PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26979714-7	2016	BBR-induced anti-apoptotic function was demonstrated by decreasing apoptotic proteins (cytochrome c, Bax, caspase3 and caspase9).	Berberine	0-3	caspase 3	Rattus norvegicus	106-114	
26788242-5	2016	BBR conferred cardioprotective effects by improving postischemic cardiac function, decreasing infarct size, reducing apoptotic index, diminishing serum creatine kinase and lactate dehydrogenase levels, upregulating SIRT1, Bcl-2 expressions, and downregulating Bax and caspase-3 expressions.	Berberine	0-3	caspase 3	Rattus norvegicus	268-277	
23499694-4	2013	We found that the effect of berberine on cell cycle arrest during ischemia was mediated by decreased p53 and cyclin D1, increased phosphorylation of Bad (higher expression of p-Bad and higher ratio of p-Bad to Bad) and decreased cleavage of caspase 3.	Berberine	28-37	caspase 3	Rattus norvegicus	241-250	
24560603-10	2014	These findings suggest that berberine-mediated neuroprotection after ischemia involves Akt/GSK3beta/ERK 1/2 survival/apoptotic signaling pathway as well as JNK and caspase-3 activity inhibition.	Berberine	28-37	caspase 3	Rattus norvegicus	164-173	
24177287-9	2013	The adjunction of berberine with verapamil improved the neurological outcome in a battery of behavioral paradigms, improved spatial memory in Morris water maze task, ameliorated the oxidative-nitrosative stress, increased acetylcholinesterase (AChE) activity, as well as improved mitochondrial complex (I, II, and IV) activity, reducing tumor necrosis factor-alpha, interleukin-1 beta and caspase-3 levels in brain tissues as compared to berberine alone group in ischemic rats.	Berberine	18-27	caspase 3	Rattus norvegicus	389-398	
25600690-8	2015	Berberine also caused decrease in TNF-alpha level and caspase-3 activity which was higher with HgCl2.	Berberine	0-9	caspase 3	Rattus norvegicus	54-63	
32964031-2	2020	We set out to investigate the impact of high-intensity interval training (HIIT) and berberine supplementation on the gene expression of angiogenesis-related factors and caspase-3 protein in rats suffering from myocardial ischemic-reperfusion injury.	Berberine	84-93	caspase 3	Rattus norvegicus	169-178	
22982719-9	2012	Decreased HIF-1alpha, caspase 9, caspase 3 and increased Bcl-2/Bax ratio were responsible for the anti-apoptosis of berberine pretreatment.	Berberine	116-125	caspase 3	Rattus norvegicus	33-42	
19424587-7	2009	The caspase-8, -9 and -3 were activated by berberine in C6 cells based on the substrate solution (PhiPhiLux-G1D1, CaspaLux 8-L1D2, CaspaLux 9-M1D2 for caspase-3, -8 and -9, respectively) and analyzed by flow cytometer and each inhibitor of caspase-8, -9 and -3 led to increase the percentage of viable C6 cells after exposure to berberine.	Berberine	43-52	caspase 3	Rattus norvegicus	151-171	
34802527-12	2021	Berberine treatment ameliorated the CPF-induced downregulation of Bcl-2, Bax translocation, and up-regulation of caspase-3 in F1 pups.	Berberine	0-9	caspase 3	Rattus norvegicus	113-122	
33407557-13	2021	CONCLUSIONS: BBR may relieve PCOS pathology and IR values by inhibiting cell apoptosis and by regulating the expression levels of TLR4, LYN, PI3K, Akt, NF-kB, TNF-alpha, IL-1, IL-6, and caspase-3.	Berberine	13-16	caspase 3	Rattus norvegicus	186-195	
22119079-4	2012	We found that the anti-apoptotic effects of berberine against ischemia were indeed mediated by the increased phosphor-activation of Akt (higher p-Akt to total Akt), leading to the intensified phosphorylation of Bad and the decreased cleavage of the pro-apoptotic protease caspase-3.	Berberine	44-53	caspase 3	Rattus norvegicus	272-281	
34483445-6	2021	Berberine significantly counteracted (P<0.05) the increase of TNF-alpha, IL-6, caspase-3 and BAX and counteracted the increase in plasma cTn-T and serum MDA.	Berberine	0-9	caspase 3	Rattus norvegicus	79-88	
30186485-12	2018	In conclusion, Berberine can inhibit the myocardium cell apoptosis of heart failure after myocardial infarction, and its mechanism may be realized by affecting the ERS in myocardial tissue of heart failure after myocardial infarction and CHOP and caspase-12 apoptotic signaling pathway, upregulating Bcl-2/Bax expression and downregulating caspase-3 expression, thus inhibiting the cardiac remodeling and protecting the cardiac function.	Berberine	15-24	caspase 3	Rattus norvegicus	340-349	
30456649-7	2019	Furthermore, berberine lowered hippocampal activity of acetylcholinesterase (AChE), malondialdehyde (MDA), protein carbonyl, activity of caspase 3, and DNA fragmentation and improved antioxidant capacity through enhancing glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase, and glutathione (GSH).	Berberine	13-22	caspase 3	Rattus norvegicus	137-146