PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34942456-12 2022 CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and MMP9 to combat colorectal cancer. Berberine 212-221 matrix metallopeptidase 9 Homo sapiens 274-278 31298400-10 2019 10 mg/L Berberine or at least 50 micromol/L Hesperidin could noticeably decrease MMP-1 expression, and at least 5 mg/L Berberine or 100 micromol/L Hesperidin could markedly reduce MMP-9 expression. Berberine 8-17 matrix metallopeptidase 9 Homo sapiens 180-185 34719112-4 2021 For the first time, this paper reviews the evidence from in vitro and in vivo experimental models to explore the anti-inflammatory effects of BBR in periodontitis and exhibits that BBR has the high potency to exert anti-inflammatory effects by reducing expression and secretion of pro-inflammatory mediators including TNF-alpha, IL-1beta, IL-17, RANKL, MMP-2, MMP-9 and MCP-1. Berberine 181-184 matrix metallopeptidase 9 Homo sapiens 360-365 33846796-12 2021 BBR inhibited cell invasion and migration, as well as the expression of MMP2, MMP4 and MMP9. Berberine 0-3 matrix metallopeptidase 9 Homo sapiens 87-91 33325633-6 2021 The berberine-mediated inhibition of MMP-2 and MMP-9 activity could be rescued by co-treatment with EGF. Berberine 4-13 matrix metallopeptidase 9 Homo sapiens 47-52 33959010-0 2021 Berberine Regulated miR150-5p to Inhibit P2X7 Receptor, EMMPRIN and MMP-9 Expression in oxLDL Induced Macrophages. Berberine 0-9 matrix metallopeptidase 9 Homo sapiens 68-73 33959010-2 2021 Our previous report showed that berberine regulates the expression of both EMMPRIN and MMP-9. Berberine 32-41 matrix metallopeptidase 9 Homo sapiens 87-92 33959010-10 2021 Accordingly, exposure to berberine markedly upregulated miR150-5p, decreased P2X7R expression and downregulated MMP-9 and EMMPRIN levels in oxLDL-induced macrophages, resulting in AMPK-alpha/MAPK (JNK, p38, and ERK) inactivation. Berberine 25-34 matrix metallopeptidase 9 Homo sapiens 112-117 33959010-11 2021 Overall, these results indicate that berberine increased miR150-5p level, subsequently inhibits P2X7R-mediated EMMPRIN and MMP-9 expression by suppressing AMPK-alpha and MAPK signaling in oxLDL-induced macrophages. Berberine 37-46 matrix metallopeptidase 9 Homo sapiens 123-128 33045871-10 2021 Besides, BBR inhibited EMT in cells by decreasing the expressions of MMP-9, N-cadherin and Vimentin and increasing E-cadherin expression. Berberine 9-12 matrix metallopeptidase 9 Homo sapiens 69-74 31298400-10 2019 10 mg/L Berberine or at least 50 micromol/L Hesperidin could noticeably decrease MMP-1 expression, and at least 5 mg/L Berberine or 100 micromol/L Hesperidin could markedly reduce MMP-9 expression. Berberine 119-128 matrix metallopeptidase 9 Homo sapiens 180-185 22381172-0 2012 Berberine suppresses the TPA-induced MMP-1 and MMP-9 expressions through the inhibition of PKC-alpha in breast cancer cells. Berberine 0-9 matrix metallopeptidase 9 Homo sapiens 47-52 30104528-5 2018 The gelatin zymography assay showed that berberine slightly inhibited MMP-9 activity in A375.S2 cells. Berberine 41-50 matrix metallopeptidase 9 Homo sapiens 70-75 28190470-9 2017 Furthermore, berberine downregulates the phosphorylation of VEGFR2 and downstream signaling members (AKT and Erk1/2), which in turn downregulates the expression of MMP2 and MMP9. Berberine 13-22 matrix metallopeptidase 9 Homo sapiens 173-177 26503508-8 2015 Interestingly, berberine suppressed cell migration through downregulation of vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-2, and MMP-9. Berberine 15-24 matrix metallopeptidase 9 Homo sapiens 158-163 25634589-13 2015 We also found that berberine-induced migration suppression was mediated by downregulation of MMP-2 and MMP-9 through phosphorylation of p38 MAPK. Berberine 19-28 matrix metallopeptidase 9 Homo sapiens 103-108 30119256-6 2018 Combined treatment of Berberine and theophylline reduced extracellular level of HMGB1 and down regulated HMGB1 and MMP-9 mRNA expression. Berberine 22-31 matrix metallopeptidase 9 Homo sapiens 115-120 24286329-6 2014 Real-time PCR and Western blotting analyses showed that levels of matrix metalloproteinase (MMP)-2, MMP-9, and urokinase-type plasminogen activator (u-PA) were reduced by berberine at both the mRNA and protein levels. Berberine 171-180 matrix metallopeptidase 9 Homo sapiens 100-105 24286329-8 2014 These results suggest that berberine effectively inhibited HASMC migration, possibly by down-regulating MMP-2, MMP-9, and u-PA; and interrupting AP-1 and NF-kappaB mediated signaling pathways. Berberine 27-36 matrix metallopeptidase 9 Homo sapiens 111-116 22381172-8 2012 RESULTS: The basal levels of both the MMP-1 and MMP-9 mRNA expressions were decreased by BBR treatment in a dose-dependent manner. Berberine 89-92 matrix metallopeptidase 9 Homo sapiens 48-53 22381172-13 2012 CONCLUSION: The TPA-induced PKC-alpha phosphorylation is suppressed and then the MMP-1 and MMP-9 expressions are also inhibited by berberine. Berberine 131-140 matrix metallopeptidase 9 Homo sapiens 91-96 19052522-0 2008 Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells. Berberine 0-9 matrix metallopeptidase 9 Homo sapiens 39-44 22140092-3 2012 In the present study, the function of berberine, a natural extract from Rhizoma coptidis, on MMP-9 and EMMPRIN expression, the role of NF-kappaB activation in oxLDL-stimulated macrophages, and the possible mechanism in which NF-kappaB activation is involved were investigated. Berberine 38-47 matrix metallopeptidase 9 Homo sapiens 93-98 22140092-4 2012 Berberine inhibited the expression of MMP-9 and EMMPRIN at both mRNA and protein levels. Berberine 0-9 matrix metallopeptidase 9 Homo sapiens 38-43 22140092-6 2012 Overall, berberine suppressed the expression of MMP-9 and EMMPRIN by at least reducing partly the activity of NF-kappaB in oxLDL-induced macrophages. Berberine 9-18 matrix metallopeptidase 9 Homo sapiens 48-53 19576641-0 2011 Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages. Berberine 0-9 matrix metallopeptidase 9 Homo sapiens 23-28 19576641-3 2011 The purpose of our study was to determine if berberine, a natural extract from Rhizoma coptidis, had any effect on the expression of MMP-9 and EMMPRIN in PMA-induced macrophages. Berberine 45-54 matrix metallopeptidase 9 Homo sapiens 133-138 19576641-6 2011 RESULTS: In the present study, we demonstrated that berberine inhibited the expression of MMP-9 and EMMPRIN at both the mRNA and protein levels in a dose-dependent manner in PMA-induced macrophages, and that it also reduced MMP-9 activity. Berberine 52-61 matrix metallopeptidase 9 Homo sapiens 90-95 19576641-6 2011 RESULTS: In the present study, we demonstrated that berberine inhibited the expression of MMP-9 and EMMPRIN at both the mRNA and protein levels in a dose-dependent manner in PMA-induced macrophages, and that it also reduced MMP-9 activity. Berberine 52-61 matrix metallopeptidase 9 Homo sapiens 224-229 19576641-8 2011 CONCLUSIONS: The data indicate that berberine reduces MMP-9 and EMMPRIN expression by suppressing the activation of p38 pathway in PMA-induced macrophages. Berberine 36-45 matrix metallopeptidase 9 Homo sapiens 54-59 21738655-5 2011 Berberine exerted anti-invasive effect on HepG2 cells through suppression of matrix metalloproteinase-9 (MMP-9) expression. Berberine 0-9 matrix metallopeptidase 9 Homo sapiens 77-103 21738655-5 2011 Berberine exerted anti-invasive effect on HepG2 cells through suppression of matrix metalloproteinase-9 (MMP-9) expression. Berberine 0-9 matrix metallopeptidase 9 Homo sapiens 105-110 21738655-7 2011 Combination treatment of ERK pathway inhibitor PD98059 or AKT pathway inhibitor LY294002 and berberine could result in a synergistic reduction on MMP-9 expression along with an inhibition of cell invasion. Berberine 93-102 matrix metallopeptidase 9 Homo sapiens 146-151 21738655-9 2011 In conclusion, our results suggest that berberine may be a potential alternative against invasive hepatoma cells through PI3K-AKT and ERK pathways-dependent downregulation of MMP-9 expression. Berberine 40-49 matrix metallopeptidase 9 Homo sapiens 175-180 18593939-8 2008 Berberine also suppressed the expression of NF-kappaB-regulated gene products involved in antiapoptosis (Bcl-xL, Survivin, IAP1, IAP2, and cFLIP), proliferation (cyclin D1), inflammation (cyclooxygenase-2), and invasion (matrix metalloproteinase-9). Berberine 0-9 matrix metallopeptidase 9 Homo sapiens 221-247 17951041-0 2008 Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes. Berberine 0-9 matrix metallopeptidase 9 Homo sapiens 31-36 17951041-3 2008 In this study, we investigated the effects of berberine on MMP-9 and IL-6 expression in normal human keratinocytes (NHK). Berberine 46-55 matrix metallopeptidase 9 Homo sapiens 59-64 17951041-4 2008 Our results demonstrated that berberine dose-dependently inhibited basal and TPA-induced expression and activity of MMP-9, and also suppressed TPA-induced IL-6 expression. Berberine 30-39 matrix metallopeptidase 9 Homo sapiens 116-121 17951041-6 2008 Therefore, berberine may be used as an effective ingredient for anti-skin aging products, which can prevent skin inflammation and the degradation of extracellular matrix proteins, including collagen, by MMPs. Berberine 11-20 matrix metallopeptidase 9 Homo sapiens 203-207