PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17561842-0 2007 Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6-OHDA-lesioned rats. Iron 55-59 hephaestin Rattus norvegicus 17-27 22350470-1 2012 Discovered over a decade ago, hephaestin (Heph) has been implicated as a ferroxidase (FOX) vital for intestinal iron absorption. Iron 112-116 hephaestin Rattus norvegicus 30-40 22350470-1 2012 Discovered over a decade ago, hephaestin (Heph) has been implicated as a ferroxidase (FOX) vital for intestinal iron absorption. Iron 112-116 hephaestin Rattus norvegicus 42-46 22350470-8 2012 Additionally, cytosolic Heph increased upon iron-deprivation but more important, decreased significantly upon copper-deprivation, mimicking the response of membrane-bound Heph. Iron 44-48 hephaestin Rattus norvegicus 24-28 22331876-1 2012 Hephaestin (Heph), a membrane-bound multicopper ferroxidase (FOX) expressed in duodenal enterocytes, is required for optimal iron absorption. Iron 125-129 hephaestin Rattus norvegicus 0-10 22331876-1 2012 Hephaestin (Heph), a membrane-bound multicopper ferroxidase (FOX) expressed in duodenal enterocytes, is required for optimal iron absorption. Iron 125-129 hephaestin Rattus norvegicus 0-4 21325818-5 2011 Expression levels of iron transport proteins including DMT1, TfR, Fpn1 and Heph were assessed by Western blot technique. Iron 21-25 hephaestin Rattus norvegicus 75-79 18974313-0 2009 Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium. Iron 0-4 hephaestin Rattus norvegicus 39-49 18974313-2 2009 Ferroportin 1 (FPN1) and hephaestin (Heph) are necessary for transport of iron out of enterocytes, but it is not known whether these two proteins interact during iron absorption. Iron 74-78 hephaestin Rattus norvegicus 25-35 18974313-2 2009 Ferroportin 1 (FPN1) and hephaestin (Heph) are necessary for transport of iron out of enterocytes, but it is not known whether these two proteins interact during iron absorption. Iron 74-78 hephaestin Rattus norvegicus 37-41 18974313-5 2009 Heph exhibited a similar though less prominent migration after iron ingestion. Iron 63-67 hephaestin Rattus norvegicus 0-4 18974313-7 2009 Thus the data indicate that FPN1 and Heph migrate and interact during iron feeding and suggest that dimeric FPN1 is associated with intact Heph. Iron 70-74 hephaestin Rattus norvegicus 37-41 17516501-0 2007 Development and iron-dependent expression of hephaestin in different brain regions of rats. Iron 16-20 hephaestin Rattus norvegicus 45-55 17516501-1 2007 It has been suggested that Hephaestin (Heph), a newly discovered ceruloplasmin homologue, is necessary for iron egress from the enterocytes into circulation via interacting with ferroportin1 (FP1). Iron 107-111 hephaestin Rattus norvegicus 27-37 17516501-1 2007 It has been suggested that Hephaestin (Heph), a newly discovered ceruloplasmin homologue, is necessary for iron egress from the enterocytes into circulation via interacting with ferroportin1 (FP1). Iron 107-111 hephaestin Rattus norvegicus 27-31 17516501-2 2007 Based on the putative function of Heph, and the similarity between the process of iron transport in the enterocytes and that in the blood-brain barrier (BBB) cells, it has also been proposed that Heph plays a similar role in exporting iron from the BBB cells and other brain cells as it works in the enterocytes via interacting with FP1. Iron 82-86 hephaestin Rattus norvegicus 196-200 17516501-2 2007 Based on the putative function of Heph, and the similarity between the process of iron transport in the enterocytes and that in the blood-brain barrier (BBB) cells, it has also been proposed that Heph plays a similar role in exporting iron from the BBB cells and other brain cells as it works in the enterocytes via interacting with FP1. Iron 235-239 hephaestin Rattus norvegicus 196-200 21473866-0 2011 Interactions between ferroportin and hephaestin in rat enterocytes are reduced after iron ingestion. Iron 85-89 hephaestin Rattus norvegicus 37-47 21473866-10 2011 Reduced interactions between Fpn and Heph after iron ingestion indicate that this is a regulatory mechanism for limiting further iron absorption. Iron 48-52 hephaestin Rattus norvegicus 37-41 21473866-10 2011 Reduced interactions between Fpn and Heph after iron ingestion indicate that this is a regulatory mechanism for limiting further iron absorption. Iron 129-133 hephaestin Rattus norvegicus 37-41 17516501-6 2007 The findings also showed that both the development and iron status have a significant effect on Heph expression and the effects of iron status are regionally specific. Iron 55-59 hephaestin Rattus norvegicus 96-100 17516501-7 2007 It was also suggested that Heph expression is probably regulated at the transcriptional level by the development and iron in these brain regions. Iron 117-121 hephaestin Rattus norvegicus 27-31 17516501-8 2007 These findings, together with other published data, support a putative role of Heph in the iron metabolism in the brain. Iron 91-95 hephaestin Rattus norvegicus 79-83 17383861-5 2007 Here, we investigated expression of iron exporters including ferroportin 1 (Fpn1), ceruloplasmin (CP) and hephaestin (Heph) and provided evidence for their existence in the heart. Iron 36-40 hephaestin Rattus norvegicus 106-116 17383861-5 2007 Here, we investigated expression of iron exporters including ferroportin 1 (Fpn1), ceruloplasmin (CP) and hephaestin (Heph) and provided evidence for their existence in the heart. Iron 36-40 hephaestin Rattus norvegicus 118-122 17561842-5 2007 Ferroportin1 (FP1) and hephaestin (HP), two newly discovered iron export proteins, cooperate in the iron export in the gut. Iron 61-65 hephaestin Rattus norvegicus 23-33 17561842-5 2007 Ferroportin1 (FP1) and hephaestin (HP), two newly discovered iron export proteins, cooperate in the iron export in the gut. Iron 100-104 hephaestin Rattus norvegicus 23-33 12008095-2 2002 Hephaestin is suggested to transport iron from intestinal enterocytes into the circulation. Iron 37-41 hephaestin Rattus norvegicus 0-10 12760904-1 2003 Release of iron from enterocytes and hepatocytes is thought to require the copper-dependent ferroxidase activity of hephaestin (Hp) and ceruloplasmin (Cp), respectively. Iron 11-15 hephaestin Rattus norvegicus 116-126 12008095-5 2002 Therefore, it is suggested that in dietary iron-deficiency, hephaestin gene expression in proximal small intestine is up-regulated to absorb more iron from diet. Iron 43-47 hephaestin Rattus norvegicus 60-70 11557513-0 2001 Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins. Iron 81-85 hephaestin Rattus norvegicus 47-57 11557513-1 2001 The membrane-bound ceruloplasmin homolog hephaestin plays a critical role in intestinal iron absorption. Iron 88-92 hephaestin Rattus norvegicus 41-51 11557513-6 2001 Variations in iron status had a small but nonsignificant effect on hephaestin expression in the duodenum. Iron 14-18 hephaestin Rattus norvegicus 67-77