PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8244453-0 1993 Chloroquine-induced inhibition of the production of TNF, but not of IL-6, is affected by disruption of iron metabolism. Iron 103-107 tumor necrosis factor Homo sapiens 52-55 7942787-9 1994 Recent speculation postulates that tumor necrosis factor may be involved in the etiology of this disease because of its location on chromosome 6 and its effect upon iron transport. Iron 165-169 tumor necrosis factor Homo sapiens 35-56 7841356-1 1994 In vitro monocyte-derived tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) production was assessed in iron deficient with anemia (IDA), iron deficient without anemia (ID) and control infants. Iron 129-133 tumor necrosis factor Homo sapiens 56-65 7841356-5 1994 After iron therapy, the LPS stimulated TNF-alpha secretion by cells of IDA infants returned to the levels observed in the other groups. Iron 6-10 tumor necrosis factor Homo sapiens 39-48 7841356-6 1994 Since TNF-alpha plays a key role in iron metabolism, we speculate that increased TNF production in IDA infants could exacerbate the inhibition of erythroid proliferation present in these conditions. Iron 36-40 tumor necrosis factor Homo sapiens 6-15 7841356-6 1994 Since TNF-alpha plays a key role in iron metabolism, we speculate that increased TNF production in IDA infants could exacerbate the inhibition of erythroid proliferation present in these conditions. Iron 36-40 tumor necrosis factor Homo sapiens 6-9 8250840-1 1993 We have investigated the effects of the pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) on the iron metabolism of the human monocytic cell line U937. Iron 180-184 tumor necrosis factor Homo sapiens 129-138 8250840-4 1993 IL-1 beta, TNF alpha and IFN gamma all decreased transferrin-iron uptake into cells, and all three cytokines had effects on the proportion of iron associated with ferritin. Iron 61-65 tumor necrosis factor Homo sapiens 11-20 8244453-8 1993 Our results demonstrated that chloroquine-induced inhibition of TNF and IL-6 production is not mediated through a lysosomotropic mechanism, and that chloroquine probably acts on TNF secretion by disrupting iron homeostasis. Iron 206-210 tumor necrosis factor Homo sapiens 178-181 1558977-1 1992 To determine whether release of tumor necrosis factor-alpha (TNF-alpha), a cytokine that affects iron homeostasis, may be selectively altered in hereditary hemochromatosis, we measured concentrations of TNF-alpha and interleukin-1 beta (IL-1 beta) in supernatants of cultured peripheral blood monocytes from 11 homozygotes for hereditary hemochromatosis, 11 healthy individuals, and five patients with iron-loading anemia. Iron 97-101 tumor necrosis factor Homo sapiens 61-70 8388290-0 1993 [Exogenous iron as a factor determining the effect of tumor necrosis factor (TNF) on the Raji cell line]. Iron 11-15 tumor necrosis factor Homo sapiens 54-75 8388290-0 1993 [Exogenous iron as a factor determining the effect of tumor necrosis factor (TNF) on the Raji cell line]. Iron 11-15 tumor necrosis factor Homo sapiens 77-80 1558977-5 1992 Mean concentrations of immunoreactive TNF-alpha in supernatants were significantly lower for subjects with hereditary hemochromatosis as compared to healthy controls (P less than .037) and patients with iron-loading anemia (P less than .005); differences between homozygotes for hemochromatosis and healthy controls were up to 4.5-fold at 4 hours (P = .008), 1.9-fold at 12 hours (P = .036), and 7.0-fold at 36 hours (P = .001). Iron 203-207 tumor necrosis factor Homo sapiens 38-47 1311994-3 1992 ), or to desferrioxamine (DFX), an iron chelator preventing the synthesis of OH., enhanced the specific binding of 125I-TNF-alpha to its receptors. Iron 35-39 tumor necrosis factor Homo sapiens 120-129 2052577-3 1991 Using primary human myoblasts, we have now examined the relationship between TNF-alpha and iron in regulating ferritin. Iron 91-95 tumor necrosis factor Homo sapiens 77-86 1558977-1 1992 To determine whether release of tumor necrosis factor-alpha (TNF-alpha), a cytokine that affects iron homeostasis, may be selectively altered in hereditary hemochromatosis, we measured concentrations of TNF-alpha and interleukin-1 beta (IL-1 beta) in supernatants of cultured peripheral blood monocytes from 11 homozygotes for hereditary hemochromatosis, 11 healthy individuals, and five patients with iron-loading anemia. Iron 97-101 tumor necrosis factor Homo sapiens 32-59 1342713-4 1992 With the mounting evidence that TNF, IL-1, and T lymphocyte cytokines affect hemopoiesis and iron metabolism it is possible that the reported discrepancy is a reflection of that inextricable interdependence between the two systems in the face of infection. Iron 93-97 tumor necrosis factor Homo sapiens 32-35 2052577-6 1991 Second, the increase in ferritin H protein synthesis observed during TNF-alpha treatment was dependent on an increase in ferritin H mRNA: actinomycin D blocked the TNF-alpha-induced changes in ferritin H but did not inhibit the translational induction of ferritin seen with iron treatment. Iron 274-278 tumor necrosis factor Homo sapiens 69-78 2052577-6 1991 Second, the increase in ferritin H protein synthesis observed during TNF-alpha treatment was dependent on an increase in ferritin H mRNA: actinomycin D blocked the TNF-alpha-induced changes in ferritin H but did not inhibit the translational induction of ferritin seen with iron treatment. Iron 274-278 tumor necrosis factor Homo sapiens 164-173 2052577-8 1991 Fourth, ferritin H induction by TNF-alpha and iron was additive over the entire range of iron concentrations, even at TNF-alpha doses known to maximally stimulate ferritin H mRNA levels. Iron 89-93 tumor necrosis factor Homo sapiens 32-41 2052577-9 1991 Nonetheless, the role of iron in translational regulation of ferritin was retained in TNF-alpha-treated cells; effective biosynthesis of TNF-alpha-induced, H-subunit-predominant ferritin protein required iron and could be enhanced by treatment of the cells with additional iron or blocked by 2,2"-dipyridyl. Iron 25-29 tumor necrosis factor Homo sapiens 86-95 2052577-9 1991 Nonetheless, the role of iron in translational regulation of ferritin was retained in TNF-alpha-treated cells; effective biosynthesis of TNF-alpha-induced, H-subunit-predominant ferritin protein required iron and could be enhanced by treatment of the cells with additional iron or blocked by 2,2"-dipyridyl. Iron 25-29 tumor necrosis factor Homo sapiens 137-146 2052577-9 1991 Nonetheless, the role of iron in translational regulation of ferritin was retained in TNF-alpha-treated cells; effective biosynthesis of TNF-alpha-induced, H-subunit-predominant ferritin protein required iron and could be enhanced by treatment of the cells with additional iron or blocked by 2,2"-dipyridyl. Iron 204-208 tumor necrosis factor Homo sapiens 137-146 2052577-9 1991 Nonetheless, the role of iron in translational regulation of ferritin was retained in TNF-alpha-treated cells; effective biosynthesis of TNF-alpha-induced, H-subunit-predominant ferritin protein required iron and could be enhanced by treatment of the cells with additional iron or blocked by 2,2"-dipyridyl. Iron 204-208 tumor necrosis factor Homo sapiens 137-146 2052577-10 1991 Finally, we observed that the TNF-alpha-mediated increase in ferritin synthesis peaked at 8 hr and was followed by a decrease in both H and L isoferritin synthesis; the addition of iron, however, reversed the late-occurring depression in ferritin synthesis. Iron 181-185 tumor necrosis factor Homo sapiens 30-39 2052577-11 1991 This suggests that TNF-alpha-induced synthesis of H-rich ferritin may reduce the regulatory pool of intracellular iron, secondarily inhibiting iron-mediated translation of ferritin mRNA. Iron 114-118 tumor necrosis factor Homo sapiens 19-28 2052577-11 1991 This suggests that TNF-alpha-induced synthesis of H-rich ferritin may reduce the regulatory pool of intracellular iron, secondarily inhibiting iron-mediated translation of ferritin mRNA. Iron 143-147 tumor necrosis factor Homo sapiens 19-28 2052577-12 1991 We conclude that TNF-alpha acts independently of iron in its induction of ferritin H mRNA but requires the presence of iron for this effect to be fully expressed at the protein level. Iron 49-53 tumor necrosis factor Homo sapiens 17-26 2052577-12 1991 We conclude that TNF-alpha acts independently of iron in its induction of ferritin H mRNA but requires the presence of iron for this effect to be fully expressed at the protein level. Iron 119-123 tumor necrosis factor Homo sapiens 17-26 34527177-0 2021 Erratum to "Sex-Specific Negative Association between Iron Intake and Cellular Aging Markers: Mediation Models Involving TNFalpha". Iron 54-58 tumor necrosis factor Homo sapiens 121-129 1700672-3 1990 High concentrations of TNF were found in serum samples of patients with severe RA, who had increased erythrocyte sedimentation rate and serum alpha 2 macroglobulin, but decreased haemoglobin and serum iron concentrations. Iron 201-205 tumor necrosis factor Homo sapiens 23-26 2016326-9 1991 This study demonstrates that the complex role of TNF and IL-1 in iron homeostasis includes modulation of the transferrin receptor. Iron 65-69 tumor necrosis factor Homo sapiens 49-52 2350350-2 1990 We recently observed that TNF leads to an increase in the synthesis of the heavy chain of ferritin, suggesting that TNF may be involved in iron homeostasis (Torti et al. Iron 139-143 tumor necrosis factor Homo sapiens 26-29 2350350-2 1990 We recently observed that TNF leads to an increase in the synthesis of the heavy chain of ferritin, suggesting that TNF may be involved in iron homeostasis (Torti et al. Iron 139-143 tumor necrosis factor Homo sapiens 116-119 34480898-0 2021 Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFalpha-mediated apoptosis. Iron 0-4 tumor necrosis factor Homo sapiens 79-87 34218987-8 2021 Similarly, FE induced a significant rise in TNFalpha, TF, fibrinogen, and PAI-1 (P-time<0.05); these parameters remained unchanged under LF and CE (P-time>0.05). Iron 11-13 tumor necrosis factor Homo sapiens 44-52 35579155-5 2022 Meantime, immune cells release immunostimulatory cytokines including TNF-alpha and IFN-gamma to downregulate the expression of SLC7A11 and SLC3A2, and reduce the absorption of cysteine, leading to lipid peroxidation and iron deposition in cancer cells. Iron 220-224 tumor necrosis factor Homo sapiens 69-78 3681344-0 1987 Recombinant human tumor necrosis factor depresses serum iron in mice. Iron 56-60 tumor necrosis factor Homo sapiens 18-39 2784116-8 1989 Although cachectin/TNF-IL 1-, or endotoxin treatment resulted in similar hypoferremia and shortened plasma iron half-life, endotoxin or cachectin/TNF treatment (but not IL 1) significantly reduced the incorporation of plasma 59Fe into newly synthesized RBCs. Iron 107-111 tumor necrosis factor Homo sapiens 9-18 2784116-8 1989 Although cachectin/TNF-IL 1-, or endotoxin treatment resulted in similar hypoferremia and shortened plasma iron half-life, endotoxin or cachectin/TNF treatment (but not IL 1) significantly reduced the incorporation of plasma 59Fe into newly synthesized RBCs. Iron 107-111 tumor necrosis factor Homo sapiens 19-22 33029199-0 2020 Efficacy of iron supplementation in patients with inflammatory bowel disease treated with anti-tumor necrosis factor-alpha agents. Iron 12-16 tumor necrosis factor Homo sapiens 95-122 16558016-2 1971 Tubercle bacilli exposed to an iron-poor medium multiplied at a slower rate but released more of the serum-tuberculostasis neutralizing factor (TNF) than the bacilli in an iron-rich medium. Iron 31-35 tumor necrosis factor Homo sapiens 101-142 16558016-2 1971 Tubercle bacilli exposed to an iron-poor medium multiplied at a slower rate but released more of the serum-tuberculostasis neutralizing factor (TNF) than the bacilli in an iron-rich medium. Iron 31-35 tumor necrosis factor Homo sapiens 144-147 34014775-9 2021 Pb, Mn, Fe, and Zn exposures were positively associated with stimulated production of IL-1beta and TNF-alpha. Iron 8-10 tumor necrosis factor Homo sapiens 99-108 33029199-3 2020 We assessed the effect of iron supplementation in patients with IBD initially treated with an anti-TNF-alpha agent. Iron 26-30 tumor necrosis factor Homo sapiens 99-108 33029199-8 2020 In a subgroup analysis of severely anemic patients with IBD, iron supplementation increased the magnitude of the improvement in Hb level (8.5 +- 1.5-11.4 +- 2.1 g/dL; p = 0.001) compared with the anti-TNF-alpha group (9.3 +- 0.8-11.4 +- 2.7 g/dL; p = 0.081). Iron 61-65 tumor necrosis factor Homo sapiens 201-210 33029199-11 2020 Conclusion: In anemic patients with IBD, anti-TNF-alpha agents led to clinically meaningful improvements in anemia independent of iron supplementation. Iron 130-134 tumor necrosis factor Homo sapiens 46-55 32276231-2 2020 This novel Ce-UiO-66/TNF material was proved to possess a high supercapacitive performance in the redox electrolyte of Fe(CN)63-/4-, and it was also the first study for Ce-UiO-66 material on the supercapacitor application. Iron 119-121 tumor necrosis factor Homo sapiens 21-24 32235809-6 2020 Immunohistochemical staining showed that >1 g of ferric iron increased iron and AGE retention in testicular interstitial tissues, which is associated with increased expression of the receptor for AGEs (RAGE), tumor necrosis factor-alpha, and nitric oxide. Iron 56-60 tumor necrosis factor Homo sapiens 209-236 31814879-0 2019 Sex-Specific Negative Association between Iron Intake and Cellular Aging Markers: Mediation Models Involving TNFalpha. Iron 42-46 tumor necrosis factor Homo sapiens 109-117 31657968-3 2020 The cascade starts with iron accumulation leading to an increase in CD68+ and CD11b+ cells responsible for initiating the inflammation.Areas covered: During inflammation, different factors and cytokines such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor alpha (TNF-alpha) actively play parts in the pathogenesis of HA and also angiogenesis. Iron 24-28 tumor necrosis factor Homo sapiens 243-270 31657968-3 2020 The cascade starts with iron accumulation leading to an increase in CD68+ and CD11b+ cells responsible for initiating the inflammation.Areas covered: During inflammation, different factors and cytokines such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor alpha (TNF-alpha) actively play parts in the pathogenesis of HA and also angiogenesis. Iron 24-28 tumor necrosis factor Homo sapiens 272-281 32210768-10 2020 The iron chelator desferrioxamine (DFO, 100 mumol/L) exerted suppressive effects on TNF-alpha mRNA levels, although no change was observed for TNF-alpha release. Iron 4-8 tumor necrosis factor Homo sapiens 84-93 31814879-7 2019 The association between dietary iron intake and cellular aging markers and TNFalpha and superoxide dismutase (SOD) was analyzed by Pearson correlation analysis and regression models adjusted by covariates. Iron 32-36 tumor necrosis factor Homo sapiens 75-83 31814879-8 2019 Simple mediation models were generated to examine whether TNFalpha mediated the association between iron intake and cellular aging markers using PROCESS macro Version 3.3. Iron 100-104 tumor necrosis factor Homo sapiens 58-66 31814879-12 2019 Moreover, iron intake was positively associated with TNFalpha in both women and men but positively associated with SOD only in men. Iron 10-14 tumor necrosis factor Homo sapiens 53-61 31814879-13 2019 Path modeling showed that TNFalpha significantly mediated the indirect detrimental effect of iron intake on LTL only in women; in men, mediation of the indirect effect of iron intake on mtDNAcn by TNFalpha did not reach significance. Iron 93-97 tumor necrosis factor Homo sapiens 26-34 31814879-14 2019 Conclusions: The study found sex-specific negative associations between dietary iron intake and cellular aging markers in that iron intake had deleterious effects on LTL attrition in women and mtDNAcn in men; only the former was partly mediated by TNFalpha. Iron 80-84 tumor necrosis factor Homo sapiens 248-256 31814879-14 2019 Conclusions: The study found sex-specific negative associations between dietary iron intake and cellular aging markers in that iron intake had deleterious effects on LTL attrition in women and mtDNAcn in men; only the former was partly mediated by TNFalpha. Iron 127-131 tumor necrosis factor Homo sapiens 248-256 30835899-4 2019 Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry. Iron 15-19 tumor necrosis factor Homo sapiens 139-148 30765134-10 2019 It was also found that TNF-alpha, GM-CSF and IFN-gamma productions from monocytes/macrophages of thalassemia patients who received iron chelator treatment were significantly higher than those produced from thalassemia patients without iron chelator treatment. Iron 131-135 tumor necrosis factor Homo sapiens 23-32 30835899-4 2019 Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry. Iron 15-19 tumor necrosis factor Homo sapiens 192-201 29980709-6 2018 Increased liver iron correlated with circulatory iron, TNF-alpha, macrophage activation (sCD163) and peroxide-stress in CD163+macrophages in patients who were iron-overloaded and died. Iron 16-20 tumor necrosis factor Homo sapiens 55-64 30704983-11 2019 Hypoxia reduced iron deprivation-associated TNF and IL1beta expression in HT-29 cells through the induction of autophagy. Iron 16-20 tumor necrosis factor Homo sapiens 44-47 30704983-13 2019 Iron blocked autophagy in Caco-2 cells, while reducing hypoxia-associated TNF and IL1beta expression through the inhibition of NF-kappaB binding to the promoter of TNF and IL1beta. Iron 0-4 tumor necrosis factor Homo sapiens 74-77 30704983-13 2019 Iron blocked autophagy in Caco-2 cells, while reducing hypoxia-associated TNF and IL1beta expression through the inhibition of NF-kappaB binding to the promoter of TNF and IL1beta. Iron 0-4 tumor necrosis factor Homo sapiens 164-167 29980709-10 2018 These results suggest that iron mediates inflammation through ADAM17 induction, resulting in macrophage activation and increased shedding of TNF-alpha and sCD163. Iron 27-31 tumor necrosis factor Homo sapiens 141-150 30961459-10 2018 In addition, both H2O2 and TNFalpha significantly (P < 0.05) upregulated hepcidin expression and marginally reduced ferroportin (Fpn) expression unlike iron treatment alone. Iron 155-159 tumor necrosis factor Homo sapiens 27-35 29771935-7 2018 Further, iron loading of macrophages prevented the pro-inflammatory response induced by LPS through reduction of NF-kappaB p65 nuclear translocation with decreased iNOS, IL-1beta, IL-6, IL-12 and TNFalpha expression. Iron 9-13 tumor necrosis factor Homo sapiens 196-204 29413111-8 2018 Furthermore, cytokine concentrations were independently associated with several mineral concentrations: IL-1beta with higher phosphorus and iron, IL-6 with higher calcium, magnesium, copper and manganese, IL-8 with higher calcium and zinc, and TNF-alpha with lower iron and manganese. Iron 265-269 tumor necrosis factor Homo sapiens 244-253 28476795-8 2017 In conclusion, increased iron in cancer cells and their microenvironment protects cancer cells from natural killer cell cytolysis by antagonizing NO- and TNFalpha-associated cytotoxicity and by up-regulation of ferritin expression in breast cancer cells. Iron 25-29 tumor necrosis factor Homo sapiens 154-162 28191453-0 2017 Anti-TNF-Mediated Modulation of Prohepcidin Improves Iron Availability in Inflammatory Bowel Disease, in an IL-6-Mediated Fashion. Iron 53-57 tumor necrosis factor Homo sapiens 5-8 28191453-5 2017 This study evaluates whether anti-TNF monoclonal antibodies therapy modurates hepcidin production and the levels of its main regulators, leading to a restoration of iron homeostasis. Iron 165-169 tumor necrosis factor Homo sapiens 34-37 28191453-14 2017 Anti-TNF therapy improves iron metabolism and, subsequently, anaemia in IBD. Iron 26-30 tumor necrosis factor Homo sapiens 5-8 25809685-0 2015 Common Variants and Haplotypes in the TF, TNF-alpha, and TMPRSS6 Genes Are Associated with Iron Status in a Female Black South African Population. Iron 91-95 tumor necrosis factor Homo sapiens 42-51 28286378-6 2017 Iron significantly reduced mRNA levels of IL-6, IL-1beta, TNF-alpha, and iNOS produced by IFN-gamma-polarized M1 macrophages. Iron 0-4 tumor necrosis factor Homo sapiens 58-67 26883495-4 2016 Enhanced FE properties from the TNF sample resulted in a turn-on field as low as 0.52 V mum(-1) at a current density of 0.1 mA cm(-2) and a field enhancement factor (beta) as high as 5.16 x 10(5). Iron 9-11 tumor necrosis factor Homo sapiens 32-35 27138103-0 2016 Deferoxamine-induced increase in the intracellular iron levels in highly aggressive breast cancer cells leads to increased cell migration by enhancing TNF-alpha-dependent NF-kappaB signaling and TGF-beta signaling. Iron 51-55 tumor necrosis factor Homo sapiens 151-160 27138103-9 2016 Collectively, our study has provided the first evidence suggesting that increased intracellular iron levels could lead to enhanced migration of aggressive breast cancer cells by increasing TNF-alpha-dependent NF-kappaB signaling and TGF-beta signaling. Iron 96-100 tumor necrosis factor Homo sapiens 189-198 26185605-5 2015 Some of the suggested pathways are via transcription modulator of hepcidin (STAT3); ferroportin 1 expression on the cells involved in iron transport; transmembrane protease 6 enzyme; and pro-inflammatory cytokines, interleukin (IL)-1, IL-6, tumor necrosis factor-alpha and IL-10. Iron 134-138 tumor necrosis factor Homo sapiens 241-268 25809685-8 2015 CONCLUSIONS: Various SNPs and allele combinations in the TF, TNF-alpha, and TMPRSS6 genes are associated with iron status in black South African women; however, these association patterns are different compared with European ancestry populations. Iron 110-114 tumor necrosis factor Homo sapiens 61-70 24376607-8 2013 In CSF, prostaglandin E2 level was positively correlated with the levels of transferrin and lactoferrin, and tumor necrosis factor-alpha level was negatively correlated with the levels of iron, transferrin and lactoferrin in CSF. Iron 188-192 tumor necrosis factor Homo sapiens 109-136 26023012-5 2015 (2) TNF-alpha accelerated iron accumulation and oxidative stress in human umbilical vein endothelial cells in a manner similar to that in MHD-PMNLs. Iron 26-30 tumor necrosis factor Homo sapiens 4-13 26023012-8 2015 (5) The index of arterial stiffness was aggravated in MHD patients and was associated with serum hepcidin and TNF-alpha levels, which could inhibit iron exit from cells. Iron 148-152 tumor necrosis factor Homo sapiens 110-119 25132469-5 2014 Additionally, iron that accumulates in macrophages in SCI increases TNF expression and the appearance of a macrophage population with a proinflammatory mixed M1/M2 phenotype. Iron 14-18 tumor necrosis factor Homo sapiens 68-71 25238834-15 2014 In conclusion, iron may stimulate the expression of pro-inflammatory genes (TNF-alpha and IL- 6), and both hepcidin and ferritin gene expression levels could be a risk factor for the development of type 2 diabetes. Iron 15-19 tumor necrosis factor Homo sapiens 76-85 24676135-7 2014 Moreover, cellular cytokines IL-1beta, IL-6, IL-8 and TNF-alpha secretion as well as NF-kappaB activation in THP-1 cells were attenuated under high iron conditions. Iron 148-152 tumor necrosis factor Homo sapiens 54-63 24676135-10 2014 Salmonella in high iron fermentation effluents had decreased invasion efficiency (-77.1%) and cellular TNF-alpha release compared to normal iron effluent. Iron 19-23 tumor necrosis factor Homo sapiens 103-112 24653700-6 2014 In addition, a connection between the loss of iron homeostasis and inflammation is starting to emerge; thus, inflammatory cytokines like TNF-alpha and IL-6 induce the synthesis of the divalent metal transporter 1 and promote iron accumulation in neurons and microglia. Iron 46-50 tumor necrosis factor Homo sapiens 137-146 24603312-6 2014 Oxidative stress (H2O2 production) appeared related to SiC particle size, while iron level regulated pro-inflammatory response (TNFalpha production). Iron 80-84 tumor necrosis factor Homo sapiens 128-136 24184477-3 2013 Iron in super paramagnetic iron-oxide nanoparticle (SPION) induces a phenotypic shift in THP1 derived M2 macrophages towards a high CD86+ and high TNF alpha+ macrophage subtype. Iron 0-4 tumor necrosis factor Homo sapiens 147-156 22000712-5 2012 We hypothesize that treatment with TNF-alpha antagonists predisposes the patient to infections and neoplasms by reversing the sequestration of host iron mediated by the cytokine and increasing available concentrations of this metal. Iron 148-152 tumor necrosis factor Homo sapiens 35-44 24455185-3 2013 Neolactoferrin saturated with iron ions increased the synthesis of pro-inflammatory cytokine TNFalpha. Iron 30-34 tumor necrosis factor Homo sapiens 93-101 23615377-4 2013 RESULTS: The women in the lowest iron tertile had higher high-sensitivity C-reactive protein (hsCRP) and tumor necrosis factor-alpha (TNF-alpha) levels than the women in the top iron tertile (p<0.01 or less for both). Iron 33-37 tumor necrosis factor Homo sapiens 105-132 23615377-4 2013 RESULTS: The women in the lowest iron tertile had higher high-sensitivity C-reactive protein (hsCRP) and tumor necrosis factor-alpha (TNF-alpha) levels than the women in the top iron tertile (p<0.01 or less for both). Iron 33-37 tumor necrosis factor Homo sapiens 134-143 23615377-8 2013 In the model to which the hemoglobin level was added as an independent variable, the levels of hemoglobin, hsCRP and TNF-alpha emerged as independent determinants of the serum iron level (R(2)= 0.192). Iron 176-180 tumor necrosis factor Homo sapiens 117-126 22476617-9 2012 HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions. Iron 34-36 tumor necrosis factor Homo sapiens 135-144 22476617-9 2012 HepG2 cells incubated with 40 muM Fe alone or Fe/glucose and challenged with IL-6 and/or CoCl(2) showed increased IL-6, NF-kappaB, and TNF-alpha mRNA expression and decreased mRNA expression of Mfn-2 in all experimental conditions. Iron 46-48 tumor necrosis factor Homo sapiens 135-144 22093255-1 2012 BACKGROUND: We previously reported that iron chelators inhibit TNFalpha-mediated induction of VCAM-1 in human dermal microvascular endothelial cells. Iron 40-44 tumor necrosis factor Homo sapiens 63-71 22093255-5 2012 RESULTS: Hypoxia and the non-iron binding hypoxia mimetic dimethyl oxallyl glycine (DMOG) inhibited TNFalpha-mediated induction of VCAM-1. Iron 29-33 tumor necrosis factor Homo sapiens 100-108 22093255-8 2012 CONCLUSION: Iron chelators, non-metal binding hypoxia mimetics, and hypoxia all inhibit TNFalpha-mediated VCAM-1 expression. Iron 12-16 tumor necrosis factor Homo sapiens 88-96 23429462-7 2013 Patients treated with steroids, immunomodulators, and/or anti-tumor necrosis factor drugs were more frequently treated with iron supplements when compared with those not treated with any medications (35.0% versus 20.9%, odds ratio, 1.94; P < 0.001). Iron 124-128 tumor necrosis factor Homo sapiens 62-83 23451225-2 2013 We hypothesized that in H. pylori infected children increased gastric concentrations of IL-1beta and/or TNF-alpha, both potent inhibitors of gastric acid secretion that is essential for iron absorption, are predictors for low blood concentrations of ferritin and haemoglobin, markers of early depletion of iron stores and anaemia, respectively. Iron 186-190 tumor necrosis factor Homo sapiens 104-113 23451225-2 2013 We hypothesized that in H. pylori infected children increased gastric concentrations of IL-1beta and/or TNF-alpha, both potent inhibitors of gastric acid secretion that is essential for iron absorption, are predictors for low blood concentrations of ferritin and haemoglobin, markers of early depletion of iron stores and anaemia, respectively. Iron 306-310 tumor necrosis factor Homo sapiens 104-113 20460119-8 2010 CONCLUSIONS: Ferroportin Q248H and low iron stores are both associated with lower circulating tumor necrosis factor-alpha, while only ferroportin Q248H is associated with lower circulating macrophage migration inhibitory factor. Iron 39-43 tumor necrosis factor Homo sapiens 94-121 21245128-8 2011 CONCLUSION: Serum levels of both hepcidin and TNF-alpha are independently associated with arterial stiffness in MHD patients, suggesting that microinflammation and iron metabolism might affect the integrity of arterial walls. Iron 164-168 tumor necrosis factor Homo sapiens 46-55 20701626-0 2011 Iron sensitizes keratinocytes and fibroblasts to UVA-mediated matrix metalloproteinase-1 through TNF-alpha and ERK activation. Iron 0-4 tumor necrosis factor Homo sapiens 97-106 20701626-10 2011 Our results indicate that iron and UVA increase MMP-1 activity in dermal fibroblasts not only directly through ERK activation but also by an indirect paracrine loop through TNF-alpha released by NHEK. Iron 26-30 tumor necrosis factor Homo sapiens 173-182 20882311-0 2011 Iron status during anti-TNF therapy in children with juvenile idiopathic arthritis. Iron 0-4 tumor necrosis factor Homo sapiens 24-27 20882311-2 2011 The aim of the study was to evaluate the effect of anti-tumor necrosis factor (TNF) therapy on their iron status. Iron 101-105 tumor necrosis factor Homo sapiens 51-77 20882311-2 2011 The aim of the study was to evaluate the effect of anti-tumor necrosis factor (TNF) therapy on their iron status. Iron 101-105 tumor necrosis factor Homo sapiens 79-82 21171611-12 2011 The induction of oxidative stress and inflammatory responses (evaluated by HO-1 mRNA expression and TNF-alpha mRNA and protein expression) revealed a reduction in inflammogenicity upon iron loading and a more inflammogenic potency of DQ12 ascribed to undissociated SiOH interacting via H-bonding with cell membrane components. Iron 185-189 tumor necrosis factor Homo sapiens 100-109 20606661-0 2010 Editorial: improved efficacy of biological maintenance therapy in "early" compared with "late" Crohn"s disease: strike while the iron is hot with anti-TNF agents? Iron 129-133 tumor necrosis factor Homo sapiens 151-154 19187935-3 2009 Under flow, iron loading to endothelial cells promoted an increased number of tumor necrosis factor-alpha-mediated firm arrest of human monocytes. Iron 12-16 tumor necrosis factor Homo sapiens 78-105 20010783-6 2010 TNF-induced necroptosis depends on receptor-interacting protein-1 kinase, mitochondrial complex I and cytosolic phospholipase A(2) activities, whereas H(2)O(2)-induced necrosis requires iron-dependent Fenton reactions. Iron 186-190 tumor necrosis factor Homo sapiens 0-3 20178892-0 2010 Tumor necrosis factor-alpha promoter variants and iron phenotypes in 785 hemochromatosis and iron overload screening (HEIRS) study participants. Iron 93-97 tumor necrosis factor Homo sapiens 0-27 20178892-1 2010 We sought to determine if TNF promoter variants could explain iron phenotype heterogeneity in adults with previous HFE genotyping. Iron 62-66 tumor necrosis factor Homo sapiens 26-29 19404207-11 2009 TNF-alpha produced by activated lymphocytes inhibited iron export from CaCo2 cells. Iron 54-58 tumor necrosis factor Homo sapiens 0-9 15968631-8 2005 The toxic concentration of IFN-gamma, and TNF-alpha was lower if the cells were iron loaded, but iron loading had no effect on the toxicity of IL-1beta. Iron 80-84 tumor necrosis factor Homo sapiens 42-51 16793032-6 2006 CONCLUSION: The IHD patients with low serum iron were associated with a pro-inflammatory state, such as increased TNF-alpha, IL-6, and hsCRP; increased anti-inflammatory activities, such as increased IL-10; decreased cardiac protective factor, such as decreased IGF-I. Iron 44-48 tumor necrosis factor Homo sapiens 114-123 16793930-0 2006 Tumor necrosis factor-alpha -308G>A allelic variant modulates iron accumulation in patients with hereditary hemochromatosis. Iron 65-69 tumor necrosis factor Homo sapiens 0-27 16793930-1 2006 BACKGROUND: In vitro and animal studies suggest that tumor necrosis factor alpha (TNF-alpha) modulates intestinal iron transport. Iron 114-118 tumor necrosis factor Homo sapiens 53-80 16793930-1 2006 BACKGROUND: In vitro and animal studies suggest that tumor necrosis factor alpha (TNF-alpha) modulates intestinal iron transport. Iron 114-118 tumor necrosis factor Homo sapiens 82-91 16793930-2 2006 We hypothesized that the effect of TNF-alpha might be particularly relevant if iron absorption is not effectively controlled by the HFE gene. Iron 79-83 tumor necrosis factor Homo sapiens 35-44 16793930-3 2006 METHODS: In patients with homozygous C282Y hemochromatosis, we investigated the influence of TNF-alpha -308G>A allelic variant on total body iron overload, determined in all patients by measuring iron removed during depletion therapy, and hepatic iron index and need for phlebotomy to prevent iron reaccumulation, measured in patient subgroups. Iron 144-148 tumor necrosis factor Homo sapiens 93-102 16793930-5 2006 Mean (SD) total body iron overload was increased 2-fold in TNF-alpha -308A allele carriers [10.9 (7.6) g] compared with homozygous carriers of the G allele [5.6 (5.0) g, P<0.001]. Iron 21-25 tumor necrosis factor Homo sapiens 59-68 16793930-6 2006 Hepatic iron index differed markedly between TNF-alpha -308A allele carriers [5.6 (3.5) micromol/g/year] and homozygous G allele carriers [3.1 (2.2) micromol/g/year, P=0.040, n=30]. Iron 8-12 tumor necrosis factor Homo sapiens 45-54 16793930-7 2006 After iron depletion, the need for phlebotomy to prevent iron reaccumulation (maintenance therapy) was substantially higher in TNF-alpha -308A allele carriers than in homozygous G allele carriers (P=0.014, n=73). Iron 57-61 tumor necrosis factor Homo sapiens 127-136 16793930-9 2006 CONCLUSION: TNF-alpha -308G>A allelic variant modulates iron accumulation in patients with hereditary (homozygous C282Y) hemochromatosis, but the effect of the TNF-alpha -308A allele on clinical manifestations of hemochromatosis was less accentuated than expected from the increased iron load associated with this allele. Iron 59-63 tumor necrosis factor Homo sapiens 12-21 18716131-1 2008 Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are significantly raised in malaria infection and TNF-alpha is thought to inhibit intestinal iron absorption and macrophage iron release. Iron 150-154 tumor necrosis factor Homo sapiens 17-38 18716131-1 2008 Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are significantly raised in malaria infection and TNF-alpha is thought to inhibit intestinal iron absorption and macrophage iron release. Iron 150-154 tumor necrosis factor Homo sapiens 46-55 18716131-1 2008 Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are significantly raised in malaria infection and TNF-alpha is thought to inhibit intestinal iron absorption and macrophage iron release. Iron 150-154 tumor necrosis factor Homo sapiens 107-116 18716131-1 2008 Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are significantly raised in malaria infection and TNF-alpha is thought to inhibit intestinal iron absorption and macrophage iron release. Iron 181-185 tumor necrosis factor Homo sapiens 17-38 18716131-1 2008 Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are significantly raised in malaria infection and TNF-alpha is thought to inhibit intestinal iron absorption and macrophage iron release. Iron 181-185 tumor necrosis factor Homo sapiens 46-55 18716131-1 2008 Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are significantly raised in malaria infection and TNF-alpha is thought to inhibit intestinal iron absorption and macrophage iron release. Iron 181-185 tumor necrosis factor Homo sapiens 107-116 18716131-6 2008 Thus, TNF appears to be a risk factor for iron deficiency and IDA in children in a malaria-endemic environment and this is likely to be due to a TNF-alpha-induced block in iron absorption. Iron 42-46 tumor necrosis factor Homo sapiens 6-9 18716131-6 2008 Thus, TNF appears to be a risk factor for iron deficiency and IDA in children in a malaria-endemic environment and this is likely to be due to a TNF-alpha-induced block in iron absorption. Iron 42-46 tumor necrosis factor Homo sapiens 145-154 17603935-0 2007 Tumor necrosis factor-alpha-induced reactive oxygen species formation is mediated by JNK1-dependent ferritin degradation and elevation of labile iron pool. Iron 145-149 tumor necrosis factor Homo sapiens 0-27 17603935-3 2007 We hypothesized that TNF-induced ROS formation is due to JNK-regulated ferritin degradation and an increase in labile iron pool (LIP). Iron 118-122 tumor necrosis factor Homo sapiens 21-24 17603935-5 2007 TNF treatment induced ROS formation, which was reduced to the control level in cells pretreated with desferrioxamine, an iron chelator. Iron 121-125 tumor necrosis factor Homo sapiens 0-3 17603935-10 2007 These data suggest that TNF-induced ROS formation is mediated by JNK1, which regulates ferritin degradation and thus the level of highly reactive iron. Iron 146-150 tumor necrosis factor Homo sapiens 24-27 18928154-6 2007 After adjustment for gender, age, hemodialysis duration, ferritin, phosphorus, waist and total fat percentages, multivariate regression analysis was performed and the association with HOMA-IR was still strong only for serum levels of iron and TNF-alpha. Iron 234-238 tumor necrosis factor Homo sapiens 243-252 16910777-7 2006 The lipid hydroperoxide scavengers, beta-hydroxytoluene and trolox, and the iron chelator, desferroxamine, showed partial recovery of TNF-induced apoptosis. Iron 76-80 tumor necrosis factor Homo sapiens 134-137 16224057-0 2005 Tumor necrosis factor-alpha-induced iron sequestration and oxidative stress in human endothelial cells. Iron 36-40 tumor necrosis factor Homo sapiens 0-27 16224057-3 2005 We tested whether TNF-alpha accelerated iron accumulation in vascular endothelium, favoring synthesis of hydroxyl radical. Iron 40-44 tumor necrosis factor Homo sapiens 18-27 16224057-9 2005 CONCLUSIONS: TNF-alpha could cause intracellular iron sequestration, which may participate importantly in the pathophysiology of atherosclerosis and cardiovascular disease. Iron 49-53 tumor necrosis factor Homo sapiens 13-22 15963385-6 2005 Only circulating interleukin-4 (IL-4) and TNF-alpha had abnormal responses with a time association to the oral iron intake. Iron 111-115 tumor necrosis factor Homo sapiens 42-51 15901240-3 2005 The aim of the present study was to examine the local effects of TNFalpha (tumour necrosis factor alpha) on small bowel iron transport and on iron transporter expression in the absence of hepcidin. Iron 120-124 tumor necrosis factor Homo sapiens 65-73 15901240-4 2005 The effects of TNFalpha on iron transport were determined using radiolabelled iron in an established Caco-2 cell model. Iron 27-31 tumor necrosis factor Homo sapiens 15-23 15901240-6 2005 TNFalpha mediated an early induction in both iron import and iron export, which were associated with increased DMT-1 and IREG-1 mRNA and protein expression (P<0.05). Iron 45-49 tumor necrosis factor Homo sapiens 0-8 15901240-6 2005 TNFalpha mediated an early induction in both iron import and iron export, which were associated with increased DMT-1 and IREG-1 mRNA and protein expression (P<0.05). Iron 61-65 tumor necrosis factor Homo sapiens 0-8 15901240-9 2005 In conclusion, TNFalpha has a direct effect on small bowel iron transporter expression and function, leading to an inhibition of iron transport. Iron 59-63 tumor necrosis factor Homo sapiens 15-23 15550384-0 2005 Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. Iron 0-4 tumor necrosis factor Homo sapiens 82-109 15749739-8 2005 Finally, iron transport into BEAS-2B cells was increased after inclusion of TNF-alpha, IFN-gamma, or LPS in the media. Iron 9-13 tumor necrosis factor Homo sapiens 76-85 16054986-5 2005 In addition, the accumulation of iron in hepatic macrophage isolated from laboratory animals chronically ingesting alcohol is associated with activation of nuclear factor-kappa B and production of tumor necrosis factor-alpha, providing a proinflammatory cellular environment also favorable for initiation and promotion of carcinogenesis. Iron 33-37 tumor necrosis factor Homo sapiens 197-224 15332399-7 2004 In the CF patients, sputum iron was positively and strongly related to IL-1beta, TNF-alpha, ferritin and microalbumin levels, but negatively related to forced expiratory volume in one second % predicted. Iron 27-31 tumor necrosis factor Homo sapiens 81-90 15507399-3 2004 Addition of iron to the culture medium did not affect the secretion of IL-2 and IL-1beta, but caused an increase in IL-6, IL-10, and TNF-alpha production. Iron 12-16 tumor necrosis factor Homo sapiens 133-142 15327997-1 2004 TNFalpha has dramatic effects on iron metabolism contributing to the generation of hypoferraemia in the anaemia of chronic disease. Iron 33-37 tumor necrosis factor Homo sapiens 0-8 15327997-2 2004 Interestingly, TNFalpha is also synthesised and released within the intestinal mucosa, suggesting that this pro-inflammatory cytokine may play a role in regulating dietary iron absorption. Iron 172-176 tumor necrosis factor Homo sapiens 15-23 15327997-4 2004 In TNFalpha-treated cells, apical iron uptake was significantly decreased and this was accompanied by a reduction in divalent metal transporter protein and mRNA expression. Iron 34-38 tumor necrosis factor Homo sapiens 3-11 15327997-5 2004 Our data suggest that TNFalpha could regulate dietary iron absorption and that the apical transport machinery is the target for these actions. Iron 54-58 tumor necrosis factor Homo sapiens 22-30 19284357-7 2005 RESULTS: Iron overload leads to inhibition of IFN-gamma, TNF-alpha, IL-12, and nitric oxide formation as well as impairment of macrophage, neutrophil, and T-cell function. Iron 9-13 tumor necrosis factor Homo sapiens 57-66 15332399-9 2004 However, changes in sputum TNF-alpha in acute patients were still closely related to changes in iron, ferritin and albumin content, and changes in IL-1beta were related to changes in sputum ferritin content. Iron 96-100 tumor necrosis factor Homo sapiens 27-36 15022609-5 2004 Decreasing concentrations of IL-1, IL-6, TNF-alpha and INF-gamma in IDA patients due to an adequate therapy by iron-containing drugs is a positive phenomenon in recovering the functional status of the immune system; it denotes that the maturation of hemoglobin-containing erythron variations and the secondary immune insufficiency are reviving. Iron 111-115 tumor necrosis factor Homo sapiens 41-50 15332399-3 2004 The current authors also determined sputum interleukin (IL)-1beta and tumour necrosis factor (TNF)-alpha levels because of their putative role in intracellular iron homeostasis. Iron 160-164 tumor necrosis factor Homo sapiens 70-104 12846752-5 2003 RESULTS: Tumor necrosis factor-alpha (TNF-alpha) levels were increased in ESRD patients at study entry and then decreased significantly over time in subjects receiving additional iron, while they increased with rhEPO alone. Iron 179-183 tumor necrosis factor Homo sapiens 9-36 14614458-8 2003 The data suggest that Myc-activation, FasL, TNFalpha, and TRAIL disturbed cellular iron homeostasis, which triggered apoptosis of ovarian carcinoma cells and that transferrin iron ensured survival by re-establishing this homeostasis. Iron 83-87 tumor necrosis factor Homo sapiens 44-52 14708625-2 2003 In this study, we determined that the generation of interferon regulatory factor-1 expression in human dermal microvascular endothelial cells was transcriptionally mediated by tumor necrosis factor-alpha or interferon-gamma via iron-dependent pathways. Iron 228-232 tumor necrosis factor Homo sapiens 176-203 14708625-6 2003 Both tumor necrosis factor-alpha and interferon-gamma-induced interferon regulatory factor-1 gene transcription, as assessed by the measurement of unspliced, nascent, heterogeneous nuclear RNA, and treatment with iron chelators blocked tumor necrosis factor-alpha or interferon-gamma mediated interferon regulatory factor-1 gene transcription. Iron 213-217 tumor necrosis factor Homo sapiens 5-32 14708625-6 2003 Both tumor necrosis factor-alpha and interferon-gamma-induced interferon regulatory factor-1 gene transcription, as assessed by the measurement of unspliced, nascent, heterogeneous nuclear RNA, and treatment with iron chelators blocked tumor necrosis factor-alpha or interferon-gamma mediated interferon regulatory factor-1 gene transcription. Iron 213-217 tumor necrosis factor Homo sapiens 236-263 12846752-5 2003 RESULTS: Tumor necrosis factor-alpha (TNF-alpha) levels were increased in ESRD patients at study entry and then decreased significantly over time in subjects receiving additional iron, while they increased with rhEPO alone. Iron 179-183 tumor necrosis factor Homo sapiens 38-47 12846752-7 2003 A significant negative correlation between iron availability, as determined by transferrin saturation, and TNF-alpha levels (P = 0.008) and a positive one between transferring saturation and IL-4 (P = 0.02) pointed to the potential role of iron to induce immunologic changes. Iron 43-47 tumor necrosis factor Homo sapiens 107-116 12846752-8 2003 Interestingly, iron therapy resulted in a slight decrease in the amounts of endogenous peroxides, which may be referred to reduced TNF-alpha concentrations since peroxide concentrations were positively correlated to TNF-alpha levels (P = 0.046) and negatively to transferrin saturation (P = 0.02). Iron 15-19 tumor necrosis factor Homo sapiens 131-140 12846752-8 2003 Interestingly, iron therapy resulted in a slight decrease in the amounts of endogenous peroxides, which may be referred to reduced TNF-alpha concentrations since peroxide concentrations were positively correlated to TNF-alpha levels (P = 0.046) and negatively to transferrin saturation (P = 0.02). Iron 15-19 tumor necrosis factor Homo sapiens 216-225 12940442-3 2003 The cytokine TNF-alpha is implicated in the regulation of iron metabolism at different levels. Iron 58-62 tumor necrosis factor Homo sapiens 13-22 12713595-2 2003 To investigate the role of iron in TNF alpha-induced VCAM-1 gene expression, human dermal microvascular endothelial cells (HDMEC) were stimulated with TNF alpha in the presence of iron chelators and examined for expression of VCAM-1. Iron 27-31 tumor necrosis factor Homo sapiens 35-44 12713595-5 2003 The effect of iron was mediated at the level of gene transcription since pretreatment with DP abrogated the TNF alpha-mediated up-regulation of VCAM-1 heterogeneous nuclear RNA. Iron 14-18 tumor necrosis factor Homo sapiens 108-117 12713595-10 2003 These data suggest that iron plays a critical role in TNF alpha mediated VCAM-1 induction in HDMEC, and the target for iron effects may be IRF-1, NF-kappa B, and potentially chromatin remodeling. Iron 24-28 tumor necrosis factor Homo sapiens 54-63 11389189-6 2001 IFN-beta decreased HO-1 expression and mitochondrial iron sequestration in IL-1beta- and TNF-alpha-challenged astroglia. Iron 53-57 tumor necrosis factor Homo sapiens 89-98 12606055-0 2003 Role of iron and ferritin in TNFalpha-induced apoptosis in HeLa cells. Iron 8-12 tumor necrosis factor Homo sapiens 29-37 12606055-1 2003 We found that tumor necrosis factor alpha (TNFalpha)-induced apoptosis in HeLa cells was accompanied by a approximately 2-fold increase in H- and L-ferritin and a decrease in transferrin receptor, two indices of increased iron availability. Iron 222-226 tumor necrosis factor Homo sapiens 14-41 12606055-1 2003 We found that tumor necrosis factor alpha (TNFalpha)-induced apoptosis in HeLa cells was accompanied by a approximately 2-fold increase in H- and L-ferritin and a decrease in transferrin receptor, two indices of increased iron availability. Iron 222-226 tumor necrosis factor Homo sapiens 43-51 12606055-2 2003 Iron supplementation and overexpression of H-ferritin or its mutant with an inactivated ferroxidase center reduced by about approximately 50% the number of apoptotic cells after TNFalpha-treatment, while overexpression of L-ferritin was ineffective. Iron 0-4 tumor necrosis factor Homo sapiens 178-186 11841920-0 2002 Iron regulation of hepatic macrophage TNFalpha expression. Iron 0-4 tumor necrosis factor Homo sapiens 38-46 12614218-13 2003 The impaired TNF-alpha transcription in cells from ID subjects indicates that the quality of the immune response is linked to the Fe status of mononuclear cells. Iron 130-132 tumor necrosis factor Homo sapiens 13-22 12069185-8 2002 Iron supplementation of macrophage cultures significantly increased interleukin-1beta-induced TNF release. Iron 0-4 tumor necrosis factor Homo sapiens 94-97 11054092-0 2000 Relationship between TNF-alpha and iron metabolism in differentiating human monocytic THP-1 cells. Iron 35-39 tumor necrosis factor Homo sapiens 21-30 11225250-6 2000 RESULT: Serum TNF alpha or IFN-gamma in RA and RA with ACD patients were higher than those in normal controls, and were inversely correlated with hemoglobin, and serum iron levels. Iron 168-172 tumor necrosis factor Homo sapiens 14-23 11054092-3 2000 In addition, we found that iron administration to PMA-differentiating cells induced the expression of TNF-alpha mRNA and TNF-alpha secretion to levels even higher than those induced by IFN-gamma alone. Iron 27-31 tumor necrosis factor Homo sapiens 102-111 11054092-3 2000 In addition, we found that iron administration to PMA-differentiating cells induced the expression of TNF-alpha mRNA and TNF-alpha secretion to levels even higher than those induced by IFN-gamma alone. Iron 27-31 tumor necrosis factor Homo sapiens 121-130 11054092-4 2000 The iron chelator desferrioxamine showed the opposite effect and reduced TNF-alpha release. Iron 4-8 tumor necrosis factor Homo sapiens 73-82 11054092-5 2000 In contrast, preincubation of the cells with iron before PMA induction resulted in a decrease of the TNF-alpha secretion induced by IFN-gamma, whereas the opposite was true after preincubation with desferrioxamine. Iron 45-49 tumor necrosis factor Homo sapiens 101-110 11054092-6 2000 The data support a co-ordinate interaction between iron and TNF-alpha in monocyte macrophages, with an iron-mediated upregulation of TNF-alpha in the early phase of differentiation and an iron-mediated inhibition at later stages. Iron 51-55 tumor necrosis factor Homo sapiens 133-142 11054092-6 2000 The data support a co-ordinate interaction between iron and TNF-alpha in monocyte macrophages, with an iron-mediated upregulation of TNF-alpha in the early phase of differentiation and an iron-mediated inhibition at later stages. Iron 103-107 tumor necrosis factor Homo sapiens 60-69 11054092-6 2000 The data support a co-ordinate interaction between iron and TNF-alpha in monocyte macrophages, with an iron-mediated upregulation of TNF-alpha in the early phase of differentiation and an iron-mediated inhibition at later stages. Iron 103-107 tumor necrosis factor Homo sapiens 133-142 11054092-6 2000 The data support a co-ordinate interaction between iron and TNF-alpha in monocyte macrophages, with an iron-mediated upregulation of TNF-alpha in the early phase of differentiation and an iron-mediated inhibition at later stages. Iron 103-107 tumor necrosis factor Homo sapiens 60-69 11054092-6 2000 The data support a co-ordinate interaction between iron and TNF-alpha in monocyte macrophages, with an iron-mediated upregulation of TNF-alpha in the early phase of differentiation and an iron-mediated inhibition at later stages. Iron 103-107 tumor necrosis factor Homo sapiens 133-142 9851740-0 1998 Differential regulation of human alveolar macrophage-derived interleukin-1beta and tumor necrosis factor-alpha by iron. Iron 114-118 tumor necrosis factor Homo sapiens 83-110 10471599-11 1999 Iron-treated A549 cells synthesized almost entirely L-ferritin whereas exposure to TNF-alpha with iron caused a dose-dependent increase in accumulation of H-type ferritin. Iron 98-102 tumor necrosis factor Homo sapiens 83-92 10444519-0 1999 Effects of TNF-alpha and IL-1beta on iron metabolism by A549 cells and influence on cytotoxicity. Iron 37-41 tumor necrosis factor Homo sapiens 11-20 10444519-4 1999 The cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta may alter iron metabolism by alveolar cells. Iron 85-89 tumor necrosis factor Homo sapiens 14-47 10444519-12 1999 These findings indicate that TNF-alpha and IL-1beta modulate iron uptake by A549 cells, with differing effects on TBI and NTBI, as well as on H-ferritin synthesis. Iron 61-65 tumor necrosis factor Homo sapiens 29-38 10444519-13 1999 Enhanced iron uptake induced by TNF-alpha and NTBI was also associated with increased cytotoxicity to A549 cells. Iron 9-13 tumor necrosis factor Homo sapiens 32-41 9851740-3 1998 We hypothesized that excess cellular iron interfered with the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1-beta) by AMs. Iron 37-41 tumor necrosis factor Homo sapiens 76-103 9851740-3 1998 We hypothesized that excess cellular iron interfered with the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1-beta) by AMs. Iron 37-41 tumor necrosis factor Homo sapiens 105-114 9851740-10 1998 Conversely, as the intensity of iron chelation increased, the release of IL-1-beta and TNF-alpha decreased, as was also shown with hydroxyl radical scavenging by dimethylthiourea. Iron 32-36 tumor necrosis factor Homo sapiens 87-96 9726030-10 1998 TNF, possibly via induction of IL-6, and IFN-gamma induce hypoferraemia, which may in part result from a decrease in tissue iron release based on a primary stimulation of ferritin synthesis. Iron 124-128 tumor necrosis factor Homo sapiens 0-3 9335326-7 1997 Conversely, the intracellular iron chelator, desferrioxamine, stimulated TNF-alpha expression. Iron 30-34 tumor necrosis factor Homo sapiens 73-82 9325328-16 1997 Furthermore, tumor necrosis factor and interleukin-1 activate NF-kappaB through different mechanisms in ECV304 cells, with the tumor necrosis factor pathway involving iron-catalyzed lipid peroxidation. Iron 167-171 tumor necrosis factor Homo sapiens 13-34 9325328-16 1997 Furthermore, tumor necrosis factor and interleukin-1 activate NF-kappaB through different mechanisms in ECV304 cells, with the tumor necrosis factor pathway involving iron-catalyzed lipid peroxidation. Iron 167-171 tumor necrosis factor Homo sapiens 127-148 9335326-0 1997 Suppression of TNF-alpha gene expression by hemin: implications for the role of iron homeostasis in host inflammatory responses. Iron 80-84 tumor necrosis factor Homo sapiens 15-24 9335326-1 1997 Tumor necrosis factor alpha (TNF-alpha) has multiple effects on iron homeostasis and erythropoiesis and has been implicated in the pathogenesis of the anemia of inflammation. Iron 64-68 tumor necrosis factor Homo sapiens 0-27 9335326-1 1997 Tumor necrosis factor alpha (TNF-alpha) has multiple effects on iron homeostasis and erythropoiesis and has been implicated in the pathogenesis of the anemia of inflammation. Iron 64-68 tumor necrosis factor Homo sapiens 29-38 9335326-2 1997 We postulated that intracellular iron in turn may regulate the expression of TNF-alpha. Iron 33-37 tumor necrosis factor Homo sapiens 77-86 9335326-6 1997 Sn-protoporphyrin, an inhibitor of heme oxygenase (which releases iron from hemin), prevented hemin-induced suppression of TNF-alpha expression. Iron 66-70 tumor necrosis factor Homo sapiens 123-132 9335326-8 1997 Thus, the expression of TNF-alpha, itself a physiological regulator of iron homeostasis, appears to be controlled by intracellular levels of iron. Iron 71-75 tumor necrosis factor Homo sapiens 24-33 9335326-8 1997 Thus, the expression of TNF-alpha, itself a physiological regulator of iron homeostasis, appears to be controlled by intracellular levels of iron. Iron 141-145 tumor necrosis factor Homo sapiens 24-33 9110146-4 1997 This study shows that treatment of Jurkat cells with iron chelator deferoxamine (DFO) strongly decreases HIV-1 Tat-potentiated TNF-induced NF-kappa B activation but does not modify NF-kappa B activation by TNF-alpha. Iron 53-57 tumor necrosis factor Homo sapiens 127-130 9153296-0 1997 Tumor necrosis factor alpha (TNFalpha) promotes growth of virulent Mycobacterium tuberculosis in human monocytes iron-mediated growth suppression is correlated with decreased release of TNFalpha from iron-treated infected monocytes. Iron 113-117 tumor necrosis factor Homo sapiens 29-37 9153296-0 1997 Tumor necrosis factor alpha (TNFalpha) promotes growth of virulent Mycobacterium tuberculosis in human monocytes iron-mediated growth suppression is correlated with decreased release of TNFalpha from iron-treated infected monocytes. Iron 113-117 tumor necrosis factor Homo sapiens 186-194 9153296-0 1997 Tumor necrosis factor alpha (TNFalpha) promotes growth of virulent Mycobacterium tuberculosis in human monocytes iron-mediated growth suppression is correlated with decreased release of TNFalpha from iron-treated infected monocytes. Iron 200-204 tumor necrosis factor Homo sapiens 29-37 9153296-0 1997 Tumor necrosis factor alpha (TNFalpha) promotes growth of virulent Mycobacterium tuberculosis in human monocytes iron-mediated growth suppression is correlated with decreased release of TNFalpha from iron-treated infected monocytes. Iron 200-204 tumor necrosis factor Homo sapiens 186-194 9153296-5 1997 The enhanced permissiveness of CytD-preincubated monocytes was found to be due to TNFalpha, however, the ability of iron to suppress M. tuberculosis growth also required preincubation with TNFalpha. Iron 116-120 tumor necrosis factor Homo sapiens 189-197 9153296-6 1997 Iron-mediated growth suppression was correlated with selective suppression of TNFalpha release from infected monocytes. Iron 0-4 tumor necrosis factor Homo sapiens 78-86 9153296-7 1997 In addition, removal of TNFalpha from CytD-treated monocytes 2 d after infection mimicked the suppressive effect of iron, suggesting that iron may also be decreasing monocyte sensitivity to exogenously added TNFalpha. Iron 116-120 tumor necrosis factor Homo sapiens 208-216 9153296-7 1997 In addition, removal of TNFalpha from CytD-treated monocytes 2 d after infection mimicked the suppressive effect of iron, suggesting that iron may also be decreasing monocyte sensitivity to exogenously added TNFalpha. Iron 138-142 tumor necrosis factor Homo sapiens 24-32 9153296-7 1997 In addition, removal of TNFalpha from CytD-treated monocytes 2 d after infection mimicked the suppressive effect of iron, suggesting that iron may also be decreasing monocyte sensitivity to exogenously added TNFalpha. Iron 138-142 tumor necrosis factor Homo sapiens 208-216 9153296-10 1997 The results of this study indicate that TNFalpha preincubation is required for human monocytes to exert an iron-mediated suppressive effect on M. tuberculosis growth. Iron 107-111 tumor necrosis factor Homo sapiens 40-48 9153296-12 1997 Iron may be an important early modulator of M. tuberculosis growth via its effects on TNFalpha. Iron 0-4 tumor necrosis factor Homo sapiens 86-94 9268159-2 1997 In the present study, we examined the effects of established and novel compounds including antioxidants, ribonucleotide reductase inhibitors, and iron chelators on NF-kappaB activation and HIV LTR-mediated gene expression induced by TNF-alpha. Iron 146-150 tumor necrosis factor Homo sapiens 233-242 9268159-6 1997 On the other hand, iron chelators desferrioxamine, pyridoxal isonicotinoyl hydrazone (PIH), and salicylaldehyde isonicotinoyl hydrazone (SIH) showed no inhibition of TNF-alpha-induced NF-kappaB DNA-binding activity. Iron 19-23 tumor necrosis factor Homo sapiens 166-175 9110146-4 1997 This study shows that treatment of Jurkat cells with iron chelator deferoxamine (DFO) strongly decreases HIV-1 Tat-potentiated TNF-induced NF-kappa B activation but does not modify NF-kappa B activation by TNF-alpha. Iron 53-57 tumor necrosis factor Homo sapiens 206-209 9110146-5 1997 The ability of iron chelators to reduce Tat-potentiated TNF-induced NF-kappa B binding activity suggests that iron and intracellular hydroxyl radicals (OH.) Iron 15-19 tumor necrosis factor Homo sapiens 56-59 9110146-5 1997 The ability of iron chelators to reduce Tat-potentiated TNF-induced NF-kappa B binding activity suggests that iron and intracellular hydroxyl radicals (OH.) Iron 110-114 tumor necrosis factor Homo sapiens 56-59 9110146-12 1997 in the presence of iron ions play a major role in HIV-1 Tat enhancement of TNF-induced NF-kappa B activation and that iron chelation may protect Jurkat T cells, at least in part, against oxidative stress induced by Tat. Iron 19-23 tumor necrosis factor Homo sapiens 75-78 9215812-0 1997 How does superoxide dismutase protect against tumor necrosis factor: a hypothesis informed by effect of superoxide on "free" iron. Iron 125-129 tumor necrosis factor Homo sapiens 46-67 9215812-8 1997 MnSOD protects against TNF by decreasing O2- attack on [4Fe-4S] clusters and thus lowering free iron. Iron 96-100 tumor necrosis factor Homo sapiens 23-26