PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26628971-15 2015 CONCLUSION: Berberine plays a protective role in vascular endothelial cell injury through inhibiting apoptosis and expression of TLR4, Myd88, NF-kappaB, IL-6 and TNF-alpha. Berberine 12-21 toll-like receptor 4 Rattus norvegicus 129-133 33235706-8 2020 Significantly decrease in activation of TLR4, Sirt1, and alpha-actin in METH-withdrawal group was found and the percentage of TLR4, Sirt1, and alpha-actin improved in berberine-treated group (P<0.001). Berberine 167-176 toll-like receptor 4 Rattus norvegicus 40-44 33235706-8 2020 Significantly decrease in activation of TLR4, Sirt1, and alpha-actin in METH-withdrawal group was found and the percentage of TLR4, Sirt1, and alpha-actin improved in berberine-treated group (P<0.001). Berberine 167-176 toll-like receptor 4 Rattus norvegicus 126-130 33407557-13 2021 CONCLUSIONS: BBR may relieve PCOS pathology and IR values by inhibiting cell apoptosis and by regulating the expression levels of TLR4, LYN, PI3K, Akt, NF-kB, TNF-alpha, IL-1, IL-6, and caspase-3. Berberine 13-16 toll-like receptor 4 Rattus norvegicus 130-134 33539718-0 2021 Berberine attenuates septic cardiomyopathy by inhibiting TLR4/NF-kappaB signalling in rats. Berberine 0-9 toll-like receptor 4 Rattus norvegicus 57-61 33539718-8 2021 DISCUSSION AND CONCLUSIONS: Berberine showed a protective effect on septic cardiomyopathy rats possibly through inhibiting the activation of TLR4/NF-kappaB signalling pathway. Berberine 28-37 toll-like receptor 4 Rattus norvegicus 141-145 34025574-15 2021 Berberine could increase the goblet cell number and villi length, and also reverse the suppressed expressions of mucin, occludin, ZO-1 and the upregulated expressions of TLR-4, NF-kappaB and TNF-alpha induced in IGT rats (P<0.05). Berberine 0-9 toll-like receptor 4 Rattus norvegicus 170-175 34489150-0 2022 Berberine-loaded nanostructured lipid carriers mitigate warm hepatic ischemia/reperfusion-induced lesion through modulation of HMGB1/TLR4/NF-kappaB signaling and autophagy. Berberine 0-9 toll-like receptor 4 Rattus norvegicus 133-137 32972060-13 2020 Conclusions: Berberine can improve myocardial injury and cardiac function in sepsis rats, the mechanism is considered to be related to that it can inhibit the activation of TLR4/NF-kappaB signaling pathway induced by LPS and further reducing the production of TNF-alpha and IL-1beta. Berberine 13-22 toll-like receptor 4 Rattus norvegicus 173-177 33626003-0 2020 Berberine inhibits liver damage in rats with non-alcoholic fatty liver disease by regulating TLR4/MyD88/NF-kappaB pathway. Berberine 0-9 toll-like receptor 4 Rattus norvegicus 93-97 33626003-10 2020 RESULTS: BBR could significantly alleviate the liver tissue steatosis and inflammatory cell infiltration; reduce the NAFLD activity scores and serum levels of ALT, AST, TC, and LDL-C; decrease the levels of TNF-alpha, IL-6, and IL-1beta, and reduce the expression of TLR4, MyD88, and NF-kappaB in the liver tissues. Berberine 9-12 toll-like receptor 4 Rattus norvegicus 267-271 33626003-12 2020 CONCLUSION: BBR alleviated the progress of NAFLD and liver damage, which might contribute to inhibit the nuclear translocation of NF-kappaB via the TLR4/MyD88/NF-kappaB pathway. Berberine 12-15 toll-like receptor 4 Rattus norvegicus 148-152 32961234-13 2020 Berberine reduced sepsis-induced PEPCK and TLR4 mRNA overexpression in the liver. Berberine 0-9 toll-like receptor 4 Rattus norvegicus 43-47 32961234-14 2020 SIGNIFICANCE: This study demonstrated berberine inhibited TLR4-mediated hyperglycemia, insulin resistance and proinflammatory molecule production, thereby increasing ApoM gene expression and plasma ApoM. Berberine 38-47 toll-like receptor 4 Rattus norvegicus 58-62 25605990-7 2015 The mRNA expression of TLR 2, TLR 4, and TLR 9 were significantly affected by berberine treatment. Berberine 78-87 toll-like receptor 4 Rattus norvegicus 30-35 30456649-8 2019 Besides, berberine attenuated inflammation-related indices, as was evident by lower levels of nuclear factor-kappa B (NF-kappaB), toll-like receptor 4 (TLR4), tumor necrosis factor alpha (TNFalpha), and interleukin 6 (IL-6). Berberine 9-18 toll-like receptor 4 Rattus norvegicus 130-150 30456649-8 2019 Besides, berberine attenuated inflammation-related indices, as was evident by lower levels of nuclear factor-kappa B (NF-kappaB), toll-like receptor 4 (TLR4), tumor necrosis factor alpha (TNFalpha), and interleukin 6 (IL-6). Berberine 9-18 toll-like receptor 4 Rattus norvegicus 152-156 30542485-7 2018 TLR4, NF-kappaB, iNOS, TNF-alpha, IL-6 and IL-10 expression was decreased following berberine intervention. Berberine 84-93 toll-like receptor 4 Rattus norvegicus 0-4 29365334-7 2018 Berberine reversed these effects and inhibited LPS-induced TLR4/TNF-alpha activation, resulting in increased insulin receptor and insulin receptor substrate-1 expression in the liver. Berberine 0-9 toll-like receptor 4 Rattus norvegicus 59-63 29365334-8 2018 These findings suggested that berberine may reduce insulin resistance, at least in part by modulating the gut microbiota along with inhibiting LPS/TLR4/TNF-alpha signaling in the liver. Berberine 30-39 toll-like receptor 4 Rattus norvegicus 147-151 29365334-0 2018 Berberine Modulates Gut Microbiota and Reduces Insulin Resistance via the TLR4 Signaling Pathway. Berberine 0-9 toll-like receptor 4 Rattus norvegicus 74-78 29604956-0 2018 Berberine ameliorates diabetic nephropathy by inhibiting TLR4/NF-kappaB pathway. Berberine 0-9 toll-like receptor 4 Rattus norvegicus 57-61 29604956-14 2018 Furthermore, blockade of TLR4/NF-kappaB pathway by resatorvid (TAK-242) or pyrrolidine dithiocarbamate aggravated the inhibitory effect of BBR on HG-induced inflammatory response and apoptosis in podocytes. Berberine 139-142 toll-like receptor 4 Rattus norvegicus 25-29 29604956-15 2018 CONCLUSIONS: Berberine ameliorated DN through relieving STZ-induced renal injury, inflammatory response, and podocyte HG-induced apoptosis via inactivating TLR4/NF-kappaB pathway. Berberine 13-22 toll-like receptor 4 Rattus norvegicus 156-160 26867315-0 2015 [Effect of Berberine on the Insulin Resistance and TLR4/IKKbeta/NF-kappaB Signaling Pathways in Skeletal Muscle of Obese Rats with Insulin Resistance]. Berberine 11-20 toll-like receptor 4 Rattus norvegicus 51-55 26867315-14 2015 Berberine could reduce the level of ET of obese rats, down-regulate the TLR4/IKKbeta/NF- kappaB inflammation signaling pathway and improve insulin resistance of skeletal muscle in obese rats. Berberine 0-9 toll-like receptor 4 Rattus norvegicus 72-76 26867315-15 2015 CONCLUSION: Our study revealed that berberine could reduce the level of ET of obese rats, down-regulate the TLR4/IKKbeta/NF-kappaB inflammation signaling pathway in skeletal muscle and berberine can improve insulin resistance of skeletal muscle through inhibiting the active of the TLR4/IKKbeta/NF-kappaB signaling pathway. Berberine 36-45 toll-like receptor 4 Rattus norvegicus 108-112 26867315-15 2015 CONCLUSION: Our study revealed that berberine could reduce the level of ET of obese rats, down-regulate the TLR4/IKKbeta/NF-kappaB inflammation signaling pathway in skeletal muscle and berberine can improve insulin resistance of skeletal muscle through inhibiting the active of the TLR4/IKKbeta/NF-kappaB signaling pathway. Berberine 36-45 toll-like receptor 4 Rattus norvegicus 282-286 26867315-15 2015 CONCLUSION: Our study revealed that berberine could reduce the level of ET of obese rats, down-regulate the TLR4/IKKbeta/NF-kappaB inflammation signaling pathway in skeletal muscle and berberine can improve insulin resistance of skeletal muscle through inhibiting the active of the TLR4/IKKbeta/NF-kappaB signaling pathway. Berberine 185-194 toll-like receptor 4 Rattus norvegicus 282-286 24188583-0 2013 Attenuation of berberine on lipopolysaccharide-induced inflammatory and apoptosis responses in beta-cells via TLR4-independent JNK/NF-kappaB pathway. Berberine 15-24 toll-like receptor 4 Rattus norvegicus 110-114 25477998-0 2014 Protective Effects of Berberine on Isoproterenol-Induced Acute Myocardial Ischemia in Rats through Regulating HMGB1-TLR4 Axis. Berberine 22-31 toll-like receptor 4 Rattus norvegicus 116-120 25477998-10 2014 Berberine can regulate HMGB1-TLR4 axis to protect myocardial ischemia. Berberine 0-9 toll-like receptor 4 Rattus norvegicus 29-33