PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34942456-12 2022 CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and MMP9 to combat colorectal cancer. Berberine 212-221 BCL2 apoptosis regulator Homo sapiens 241-245 16505103-5 2006 Berberine also significantly (P < 0.05-0.001) enhanced apoptosis of DU145 and LNCaP cells with induction of a higher ratio of Bax/Bcl-2 proteins, disruption of mitochondrial membrane potential, and activation of caspase-9, caspase-3, and poly(ADP-ribose) polymerase. Berberine 0-9 BCL2 apoptosis regulator Homo sapiens 133-138 33174291-0 2021 Apoptotic effect of berberine via Bcl-2, ROR1, and mir-21 in patients with B-chronic lymphocytic leukemia. Berberine 20-29 BCL2 apoptosis regulator Homo sapiens 34-39 35085532-5 2022 Berberine had an antagonistic effect for the majority of genes mutual for AD and toxic metal mixture: ACHE, APP, BAX, BCL2, CASP3, HMOX1, IL1B, MAPT, SOD2, TNF. Berberine 0-9 BCL2 apoptosis regulator Homo sapiens 118-122 34258700-8 2021 BBR and UMB reduced the expression of pro-apoptotic protein Bax and apoptotic protein caspase-3 as well as increased the expression of anti-apoptotic protein Bcl-2. Berberine 0-3 BCL2 apoptosis regulator Homo sapiens 158-163 34943140-2 2021 Berberine also appears to reduce the bcl-2 and XIAP expression-proteins responsible for the inhibition of apoptosis. Berberine 0-9 BCL2 apoptosis regulator Homo sapiens 37-42 33174291-9 2021 Examination of treated cells demonstrated that berberine decreased Bcl-2 and ROR1 levels. Berberine 47-56 BCL2 apoptosis regulator Homo sapiens 67-72 33174291-10 2021 Although western blot results did not show any change in Bax as a pro-apoptotic protein, an increased Bax/Bcl-2 ratio indicated that mitochondrial pathway is involved in berberine-induced apoptosis of CLL cells. Berberine 170-179 BCL2 apoptosis regulator Homo sapiens 106-111 33174291-12 2021 Our findings describe some of the molecular mechanisms of berberine by decreasing Bcl-2, ROR1, and mir-21 which may be considered as a novel apoptosis inducer in CLL cells. Berberine 58-67 BCL2 apoptosis regulator Homo sapiens 82-87 33312221-5 2020 Both BBR and miR-214-3p mimic reduced the cell viability, repressed migration and invasion capacities, increased rates of total apoptotic cells and ratio of Bax/Bcl-2, and increased the percentage of G2/M cells of MCF-7 and MDA-MB-231 cells by colony formation and CKK8 assay, scratch wound healing and gelatin-based 3D conformation assay, transwell invasion assay, and cell cycle analysis, respectively. Berberine 5-8 BCL2 apoptosis regulator Homo sapiens 161-166 31688419-5 2020 Further studies demonstrated that berberine suppressed the production of intracellular reactive oxygen species, restored the mitochondrial transmembrane potential, increased Bcl-2/Bax ratio, and decreased caspase-3 activation that induced by rotenone. Berberine 34-43 BCL2 apoptosis regulator Homo sapiens 174-179 33045871-9 2021 BBR promoted cell apoptosis by increasing Bax and C caspase-3 expressions and decreasing Bcl-2 expression. Berberine 0-3 BCL2 apoptosis regulator Homo sapiens 89-94 31399854-11 2020 In addition, BBR induced apoptosis in EMT-like HCoEpiC cells in a concentration-dependent manner with upregulation of Bax and downregulation of Bcl-2. Berberine 13-16 BCL2 apoptosis regulator Homo sapiens 144-149 31743135-9 2020 Moreover, BBR inhibited the expression of Bax, Bcl-2, c-Myc, and Vimentin and up-regulated the cytokeratin expression in SW480 cells. Berberine 10-13 BCL2 apoptosis regulator Homo sapiens 47-52 32272506-9 2020 Furthermore, the knockdown of Bcl-2/adenovirus E18-19-kDa interacting protein 3 (BNIP3) expression attenuated the effects of BBR on mitophagy induction to some extent, suggesting that the BBR-induced mitophagy may be, at least in part, mediated in a BNIP3-dependent manner. Berberine 125-128 BCL2 apoptosis regulator Homo sapiens 30-79 32272506-9 2020 Furthermore, the knockdown of Bcl-2/adenovirus E18-19-kDa interacting protein 3 (BNIP3) expression attenuated the effects of BBR on mitophagy induction to some extent, suggesting that the BBR-induced mitophagy may be, at least in part, mediated in a BNIP3-dependent manner. Berberine 188-191 BCL2 apoptosis regulator Homo sapiens 30-79 31173223-0 2019 Long non-coding RNA CASC2 enhances berberine-induced cytotoxicity in colorectal cancer cells by silencing BCL2. Berberine 35-44 BCL2 apoptosis regulator Homo sapiens 106-110 31173223-6 2019 In addition, RNA immunoprecipitation, chromatin immunoprecipitation and western blot analysis were used to identify the functional regulation of CASC2/EZH2/BCL2 axis in berberine-induced CRC cell apoptosis. Berberine 169-178 BCL2 apoptosis regulator Homo sapiens 156-160 31173223-9 2019 Subsequently, the downstream antiapoptotic gene BCL2 was identified as a functional target of the berberine/CASC2 mechanism, as BCL2 reversed the berberine/CASC2-induced cell cytotoxicity. Berberine 98-107 BCL2 apoptosis regulator Homo sapiens 48-52 31173223-9 2019 Subsequently, the downstream antiapoptotic gene BCL2 was identified as a functional target of the berberine/CASC2 mechanism, as BCL2 reversed the berberine/CASC2-induced cell cytotoxicity. Berberine 98-107 BCL2 apoptosis regulator Homo sapiens 128-132 31173223-9 2019 Subsequently, the downstream antiapoptotic gene BCL2 was identified as a functional target of the berberine/CASC2 mechanism, as BCL2 reversed the berberine/CASC2-induced cell cytotoxicity. Berberine 146-155 BCL2 apoptosis regulator Homo sapiens 48-52 31173223-9 2019 Subsequently, the downstream antiapoptotic gene BCL2 was identified as a functional target of the berberine/CASC2 mechanism, as BCL2 reversed the berberine/CASC2-induced cell cytotoxicity. Berberine 146-155 BCL2 apoptosis regulator Homo sapiens 128-132 30681073-0 2019 Berberine Promotes Apoptosis of Colorectal Cancer via Regulation of the Long Non-Coding RNA (lncRNA) Cancer Susceptibility Candidate 2 (CASC2)/AU-Binding Factor 1 (AUF1)/B-Cell CLL/Lymphoma 2 (Bcl-2) Axis. Berberine 0-9 BCL2 apoptosis regulator Homo sapiens 170-191 30681073-0 2019 Berberine Promotes Apoptosis of Colorectal Cancer via Regulation of the Long Non-Coding RNA (lncRNA) Cancer Susceptibility Candidate 2 (CASC2)/AU-Binding Factor 1 (AUF1)/B-Cell CLL/Lymphoma 2 (Bcl-2) Axis. Berberine 0-9 BCL2 apoptosis regulator Homo sapiens 193-198 30681073-10 2019 In addition, anti-apoptotic gene Bcl-2 was suppressed by berberine treatment and lncRNA CASC2, inducing the pro-apoptotic effects. Berberine 57-66 BCL2 apoptosis regulator Homo sapiens 33-38 30681073-12 2019 CONCLUSIONS Our study reveals that lncRNA CASC2 mediates the berberine-induced pro-apoptotic effect via inhibition of Bcl-2 expression at the post-transcriptional level. Berberine 61-70 BCL2 apoptosis regulator Homo sapiens 118-123 30396091-0 2019 The impact of Keap1/Nrf2, P38MAPK/NF-kappaB and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity. Berberine 115-124 BCL2 apoptosis regulator Homo sapiens 52-56 27904693-5 2016 Berberine also downregulated the expression of SP1, CCND1, and BCL2, determined with western blotting. Berberine 0-9 BCL2 apoptosis regulator Homo sapiens 63-67 28679068-2 2018 In present study, berberine hydrochloride (BER) triggered proliferative inhibition and G2/M arrest in AGS cells, down-regulated protein expression of cyclin B1, Bcl-2, up-regulated expression of p21, p53 and cleaved caspase 3, but showed no effect on protein expression of CHOP, Bip, and caspase 4. Berberine 43-46 BCL2 apoptosis regulator Homo sapiens 161-166 29732634-4 2018 Well-known pathways such as Pl3K/Akt/Bcl-2 pathway, Nrf2/HO-1 pathway, and MAPK signaling pathway help berberine to protect neurons through antiapoptotic, antioxidative, and anti-inflammatory activities. Berberine 103-112 BCL2 apoptosis regulator Homo sapiens 37-42 30272344-5 2018 Berberine treatment inhibited apoptosis of hippocampal pyramidal neurons and increased apoptosis regulator Bcl-2 and Bcl-w expression. Berberine 0-9 BCL2 apoptosis regulator Homo sapiens 107-112 29260413-8 2018 Our study confirmed the protective effect of berberine against H/R-induced apoptosis in HK-2 cells through promoting cells viability, inhibiting cells apoptosis, and down-regulating p-P38, caspase-3, caspase-9 as well as SPHK1, while up regulating the ratio of Bcl-2/Bax. Berberine 45-54 BCL2 apoptosis regulator Homo sapiens 261-266 27904693-8 2016 Therefore, we conclude that berberine treatment suppresses cancer cell growth by regulating miR-22-3p and SP1 and its downstream targets, CCND1 and BCL2, in HCC. Berberine 28-37 BCL2 apoptosis regulator Homo sapiens 148-152 26503508-5 2015 Moreover, berberine activated the mitochondria-dependent apoptotic signaling pathway by upregulating pro-apoptotic factors, such as Bax, Bad, Apaf-1, and the active form of caspase-9, and downregulating anti-apoptotic factors, such as Bcl-2 and Bcl-xL. Berberine 10-19 BCL2 apoptosis regulator Homo sapiens 235-240 27177238-7 2016 After treatment of BBR and cisplatin, the cellular pro-apoptotic capase-3 and cleaved capspase-3 and caspase-9 were upregulated and the anti-apoptotic Bcl-2 was downregulated. Berberine 19-22 BCL2 apoptosis regulator Homo sapiens 151-156 27398330-7 2016 Mechanistically, berberine inhibits PI3K/AKT activation that, in turn, results in up-regulating the expression of Bax, and PARP and down-regulating the expression of Bcl-2 and caspase3. Berberine 17-26 BCL2 apoptosis regulator Homo sapiens 166-171 23247593-7 2013 Meanwhile, berberine dose-dependently induced ROS generation, G(2)/M phase arrest and apoptosis in U266 cells, and decreased the levels of miR-21 and Bcl-2. Berberine 11-20 BCL2 apoptosis regulator Homo sapiens 150-155 26400287-3 2015 Berberine was reported to inhibit the proliferation of A431 cells in a dose- and time-dependent manner and was observed to induce a series of biochemical events, including the loss of mitochondrial membrane potential, release of cytochrome-c to cytosol, induction of proteins of the Bcl-2 family and caspases, and the cleavage of poly(ADP)-ribose polymerase. Berberine 0-9 BCL2 apoptosis regulator Homo sapiens 283-288 23247593-12 2013 CONCLUSION: In U266 cells, berberine suppresses NF-kappaB nuclear translocation via Set9-mediated lysine methylation, leads to decrease in the levels miR21 and Bcl-2, which induces ROS generation and apoptosis. Berberine 27-36 BCL2 apoptosis regulator Homo sapiens 160-165 20930370-7 2010 Berberine also markedly enhanced apoptosis in T98G cells through the induction of a higher ratio of Bax/Bcl-2 proteins, disruption of the mitochondrial membrane potential, activation of caspase-9 and -3, and cleavage of the poly(ADP-ribose) polymerase (PARP). Berberine 0-9 BCL2 apoptosis regulator Homo sapiens 104-109 20691179-8 2010 Western blotting with treated cells revealed that berberine induces apoptosis in MCF-7 cells through a mitochondria-dependent pathway by increasing levels of cytoplasmic cytochrome c, caspase-9 activity and cleavage of PARP while decreasing levels of Bcl-2. Berberine 50-59 BCL2 apoptosis regulator Homo sapiens 251-256 24278513-6 2010 Bax, caspase-3, p53, p38, and JNK activation increased, but activation of Bcl-2, ERK, and HO-1 decreased with berberine treatment with or without irradiation. Berberine 110-119 BCL2 apoptosis regulator Homo sapiens 74-79 23682426-10 2012 Decrease of Bcl-2 and increase of Bax in mRNA and/or protein expressions showed that the Bcl-2 family proteins were involved in berberine-induced apoptosis. Berberine 128-137 BCL2 apoptosis regulator Homo sapiens 12-17 23682426-10 2012 Decrease of Bcl-2 and increase of Bax in mRNA and/or protein expressions showed that the Bcl-2 family proteins were involved in berberine-induced apoptosis. Berberine 128-137 BCL2 apoptosis regulator Homo sapiens 89-94 22850597-4 2012 In additional studies, treatment of QBC939 cells with different concentrations (10, 40, 80 muM) of berberine for 48 h resulted in a significant dose-dependent increase in apoptosis compared to the non-berberine-treated control, which was associated with an increased expression of pro-apoptotic protein Bax and decreased expression of anti-apoptotic proteins Bcl-2 and Bcl-xL. Berberine 99-108 BCL2 apoptosis regulator Homo sapiens 359-364 20656010-4 2010 We found that Bcl-2/Bax ratio was significantly decreased and cytochrome c was released from mitochondrion to cytosol, which indicated that the mitochondrial pathway was activated by berberine. Berberine 183-192 BCL2 apoptosis regulator Homo sapiens 14-19 18459128-5 2009 The berberine-induced apoptosis of both the A549 and H1299 human lung cancer cells was associated with the disruption of mitochondrial membrane potential, reduction in the levels of Bcl-2, Bcl-xl while increase in Bax, Bak, and activation of caspase-3. Berberine 4-13 BCL2 apoptosis regulator Homo sapiens 182-187 19846952-4 2009 Berberine-induced apoptosis was associated with a reduction of the mitochondrial membrane potential associated with changes in the Bax/Bcl-2 ratio, release of cytochrome c from mitochondria and activation of down stream caspase-3. Berberine 0-9 BCL2 apoptosis regulator Homo sapiens 135-140 18379040-6 2008 Berberine treatment also markedly enhanced apoptosis in T98G cells through the induction of a higher ratio of the Bax/Bcl-2 proteins, the disruption of mitochondrial membrane potential, and the activation of procaspase-9, caspase-9, caspase-3, and poly(ADP-ribose) polymerase (PARP). Berberine 0-9 BCL2 apoptosis regulator Homo sapiens 118-123 18451495-4 2008 Combined treatment with berberine and cisplatin acted in concert to induce loss of mitochondrial membrane potential (Delta Psi m), release of cytochrome-c from mitochondria, and decreased expression of antiapoptotic Bcl-2, Bcl-x/L, resulting in activation of caspases and apoptosis. Berberine 24-33 BCL2 apoptosis regulator Homo sapiens 216-221 17970084-3 2007 Berberine enhanced the apoptosis of Ca Ski cells with the induction of a higher ratio of p53 and Bax/Bcl-2 proteins, increased levels of reactive oxygen species (ROS) and Ca2+, disruption of the mitochondrial membrane potential, and promotion of caspase-3 activity. Berberine 0-9 BCL2 apoptosis regulator Homo sapiens 101-106 17673978-4 2007 Treatment of SW620 cells with 50 microM berberine resulted in activation of the caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c; whereas, the expression of BID and anti-apoptosis factor c-IAP1, Bcl-2, and Bcl-(XL) were decreased markedly. Berberine 40-49 BCL2 apoptosis regulator Homo sapiens 249-254