PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14623077-14 2003 Further studies showed that PFKFB-1 and PFKFB-2 were highly responsive to hypoxia mimics such as transition metals, iron chelators and inhibitors of HIF hydroxylases, suggesting that the hypoxia responsiveness of these genes is also regulated by HIF proteins. Iron 116-120 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Mus musculus 28-35