in the hippocampus were suppressed after berberine administration. Berberine 21-30 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 178-187 28842306-7 2017 In addition, chronic berberine treatment inhibited nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) signaling pathway as the phosphorylated proteins of NF-kappaB, IkappaB kinase (IKK)alpha and IKKbeta in the hippocampus were suppressed after berberine administration. Berberine 268-277 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 115-124 28842306-8 2017 Furthermore, inducible nitric oxide synthase (iNOS), one downstream target of NF-kappaB signaling pathway was also inhibited by berberine. Berberine 128-137 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 78-87 27702567-9 2016 In addition, berberine reduced the elevated levels of serum TNF-alpha, IL-6 and MCP-1 and the expressions of TNF-alpha, IL-6 and MCP-1 and attenuated the phosphorylation of JNK and IKKbeta and the expression of NF-kappaB p65 in the obese adipose tissue, Raw264.7 macrophages and 3T3-L1 adipocytes, respectively. Berberine 13-22 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 211-220 24838344-9 2015 Berberine inhibited Nuclear Factor kappa-B (NF-kappaB) activity, reduced the expression of cyclin D1 and survivin, induced phosphorylation of p53 and increased caspase-3 cleavage in vitro. Berberine 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 20-42 24838344-9 2015 Berberine inhibited Nuclear Factor kappa-B (NF-kappaB) activity, reduced the expression of cyclin D1 and survivin, induced phosphorylation of p53 and increased caspase-3 cleavage in vitro. Berberine 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 44-53 24838344-12 2015 Our data suggests that berberine suppresses colon epithelial proliferation and tumorigenesis via AMPK dependent inhibition of mTOR activity and AMPK independent inhibition of NF-kappaB. Berberine 23-32 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 175-184 29100319-4 2017 Together, berberine and cinnamaldehyde reduced mouse susceptibility to urethane-induced lung carcinogenesis, and reversed the urethane-induced AMPK, mTOR, AQP-1, and NF-kappaB expression patterns. Berberine 10-19 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 166-175 25546475-11 2014 In mixed glial cultures, berberine reduced TLR4/MyD88/NF-kappaB signaling. Berberine 25-34 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 54-63 24188583-0 2013 Attenuation of berberine on lipopolysaccharide-induced inflammatory and apoptosis responses in beta-cells via TLR4-independent JNK/NF-kappaB pathway. Berberine 15-24 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 131-140 24188583-10 2013 BBR, TAK-242 or SP-600125 (1 muM) could significantly reduce the levels of MCP-1, IL-6 and TNF-alpha, insulin and JNK and NF-kappaB phosphorylation in NIT-1 cells, as well as the p65 NF-kappaB in INS-1 cells. Berberine 0-3 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 122-131 22943182-0 2012 Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways. Berberine 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 91-112 22943182-8 2012 Moreover, berberine strongly inhibited the nuclear factor-kappaB (NF-kappaB) activation, presumably through blocking the phosphoinositide 3-kinase/protein kinase B and mitogen-activated protein kinase signalling pathways. Berberine 10-19 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 43-64 22943182-8 2012 Moreover, berberine strongly inhibited the nuclear factor-kappaB (NF-kappaB) activation, presumably through blocking the phosphoinositide 3-kinase/protein kinase B and mitogen-activated protein kinase signalling pathways. Berberine 10-19 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 66-75 22943182-9 2012 CONCLUSIONS: Our data indicated berberine is a potent suppressor of neuroflammation, presumably through inhibition of NF-kappaB activation, and suggested berberine has therapeutic potential for the treatment of neuroinflammation that is involved in neurological diseases such as AD. Berberine 32-41 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 118-127 22173918-12 2012 Activation of signaling pathways involved in stimulation of proinflammatory cytokine production, including MAPK and NF-kappaB, in colonic macrophages and epithelial cells from DSS-treated mice was decreased by berberine. Berberine 210-219 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 116-125 20447389-9 2010 After berberine treatment, the immunostaining of NF-kappaB was decreased, and the reduced degradation of I kappaB-alpha level was partially restored. Berberine 6-15 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 49-58 20447389-11 2010 In conclusion, the ameliorative effects of berberine on extracellular matrix accumulation might associate with its inhibitory function on NF-kappaB signal pathway. Berberine 43-52 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 138-147 19107816-0 2009 Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells. Berberine 28-37 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 82-90