PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31213851-0 2019 Deferoxamine-induced high expression of TfR1 and DMT1 enhanced iron uptake in triple-negative breast cancer cells by activating IL-6/PI3K/AKT pathway. Iron 63-67 AKT serine/threonine kinase 1 Homo sapiens 138-141 31213851-10 2019 The activated IL-6/PI3K/AKT pathway upregulated the expression of iron-uptake related proteins, TfR1 and DMT1, leading to increased iron uptakes. Iron 66-70 AKT serine/threonine kinase 1 Homo sapiens 24-27 31213851-10 2019 The activated IL-6/PI3K/AKT pathway upregulated the expression of iron-uptake related proteins, TfR1 and DMT1, leading to increased iron uptakes. Iron 132-136 AKT serine/threonine kinase 1 Homo sapiens 24-27 26125440-7 2015 Several key studies have revealed that iron chelation can target the AKT, ERK, JNK, p38, STAT3, TGF-beta, Wnt and autophagic pathways to subsequently inhibit cellular proliferation, the epithelial-mesenchymal transition (EMT) and metastasis. Iron 39-43 AKT serine/threonine kinase 1 Homo sapiens 69-72 30873034-9 2019 Further studies showed that icariin attenuated iron overload induced inactivation of the PI3K/AKT/mTOR pathway and activation of the ERK1/2 and JNK pathways. Iron 47-51 AKT serine/threonine kinase 1 Homo sapiens 94-97 30267477-0 2018 Proteomic Profiling of Iron-Treated Ovarian Cells Identifies AKT Activation that Modulates the CLEAR Network. Iron 23-27 AKT serine/threonine kinase 1 Homo sapiens 61-64 30267477-8 2018 Collectively, these findings support use of RPPA/IPA technology to predict functional responses to iron and further implicate AKT pathway and MiTF members in iron-induced cellular responses in ovarian cells. Iron 158-162 AKT serine/threonine kinase 1 Homo sapiens 126-129 29380557-0 2018 hmSOD1 gene mutation-induced disturbance in iron metabolism is mediated by impairment of Akt signalling pathway. Iron 44-48 AKT serine/threonine kinase 1 Homo sapiens 89-92 29380557-3 2018 We hypothesize that an impaired Akt-FOXO3a signalling pathway triggers changes in the iron metabolism in the muscles of transgenic animals. Iron 86-90 AKT serine/threonine kinase 1 Homo sapiens 32-35 29380557-16 2018 CONCLUSIONS: Our data suggest that impairment of insulin signalling and iron metabolism in the skeletal muscle precedes muscle atrophy and is mediated by changes in Akt/FOXO3a signalling pathways. Iron 72-76 AKT serine/threonine kinase 1 Homo sapiens 165-168 26854247-0 2016 Iron-induced oxidative stress activates AKT and ERK1/2 and decreases Dyrk1B and PRMT1 in neuroblastoma SH-SY5Y cells. Iron 0-4 AKT serine/threonine kinase 1 Homo sapiens 40-43 28833753-11 2017 Iron-saturated Lf (holo-Lf) increased TE expression and promoted Akt1 phosphorylation, when compared to those parameters in cells treated with iron-free Lf (apo-Lf). Iron 0-4 AKT serine/threonine kinase 1 Homo sapiens 65-69 26854247-7 2016 Interestingly, iron increased the activity of ERK and AKT and reduced DyrK1B. Iron 15-19 AKT serine/threonine kinase 1 Homo sapiens 54-57 25594146-5 2015 RESULTS: In FSECs treated with catalytic iron for up to 6 days, we observed an increase in cell viability, NO production, and p53, pan-Ras, ERK/MAPK, PI3K/Akt, Ki67, and c-Myc activations (P < 0.05) in a dose-dependent and time-dependent manner. Iron 41-45 AKT serine/threonine kinase 1 Homo sapiens 155-158 32262777-9 2015 Internalized nanoparticles released free iron complexes into the cytoplasm, which triggered ROS down-regulation and induced apoptosis through activating AKT and MAPKs pathways. Iron 41-45 AKT serine/threonine kinase 1 Homo sapiens 153-156 23184650-0 2013 Akt/Nrf2 activated upregulation of heme oxygenase-1 involves in the role of Rg1 against ferrous iron-induced neurotoxicity in SK-N-SH cells. Iron 96-100 AKT serine/threonine kinase 1 Homo sapiens 0-3 24641804-9 2014 This iron-induced apoptosis was linked to enhanced caspase 8, reduced Bcl-2, Bcl-xL, phosphorylated Akt and GATA-4. Iron 5-9 AKT serine/threonine kinase 1 Homo sapiens 100-103 24641804-11 2014 In iron pretreated cardiomyocytes, the siRNA2 transfection further increased caspase 8 expression and decreased the expression of GATA-4, Bcl-2, Bcl-xL and phosphorylated Akt than iron pretreatment alone, but caspase 9 levels remained unchanged. Iron 3-7 AKT serine/threonine kinase 1 Homo sapiens 171-174 25239763-9 2014 Taken together, these results show that BDNF and GDNF ameliorate iron accumulation via the ERK/Akt pathway, followed by inhibition of IRP1 and DMT1+IRE expression, which may provide new targets for the neuroprotective effects of these neurotrophic factors. Iron 65-69 AKT serine/threonine kinase 1 Homo sapiens 95-98 22332905-6 2012 Mechanistically, the complex of Lf and LfR is internalized through clathrin-mediated endocytosis; both iron-free apo-Lf and iron-saturated holo-Lf activate the PI3K/Akt pathway, whereas only apo-Lf triggers ERK1/2 signaling. Iron 103-107 AKT serine/threonine kinase 1 Homo sapiens 165-168 22332905-6 2012 Mechanistically, the complex of Lf and LfR is internalized through clathrin-mediated endocytosis; both iron-free apo-Lf and iron-saturated holo-Lf activate the PI3K/Akt pathway, whereas only apo-Lf triggers ERK1/2 signaling. Iron 124-128 AKT serine/threonine kinase 1 Homo sapiens 165-168 33821487-8 2021 It summarises the excess-iron-induced alterations in MSC components, processes and discusses signalling pathways involving ROS, PI3K/AKT, MAPK, p53, AMPK/MFF/DRP1 and Wnt. Iron 25-29 AKT serine/threonine kinase 1 Homo sapiens 133-136 21742779-0 2011 Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation. Iron 23-27 AKT serine/threonine kinase 1 Homo sapiens 138-141 21672148-8 2011 In vivo rapamycin treatment induced higher degree of RICTOR and AKT Ser(473) expression directly correlating with long-term rapamycin exposure, FE(PO4) and HOMA index. Iron 144-146 AKT serine/threonine kinase 1 Homo sapiens 64-67 20947636-3 2011 Using an iron-overloaded gerbil model, we show that increased cardiac iron is associated with reduced activation of Akt (Ser473 and Thr308), diminished phosphorylation of the proapoptotic regulator Bad (Ser136), and an increased Bax/Bcl-2 ratio. Iron 70-74 AKT serine/threonine kinase 1 Homo sapiens 116-119 19134195-5 2009 We also showed Akt/GSK-3beta signaling pathways are involved in iron nanoparticle-induced cell permeability. Iron 64-68 AKT serine/threonine kinase 1 Homo sapiens 15-18 19134195-6 2009 The inhibition of ROS demonstrate ROS play a major role in regulating Akt/GSK-3beta - mediated cell permeability upon iron nanoparticle exposure. Iron 118-122 AKT serine/threonine kinase 1 Homo sapiens 70-73 16624972-4 2006 Treatment of E47, but not C34 cells, with arachidonic acid and iron (AA+Fe) led to a decrease in the phosphorylation state of AKT. Iron 63-67 AKT serine/threonine kinase 1 Homo sapiens 126-129 16624972-4 2006 Treatment of E47, but not C34 cells, with arachidonic acid and iron (AA+Fe) led to a decrease in the phosphorylation state of AKT. Iron 72-74 AKT serine/threonine kinase 1 Homo sapiens 126-129 16624972-6 2006 LY294002 and down-regulation of endogenous AKT with small interference RNAs increased the toxicity of AA+Fe in E47 cells. Iron 105-107 AKT serine/threonine kinase 1 Homo sapiens 43-46 18557926-7 2008 Akt/ERK signalling but not p38 activation was abolished in the presence of the iron chelator desferroxamine that blocks formation of hydroxyl ( OH) radicals. Iron 79-83 AKT serine/threonine kinase 1 Homo sapiens 0-3 17936676-0 2008 Iron increases MMP-9 expression through activation of AP-1 via ERK/Akt pathway in human head and neck squamous carcinoma cells. Iron 0-4 AKT serine/threonine kinase 1 Homo sapiens 67-70 17936676-7 2008 Studies using specific inhibitors of extracellular signal-regulated kinase (ERK1/2) and of Akt (SH-5) demonstrated that iron regulated MMP-9 through ERK1/2 and Akt, and that ERK1/2 was an upstream activator of Akt. Iron 120-124 AKT serine/threonine kinase 1 Homo sapiens 91-94 17936676-7 2008 Studies using specific inhibitors of extracellular signal-regulated kinase (ERK1/2) and of Akt (SH-5) demonstrated that iron regulated MMP-9 through ERK1/2 and Akt, and that ERK1/2 was an upstream activator of Akt. Iron 120-124 AKT serine/threonine kinase 1 Homo sapiens 160-163 17936676-7 2008 Studies using specific inhibitors of extracellular signal-regulated kinase (ERK1/2) and of Akt (SH-5) demonstrated that iron regulated MMP-9 through ERK1/2 and Akt, and that ERK1/2 was an upstream activator of Akt. Iron 120-124 AKT serine/threonine kinase 1 Homo sapiens 160-163 10861214-2 2000 They display a bimodal behaviour (characterized by an "alkaline" and an "acid" transition), which indicates that (at least) two protonating groups change their pK(b) values upon reduction (and/or oxidation) of the iron atom in haem. Iron 214-218 AKT serine/threonine kinase 1 Homo sapiens 160-164 34119884-7 2021 In addition, the blockage of bypassing EGFR/AKT/NF-kB/IkB signaling pathway is greatly enhanced via elevated intracellular PMA/Fe-HSA@DOX nanoparticles (NPs). Iron 127-129 AKT serine/threonine kinase 1 Homo sapiens 44-47 35484240-6 2022 We demonstrate that apoE signals to activate the PI3K/AKT pathway that then inhibits the autophagic degradation of ferritin (ferritinophagy), thus averting iron-dependent lipid peroxidation. Iron 156-160 AKT serine/threonine kinase 1 Homo sapiens 54-57 32794021-0 2021 Homocysteine-induced decrease in HUVEC cells" resistance to oxidative stress is mediated by Akt-dependent changes in iron metabolism. Iron 117-121 AKT serine/threonine kinase 1 Homo sapiens 92-95 32828744-6 2020 The results of the current work indicated that taxifolin inhibited iron-induced apoptosis and enhanced hepatocellular survival as demonstrated by decreased activity of caspase-3 and activation of the pro-survival signaling PI3K/AKT, respectively. Iron 67-71 AKT serine/threonine kinase 1 Homo sapiens 228-231 32691165-6 2020 For this reason, we analyzed the effect of the iron chelating compounds of ME0053, ME0055 and ME0192 on cell viability and proliferation rate both through ERK/MAPK and PI3K/AKT signal paths, and through the oncogenic Speedy/RINGO protein that is likely to have a regulatory effect on these two signaling pathways. Iron 47-51 AKT serine/threonine kinase 1 Homo sapiens 173-176