PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3047970-1 1988 Problems of ferrokinetics, participation of metalloproteins transferrin, ferritin and lactoferrin in metabolism of iron at the step of the metal absorption, transport of iron by means of transferrin, haptoglobin and hemopexin, interaction of transferrin with reticulocytes, deposition of iron in ferritin, mobilization of iron from ferritin via ceruloplasmin are considered. Iron 115-119 haptoglobin Homo sapiens 200-211 9244773-7 1997 A reduction in serum haptoglobin concentration was shown to be accompanied by a decrease of serum iron concentration. Iron 98-102 haptoglobin Homo sapiens 21-32 10528321-1 1999 INTRODUCTION: Haptoglobin is a transport protein and protects organism against iron loss and it should be involved in central nervous system infectious process. Iron 79-83 haptoglobin Homo sapiens 14-25 31786754-8 2020 A significant negative correlation was observed between Delta haptoglobin concentration and Delta serum iron concentration (r = - 0.551, p = 0.027). Iron 104-108 haptoglobin Homo sapiens 62-73 14497367-0 1962 Estimation of haptoglobin using haemoglobin labelled with radioactive iron-59. Iron 70-74 haptoglobin Homo sapiens 14-25 31724044-2 2019 Humans store iron bound to various proteins such as hemoglobin, haptoglobin, transferrin, ferritin, and lactoferrin, limiting the availability of free iron for pathogenic bacteria. Iron 13-17 haptoglobin Homo sapiens 64-75 32439379-2 2020 Haptoglobin (Hp) removes free hemoglobin and protects from iron-induced oxidative damage, inflammatory response, atherosclerosis and cerebrovascular diseases. Iron 59-63 haptoglobin Homo sapiens 0-11 31221534-1 2020 INTRODUCTION AND OBJECTIVES: Haptoglobin is a protein involved in the protection against oxidative damage caused by iron in haemoglobin. Iron 116-120 haptoglobin Homo sapiens 29-40 31819010-7 2020 The human acute phase protein haptoglobin (Hp) protects the host from oxidative damage by clearing hemoglobin that has leaked from red blood cells and also restricts the availability of extracellular Hb-bound iron to invading pathogens. Iron 209-213 haptoglobin Homo sapiens 30-41 31455889-3 2019 The haemoprotein scavengers haptoglobin and haemopexin act to limit circulating levels of free haemoglobin, haem and iron - potentially toxic species that are released from injured RBCs. Iron 117-121 haptoglobin Homo sapiens 28-39 30528492-2 2019 Haptoglobin (Hp) is an acute phase reactant that scavenges extracorpuscular hemoglobin from circulation and prevents heme-iron oxidative damage. Iron 122-126 haptoglobin Homo sapiens 0-11 30232287-3 2018 Human haptoglobin binds CFH with high affinity and, therefore, can potentially reduce iron availability and oxidative activity. Iron 86-90 haptoglobin Homo sapiens 6-17 30232287-6 2018 We found, in this S. aureus pneumonia model inducing septic shock, that commercial human haptoglobin concentrate infusions over 48-hours bind canine CFH, increase CFH clearance, and lower circulating iron. Iron 200-204 haptoglobin Homo sapiens 89-100 29134616-3 2018 The aim of the study was to investigate zonulin levels in patients with early stages of CKD and its possible correlation with inflammation, anemia and iron status parameters. Iron 151-155 haptoglobin Homo sapiens 40-47 29298491-0 2018 Is Magnetic Resonance Imaging Detection of Kidney Iron Deposition Increased in Haptoglobin 2-2 Genotype Carriers with Type 1 Diabetes? Iron 50-54 haptoglobin Homo sapiens 79-90 30250850-0 2018 The Iron-Klotho-VDR Axis Is a Major Determinant of Proximal Convoluted Tubule Injury in Haptoglobin 2-2 Genotype Diabetic Nephropathy Patients and Mice. Iron 4-8 haptoglobin Homo sapiens 88-99 25958740-1 2016 BACKGROUND: Haptoglobin (Hp) is one of the acute phase proteins, whose main function is to bind free haemoglobin (Hb) and transport it to the liver for degradation and iron recycling. Iron 168-172 haptoglobin Homo sapiens 12-23 29070546-4 2017 Key players in mammalian iron trafficking include several types of cells important to iron acquisition, homeostasis, and hematopoiesis (enterocytes, hepatocytes, macrophages, hematopoietic cells, and in the case of pregnancy, placental syncytiotrophoblast cells) and several forms of chaperone proteins, including, for nonheme iron, the transport protein transferrin and the intracellular iron-storage protein ferritin, and for heme iron, the chaperone proteins haptoglobin and hemopexin. Iron 25-29 haptoglobin Homo sapiens 462-473 28410926-1 2017 Findings of increased hemoglobin inside the HDL proteome among persons with diabetes who have haptoglobin 2-2 genotype suggest that iron-induced lipid peroxidation may be involved in diabetic kidney disease. Iron 132-136 haptoglobin Homo sapiens 94-105 27507623-0 2016 Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function. Iron 112-116 haptoglobin Homo sapiens 45-56 27107558-5 2016 An ~10-fold increase in ceruloplasmin and ~4-fold increase in haptoglobin gene expression suggested a possible association between vitamin D and iron homeostasis. Iron 145-149 haptoglobin Homo sapiens 62-73 26370551-1 2015 Haptoglobin (Hp), a heme-Iron chelator, has different isoforms which are associated with variable tendency toward infections: Hp 1-1, Hp 2-1, and Hp 2-2. Iron 25-29 haptoglobin Homo sapiens 0-11 26228081-7 2015 Stratified analysis by haptoglobin phenotype was performed to determine effect of haptoglobin phenotype on serum iron parameter differences between PD cases and controls and to investigate its role in the protective effect of smoking on PD risk. Iron 113-117 haptoglobin Homo sapiens 82-93 26228081-11 2015 CONCLUSIONS: Our results report for the first time that the haptoglobin phenotype may be a contributor of iron levels abnormalities in PD patients. Iron 106-110 haptoglobin Homo sapiens 60-71 26268514-5 2015 Haptoglobin (Hp) protein is the main line of defense against the oxidative effects of Hemoglobin/Iron. Iron 97-101 haptoglobin Homo sapiens 0-11 24075749-3 2013 We studied whether common variants of haptoglobin (Hp), which facilitates the removal of free hemoglobin and protects tissues from heme-iron induced oxidative damage, would modify the inflammatory response to IPH and the risk of unstable carotid stenosis (CS) and major cardiovascular diseases. Iron 136-140 haptoglobin Homo sapiens 38-49 26211665-1 2015 Haptoglobin (Hp) is an acute-phase protein that is produced by the liver to capture the iron that is present in the blood circulation, thus avoiding its accumulation in the blood. Iron 88-92 haptoglobin Homo sapiens 0-11 25380935-5 2014 Taking into consideration iron metabolism, including its absorption in the gut, the aim of this study was to assess zonulin levels in heart transplant recipients and their possible correlations with iron status, immunosuppressive therapy, and kidney function. Iron 26-30 haptoglobin Homo sapiens 116-123 25380935-5 2014 Taking into consideration iron metabolism, including its absorption in the gut, the aim of this study was to assess zonulin levels in heart transplant recipients and their possible correlations with iron status, immunosuppressive therapy, and kidney function. Iron 199-203 haptoglobin Homo sapiens 116-123 24974683-0 2014 Haptoglobin 2-2 phenotype is associated with decreased serum iron levels in endstage renal disease patients resistant to rhEPO therapy. Iron 61-65 haptoglobin Homo sapiens 0-11 24255894-4 2013 Haptoglobin (Hp) is an antioxidant plasma protein which binds free hemoglobin, thus preventing heme-iron mediated oxidation. Iron 100-104 haptoglobin Homo sapiens 0-11 26228081-0 2015 Haptoglobin phenotype modifies serum iron levels and the effect of smoking on Parkinson disease risk. Iron 37-41 haptoglobin Homo sapiens 0-11 22465143-0 2012 Haptoglobin genotype and its role in determining heme-iron mediated vascular disease. Iron 54-58 haptoglobin Homo sapiens 0-11 22702311-0 2013 Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine beta145. Iron 49-53 haptoglobin Homo sapiens 0-11 23469912-4 2013 Haptoglobin (Hp) is a plasma protein that binds free hemoglobin and prevents heme-iron mediated oxidation. Iron 82-86 haptoglobin Homo sapiens 0-11 22465143-1 2012 Haptoglobin (Hp) is a hemoglobin (Hb) binding protein whose major function is to prevent heme-iron mediated oxidation. Iron 94-98 haptoglobin Homo sapiens 0-11 19960042-2 2009 Haptoglobin has a crucial role in free hemoglobin iron recovery, and exists as three major types: Hp1-1, Hp2-1 and Hp2-2. Iron 50-54 haptoglobin Homo sapiens 0-11 22033148-2 2012 Iron proteins influencing the innate immune response include hepcidin, lactoferrin, siderocalin, haptoglobin, hemopexin, Nramp1, ferroportin and the transferrin receptor. Iron 0-4 haptoglobin Homo sapiens 97-108 19775690-0 2010 The haptoglobin 2-2 genotype is associated with increased redox active hemoglobin derived iron in the atherosclerotic plaque. Iron 90-94 haptoglobin Homo sapiens 4-15 18619522-7 2009 In humans, a polymorphism for haptoglobin associated with increased cardiovascular disease is also characterized by increased lesional iron. Iron 135-139 haptoglobin Homo sapiens 30-41 19717155-0 2009 WITHDRAWN: The Haptoglobin 2-2 genotype is associated with increased redox active hemoglobin derived iron in the atherosclerotic plaque. Iron 101-105 haptoglobin Homo sapiens 15-26 21315066-1 2011 BACKGROUND: Haptoglobin (Hp) and ceruloplasmin (CP) are 2 plasma antioxidants playing a role in preventing iron-induced oxidative damage. Iron 107-111 haptoglobin Homo sapiens 12-23 21316675-0 2011 Association of haptoglobin genotype and common cardiovascular risk factors with the amount of iron in atherosclerotic carotid plaques. Iron 94-98 haptoglobin Homo sapiens 15-26 21637505-1 2009 Haptoglobin is a plasma hemoglobin-binding protein that limits iron loss during normal erythrocyte turnover and hemolysis, thereby preventing oxidative damage mediated by iron excess in the circulation. Iron 63-67 haptoglobin Homo sapiens 0-11 21637505-1 2009 Haptoglobin is a plasma hemoglobin-binding protein that limits iron loss during normal erythrocyte turnover and hemolysis, thereby preventing oxidative damage mediated by iron excess in the circulation. Iron 171-175 haptoglobin Homo sapiens 0-11 18330662-7 2008 Iron depletion was significantly correlated with raised levels of indices of inflammation, C-reactive protein (CRP), orosomucoid and haptoglobin), and with the white blood cell count. Iron 0-4 haptoglobin Homo sapiens 133-144 18554871-3 2008 The haptoglobin HP2-2 genotype has been associated with idiopathic generalized epilepsies and altered iron metabolism in children with alpha-thalassaemia can potentially interfere with neurotransmission and increase the risk of seizures. Iron 102-106 haptoglobin Homo sapiens 4-15 18848136-0 2008 Haptoglobin genotype is a major determinant of the amount of iron in the human atherosclerotic plaque. Iron 61-65 haptoglobin Homo sapiens 0-11 18848136-1 2008 OBJECTIVES: We sought to test the hypothesis that haptoglobin (Hp) genotype is a determinant of the amount of iron in the atherosclerotic plaque. Iron 110-114 haptoglobin Homo sapiens 50-61 18771759-3 2008 Iron availability to cells also depends on haptoglobin (Hp) phenotypes. Iron 0-4 haptoglobin Homo sapiens 43-54 18363910-4 2008 The Hpt main function is to bind and carry to the liver free haemoglobin for degradation and iron recycling. Iron 93-97 haptoglobin Homo sapiens 4-7 17674967-2 2007 In such cases, haptoglobin and ferritin are up-regulated to sequester free Hb and iron in the circulation. Iron 82-86 haptoglobin Homo sapiens 15-26 18297891-5 2007 There is evidence to suggest that the apparent detrimental effect of iron supplementation may vary according to levels of antecedent iron status, the presence of hemoglobinopathies and glucose-6-phosphate dehydrogenase (G6PD) deficiency, and other host genetic variants, such as variants in haptoglobin. Iron 69-73 haptoglobin Homo sapiens 291-302 16597321-0 2006 Iron and infection: effects of host iron status and the iron-regulatory genes haptoglobin and NRAMP1 (SLC11A1) on host-pathogen interactions in tuberculosis and HIV. Iron 0-4 haptoglobin Homo sapiens 78-89 16597321-6 2006 We then examine the putative role of iron-related host genes by focussing on two candidate genes, haptoglobin and NRAMP1, for which there are common polymorphic variants in humans with strong evidence of functionally distinct biochemical phenotypes that would be predicted to influence the course of HIV and TB infections. Iron 37-41 haptoglobin Homo sapiens 98-109 12005209-2 2002 Among them, the genetic polymorphism of the hemoglobin (Hb)-binding plasma protein haptoglobin (Hp) has been shown to affect iron turnover. Iron 125-129 haptoglobin Homo sapiens 83-94 16630378-8 2006 Among the iron-related parameters investigated in the patients, only total iron-binding capacity and the serum concentration of haptoglobin differed significantly with haptoglobin phenotype. Iron 10-14 haptoglobin Homo sapiens 168-179 16630378-8 2006 Among the iron-related parameters investigated in the patients, only total iron-binding capacity and the serum concentration of haptoglobin differed significantly with haptoglobin phenotype. Iron 75-79 haptoglobin Homo sapiens 168-179 16256097-3 2006 Haptoglobin (Hp) is a plasma protein participating in iron metabolism. Iron 54-58 haptoglobin Homo sapiens 0-11 16256097-5 2006 We investigated the relationship between vitamin C, iron status and haptoglobin polymorphism in Chinese men and women. Iron 52-56 haptoglobin Homo sapiens 68-79 16637741-3 2006 Haptoglobin polymorphisms result in proteins with altered haemoglobin-binding capacity and different antioxidant, iron-recycling, and immune functions. Iron 114-118 haptoglobin Homo sapiens 0-11 16637741-12 2006 CONCLUSIONS: The finding that haptoglobin 2-2 genotype is a risk factor for anaemia in children in a malaria-endemic area may reflect the reduced ability of the Hp2-2 polymer to scavenge free haemoglobin-iron following malaria-induced haemolysis. Iron 204-208 haptoglobin Homo sapiens 30-41 16681422-6 2006 CONCLUSIONS: The antioxidant role of haptoglobin and the phenotype dependence were confirmed for preventing possible oxidative damage induced by free hemoglobin and iron release during its catabolism. Iron 165-169 haptoglobin Homo sapiens 37-48 15193975-5 2004 The identification of functional differences in haptoglobin molecules resulting from relatively common polymorphisms has further elucidated the importance of haptoglobin in iron homeostasis and in disease processes influenced by iron metabolism. Iron 173-177 haptoglobin Homo sapiens 48-59 15193975-5 2004 The identification of functional differences in haptoglobin molecules resulting from relatively common polymorphisms has further elucidated the importance of haptoglobin in iron homeostasis and in disease processes influenced by iron metabolism. Iron 173-177 haptoglobin Homo sapiens 158-169 15193975-5 2004 The identification of functional differences in haptoglobin molecules resulting from relatively common polymorphisms has further elucidated the importance of haptoglobin in iron homeostasis and in disease processes influenced by iron metabolism. Iron 229-233 haptoglobin Homo sapiens 48-59 15193975-5 2004 The identification of functional differences in haptoglobin molecules resulting from relatively common polymorphisms has further elucidated the importance of haptoglobin in iron homeostasis and in disease processes influenced by iron metabolism. Iron 229-233 haptoglobin Homo sapiens 158-169 12446481-2 2002 It has been reported that individuals with the haptoglobin 2-2 type manifest increased iron concentrations, including serum iron, transferrin saturation, and ferritin. Iron 87-91 haptoglobin Homo sapiens 47-58 12446481-2 2002 It has been reported that individuals with the haptoglobin 2-2 type manifest increased iron concentrations, including serum iron, transferrin saturation, and ferritin. Iron 124-128 haptoglobin Homo sapiens 47-58 12446481-8 2002 CONCLUSIONS: The effect of haptoglobin type on iron homeostasis cannot account for the marked phenotypic variation that is seen in patients homozygous for the HFE C282Y mutation. Iron 47-51 haptoglobin Homo sapiens 27-38 12392310-2 2002 The molecular variation of haptoglobin is one of the genetic factors influencing iron status in Caucasians. Iron 81-85 haptoglobin Homo sapiens 27-38 12392310-4 2002 We wanted to investigate the effect of haptoglobin polymorphism on iron status in blacks. Iron 67-71 haptoglobin Homo sapiens 39-50 12392310-7 2002 We compared iron status indices according to haptoglobin type. Iron 12-16 haptoglobin Homo sapiens 45-56 11017940-0 2000 The haptoglobin 2-2 phenotype affects serum markers of iron status in healthy males. Iron 55-59 haptoglobin Homo sapiens 4-15 11017940-2 2000 We hypothesized that the genetic polymorphism of haptoglobin (Hp), a hemoglobin-binding plasma protein, could affect iron status. Iron 117-121 haptoglobin Homo sapiens 49-60 11738096-3 2001 We hypothesized that the genetic haptoglobin (Hp) polymorphism, because of its effect on iron metabolism, could be a modifying factor that influences the clinical presentation of hereditary hemochromatosis. Iron 89-93 haptoglobin Homo sapiens 33-44