PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17409437-2 2007 Tolfenamic acid, a nonsteroidal anti-inflammatory drug, decreases Sp protein expression in Panc-1 and L3.6pl pancreatic cancer cells, and this was accompanied by decreased VEGFR1 protein and mRNA and decreased luciferase activity on cells transfected with constructs (pVEGFR1) containing VEGFR1 promoter inserts. tolfenamic acid 0-15 fms related receptor tyrosine kinase 1 Homo sapiens 172-178 17409437-2 2007 Tolfenamic acid, a nonsteroidal anti-inflammatory drug, decreases Sp protein expression in Panc-1 and L3.6pl pancreatic cancer cells, and this was accompanied by decreased VEGFR1 protein and mRNA and decreased luciferase activity on cells transfected with constructs (pVEGFR1) containing VEGFR1 promoter inserts. tolfenamic acid 0-15 fms related receptor tyrosine kinase 1 Homo sapiens 269-275 17409437-4 2007 These results show that VEGFR1 is regulated by Sp proteins and that treatment with tolfenamic acid decreases expression of this critical angiogenic factor. tolfenamic acid 83-98 fms related receptor tyrosine kinase 1 Homo sapiens 24-30 17409437-5 2007 Moreover, in vitro studies in Panc-1 cells show that activation of VEGFR1 by VEGFB to increase mitogen-activated protein kinase 1/2 phosphorylation and cell migration on collagen-coated plates is also inhibited by tolfenamic acid. tolfenamic acid 214-229 fms related receptor tyrosine kinase 1 Homo sapiens 67-73