PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34558857-8 2021 A high-iron diet (2% carbonyl iron) suppressed duodenal DMT1 levels in both wild-type and Hjv-/- mice; however, it did not affect duodenal ferroportin expression in Hjv-/- mice, and only reduced it in wild-type mice. Iron 30-34 hemojuvelin BMP co-receptor Mus musculus 90-93 33942901-4 2021 Considering the central role of the TMPRSS6/HJV/hepcidin axis in iron homeostasis, the inhibition of TMPRSS6 expression represents a promising therapeutic strategy to increase hepcidin production and ameliorate anaemia and iron overload in beta-thalassaemia. Iron 65-69 hemojuvelin BMP co-receptor Mus musculus 44-47 30213871-2 2018 Iron-dependent hepcidin induction requires hemojuvelin (HJV), a bone morphogenetic protein (BMP) coreceptor that is disrupted in juvenile hemochromatosis, causing dramatic hepcidin deficiency and tissue iron overload. Iron 0-4 hemojuvelin BMP co-receptor Mus musculus 43-54 35194137-1 2022 Hemojuvelin (HJV) enhances signaling to the iron hormone hepcidin and its deficiency causes iron overload, a risk factor for hepatocellular carcinoma (HCC). Iron 44-48 hemojuvelin BMP co-receptor Mus musculus 0-11 35194137-1 2022 Hemojuvelin (HJV) enhances signaling to the iron hormone hepcidin and its deficiency causes iron overload, a risk factor for hepatocellular carcinoma (HCC). Iron 44-48 hemojuvelin BMP co-receptor Mus musculus 13-16 35194137-1 2022 Hemojuvelin (HJV) enhances signaling to the iron hormone hepcidin and its deficiency causes iron overload, a risk factor for hepatocellular carcinoma (HCC). Iron 92-96 hemojuvelin BMP co-receptor Mus musculus 0-11 35194137-1 2022 Hemojuvelin (HJV) enhances signaling to the iron hormone hepcidin and its deficiency causes iron overload, a risk factor for hepatocellular carcinoma (HCC). Iron 92-96 hemojuvelin BMP co-receptor Mus musculus 13-16 33180328-4 2021 TMPRSS6, a membrane serine protease expressed selectively in the liver, participates in regulating hepcidin production in response to iron stores by cleaving hemojuvelin (HJV). Iron 134-138 hemojuvelin BMP co-receptor Mus musculus 158-169 30213871-2 2018 Iron-dependent hepcidin induction requires hemojuvelin (HJV), a bone morphogenetic protein (BMP) coreceptor that is disrupted in juvenile hemochromatosis, causing dramatic hepcidin deficiency and tissue iron overload. Iron 0-4 hemojuvelin BMP co-receptor Mus musculus 56-59 30213871-2 2018 Iron-dependent hepcidin induction requires hemojuvelin (HJV), a bone morphogenetic protein (BMP) coreceptor that is disrupted in juvenile hemochromatosis, causing dramatic hepcidin deficiency and tissue iron overload. Iron 203-207 hemojuvelin BMP co-receptor Mus musculus 43-54 30213871-2 2018 Iron-dependent hepcidin induction requires hemojuvelin (HJV), a bone morphogenetic protein (BMP) coreceptor that is disrupted in juvenile hemochromatosis, causing dramatic hepcidin deficiency and tissue iron overload. Iron 203-207 hemojuvelin BMP co-receptor Mus musculus 56-59 29636509-6 2018 Rescue experiments that block hepcidin up-regulation and restore iron levels in Tmprss6-/- mice via anti-hemojuvelin (HJV) therapy, revert the obesity-resistant phenotype of Tmprss6-/- mice. Iron 65-69 hemojuvelin BMP co-receptor Mus musculus 118-121 29021231-1 2017 Lack of either bone morphogenetic protein 6 (BMP6) or the BMP coreceptor hemojuvelin (HJV) in mice leads to a similar phenotype with hepcidin insufficiency, hepatic iron loading, and extrahepatic iron accumulation in males. Iron 165-169 hemojuvelin BMP co-receptor Mus musculus 73-84 29021231-1 2017 Lack of either bone morphogenetic protein 6 (BMP6) or the BMP coreceptor hemojuvelin (HJV) in mice leads to a similar phenotype with hepcidin insufficiency, hepatic iron loading, and extrahepatic iron accumulation in males. Iron 165-169 hemojuvelin BMP co-receptor Mus musculus 86-89 29021231-1 2017 Lack of either bone morphogenetic protein 6 (BMP6) or the BMP coreceptor hemojuvelin (HJV) in mice leads to a similar phenotype with hepcidin insufficiency, hepatic iron loading, and extrahepatic iron accumulation in males. Iron 196-200 hemojuvelin BMP co-receptor Mus musculus 73-84 29021231-1 2017 Lack of either bone morphogenetic protein 6 (BMP6) or the BMP coreceptor hemojuvelin (HJV) in mice leads to a similar phenotype with hepcidin insufficiency, hepatic iron loading, and extrahepatic iron accumulation in males. Iron 196-200 hemojuvelin BMP co-receptor Mus musculus 86-89 26845567-7 2016 Hemojuvelin was detected in the plasma membrane-enriched fractions of control animals as a full length protein of approximately 52 kDa; in iron deficient animals, the full length protein was partially cleaved at the N-terminus, resulting in an additional weak band of approximately 47 kDa. Iron 139-143 hemojuvelin BMP co-receptor Mus musculus 0-11 28203489-0 2016 Effects of Anti-repulsive Guidance Molecule C (RGMc/Hemojuvelin) Antibody on Hepcidin and Iron in Mouse Liver and Tumor Xenografts. Iron 90-94 hemojuvelin BMP co-receptor Mus musculus 47-51 28203489-12 2016 CONCLUSION: Anti-hemojuvelin antibody successfully reduces hepcidin in both tumors and livers but has different effects in these target organs: it reduces iron content and ferritin in the liver, but does not reduce iron content or ferritin in tumors, and does not inhibit tumor growth. Iron 155-159 hemojuvelin BMP co-receptor Mus musculus 17-28 27046124-3 2016 Hjv(-/-) mice accumulate excess iron in retina and exhibit aberrant vascularization and angiomas. Iron 32-36 hemojuvelin BMP co-receptor Mus musculus 0-3 27864295-9 2017 Together, these data demonstrate that ECs are the predominant source of BMP6 in the liver and support a model in which EC BMP6 has paracrine actions on hepatocyte hemojuvelin to regulate hepcidin transcription and maintain systemic iron homeostasis. Iron 232-236 hemojuvelin BMP co-receptor Mus musculus 163-174 28115312-10 2017 The responses in wild-type and hemojuvelin-null female mice were remarkably similar, highlighting a conserved mechanism of sex-dependent protection from iron-overload-mediated cardiac injury. Iron 153-157 hemojuvelin BMP co-receptor Mus musculus 31-42 27072365-1 2016 Hemojuvelin (HJV) regulates iron homeostasis by direct interaction with bone morphogenetic protein (BMP) ligands to induce hepcidin expression through the BMP signaling pathway in the liver. Iron 28-32 hemojuvelin BMP co-receptor Mus musculus 0-11 27072365-1 2016 Hemojuvelin (HJV) regulates iron homeostasis by direct interaction with bone morphogenetic protein (BMP) ligands to induce hepcidin expression through the BMP signaling pathway in the liver. Iron 28-32 hemojuvelin BMP co-receptor Mus musculus 13-16 27072365-5 2016 Expression of this mutant Hjv in the liver of Hjv(-/-) mice dramatically attenuated its induction of BMP signaling and hepcidin mRNA, suggesting that interaction with neogenin is critical for the iron regulatory function of HJV. Iron 196-200 hemojuvelin BMP co-receptor Mus musculus 26-29 27072365-5 2016 Expression of this mutant Hjv in the liver of Hjv(-/-) mice dramatically attenuated its induction of BMP signaling and hepcidin mRNA, suggesting that interaction with neogenin is critical for the iron regulatory function of HJV. Iron 196-200 hemojuvelin BMP co-receptor Mus musculus 46-49 25608116-1 2015 AIMS: Hereditary hemochromatosis (HH) is an iron overload disease that is caused by mutations in HFE, HJV, and several other genes. Iron 44-48 hemojuvelin BMP co-receptor Mus musculus 102-105 26077449-5 2016 Importantly our aging studies with the hemojuvelin knockout mice showed advanced liver disease in association with steatosis in the absence of a diabetic state which recapitulates the essential pathological features seen in clinical iron-overload. Iron 233-237 hemojuvelin BMP co-receptor Mus musculus 39-50 26027705-3 2015 Hemojuvelin (HVJ) is a membrane-bound and soluble protein in mammals that is responsible for the iron overload condition known as juvenile hemochromatosis. Iron 97-101 hemojuvelin BMP co-receptor Mus musculus 0-11 26027705-8 2015 These results indicated that HJV(-/-) mice would be a useful model to study cognitive impairment induced by iron overload in brain. Iron 108-112 hemojuvelin BMP co-receptor Mus musculus 29-32 25608116-5 2015 RESULTS: Hfe(-/-)Hjv(-/-) mice developed iron overload in multiple organs at levels comparable to Hjv(-/-) mice. Iron 41-45 hemojuvelin BMP co-receptor Mus musculus 17-20 25608116-6 2015 After an acute delivery of iron, the expression of hepcidin (i.e., Hamp1 mRNA) was increased in the livers of wild-type and Hfe(-/-) mice, but not in either Hjv(-/-) or Hfe(-/-)Hjv(-/-) mice. Iron 27-31 hemojuvelin BMP co-receptor Mus musculus 177-180 24808863-5 2014 The BMP/HJV/SMAD pathway is the major regulator of hepcidin expression that responds to iron status. Iron 88-92 hemojuvelin BMP co-receptor Mus musculus 8-11 25609138-12 2015 Single Hjv(-)/(-) and double Hfe(-)/(-)Hjv(-)/(-) mice exhibit comparable iron overload. Iron 74-78 hemojuvelin BMP co-receptor Mus musculus 39-42 25220979-3 2014 In hemojuvelin-knockout mice, a model of the disease, males load more cardiac iron than females. Iron 78-82 hemojuvelin BMP co-receptor Mus musculus 3-14 25609138-0 2015 Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin. Iron 46-50 hemojuvelin BMP co-receptor Mus musculus 8-11 25609138-7 2015 As expected, Hfe (-)/(-) and Hjv (-)/(-) mice developed relatively mild or severe iron overload, respectively, which corresponded to the degree of hepcidin inhibition. Iron 82-86 hemojuvelin BMP co-receptor Mus musculus 29-32 25609138-10 2015 Our results provide genetic evidence that Hfe and Hjv operate in the same pathway for the regulation of hepcidin expression and iron metabolism. Iron 128-132 hemojuvelin BMP co-receptor Mus musculus 50-53 25501544-1 2015 Hemojuvelin (Hjv) is a membrane protein that controls body iron metabolism by enhancing signaling to hepcidin. Iron 59-63 hemojuvelin BMP co-receptor Mus musculus 0-11 25501544-1 2015 Hemojuvelin (Hjv) is a membrane protein that controls body iron metabolism by enhancing signaling to hepcidin. Iron 59-63 hemojuvelin BMP co-receptor Mus musculus 13-16 25501544-2 2015 Hjv mutations cause juvenile hemochromatosis, a disease of systemic iron overload. Iron 68-72 hemojuvelin BMP co-receptor Mus musculus 0-3 25501544-5 2015 The aim of this study was to investigate the pathological implications of parenchymal iron overload due to Hjv ablation in the fatty liver. Iron 86-90 hemojuvelin BMP co-receptor Mus musculus 107-110 25501544-8 2015 As expected, all Hjv(-/-) mice manifested higher serum and hepatic iron and diminished hepcidin levels compared with WT controls. Iron 67-71 hemojuvelin BMP co-receptor Mus musculus 17-20 24812553-1 2014 PURPOSE: Loss-of-function mutations in hemojuvelin (HJV) cause juvenile hemochromatosis, an iron-overload disease. Iron 92-96 hemojuvelin BMP co-receptor Mus musculus 39-50 24812553-1 2014 PURPOSE: Loss-of-function mutations in hemojuvelin (HJV) cause juvenile hemochromatosis, an iron-overload disease. Iron 92-96 hemojuvelin BMP co-receptor Mus musculus 52-55 24812553-2 2014 Deletion of Hjv in mice results in excessive iron accumulation and morphologic changes in the retina. Iron 45-49 hemojuvelin BMP co-receptor Mus musculus 12-15 22244935-1 2012 Cell surface proteins Hfe, Tfr2, hemojuvelin and Tmprss6 play key roles in iron homeostasis. Iron 75-79 hemojuvelin BMP co-receptor Mus musculus 33-44 24409331-4 2014 Hjv-/- mice developed systemic iron overload under all regimens. Iron 31-35 hemojuvelin BMP co-receptor Mus musculus 0-3 24409331-9 2014 These findings suggest that Hjv is not required for sensing of body iron levels and merely functions as an enhancer for iron signaling to hepcidin. Iron 120-124 hemojuvelin BMP co-receptor Mus musculus 28-31 22875629-5 2013 We also used this validated assay to measure serum soluble hemojuvelin concentrations in mice receiving an acute low iron or high iron treatment. Iron 117-121 hemojuvelin BMP co-receptor Mus musculus 59-70 22875629-5 2013 We also used this validated assay to measure serum soluble hemojuvelin concentrations in mice receiving an acute low iron or high iron treatment. Iron 130-134 hemojuvelin BMP co-receptor Mus musculus 59-70 22875629-8 2013 After acute low iron diet treatment in these mice, serum soluble hemojuvelin levels were increased and correlated with lowered serum iron levels and decreased hepatic hepcidin expression. Iron 16-20 hemojuvelin BMP co-receptor Mus musculus 65-76 22875629-8 2013 After acute low iron diet treatment in these mice, serum soluble hemojuvelin levels were increased and correlated with lowered serum iron levels and decreased hepatic hepcidin expression. Iron 133-137 hemojuvelin BMP co-receptor Mus musculus 65-76 22875629-11 2013 This assay may provide a useful tool to elucidate the source and physiological role of serum soluble hemojuvelin in hepcidin regulation and iron metabolism using well-established mouse models of iron-related disorders. Iron 195-199 hemojuvelin BMP co-receptor Mus musculus 101-112 24409331-1 2014 Hemojuvelin (Hjv) is a bone morphogenetic protein (BMP) co-receptor involved in the control of systemic iron homeostasis. Iron 104-108 hemojuvelin BMP co-receptor Mus musculus 0-11 24409331-1 2014 Hemojuvelin (Hjv) is a bone morphogenetic protein (BMP) co-receptor involved in the control of systemic iron homeostasis. Iron 104-108 hemojuvelin BMP co-receptor Mus musculus 13-16 22629388-0 2012 Effect of iron overload and iron deficiency on liver hemojuvelin protein. Iron 10-14 hemojuvelin BMP co-receptor Mus musculus 53-64 21993681-2 2012 Mice deficient in transferrin (Tf(hpx/hpx)) and hemojuvelin (Hjv(-/-)), a gene mutated in juvenile hemochromatosis, a disease of hepcidin deficiency and iron overload, were generated. Iron 153-157 hemojuvelin BMP co-receptor Mus musculus 48-59 21993681-2 2012 Mice deficient in transferrin (Tf(hpx/hpx)) and hemojuvelin (Hjv(-/-)), a gene mutated in juvenile hemochromatosis, a disease of hepcidin deficiency and iron overload, were generated. Iron 153-157 hemojuvelin BMP co-receptor Mus musculus 61-69 21943374-0 2012 Iron-mediated retinal degeneration in haemojuvelin-knockout mice. Iron 0-4 hemojuvelin BMP co-receptor Mus musculus 38-50 21943374-1 2012 Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE (human leucocyte antigen-like protein involved in iron homoeostasis), transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin). Iron 122-126 hemojuvelin BMP co-receptor Mus musculus 271-274 21943374-1 2012 Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE (human leucocyte antigen-like protein involved in iron homoeostasis), transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin). Iron 122-126 hemojuvelin BMP co-receptor Mus musculus 276-288 21943374-5 2012 Hjv-/- mice at >=18 months of age had increased iron accumulation in the retina with marked morphological damage compared with age-matched controls; these changes were not found in younger mice. Iron 51-55 hemojuvelin BMP co-receptor Mus musculus 0-3 21943374-12 2012 Taken together, these results confirm the biological importance of HJV in the regulation of iron homoeostasis in the retina and in RPE. Iron 92-96 hemojuvelin BMP co-receptor Mus musculus 67-70 22629388-2 2012 The purpose of this study was to determine Hjv protein levels in mice and rats subjected to iron overload and iron deficiency. Iron 92-96 hemojuvelin BMP co-receptor Mus musculus 43-46 20542038-5 2010 In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease. Iron 25-29 hemojuvelin BMP co-receptor Mus musculus 143-154 21936923-1 2011 BACKGROUND: Hemojuvelin (HJV) is one of essential components for expression of hepcidin, a hormone which regulates iron transport. Iron 115-119 hemojuvelin BMP co-receptor Mus musculus 12-23 21936923-1 2011 BACKGROUND: Hemojuvelin (HJV) is one of essential components for expression of hepcidin, a hormone which regulates iron transport. Iron 115-119 hemojuvelin BMP co-receptor Mus musculus 25-28 21493799-3 2011 In the present study, we show in mice that loss of hemojuvelin specifically in the liver leads to decreased liver hepcidin production and increased tissue and serum iron levels. Iron 165-169 hemojuvelin BMP co-receptor Mus musculus 51-62 21480335-2 2011 Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload. Iron 148-152 hemojuvelin BMP co-receptor Mus musculus 49-60 21480335-2 2011 Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload. Iron 148-152 hemojuvelin BMP co-receptor Mus musculus 62-65 21480335-2 2011 Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload. Iron 195-199 hemojuvelin BMP co-receptor Mus musculus 49-60 21480335-2 2011 Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload. Iron 195-199 hemojuvelin BMP co-receptor Mus musculus 62-65 21480335-2 2011 Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload. Iron 195-199 hemojuvelin BMP co-receptor Mus musculus 49-60 21480335-2 2011 Mutations in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6) prevent appropriate hepcidin response to iron, allowing increased absorption of dietary iron, and eventually iron overload. Iron 195-199 hemojuvelin BMP co-receptor Mus musculus 62-65 21187450-2 2011 Although our previous studies have shown that hemojuvelin regulates hepcidin expression and iron metabolism through the BMP pathway, the role of the BMP signaling mediated by Dragon remains largely unknown. Iron 92-96 hemojuvelin BMP co-receptor Mus musculus 46-57 20940420-2 2011 In the liver, iron-dependent hepcidin activation is regulated through Bmp6 and its membrane receptor hemojuvelin (Hjv), whereas, in response to iron deficiency, hepcidin repression seems to be controlled by a pathway involving the serine protease matriptase-2 (encoded by Tmprss6). Iron 14-18 hemojuvelin BMP co-receptor Mus musculus 101-112 20940420-2 2011 In the liver, iron-dependent hepcidin activation is regulated through Bmp6 and its membrane receptor hemojuvelin (Hjv), whereas, in response to iron deficiency, hepcidin repression seems to be controlled by a pathway involving the serine protease matriptase-2 (encoded by Tmprss6). Iron 14-18 hemojuvelin BMP co-receptor Mus musculus 114-117 20858542-1 2010 Repulsive guidance molecule c (RGMc; gene symbol: Hfe2) plays a critical role in iron metabolism. Iron 81-85 hemojuvelin BMP co-receptor Mus musculus 0-29 20858542-1 2010 Repulsive guidance molecule c (RGMc; gene symbol: Hfe2) plays a critical role in iron metabolism. Iron 81-85 hemojuvelin BMP co-receptor Mus musculus 31-35 20858542-1 2010 Repulsive guidance molecule c (RGMc; gene symbol: Hfe2) plays a critical role in iron metabolism. Iron 81-85 hemojuvelin BMP co-receptor Mus musculus 50-54 21748766-0 2011 Conditional disruption of mouse HFE2 gene: maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin. Iron 67-71 hemojuvelin BMP co-receptor Mus musculus 32-36 21748766-1 2011 UNLABELLED: Mutations of the HFE2 gene are linked to juvenile hemochromatosis, a severe hereditary iron overload disease caused by chronic hyperabsorption of dietary iron. Iron 99-103 hemojuvelin BMP co-receptor Mus musculus 29-33 21748766-6 2011 The hepatic ablation of Hjv resulted in iron overload, quantitatively comparable to that observed in ubiquitous Hjv-/- mice. Iron 40-44 hemojuvelin BMP co-receptor Mus musculus 24-27 21748766-7 2011 Serum iron and ferritin levels, transferrin saturation, and liver iron content were significantly (P < 0.001) elevated in liver-specific Hjv-/- mice. Iron 6-10 hemojuvelin BMP co-receptor Mus musculus 140-143 21748766-7 2011 Serum iron and ferritin levels, transferrin saturation, and liver iron content were significantly (P < 0.001) elevated in liver-specific Hjv-/- mice. Iron 66-70 hemojuvelin BMP co-receptor Mus musculus 140-143 21748766-11 2011 CONCLUSION: The hemochromatotic phenotype of liver-specific Hjv-/- mice suggests that hepatic Hjv is necessary and sufficient to regulate hepcidin expression and control systemic iron homeostasis. Iron 179-183 hemojuvelin BMP co-receptor Mus musculus 94-97 20542038-5 2010 In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease. Iron 25-29 hemojuvelin BMP co-receptor Mus musculus 156-159 20542038-5 2010 In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease. Iron 198-202 hemojuvelin BMP co-receptor Mus musculus 143-154 20542038-5 2010 In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease. Iron 198-202 hemojuvelin BMP co-receptor Mus musculus 156-159 20542038-5 2010 In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease. Iron 198-202 hemojuvelin BMP co-receptor Mus musculus 143-154 20542038-5 2010 In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease. Iron 198-202 hemojuvelin BMP co-receptor Mus musculus 156-159 20542038-5 2010 In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease. Iron 198-202 hemojuvelin BMP co-receptor Mus musculus 143-154 20542038-5 2010 In mice, deletion of the iron hormone hepcidin and any of 8 genes that regulate its biology, including Hfe, transferrin receptor 2 (Tfr2), and hemojuvelin (Hjv) (which all sense the accumulation of iron that hepcidin corrects) or ferroportin (Fpn) (the cellular iron exporter down-regulated by hepcidin), cause iron overload but not organ disease. Iron 198-202 hemojuvelin BMP co-receptor Mus musculus 156-159 20363739-8 2010 Furthermore, iron depletion in Hjv(-/-) mice decreased hepatic BMP6 mRNA. Iron 13-17 hemojuvelin BMP co-receptor Mus musculus 31-34 20065295-2 2010 RGMc, also called hemojuvelin (HJV), is essential for iron homeostasis. Iron 54-58 hemojuvelin BMP co-receptor Mus musculus 0-4 20200349-6 2010 In contrast, mice deficient for both Tmprss6 and hemojuvelin (Hjv), a BMP coreceptor that augments hepcidin expression in hepatocytes, showed markedly decreased hepatic levels of hepcidin and Id1 mRNA, markedly increased hepatic Bmp6 mRNA levels, and systemic iron overload similar to mice deficient for Hjv alone. Iron 260-264 hemojuvelin BMP co-receptor Mus musculus 49-60 20200349-6 2010 In contrast, mice deficient for both Tmprss6 and hemojuvelin (Hjv), a BMP coreceptor that augments hepcidin expression in hepatocytes, showed markedly decreased hepatic levels of hepcidin and Id1 mRNA, markedly increased hepatic Bmp6 mRNA levels, and systemic iron overload similar to mice deficient for Hjv alone. Iron 260-264 hemojuvelin BMP co-receptor Mus musculus 62-65 20065295-2 2010 RGMc, also called hemojuvelin (HJV), is essential for iron homeostasis. Iron 54-58 hemojuvelin BMP co-receptor Mus musculus 18-29 20065295-2 2010 RGMc, also called hemojuvelin (HJV), is essential for iron homeostasis. Iron 54-58 hemojuvelin BMP co-receptor Mus musculus 31-34 19751239-2 2009 Iron excess is regulated through a pathway involving the cell surface receptor hemojuvelin (HFE2) that stimulates expression of the hepcidin encoding gene (HAMP). Iron 0-4 hemojuvelin BMP co-receptor Mus musculus 79-90 19249912-8 2010 Phlebotomies reduced hepatic iron overload in Hjv-/- mice by 80 %. Iron 29-33 hemojuvelin BMP co-receptor Mus musculus 46-49 19751239-2 2009 Iron excess is regulated through a pathway involving the cell surface receptor hemojuvelin (HFE2) that stimulates expression of the hepcidin encoding gene (HAMP). Iron 0-4 hemojuvelin BMP co-receptor Mus musculus 92-96 19751239-7 2009 Mice lacking functional matriptase-2 and hemojuvelin exhibited low Hamp (Hamp1) expression, high serum and liver iron, and high transferrin saturation. Iron 113-117 hemojuvelin BMP co-receptor Mus musculus 41-52 19234060-1 2009 Mutations in hemojuvelin (HJV) cause severe juvenile hemochromatosis, characterized by iron loading of the heart, liver, and pancreas. Iron 87-91 hemojuvelin BMP co-receptor Mus musculus 13-24 19191760-1 2009 Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin). Iron 122-126 hemojuvelin BMP co-receptor Mus musculus 256-259 19191760-1 2009 Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin). Iron 122-126 hemojuvelin BMP co-receptor Mus musculus 261-273 19191760-1 2009 Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin). Iron 122-126 hemojuvelin BMP co-receptor Mus musculus 256-259 19191760-1 2009 Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE [HLA-like protein involved in iron (Fe) homoeostasis], transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin). Iron 122-126 hemojuvelin BMP co-receptor Mus musculus 261-273 19234060-1 2009 Mutations in hemojuvelin (HJV) cause severe juvenile hemochromatosis, characterized by iron loading of the heart, liver, and pancreas. Iron 87-91 hemojuvelin BMP co-receptor Mus musculus 26-29 19234060-2 2009 Knockout (KO) mice lacking HJV (Hjv-/-) spontaneously load with dietary iron and, therefore, present a model for hereditary hemochromatosis (HH). Iron 72-76 hemojuvelin BMP co-receptor Mus musculus 27-30 19234060-11 2009 In Hjv-/- mice, liver and heart iron burden was effectively reduced with deferasirox 100 mg/kg (P<0.05). Iron 32-36 hemojuvelin BMP co-receptor Mus musculus 3-6 17264300-6 2007 Membrane HJV (m-HJV) is mainly composed of the cleaved protein, and its level is increased by iron in wild-type (WT) mice but not in the mutants. Iron 94-98 hemojuvelin BMP co-receptor Mus musculus 9-12 18997172-3 2009 Hemojuvelin, a protein critical for maintaining appropriate levels of hepcidin, acts as a coreceptor for BMP2 and BMP4, thereby providing a link between iron homeostasis and the BMP-signaling pathway. Iron 153-157 hemojuvelin BMP co-receptor Mus musculus 0-11 18521557-8 2008 Accordingly, the messenger ribonucleic acid (mRNA) concentrations of the hepcidin iron-sensing molecule hemojuvelin were not significantly changed upon Kupffer cell depletion. Iron 82-86 hemojuvelin BMP co-receptor Mus musculus 104-115 19252486-1 2009 Juvenile hemochromatosis is an iron-overload disorder caused by mutations in the genes encoding the major iron regulatory hormone hepcidin (HAMP) and hemojuvelin (HFE2). Iron 31-35 hemojuvelin BMP co-receptor Mus musculus 163-167 19252486-5 2009 In vivo, HJV.Fc or a neutralizing antibody to BMP6 inhibits hepcidin expression and increases serum iron, whereas DRAGON.Fc has no effect. Iron 100-104 hemojuvelin BMP co-receptor Mus musculus 9-12 17938254-0 2008 Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis. Iron 78-82 hemojuvelin BMP co-receptor Mus musculus 34-45 17938254-4 2008 s-HJV is decreased by iron in vitro and increased by iron deficiency in vivo. Iron 22-26 hemojuvelin BMP co-receptor Mus musculus 2-5 17938254-10 2008 The release of s-HJV might be a tissue-specific mechanism, signaling the local iron requests of hypoxic skeletal muscles independently of the oxygen status of the liver. Iron 79-83 hemojuvelin BMP co-receptor Mus musculus 17-20 17264300-6 2007 Membrane HJV (m-HJV) is mainly composed of the cleaved protein, and its level is increased by iron in wild-type (WT) mice but not in the mutants. Iron 94-98 hemojuvelin BMP co-receptor Mus musculus 16-19 16868025-0 2006 Complex biosynthesis of the muscle-enriched iron regulator RGMc. Iron 44-48 hemojuvelin BMP co-receptor Mus musculus 59-63 17255318-1 2007 Genetic iron overload, or hemochromatosis, can be caused by mutations in HFE, hemojuvelin, and hepcidin genes. Iron 8-12 hemojuvelin BMP co-receptor Mus musculus 78-89 16868025-2 2006 Mutations in this gene have been linked to the severe iron storage disease, juvenile hemochromatosis, although the mechanisms of action of RGMc in iron metabolism are unknown. Iron 147-151 hemojuvelin BMP co-receptor Mus musculus 139-143 15737887-2 2005 Four genes are responsible for the distinct types of non-HFE haemochromatosis: hepcidin and hemojuvelin are the genes involved in type 2 or juvenile haemochromatosis, transferrin receptor 2 is involved in type 3 haemochromatosis, and ferroportin 1 is mutated in type 4, the atypical dominant form of primary iron overload. Iron 308-312 hemojuvelin BMP co-receptor Mus musculus 92-103 16132052-5 2005 In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body"s iron status, and demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability. Iron 143-147 hemojuvelin BMP co-receptor Mus musculus 174-177 16132052-5 2005 In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body"s iron status, and demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability. Iron 227-231 hemojuvelin BMP co-receptor Mus musculus 174-177 16132052-5 2005 In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body"s iron status, and demonstrated that HAMP negatively regulates cellular iron efflux by affecting the ferroportin cell surface availability. Iron 227-231 hemojuvelin BMP co-receptor Mus musculus 174-177 16801541-1 2006 Recently, it has been suggested that hepcidin, a peptide involved in iron homeostasis, is regulated by bone morphogenetic proteins (BMPs), apparently by binding to hemojuvelin (Hjv) as a coreceptor and signaling through Smad4. Iron 69-73 hemojuvelin BMP co-receptor Mus musculus 177-180 16083989-3 2005 RESULTS: Iron initially accumulated in spleen macrophages but with subsequent increase in macrophage ferroportin and ferritin expression its content in the spleen decreased while a progressive storage of iron occurred within hepatocytes which was paralleled by a significant increase in hepcidin and hemojuvelin expression. Iron 9-13 hemojuvelin BMP co-receptor Mus musculus 300-311 16075054-4 2005 These mutant mice will allow further investigation into the role of HJV in the regulation of iron homeostasis, a role that to date remains elusive. Iron 93-97 hemojuvelin BMP co-receptor Mus musculus 68-71 16075058-0 2005 Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. Iron 37-41 hemojuvelin BMP co-receptor Mus musculus 0-11 16075058-0 2005 Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. Iron 84-88 hemojuvelin BMP co-receptor Mus musculus 0-11 16075058-4 2005 Here we show that, within the liver, mouse Hjv is selectively expressed by periportal hepatocytes and also that Hjv-mutant mice exhibit iron overload as well as a dramatic decrease in hepcidin expression. Iron 136-140 hemojuvelin BMP co-receptor Mus musculus 43-46 16075058-4 2005 Here we show that, within the liver, mouse Hjv is selectively expressed by periportal hepatocytes and also that Hjv-mutant mice exhibit iron overload as well as a dramatic decrease in hepcidin expression. Iron 136-140 hemojuvelin BMP co-receptor Mus musculus 112-115 16075058-5 2005 Our findings define a key role for Hjv in dietary iron sensing and also reveal that cytokine-induced inflammation regulates hepcidin expression through an Hjv-independent pathway. Iron 50-54 hemojuvelin BMP co-receptor Mus musculus 35-38 16075059-5 2005 We have disrupted the murine Hjv gene and shown that Hjv-/- mice have markedly increased iron deposition in liver, pancreas, and heart but decreased iron levels in tissue macrophages. Iron 89-93 hemojuvelin BMP co-receptor Mus musculus 29-32 16075059-5 2005 We have disrupted the murine Hjv gene and shown that Hjv-/- mice have markedly increased iron deposition in liver, pancreas, and heart but decreased iron levels in tissue macrophages. Iron 89-93 hemojuvelin BMP co-receptor Mus musculus 53-56 16075059-5 2005 We have disrupted the murine Hjv gene and shown that Hjv-/- mice have markedly increased iron deposition in liver, pancreas, and heart but decreased iron levels in tissue macrophages. Iron 149-153 hemojuvelin BMP co-receptor Mus musculus 53-56 15192150-6 2004 Studies in humans and mice have shown that this iron-dependent pathway requires the presence of Hfe, hemojuvelin, and probably transferrin receptor 2 (tfr-2). Iron 48-52 hemojuvelin BMP co-receptor Mus musculus 101-112 15590393-10 2004 INTERPRETATION AND CONCLUSIONS: The facts that HJV protein is expressed in the liver and mutations in the HJV gene induce hepatic iron accumulation point to a possibility that HJV protein may modulate iron transport in hepatocytes. Iron 130-134 hemojuvelin BMP co-receptor Mus musculus 106-109 15590393-10 2004 INTERPRETATION AND CONCLUSIONS: The facts that HJV protein is expressed in the liver and mutations in the HJV gene induce hepatic iron accumulation point to a possibility that HJV protein may modulate iron transport in hepatocytes. Iron 130-134 hemojuvelin BMP co-receptor Mus musculus 106-109 15590393-10 2004 INTERPRETATION AND CONCLUSIONS: The facts that HJV protein is expressed in the liver and mutations in the HJV gene induce hepatic iron accumulation point to a possibility that HJV protein may modulate iron transport in hepatocytes. Iron 201-205 hemojuvelin BMP co-receptor Mus musculus 47-50 15590393-10 2004 INTERPRETATION AND CONCLUSIONS: The facts that HJV protein is expressed in the liver and mutations in the HJV gene induce hepatic iron accumulation point to a possibility that HJV protein may modulate iron transport in hepatocytes. Iron 201-205 hemojuvelin BMP co-receptor Mus musculus 106-109 15590393-10 2004 INTERPRETATION AND CONCLUSIONS: The facts that HJV protein is expressed in the liver and mutations in the HJV gene induce hepatic iron accumulation point to a possibility that HJV protein may modulate iron transport in hepatocytes. Iron 201-205 hemojuvelin BMP co-receptor Mus musculus 106-109 15590393-11 2004 The wide expression of HJV as shown in the present study suggests that its role in regulating iron allocation could be extended to other tissues beyond the liver. Iron 94-98 hemojuvelin BMP co-receptor Mus musculus 23-26