PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33532991-8	2021	CONCLUSIONS: These studies demonstrate that iron negatively regulates P-gp expression at the BBB, potentially impacting CNS drug delivery and brain beta-amyloid clearance.	Iron	44-48	ATP binding cassette subfamily B member 1	Homo sapiens	70-74	
33532991-0	2021	Increasing Intracellular Levels of Iron with Ferric Ammonium Citrate Leads to Reduced P-glycoprotein Expression in Human Immortalised Brain Microvascular Endothelial Cells.	Iron	35-39	ATP binding cassette subfamily B member 1	Homo sapiens	86-100	
33532991-2	2021	Zinc and copper are reported to modulate BBB expression and function of P-gp; however, the impact of exogenous iron, which accumulates in AD, on P-gp dynamics remains unknown.	Iron	111-115	ATP binding cassette subfamily B member 1	Homo sapiens	145-149	
27866158-3	2016	We previously demonstrated by using tumor cells that glutathione S-transferase P1 (GSTP1) sequesters NO as dinitrosyl-dithiol iron complexes (DNICs) and inhibits NO-mediated iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1).	Iron	174-178	ATP binding cassette subfamily B member 1	Homo sapiens	218-248	
33532991-7	2021	While P-gp/MDR1 downregulation was associated with elevated ROS and intracellular iron, MDR1 downregulation was not attenuated with the antioxidant N-acetylcysteine nor the iron chelators desferrioxamine and deferiprone, suggesting the involvement of a ROS-independent mechanism or incomplete iron chelation.	Iron	82-86	ATP binding cassette subfamily B member 1	Homo sapiens	6-10	
33532991-7	2021	While P-gp/MDR1 downregulation was associated with elevated ROS and intracellular iron, MDR1 downregulation was not attenuated with the antioxidant N-acetylcysteine nor the iron chelators desferrioxamine and deferiprone, suggesting the involvement of a ROS-independent mechanism or incomplete iron chelation.	Iron	82-86	ATP binding cassette subfamily B member 1	Homo sapiens	11-15	
31888888-0	2020	Unshielding Multidrug Resistant Cancer through Selective Iron Depletion of P-Glycoprotein-Expressing Cells.	Iron	57-61	ATP binding cassette subfamily B member 1	Homo sapiens	75-89	
31888888-5	2020	Strikingly, iron depletion was more pronounced in MDR cells due to the Pgp-mediated efflux of NSC297366-iron complexes.	Iron	12-16	ATP binding cassette subfamily B member 1	Homo sapiens	71-74	
31888888-5	2020	Strikingly, iron depletion was more pronounced in MDR cells due to the Pgp-mediated efflux of NSC297366-iron complexes.	Iron	104-108	ATP binding cassette subfamily B member 1	Homo sapiens	71-74	
18385176-3	2008	Hypoxia-inducible factor (HIF)-1alpha, which is upregulated by a decreased availability of oxygen and iron, controls the expression of membrane transporters, such as P-glycoprotein (Pgp), which actively extrude the anticancer drugs.	Iron	102-106	ATP binding cassette subfamily B member 1	Homo sapiens	182-185	
20185911-4	2010	To investigate the relationship of iron with MDR and early growth response gene-1 (EGR1), we investigated the effect of iron deprivation on expression and/or function of multidrug resistance-1 (MDR1), early growth response gene-1 (EGR1), ferritin heavy chain gene (H-Fn) and MDR1-encoded P-glycoprotein (P-gp) in the K562 leukemic cell line.	Iron	120-124	ATP binding cassette subfamily B member 1	Homo sapiens	170-192	
20185911-10	2010	CONCLUSIONS: These results suggest a close relationship between iron deprivation and reduced MDR1/P-gp expression and function.	Iron	64-68	ATP binding cassette subfamily B member 1	Homo sapiens	93-97	
20185911-10	2010	CONCLUSIONS: These results suggest a close relationship between iron deprivation and reduced MDR1/P-gp expression and function.	Iron	64-68	ATP binding cassette subfamily B member 1	Homo sapiens	98-102	
18385176-3	2008	Hypoxia-inducible factor (HIF)-1alpha, which is upregulated by a decreased availability of oxygen and iron, controls the expression of membrane transporters, such as P-glycoprotein (Pgp), which actively extrude the anticancer drugs.	Iron	102-106	ATP binding cassette subfamily B member 1	Homo sapiens	166-180	
17495413-8	2007	The in vitro model of I/R showed that lipid peroxidation is a trigger of the injury, and superoxide and iron ion participate in TJ opening and decrease in P-gp function.	Iron	104-108	ATP binding cassette subfamily B member 1	Homo sapiens	155-159	
18473833-11	2008	Particularly, mutations of cytochrome b gene of ETC or changes in iron homeostasis by mitochondrial enzyme aconitase alter sensitivity of MDR1 and regulate resistance level to anti-parasitic drugs.	Iron	66-70	ATP binding cassette subfamily B member 1	Homo sapiens	138-142