PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27239214-9 2016 High doses of BBR induced apoptosis of activated HSC, which was mediated by loss of mitochondrial membrane potential and Bcl-2/Bax imbalance. Berberine 14-17 BCL2 associated X, apoptosis regulator Rattus norvegicus 127-130 28656094-7 2017 Moreover, berberine showed anti-apoptotic effects by reducing the glutamate-evoked caspase-3 and bax/bcl-2 overexpression. Berberine 10-19 BCL2 associated X, apoptosis regulator Rattus norvegicus 97-100 26979714-7 2016 BBR-induced anti-apoptotic function was demonstrated by decreasing apoptotic proteins (cytochrome c, Bax, caspase3 and caspase9). Berberine 0-3 BCL2 associated X, apoptosis regulator Rattus norvegicus 101-104 28763751-10 2017 Histological and immunohistochemical examination showed improved histological structure and decreased expression of Bax in liver of MTX-induced rats treated with BBR. Berberine 162-165 BCL2 associated X, apoptosis regulator Rattus norvegicus 116-119 19424587-6 2009 Western blotting assay also showed that berberine inhibited the levels of anti-apoptotic protein Bcl-2 but increased the levels of pro-apoptotic protein Bax before leading to a decrease in the levels of mitochondrial membrane potential (DeltaPsim) followed by cytochrome c release that caused the activations of capase-9 and -3 for apoptotic occurrence. Berberine 40-49 BCL2 associated X, apoptosis regulator Rattus norvegicus 153-156 26788242-5 2016 BBR conferred cardioprotective effects by improving postischemic cardiac function, decreasing infarct size, reducing apoptotic index, diminishing serum creatine kinase and lactate dehydrogenase levels, upregulating SIRT1, Bcl-2 expressions, and downregulating Bax and caspase-3 expressions. Berberine 0-3 BCL2 associated X, apoptosis regulator Rattus norvegicus 260-263 26550442-12 2015 Berberine up-regulates the expression of Bcl-2 and mitochondrial cytochrome c and down-regulates the expression of Bax and cytosolic cytochrome c. In conclusion, berberine protects the heart from ischemia/reperfusion injury via attenuating mitochondrial dysfunction and myocardial apoptosis. Berberine 0-9 BCL2 associated X, apoptosis regulator Rattus norvegicus 115-118 26550442-12 2015 Berberine up-regulates the expression of Bcl-2 and mitochondrial cytochrome c and down-regulates the expression of Bax and cytosolic cytochrome c. In conclusion, berberine protects the heart from ischemia/reperfusion injury via attenuating mitochondrial dysfunction and myocardial apoptosis. Berberine 162-171 BCL2 associated X, apoptosis regulator Rattus norvegicus 115-118 25600690-9 2015 Furthermore, treatment with BN inhibited apoptosis, as indicated by the reduction of Bax/Bcl-2 ratio in brain tissue. Berberine 28-30 BCL2 associated X, apoptosis regulator Rattus norvegicus 85-88 22982719-9 2012 Decreased HIF-1alpha, caspase 9, caspase 3 and increased Bcl-2/Bax ratio were responsible for the anti-apoptosis of berberine pretreatment. Berberine 116-125 BCL2 associated X, apoptosis regulator Rattus norvegicus 63-66 19424587-9 2009 These results demonstrate that the cytotoxicity of berberine in C6 rat glioma cells is attributable to apoptosis mainly through induced G2/M-arrested cells, in an ER-dependent manner, via a mitochondria-dependent caspase pathway regulated by Bax and Bcl-2. Berberine 51-60 BCL2 associated X, apoptosis regulator Rattus norvegicus 242-245 26629148-0 2015 Berberine alleviates preeclampsia possibly by regulating the expression of interleukin-2/interleukin-10 and Bcl-2/Bax. Berberine 0-9 BCL2 associated X, apoptosis regulator Rattus norvegicus 114-117 26629148-12 2015 Berberine up-regulated Bcl-2 and down-regulated Bax in the placenta of SD rats with preeclampsia. Berberine 0-9 BCL2 associated X, apoptosis regulator Rattus norvegicus 48-51 34483445-6 2021 Berberine significantly counteracted (P<0.05) the increase of TNF-alpha, IL-6, caspase-3 and BAX and counteracted the increase in plasma cTn-T and serum MDA. Berberine 0-9 BCL2 associated X, apoptosis regulator Rattus norvegicus 93-96 34802527-12 2021 Berberine treatment ameliorated the CPF-induced downregulation of Bcl-2, Bax translocation, and up-regulation of caspase-3 in F1 pups. Berberine 0-9 BCL2 associated X, apoptosis regulator Rattus norvegicus 73-76 30186432-0 2018 Therapeutic effect of berberine on renal ischemia-reperfusion injury in rats and its effect on Bax and Bcl-2. Berberine 22-31 BCL2 associated X, apoptosis regulator Rattus norvegicus 95-98 31828466-8 2020 Moreover, BBR significantly suppressed cytochrome c expression, upregulated the ratio of Bcl-2/Bax, and ameliorated mitochondrial dysfunction by optimizing mitochondria membrane potential (DeltaPsim) status and ATP production. Berberine 10-13 BCL2 associated X, apoptosis regulator Rattus norvegicus 95-98 31795609-9 2019 Berberine also increased cell proliferation and short-term memory, as well as decreasing the expression of GFAP, Iba1, Bax, and cytochrome c and increasing Bcl-2 expression. Berberine 0-9 BCL2 associated X, apoptosis regulator Rattus norvegicus 119-122 30186485-12 2018 In conclusion, Berberine can inhibit the myocardium cell apoptosis of heart failure after myocardial infarction, and its mechanism may be realized by affecting the ERS in myocardial tissue of heart failure after myocardial infarction and CHOP and caspase-12 apoptotic signaling pathway, upregulating Bcl-2/Bax expression and downregulating caspase-3 expression, thus inhibiting the cardiac remodeling and protecting the cardiac function. Berberine 15-24 BCL2 associated X, apoptosis regulator Rattus norvegicus 306-309 30186432-1 2018 This study aimed to investigate the therapeutic effect of berberine on renal ischemia-reperfusion injury in rats and its effect on Bax and Bcl-2. Berberine 58-67 BCL2 associated X, apoptosis regulator Rattus norvegicus 131-134 30186432-13 2018 In conclusion, berberine can effectively improve renal function in rats with renal ischemia-reperfusion injury by inhibiting Bax expression and promoting Bcl-2 expression. Berberine 15-24 BCL2 associated X, apoptosis regulator Rattus norvegicus 125-128