PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9048573-12	1997	The Kcat thio effects [Kcat(ATP)/Kcat(ATP gamma S)] were inversely correlated with metal thiophilicity in both wild-type and D314E mutant Csk reactions, although the relationship was less pronounced in the latter.	Metals	83-88	C-terminal Src kinase	Homo sapiens	138-141	
11162381-0	2001	Affinity purification of Csk protein tyrosine kinase based on its catalytic requirement for divalent metal cations.	Metals	101-106	C-terminal Src kinase	Homo sapiens	25-28	
10220355-0	1999	Substitution studies of the second divalent metal cation requirement of protein tyrosine kinase CSK.	Metals	44-49	C-terminal Src kinase	Homo sapiens	96-99	
10220355-4	1999	In this paper, we report that several divalent metal cations, such as Mn2+, Co2+, Ni2+, and Zn2+ bind to the second Mg2+-binding site of Csk with up to 13200-fold higher affinity than Mg2+.	Metals	47-52	C-terminal Src kinase	Homo sapiens	137-140	
10220355-6	1999	Substitution by these divalent metal cations resulted in varied levels of Csk activity, with Mn2+ even more effective than Mg2+.	Metals	31-36	C-terminal Src kinase	Homo sapiens	74-77	
10220355-11	1999	These results suggest that the divalent metal activator is an important element in determining the affinity between Csk and the phosphate-accepting substrate.	Metals	40-45	C-terminal Src kinase	Homo sapiens	116-119	
17149882-3	2006	Taking advantage of this high affinity, we examined hydroxamates as metal-mediated inhibitors against C-terminal Src kinase (Csk), a protein tyrosine kinase.	Metals	68-73	C-terminal Src kinase	Homo sapiens	102-123	
17149882-3	2006	Taking advantage of this high affinity, we examined hydroxamates as metal-mediated inhibitors against C-terminal Src kinase (Csk), a protein tyrosine kinase.	Metals	68-73	C-terminal Src kinase	Homo sapiens	125-128	
17149882-5	2006	Four classes of phenylalanine and tyrosine hydroxamate derivatives were synthesized and evaluated as metal-mediated inhibitors of Csk, leading to improved inhibition and a better understanding of the structure-activity relationships.	Metals	101-106	C-terminal Src kinase	Homo sapiens	130-133