PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19267872-0	2009	Additive effects of chlorin e6 and metal ion binding on the thermal stability of rhodopsin in vitro.	Metals	35-40	rhodopsin	Homo sapiens	81-90	
10358054-3	1999	By substituting histidines for residues at the cytoplasmic ends of helices III and VI in retinal rhodopsin, we engineered a metal-binding site whose occupancy by Zn(II) prevented the receptor from activating a retinal G protein, Gt (Sheikh, S. P., Zvyaga, T. A. , Lichtarge, O., Sakmar, T. P., and Bourne, H. R. (1996) Nature 383, 347-350).	Metals	124-129	rhodopsin	Homo sapiens	97-106	
17170198-3	2007	In this construct, free metal ions had no agonistic effect in accordance with the optimal geometry of the metal ion site in molecular models built over the inactive form of rhodopsin.	Metals	106-111	rhodopsin	Homo sapiens	173-182	
17170198-8	2007	It is proposed that in rhodopsin-like 7TM receptors, small-molecule compounds in general act as agonists in a similar manner as here demonstrated with the artificial, metal ion site anchored chelators, by holding TM-VI bent inward.	Metals	167-172	rhodopsin	Homo sapiens	23-32	
16567806-4	2006	In molecular models built over the backbone conformation of the inactive rhodopsin structure, the heavy atoms that coordinate the metal ion were located too far away from each other to form high affinity metal ion sites in both the bidentate and potential tridentate settings.	Metals	130-135	rhodopsin	Homo sapiens	73-82	
16567806-4	2006	In molecular models built over the backbone conformation of the inactive rhodopsin structure, the heavy atoms that coordinate the metal ion were located too far away from each other to form high affinity metal ion sites in both the bidentate and potential tridentate settings.	Metals	204-209	rhodopsin	Homo sapiens	73-82	
10683246-3	2000	We had modeled the mu-opioid receptor (muR) based on the low-resolution structure of rhodopsin by G. F. X. Schertler, C. Villa, and R. Henderson (1993, Nature 362, 770-772) and proposed that metal ions may be directly involved in the binding of ligands and receptor activation (B. S. Zhorov and V. S. Ananthanarayanan, 1998, J. Biomol.	Metals	191-196	rhodopsin	Homo sapiens	85-94	
8848049-0	1996	Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. A large superfamily of receptors containing seven transmembrane (TM) helices transmits hormonal and sensory signals across the plasma membrane to heterotrimeric G proteins at the cytoplasmic face of the membrane.	Metals	32-37	rhodopsin	Homo sapiens	0-9	
13622675-0	1959	Does rhodopsin contain a trace metal.	Metals	31-36	rhodopsin	Homo sapiens	5-14