PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2312055-0 1990 Transferrin receptor expression in rat liver: immunohistochemical and biochemical analysis of the effect of age and iron storage. Iron 116-120 transferrin receptor Rattus norvegicus 0-20 2393007-4 1990 We previously described a transferrin receptor (TfR) mechanism that controls iron entry into rat mammary tissue. Iron 77-81 transferrin receptor Rattus norvegicus 26-46 2393007-4 1990 We previously described a transferrin receptor (TfR) mechanism that controls iron entry into rat mammary tissue. Iron 77-81 transferrin receptor Rattus norvegicus 48-51 2393007-5 1990 In this study lactating rats were used to determine effects of varying dietary iron during gestation and lactation on mammary TfR and MFe. Iron 79-83 transferrin receptor Rattus norvegicus 126-129 2393007-6 1990 Dams fed low-iron diets had a small increase in TfR, lower hematological indices (p less than 0.005), and lower MFe (p less than 0.005) than did controls or dams fed high iron. Iron 13-17 transferrin receptor Rattus norvegicus 48-51 2393007-7 1990 Dams fed the high-iron diet had a significant increase in TfR without a concomitant increase in MFe. Iron 18-22 transferrin receptor Rattus norvegicus 58-61 35182697-8 2022 The HIBD group insult significantly increased reactive oxygen species levels, as well as the protein levels of iron metabolism-related proteins transferrin receptor (TFRC), ferritin heavy chain (FHC), and ferritin light chain (FLC), while reducing the levels of Solute Carrier Family 7 Member 11 (SLC7A11), glutathione (GSH), and GPX4. Iron 111-115 transferrin receptor Rattus norvegicus 166-170 34600467-8 2021 For all evaluated RG, Tfrc expression significantly increased in iron-deficient animal livers compared to the iron-replete pair-fed controls; however, the relative induction varied nearly 4-fold between the most suitable (Rpl19) and least suitable (Gapdh) RG. Iron 65-69 transferrin receptor Rattus norvegicus 22-26 35182697-8 2022 The HIBD group insult significantly increased reactive oxygen species levels, as well as the protein levels of iron metabolism-related proteins transferrin receptor (TFRC), ferritin heavy chain (FHC), and ferritin light chain (FLC), while reducing the levels of Solute Carrier Family 7 Member 11 (SLC7A11), glutathione (GSH), and GPX4. Iron 111-115 transferrin receptor Rattus norvegicus 144-164 34071287-3 2021 In the brain, HO-1 and the iron regulatory receptor, transferrin receptor-1 (TfR1), are known to be involved in iron homeostasis, oxidative stress, and cellular adaptive mechanisms. Iron 27-31 transferrin receptor Rattus norvegicus 53-75 34071287-3 2021 In the brain, HO-1 and the iron regulatory receptor, transferrin receptor-1 (TfR1), are known to be involved in iron homeostasis, oxidative stress, and cellular adaptive mechanisms. Iron 27-31 transferrin receptor Rattus norvegicus 77-81 34071287-3 2021 In the brain, HO-1 and the iron regulatory receptor, transferrin receptor-1 (TfR1), are known to be involved in iron homeostasis, oxidative stress, and cellular adaptive mechanisms. Iron 112-116 transferrin receptor Rattus norvegicus 53-75 34071287-3 2021 In the brain, HO-1 and the iron regulatory receptor, transferrin receptor-1 (TfR1), are known to be involved in iron homeostasis, oxidative stress, and cellular adaptive mechanisms. Iron 112-116 transferrin receptor Rattus norvegicus 77-81 30968973-9 2019 The increased transferrin receptor and decreased L-ferritin levels after hypobaric hypoxia were indicative of a low-iron phenotype, while FPN1 levels remained unchanged. Iron 116-120 transferrin receptor Rattus norvegicus 14-34 35089637-7 2022 Knockdown of PCBP2 but not PCBP1 significantly decreased both TfR1 and FTH expression in MM cells with inhibition of proliferation, indicating stagnation of intracellular iron transport. Iron 171-175 transferrin receptor Rattus norvegicus 62-66 3170563-1 1988 The effect of changes in cellular iron metabolism on the surface expression of transferrin receptors (TfR) was examined in primary cultures of hepatocytes from adult rats. Iron 34-38 transferrin receptor Rattus norvegicus 79-100 3170563-1 1988 The effect of changes in cellular iron metabolism on the surface expression of transferrin receptors (TfR) was examined in primary cultures of hepatocytes from adult rats. Iron 34-38 transferrin receptor Rattus norvegicus 102-105 3170563-3 1988 Following 24 h of treatment with the iron chelator, desferrioxamine, or with succinylacetone, an inhibitor of heme synthesis, the number of TfR at the cell surface was increased severalfold, with no significant change in receptor affinity (KD) for transferrin. Iron 37-41 transferrin receptor Rattus norvegicus 140-143 31518742-7 2020 RESULTS: Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload. Iron 9-13 transferrin receptor Rattus norvegicus 69-89 31518742-7 2020 RESULTS: Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload. Iron 9-13 transferrin receptor Rattus norvegicus 91-94 31518742-7 2020 RESULTS: Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload. Iron 172-176 transferrin receptor Rattus norvegicus 69-89 31518742-7 2020 RESULTS: Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload. Iron 172-176 transferrin receptor Rattus norvegicus 91-94 32260496-10 2020 The correlations of serum hepcidin and erythroferrone with liver DMT1 and TfR represent significant mechanisms of Fe homeostasis. Iron 114-116 transferrin receptor Rattus norvegicus 74-77 32180038-9 2020 In PC12 cells, a significant increase of transferrin receptor (TfR) mRNA expression was linked to Mn exposure and accompanied by elevated Fe uptake. Iron 138-140 transferrin receptor Rattus norvegicus 41-61 32180038-9 2020 In PC12 cells, a significant increase of transferrin receptor (TfR) mRNA expression was linked to Mn exposure and accompanied by elevated Fe uptake. Iron 138-140 transferrin receptor Rattus norvegicus 63-66 2624102-0 1989 Transferrin receptor expression in normal, iron-deficient and iron-overloaded rats. Iron 43-47 transferrin receptor Rattus norvegicus 0-20 2624102-0 1989 Transferrin receptor expression in normal, iron-deficient and iron-overloaded rats. Iron 62-66 transferrin receptor Rattus norvegicus 0-20 2624102-5 1989 Although the tissue distribution pattern of TfR-positive cells was similar in normal, iron-deficient and iron-overloaded rats, the staining intensity and number of TfR-positive cells were obviously higher in iron-deficient, and lower in iron-overloaded rats. Iron 86-90 transferrin receptor Rattus norvegicus 44-47 2624102-5 1989 Although the tissue distribution pattern of TfR-positive cells was similar in normal, iron-deficient and iron-overloaded rats, the staining intensity and number of TfR-positive cells were obviously higher in iron-deficient, and lower in iron-overloaded rats. Iron 105-109 transferrin receptor Rattus norvegicus 44-47 2624102-5 1989 Although the tissue distribution pattern of TfR-positive cells was similar in normal, iron-deficient and iron-overloaded rats, the staining intensity and number of TfR-positive cells were obviously higher in iron-deficient, and lower in iron-overloaded rats. Iron 105-109 transferrin receptor Rattus norvegicus 44-47 2624102-5 1989 Although the tissue distribution pattern of TfR-positive cells was similar in normal, iron-deficient and iron-overloaded rats, the staining intensity and number of TfR-positive cells were obviously higher in iron-deficient, and lower in iron-overloaded rats. Iron 105-109 transferrin receptor Rattus norvegicus 44-47 2624102-6 1989 We conclude that TfR expression is negatively regulated by the tissue concentration of iron. Iron 87-91 transferrin receptor Rattus norvegicus 17-20 3379048-4 1988 The results are compatible with a model in which iron, at transferrin concentrations above that needed to saturate the transferrin receptor, is taken up from transferrin predominantly by mechanisms located to or contiguous with the plasma membrane. Iron 49-53 transferrin receptor Rattus norvegicus 119-139 33157209-1 2021 Iron overload triggers the ferroptosis in the heart following ischemia/reperfusion (I/R) and transferrin receptor 1 (TfR1) charges the cellular iron uptake. Iron 144-148 transferrin receptor Rattus norvegicus 93-115 33157209-1 2021 Iron overload triggers the ferroptosis in the heart following ischemia/reperfusion (I/R) and transferrin receptor 1 (TfR1) charges the cellular iron uptake. Iron 144-148 transferrin receptor Rattus norvegicus 117-121 31787896-4 2019 Here, we used a PAE rat model to analyze messenger RNA (mRNA) and protein expression of iron homeostasis genes such as transferrin receptor (TfR), divalent metal transporter (DMT1), ferroportin (FPN1), and ferritin (FT) in brain areas associated with memory formation such as the prefrontal cortex (PFC), ventral tegmental area, and hippocampus. Iron 88-92 transferrin receptor Rattus norvegicus 119-139 31787896-4 2019 Here, we used a PAE rat model to analyze messenger RNA (mRNA) and protein expression of iron homeostasis genes such as transferrin receptor (TfR), divalent metal transporter (DMT1), ferroportin (FPN1), and ferritin (FT) in brain areas associated with memory formation such as the prefrontal cortex (PFC), ventral tegmental area, and hippocampus. Iron 88-92 transferrin receptor Rattus norvegicus 141-144 30833328-7 2019 In conclusion, both the MCRC and TfR1 mediate hTf uptake across apical brush border membranes of PTECs and reciprocally respond to decreased cellular iron. Iron 150-154 transferrin receptor Rattus norvegicus 33-37 28993186-11 2017 These events paralleled the increased expression of ferritins and transferrin and a decrease in the expression of TFR-1 in iron-fed rats with aging, thereby maintaining iron homeostasis in the retina. Iron 123-127 transferrin receptor Rattus norvegicus 114-119 30027360-8 2018 In addition, significantly up-regulated expression of FtH and FtL mRNA, and markedly down-regulated expression of Tfr1, Dmt1 + IRE and Ireg1 mRNA, were observed in the iron overload group compared with the control group. Iron 168-172 transferrin receptor Rattus norvegicus 114-118 30027360-10 2018 Tfr1, Dmt1, ferritin and ferroportin1 exist in bone tissue of rats, and they may be involved in the pathological process of iron overload-induced bone lesion. Iron 124-128 transferrin receptor Rattus norvegicus 0-4 30051477-2 2018 We showed the role of iron in cisplatin-induced nephrotoxicity that entrance to the cell via transferrin receptor (TfR) as a gatekeeper for iron uptake. Iron 22-26 transferrin receptor Rattus norvegicus 115-118 30051477-2 2018 We showed the role of iron in cisplatin-induced nephrotoxicity that entrance to the cell via transferrin receptor (TfR) as a gatekeeper for iron uptake. Iron 140-144 transferrin receptor Rattus norvegicus 115-118 30051477-10 2018 CONCLUSIONS: The results supported a role for iron in cisplatin-induced nephrotoxicity and TfR may serve as an important source of iron. Iron 131-135 transferrin receptor Rattus norvegicus 91-94 28993186-11 2017 These events paralleled the increased expression of ferritins and transferrin and a decrease in the expression of TFR-1 in iron-fed rats with aging, thereby maintaining iron homeostasis in the retina. Iron 169-173 transferrin receptor Rattus norvegicus 114-119 27578012-3 2017 Here, we systematically investigated iron content and the expression of two major iron importers, transferrin receptor 1 (TfR1) and divalent metal transporter (DMT1), two iron exporters, ferroportin 1 (Fpn1) and ceruloplasmin (CP), and hepcidin, along with the pathological hallmarks of Parkinson"s (PD) and Alzheimer"s diseases (AD) in the brain of young (3 months), adult (12 months), and aged (24 months) rats. Iron 82-86 transferrin receptor Rattus norvegicus 98-120 27578012-3 2017 Here, we systematically investigated iron content and the expression of two major iron importers, transferrin receptor 1 (TfR1) and divalent metal transporter (DMT1), two iron exporters, ferroportin 1 (Fpn1) and ceruloplasmin (CP), and hepcidin, along with the pathological hallmarks of Parkinson"s (PD) and Alzheimer"s diseases (AD) in the brain of young (3 months), adult (12 months), and aged (24 months) rats. Iron 82-86 transferrin receptor Rattus norvegicus 98-120 28629118-10 2017 This study indicates that long-term Dex exposure reduces liver iron content, which is closely associated with down-regulated hepatic TFR1 protein expression. Iron 63-67 transferrin receptor Rattus norvegicus 133-137 26276291-8 2015 CONCLUSIONS: Tf and TfR were important transporters in brain tissue excessive load iron transport after ICH, and detecting the expression levels of the two indicators can provide a reference for prognosis treatment in ICH. Iron 83-87 transferrin receptor Rattus norvegicus 20-23 28243203-7 2017 These findings suggest that the nifedipine-induced increase in cell iron may mainly be due to the corresponding increase in TfR1 and DMT1 expression and also imply that the effects of nifedipine on iron transport in proximal tubule cells can not explain the increase in urinary iron excretion. Iron 68-72 transferrin receptor Rattus norvegicus 124-128 27403535-5 2016 Reduced erythropoietic iron utilization was characterized by down-regulation of the transferrin receptor 1 (TfR1) on reticulocytes and modest increased iron storage in the spleen. Iron 23-27 transferrin receptor Rattus norvegicus 84-106 27403535-5 2016 Reduced erythropoietic iron utilization was characterized by down-regulation of the transferrin receptor 1 (TfR1) on reticulocytes and modest increased iron storage in the spleen. Iron 23-27 transferrin receptor Rattus norvegicus 108-112 28243203-3 2017 We speculated that nifedipine might inhibit the TfR1/ DMT1 (transferrin receptor 1/divalent metal transporter1)-mediated iron uptake by proximal tubule cells in addition to blocking L-type Ca2+ channels, leading to an increase in iron in lumen-fluid and then urinary iron excretion. Iron 121-125 transferrin receptor Rattus norvegicus 48-52 28243203-3 2017 We speculated that nifedipine might inhibit the TfR1/ DMT1 (transferrin receptor 1/divalent metal transporter1)-mediated iron uptake by proximal tubule cells in addition to blocking L-type Ca2+ channels, leading to an increase in iron in lumen-fluid and then urinary iron excretion. Iron 230-234 transferrin receptor Rattus norvegicus 48-52 28243203-3 2017 We speculated that nifedipine might inhibit the TfR1/ DMT1 (transferrin receptor 1/divalent metal transporter1)-mediated iron uptake by proximal tubule cells in addition to blocking L-type Ca2+ channels, leading to an increase in iron in lumen-fluid and then urinary iron excretion. Iron 230-234 transferrin receptor Rattus norvegicus 48-52 27747853-9 2017 As a consequence, the expression of TfR1 (R = 0.7, p < 0.05) was increased, reflecting a facilitated entrance of iron to the cells. Iron 116-120 transferrin receptor Rattus norvegicus 36-40 26484920-2 2016 We have shown in this study that chelatable iron accumulates in the aged rat brain along with overexpression of transferrin receptor 1 (TfR1) and ferritin, accompanied by significant alterations in amyloid-beta (Abeta) peptide homeostasis in the aging brain, such as an increased production of the amyloid-beta protein precursor, a decreased level of neprilysin, and increased accumulation of Abeta42. Iron 44-48 transferrin receptor Rattus norvegicus 112-134 26484920-2 2016 We have shown in this study that chelatable iron accumulates in the aged rat brain along with overexpression of transferrin receptor 1 (TfR1) and ferritin, accompanied by significant alterations in amyloid-beta (Abeta) peptide homeostasis in the aging brain, such as an increased production of the amyloid-beta protein precursor, a decreased level of neprilysin, and increased accumulation of Abeta42. Iron 44-48 transferrin receptor Rattus norvegicus 136-140 26484920-3 2016 When aged rats are given daily the iron chelator, deferasirox, over a period of more than 4 months starting from the 18th month, the age-related accumulation of iron and overexpression of TfR1 and ferritin in the brain are significantly prevented. Iron 35-39 transferrin receptor Rattus norvegicus 188-192 26484920-6 2016 The analysis of the results together suggests that iron accumulation and oxidative stress interact at multiple levels that include transcriptional and post-transcriptional mechanisms to bring about changes in the expression levels of TfR1 and ferritin and also alterations in Abeta peptide metabolism in the aging rat brain. Iron 51-55 transferrin receptor Rattus norvegicus 234-238 25649872-4 2015 Zip8, DMT1, and Steap2 co-localize with the transferrin receptor/transferrin complex, suggesting they may be involved in transferrin receptor/transferrin-mediated iron assimilation. Iron 163-167 transferrin receptor Rattus norvegicus 44-64 25649872-4 2015 Zip8, DMT1, and Steap2 co-localize with the transferrin receptor/transferrin complex, suggesting they may be involved in transferrin receptor/transferrin-mediated iron assimilation. Iron 163-167 transferrin receptor Rattus norvegicus 121-141 25385842-0 2014 Hyperinsulinemia induces hepatic iron overload by increasing liver TFR1 via the PI3K/IRP2 pathway. Iron 33-37 transferrin receptor Rattus norvegicus 67-71 25385842-9 2014 In conclusion, the findings of this study indicate that hyperinsulnemia could induce hepatic iron overload by upregulating liver TFR1 via the PI3K/AKT/mTOR/IRP2 pathway, which may be one of the main reasons for the occurrence of DIOS. Iron 93-97 transferrin receptor Rattus norvegicus 129-133 24365882-10 2014 In contrast, a decreased TfR1 level was detected by IL-6 and iron alone, whereas combination of iron and AP cytokines (mainly IL-6) abrogated the downregulation of TfR1. Iron 61-65 transferrin receptor Rattus norvegicus 25-29 23900040-8 2014 Since TFR1 is inversely regulated by iron, our results suggest that the increase in intracellular iron with aging and heat stress lower TFR1 expression. Iron 37-41 transferrin receptor Rattus norvegicus 6-10 24365882-10 2014 In contrast, a decreased TfR1 level was detected by IL-6 and iron alone, whereas combination of iron and AP cytokines (mainly IL-6) abrogated the downregulation of TfR1. Iron 96-100 transferrin receptor Rattus norvegicus 164-168 23900040-8 2014 Since TFR1 is inversely regulated by iron, our results suggest that the increase in intracellular iron with aging and heat stress lower TFR1 expression. Iron 37-41 transferrin receptor Rattus norvegicus 136-140 23900040-8 2014 Since TFR1 is inversely regulated by iron, our results suggest that the increase in intracellular iron with aging and heat stress lower TFR1 expression. Iron 98-102 transferrin receptor Rattus norvegicus 6-10 23900040-8 2014 Since TFR1 is inversely regulated by iron, our results suggest that the increase in intracellular iron with aging and heat stress lower TFR1 expression. Iron 98-102 transferrin receptor Rattus norvegicus 136-140 19943190-7 2010 Results indicate that TfR, H-ferritin, and IRP2 mRNA expression was differentially affected by aging and by neonatal iron treatment in all three brain regions. Iron 117-121 transferrin receptor Rattus norvegicus 22-25 23994517-6 2013 The greatest increase in muscle iron content occurred during the period of animal growth and was associated with downregulation of TfR1 and IRP2 expression. Iron 32-36 transferrin receptor Rattus norvegicus 131-135 23894616-1 2013 Previous studies have shown that the small molecule iron transport inhibitor ferristatin (NSC30611) acts by down-regulating transferrin receptor-1 (TfR1) via receptor degradation. Iron 52-56 transferrin receptor Rattus norvegicus 124-146 23894616-1 2013 Previous studies have shown that the small molecule iron transport inhibitor ferristatin (NSC30611) acts by down-regulating transferrin receptor-1 (TfR1) via receptor degradation. Iron 52-56 transferrin receptor Rattus norvegicus 148-152 23117987-11 2013 Both ferritin (Ft) and transferrin receptor (TfR) are routinely used as indicators of labile iron pool. Iron 93-97 transferrin receptor Rattus norvegicus 45-48 21061168-2 2011 The first step of iron transport from the blood to the brain is transferrin receptor (TfR)-mediated endocytosis in the capillary endothelial cells. Iron 18-22 transferrin receptor Rattus norvegicus 64-84 21061168-2 2011 The first step of iron transport from the blood to the brain is transferrin receptor (TfR)-mediated endocytosis in the capillary endothelial cells. Iron 18-22 transferrin receptor Rattus norvegicus 86-89 21061168-8 2011 Furthermore, the expression of Tf and TfR in the blood vessels precedes its expression in oligodendrocytes, the main iron-storing cells in the vertebrate brain. Iron 117-121 transferrin receptor Rattus norvegicus 38-41 21061168-10 2011 The specific expression of Tf and TfR in brain perivascular cells and MTP-1 and hephaestin in endothelial cells suggest the possibility that trafficking of elemental iron through perivascular cells may be instrumental in the distribution of iron in the developing central nervous system. Iron 166-170 transferrin receptor Rattus norvegicus 34-37 20411304-9 2010 The data suggested that the induced elevation of NO level by exercise lead to the up-regulation of both TfR1 and DMT1 (IRE), which in turn increasing the iron absorption in skeletal muscle. Iron 154-158 transferrin receptor Rattus norvegicus 104-108 19501056-2 2009 At cellular level, the maintenance of iron homeostasis is largely accomplished by the transferrin receptor (TfR-1) and by ferritin, whose expression is mainly regulated post-transcriptionally by iron regulatory proteins (IRPs). Iron 38-42 transferrin receptor Rattus norvegicus 86-106 20511703-9 2010 The findings suggested that diabetes mellitus (DM) induced the iron overload in the myocardium, at least in part by up-regulation of TfR. Iron 63-67 transferrin receptor Rattus norvegicus 133-136 19501056-2 2009 At cellular level, the maintenance of iron homeostasis is largely accomplished by the transferrin receptor (TfR-1) and by ferritin, whose expression is mainly regulated post-transcriptionally by iron regulatory proteins (IRPs). Iron 38-42 transferrin receptor Rattus norvegicus 108-113 19501056-9 2009 Our results indicate that estrogen level changes can regulate the binding activity of the IRP1, and consequently ferritin and TfR-1 expression in adipose tissue, suggesting a relationship among serum and tissue iron parameters, estrogen status and adiposity. Iron 211-215 transferrin receptor Rattus norvegicus 126-131 19877527-7 2009 CONCLUSION: vitamin A deficiency can change cellular iron metabolism by inducing IRP2-Fn-TFR pathway. Iron 53-57 transferrin receptor Rattus norvegicus 89-92 19643212-5 2009 Intracellular iron status was assessed by measuring iron content in cell layers and changes in transferrin receptor (TrfR) and ferritin gene and protein expression. Iron 14-18 transferrin receptor Rattus norvegicus 95-115 19643212-5 2009 Intracellular iron status was assessed by measuring iron content in cell layers and changes in transferrin receptor (TrfR) and ferritin gene and protein expression. Iron 14-18 transferrin receptor Rattus norvegicus 117-121 19643212-9 2009 Iron accumulation resulted in rapid and sustained down-regulation of TrfR gene and protein levels (within 24 h) and up-regulation of light and heavy chain ferritin protein levels at late differentiation (day 20, D20). Iron 0-4 transferrin receptor Rattus norvegicus 69-73 19877527-9 2009 Taken together, these results indicate that vitamin A deficiency can regulate iron metabolism by IRP2-TFR-Fn pathway. Iron 78-82 transferrin receptor Rattus norvegicus 102-105 18849539-10 2008 Enhanced TfR-mediated influx of Fe from the blood and ferroportin-mediated expelling Fe toward the CSF may compromise DMT1-mediated efflux, leading to an increased Fe concentration in the CSF as seen in Mn-exposed animals. Iron 32-34 transferrin receptor Rattus norvegicus 9-12 19176888-11 2009 Further analysis indicated that iron levels in the fetal, and not maternal, liver regulate the expression of liver transferrin receptor and hepcidin expression in the mother. Iron 32-36 transferrin receptor Rattus norvegicus 115-135 18586688-10 2008 Selective expression of Tfrc in proliferative lesions suggests an involvement of changes in iron homeostasis during the process of tumor promotion/progression driven by FB or PB. Iron 92-96 transferrin receptor Rattus norvegicus 24-28 18420243-1 2008 Confocal microscopy was used to investigate the effects of manganese (Mn) and iron (Fe) exposure on the subcellular distribution of metal transporting proteins, i.e., divalent metal transporter 1 (DMT1), metal transporter protein 1 (MTP1), and transferrin receptor (TfR), in the rat intact choroid plexus which comprises the blood-cerebrospinal fluid barrier. Iron 84-86 transferrin receptor Rattus norvegicus 244-264 18555617-5 2008 The levels of iron regulatory factors, including transferrin receptor 1 (TfR1), ferritin (Fn), and iron regulatory protein1 (IRP1), were all changed in the iron deposition regions of the PS-exposed rat brain, accompanied by intensified oxidative stress. Iron 14-18 transferrin receptor Rattus norvegicus 49-71 18555617-5 2008 The levels of iron regulatory factors, including transferrin receptor 1 (TfR1), ferritin (Fn), and iron regulatory protein1 (IRP1), were all changed in the iron deposition regions of the PS-exposed rat brain, accompanied by intensified oxidative stress. Iron 14-18 transferrin receptor Rattus norvegicus 73-77 18549825-7 2008 This activates HIF-1alpha that induces the expression of TfR, which in turn increases Tf uptake and iron accumulation and exacerbates oxidative damage that increases the lipid peroxidation. Iron 100-104 transferrin receptor Rattus norvegicus 57-60 18420243-1 2008 Confocal microscopy was used to investigate the effects of manganese (Mn) and iron (Fe) exposure on the subcellular distribution of metal transporting proteins, i.e., divalent metal transporter 1 (DMT1), metal transporter protein 1 (MTP1), and transferrin receptor (TfR), in the rat intact choroid plexus which comprises the blood-cerebrospinal fluid barrier. Iron 84-86 transferrin receptor Rattus norvegicus 266-269 18420243-7 2008 These results suggest that early events in the tissue response to Mn or Fe exposure involve microtubule-dependent, intracellular trafficking of MTP1 and TfR. Iron 72-74 transferrin receptor Rattus norvegicus 153-156 17091493-1 2007 Transferrin receptors (Tfrc) are membrane bound glycoproteins which function to mediate cellular uptake of iron from transferrin. Iron 107-111 transferrin receptor Rattus norvegicus 0-21 18709494-10 2008 And, elevated IRP1 expression might be associated with the increased TfR and decreased ferritin expression, leading to subsequent iron accumulation and possible increased vulnerability to oxidative damage in hippocampus. Iron 130-134 transferrin receptor Rattus norvegicus 69-72 17091493-1 2007 Transferrin receptors (Tfrc) are membrane bound glycoproteins which function to mediate cellular uptake of iron from transferrin. Iron 107-111 transferrin receptor Rattus norvegicus 23-27 17091493-8 2007 It is suggested that Tfrc are required for uptake of iron for cell proliferation and maturation in the pineal gland upto 6 weeks of age. Iron 53-57 transferrin receptor Rattus norvegicus 21-25 17091493-12 2007 It is concluded that increased expression of Tfrc in response to hypoxia leads to excess cellular uptake of iron which may be damaging to the cells. Iron 108-112 transferrin receptor Rattus norvegicus 45-49 16879716-5 2006 (59)Fe occurred in significantly lower amounts in the postvascular compartment in Belgrade b/b rats, indicating impaired iron uptake by transferrin receptor and DMT1-expressing neurons. Iron 121-125 transferrin receptor Rattus norvegicus 136-156 17460390-7 2007 Real-time polymerase chain reaction (PCR) showed that the mRNA expression of TfR, iron-responsive element-negative DMT1, FPN, and hepcidin mRNA increased ~1.9-fold, ~1.7-fold, ~2.3-fold, and ~4.7-fold, respectively, after angiotensin II infusion as compared with that of untreated controls, and that these increases could be suppressed by the concomitant administration of losartan. Iron 82-86 transferrin receptor Rattus norvegicus 77-80 16545456-1 2006 Previous studies in this laboratory indicated that manganese (Mn) exposure in vitro increases the expression of transferrin receptor (TfR) by enhancing the binding of iron regulatory proteins (IRPs) to iron responsive element-containing RNA. Iron 167-171 transferrin receptor Rattus norvegicus 112-132 16545456-1 2006 Previous studies in this laboratory indicated that manganese (Mn) exposure in vitro increases the expression of transferrin receptor (TfR) by enhancing the binding of iron regulatory proteins (IRPs) to iron responsive element-containing RNA. Iron 167-171 transferrin receptor Rattus norvegicus 134-137 16545456-2 2006 The current study further tested the hypothesis that in vivo exposure to Mn increased TfR expression at both blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) barrier (BCB), which contributes to altered iron (Fe) homeostasis in the CSF. Iron 215-219 transferrin receptor Rattus norvegicus 86-89 16545456-2 2006 The current study further tested the hypothesis that in vivo exposure to Mn increased TfR expression at both blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) barrier (BCB), which contributes to altered iron (Fe) homeostasis in the CSF. Iron 221-223 transferrin receptor Rattus norvegicus 86-89 15140607-5 2004 Transferrin receptor expression was increased with iron chelation demonstrating that a global decrease in protein synthesis could not account for the Thy1 changes. Iron 51-55 transferrin receptor Rattus norvegicus 0-20 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. Iron 114-118 transferrin receptor Rattus norvegicus 40-60 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. Iron 114-118 transferrin receptor Rattus norvegicus 62-65 15878745-3 2005 Two proteins involved in iron metabolism that are expressed in the kidney are the divalent metal transporter, DMT1 (Slc11a2), and the Transferrin Receptor (TfR). Iron 25-29 transferrin receptor Rattus norvegicus 134-154 15878745-3 2005 Two proteins involved in iron metabolism that are expressed in the kidney are the divalent metal transporter, DMT1 (Slc11a2), and the Transferrin Receptor (TfR). Iron 25-29 transferrin receptor Rattus norvegicus 156-159 15878745-9 2005 Increased renal TfR expression was also observed in STZ-diabetic Wistar rats together with elevated cellular iron accumulation. Iron 109-113 transferrin receptor Rattus norvegicus 16-19 16140386-3 2006 Furthermore, our study examined the effect of Fe status on astrocytic transferrin receptor (TfR) and divalent metal transporter (DMT-1) levels and their relationship to Mn uptake, as both have been implicated as putative Mn transporters. Iron 46-48 transferrin receptor Rattus norvegicus 92-95 16140386-8 2006 TfR levels were significantly increased (p<0.05) due to ID and decreased in astrocytes exposed to +Fe treatments. Iron 102-104 transferrin receptor Rattus norvegicus 0-3 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. Iron 148-152 transferrin receptor Rattus norvegicus 40-60 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. Iron 148-152 transferrin receptor Rattus norvegicus 62-65 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. Iron 157-159 transferrin receptor Rattus norvegicus 40-60 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. Iron 157-159 transferrin receptor Rattus norvegicus 62-65 16137791-3 2005 We speculated the increased NTBI and Tf-Fe uptake induced by NGF treatment might be associated with the increased expression of DMT1 and TfR. Iron 40-42 transferrin receptor Rattus norvegicus 137-140 15009675-11 2004 These results demonstrate that both iron accumulation and deprivation modulate the synthesis of ferritin and TfR in astrocytes and that protein synthesis is required to prevent iron-mediated toxicity in astrocytes. Iron 36-40 transferrin receptor Rattus norvegicus 109-112 12621119-2 2003 The membrane proteins that mediate iron transport [transferrin receptor (TfR) and divalent metal transporter 1 (DMT-1)] and the iron regulatory proteins (IRP-1 and IRP-2) that stabilize their mRNAs undergo regional developmental changes in the iron-sufficient rat brain between postnatal day (P) 5 and 15. Iron 35-39 transferrin receptor Rattus norvegicus 51-71 15009675-6 2004 Application of FAC to astrocyte cultures caused a strong increase in the cellular content of the iron storage protein ferritin and a decrease in the amount of transferrin receptor (TfR), which is involved in the transferrin-mediated uptake of iron into cells. Iron 243-247 transferrin receptor Rattus norvegicus 159-179 15009675-6 2004 Application of FAC to astrocyte cultures caused a strong increase in the cellular content of the iron storage protein ferritin and a decrease in the amount of transferrin receptor (TfR), which is involved in the transferrin-mediated uptake of iron into cells. Iron 243-247 transferrin receptor Rattus norvegicus 181-184 12767048-11 2003 However, iron status had no significant effect on DMT1 (IRE) and DMT1 (non-IRE) mRNAs expression in the heart, although it can significantly influence heart transferrin receptor (TfR) mRNA expression. Iron 9-13 transferrin receptor Rattus norvegicus 157-177 12767048-11 2003 However, iron status had no significant effect on DMT1 (IRE) and DMT1 (non-IRE) mRNAs expression in the heart, although it can significantly influence heart transferrin receptor (TfR) mRNA expression. Iron 9-13 transferrin receptor Rattus norvegicus 179-182 12729948-3 2003 In vitro manganese exposure altered the cellular abundance of TfR, H-/L-ferritin, and m-aconitase, resulting in an increase in labile iron. Iron 134-138 transferrin receptor Rattus norvegicus 62-65 12621119-2 2003 The membrane proteins that mediate iron transport [transferrin receptor (TfR) and divalent metal transporter 1 (DMT-1)] and the iron regulatory proteins (IRP-1 and IRP-2) that stabilize their mRNAs undergo regional developmental changes in the iron-sufficient rat brain between postnatal day (P) 5 and 15. Iron 35-39 transferrin receptor Rattus norvegicus 73-76 12085354-2 2002 The aim of the present study was to address the regulation of transferrin receptor (TfR), which mediates cellular iron uptake, during I/R. Iron 114-118 transferrin receptor Rattus norvegicus 62-82 12608731-0 2003 Gene expression of transferrin and transferrin receptor in brains of control vs. iron-deficient rats. Iron 81-85 transferrin receptor Rattus norvegicus 35-55 12608731-1 2003 The mechanism of the regulation of transferrin (Tf) and transferrin receptor (TfR) levels in rat brain by dietary iron status is not fully elucidated. Iron 114-118 transferrin receptor Rattus norvegicus 56-76 12608731-1 2003 The mechanism of the regulation of transferrin (Tf) and transferrin receptor (TfR) levels in rat brain by dietary iron status is not fully elucidated. Iron 114-118 transferrin receptor Rattus norvegicus 78-81 12608731-3 2003 In a region-specific fashion, iron-deficient diet decreased significantly brain iron concentration by 22-63%, and increased Tf level by 22-130% and TfR level by 74% in thalamus and 40% in cortex. Iron 30-34 transferrin receptor Rattus norvegicus 148-151 12429868-1 2002 The membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake. Iron 110-114 transferrin receptor Rattus norvegicus 13-33 12429868-1 2002 The membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake. Iron 175-179 transferrin receptor Rattus norvegicus 13-33 12547229-9 2002 The uptake of transferrin-bound iron and expression of functional TfR1 was shown to occur mainly in crypt cells and to be proportional to the plasma concentration of iron. Iron 166-170 transferrin receptor Rattus norvegicus 66-70 12547229-6 2002 In most experiments the function of the TfR1 was assessed by the uptake of radiolabeled transferrin-bound iron given intravenously. Iron 106-110 transferrin receptor Rattus norvegicus 40-44 12085354-2 2002 The aim of the present study was to address the regulation of transferrin receptor (TfR), which mediates cellular iron uptake, during I/R. Iron 114-118 transferrin receptor Rattus norvegicus 84-87 12085354-9 2002 The increased expression of TfR at the cell surface resulted in increased uptake of transferrin-bound-iron into surviving liver slices; however, iron was not incorporated into ferritin. Iron 102-106 transferrin receptor Rattus norvegicus 28-31 12085354-9 2002 The increased expression of TfR at the cell surface resulted in increased uptake of transferrin-bound-iron into surviving liver slices; however, iron was not incorporated into ferritin. Iron 145-149 transferrin receptor Rattus norvegicus 28-31 12085354-10 2002 In conclusion, HIF-1 mediated activation of TfR gene transcription and IRP-mediated increase of TfR mRNA stability ensure a steady induction of TfR, and hence higher iron uptake in reperfused rat liver. Iron 166-170 transferrin receptor Rattus norvegicus 96-99 12085354-10 2002 In conclusion, HIF-1 mediated activation of TfR gene transcription and IRP-mediated increase of TfR mRNA stability ensure a steady induction of TfR, and hence higher iron uptake in reperfused rat liver. Iron 166-170 transferrin receptor Rattus norvegicus 96-99 12085354-11 2002 TfR-mediated entry of the metal into liver cells may represent a source of catalytically active iron, which may play a role in reperfusion damage. Iron 96-100 transferrin receptor Rattus norvegicus 0-3 11378262-1 2001 OBJECTIVE: Serum levels of the soluble transferrin receptor (sTfR) vary depending on the erythropoietic activity and iron status. Iron 117-121 transferrin receptor Rattus norvegicus 39-59 12401947-11 2002 The neuronal transferrin receptor expression by P21 coincides with a drop in transferrin-IR and iron transport into the brain at this age, suggesting that neuronal transferrin receptor mRNA is posttranscriptionally regulated by the lowered iron availability from this developmental stage onwards. Iron 96-100 transferrin receptor Rattus norvegicus 13-33 12401947-11 2002 The neuronal transferrin receptor expression by P21 coincides with a drop in transferrin-IR and iron transport into the brain at this age, suggesting that neuronal transferrin receptor mRNA is posttranscriptionally regulated by the lowered iron availability from this developmental stage onwards. Iron 240-244 transferrin receptor Rattus norvegicus 13-33 12401947-11 2002 The neuronal transferrin receptor expression by P21 coincides with a drop in transferrin-IR and iron transport into the brain at this age, suggesting that neuronal transferrin receptor mRNA is posttranscriptionally regulated by the lowered iron availability from this developmental stage onwards. Iron 240-244 transferrin receptor Rattus norvegicus 164-184 11709207-3 2001 Such increases in tissue iron content may be attributed to the stabilisation of IRP-2 by aluminium thereby promoting transferrin receptor synthesis while blocking ferritin synthesis. Iron 25-29 transferrin receptor Rattus norvegicus 117-137 11255270-1 2001 BACKGROUND AND OBJECTIVES: Transferrin receptor (TfR) expression in erythroid cells is regulated by a number of factors, including iron status and erythropoietin (Epo) stimulation. Iron 131-135 transferrin receptor Rattus norvegicus 27-47 11255270-1 2001 BACKGROUND AND OBJECTIVES: Transferrin receptor (TfR) expression in erythroid cells is regulated by a number of factors, including iron status and erythropoietin (Epo) stimulation. Iron 131-135 transferrin receptor Rattus norvegicus 49-52 11255270-5 2001 DESIGN AND METHODS: We measured directly the total number of reticulocyte TfR in normal rats of different age and iron status, as well as in animals experiencing various conditions and treatments aimed at altering erythropoietic activity and iron status, including rHuEpo therapy, hemolytic anemia, phlebotomies, hypertransfusions, thiamphenicol-induced red cell aplasia or inflammation. Iron 114-118 transferrin receptor Rattus norvegicus 74-77 10892882-20 2000 In contrast, Tf, mainly synthesized by RPE cells and detected in OS and IS areas, probably helps to transport iron to photoreceptors through their Tf-R. Iron 110-114 transferrin receptor Rattus norvegicus 147-151 10529482-0 1999 Iron-independent neuronal expression of transferrin receptor mRNA in the rat. Iron 0-4 transferrin receptor Rattus norvegicus 40-60 10859223-1 2000 Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor (TfR)-transferrin cycle and the activity of the divalent metal transporter (DMT1), although DMT1 cannot be detected morphologically in crypt cells. Iron 14-18 transferrin receptor Rattus norvegicus 119-139 10859223-1 2000 Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor (TfR)-transferrin cycle and the activity of the divalent metal transporter (DMT1), although DMT1 cannot be detected morphologically in crypt cells. Iron 14-18 transferrin receptor Rattus norvegicus 141-144 10859223-1 2000 Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor (TfR)-transferrin cycle and the activity of the divalent metal transporter (DMT1), although DMT1 cannot be detected morphologically in crypt cells. Iron 73-77 transferrin receptor Rattus norvegicus 119-139 10859223-1 2000 Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor (TfR)-transferrin cycle and the activity of the divalent metal transporter (DMT1), although DMT1 cannot be detected morphologically in crypt cells. Iron 73-77 transferrin receptor Rattus norvegicus 141-144 10864004-2 2000 One hypothesis suggests that an interaction between the transferrin receptor (TfR) and the haemochromatosis protein (HFE) regulates the level of iron loading in crypt cells. Iron 145-149 transferrin receptor Rattus norvegicus 56-76 10864004-2 2000 One hypothesis suggests that an interaction between the transferrin receptor (TfR) and the haemochromatosis protein (HFE) regulates the level of iron loading in crypt cells. Iron 145-149 transferrin receptor Rattus norvegicus 78-81 10864004-5 2000 This suggests that TfR may play a role in the regulation and/or mechanism of iron absorption. Iron 77-81 transferrin receptor Rattus norvegicus 19-22 10864004-6 2000 We investigated TfR function and distribution by measuring iron uptake from plasma transferrin and by immunohistochemistry. Iron 59-63 transferrin receptor Rattus norvegicus 16-19 10864004-14 2000 We hypothesise that TfR in the supranuclear region of villus enterocytes may play a role in iron absorption. Iron 92-96 transferrin receptor Rattus norvegicus 20-23 10690503-4 2000 Iron-containing transferrin has a high affinity for the transferrin receptor, which is present on all cells with a requirement for Fe. Iron 0-4 transferrin receptor Rattus norvegicus 56-76 10690503-4 2000 Iron-containing transferrin has a high affinity for the transferrin receptor, which is present on all cells with a requirement for Fe. Iron 131-133 transferrin receptor Rattus norvegicus 56-76 10722800-3 2000 Transferrin receptor mRNA was reduced in myocytes exposed to various concentrations of iron for 3 days and this decline was associated with a 63% decline in iron-response element (IRE) binding of iron regulatory protein-1, indicating that myocytes utilize IRE-dependent mechanisms to modulate gene expression. Iron 87-91 transferrin receptor Rattus norvegicus 0-20 10722800-3 2000 Transferrin receptor mRNA was reduced in myocytes exposed to various concentrations of iron for 3 days and this decline was associated with a 63% decline in iron-response element (IRE) binding of iron regulatory protein-1, indicating that myocytes utilize IRE-dependent mechanisms to modulate gene expression. Iron 157-161 transferrin receptor Rattus norvegicus 0-20 10440210-10 1999 CONCLUSION: The combined findings of this study were that, in the dietary iron-loaded rat model, increased iron stores were localized to periportal hepatocytes and that these same hepatocytes also had increased ferritin, transferrin receptor and transferrin protein expression. Iron 74-78 transferrin receptor Rattus norvegicus 221-241 10444608-15 1999 The findings demonstrated that the increased cellular Fe uptake in exercised rats was a consequence of the increased TfR expression rather than the changes in TfR affinity and Tf recycling time. Iron 54-56 transferrin receptor Rattus norvegicus 117-120 10440210-10 1999 CONCLUSION: The combined findings of this study were that, in the dietary iron-loaded rat model, increased iron stores were localized to periportal hepatocytes and that these same hepatocytes also had increased ferritin, transferrin receptor and transferrin protein expression. Iron 107-111 transferrin receptor Rattus norvegicus 221-241 8608889-2 1996 This study aimed to determine the regulation of transferrin receptor and ferritin messenger RNA (mRNA) in the rat gastrointestinal tract in response to dietary iron changes. Iron 160-164 transferrin receptor Rattus norvegicus 48-68 9657110-1 1998 Transferrin receptor (TfR) and ferritin, key proteins of cellular iron metabolism, are coordinately and divergently controlled by cytoplasmic proteins (iron regulatory proteins, IRP-1 and IRP-2) that bind to conserved mRNA motifs called iron-responsive elements (IRE). Iron 66-70 transferrin receptor Rattus norvegicus 0-20 9657110-1 1998 Transferrin receptor (TfR) and ferritin, key proteins of cellular iron metabolism, are coordinately and divergently controlled by cytoplasmic proteins (iron regulatory proteins, IRP-1 and IRP-2) that bind to conserved mRNA motifs called iron-responsive elements (IRE). Iron 66-70 transferrin receptor Rattus norvegicus 22-25 9657110-1 1998 Transferrin receptor (TfR) and ferritin, key proteins of cellular iron metabolism, are coordinately and divergently controlled by cytoplasmic proteins (iron regulatory proteins, IRP-1 and IRP-2) that bind to conserved mRNA motifs called iron-responsive elements (IRE). Iron 152-156 transferrin receptor Rattus norvegicus 0-20 9657110-1 1998 Transferrin receptor (TfR) and ferritin, key proteins of cellular iron metabolism, are coordinately and divergently controlled by cytoplasmic proteins (iron regulatory proteins, IRP-1 and IRP-2) that bind to conserved mRNA motifs called iron-responsive elements (IRE). Iron 152-156 transferrin receptor Rattus norvegicus 22-25 9657110-2 1998 IRP, in response to specific stimuli (low iron levels, growth and stress signals) are activated and prevent TfR mRNA degradation and ferritin mRNA translation by hindering ferritin mRNA binding to polysomes. Iron 42-46 transferrin receptor Rattus norvegicus 108-111 9714152-1 1998 In order to characterize the mechanism by which Iron (Fe) is taken up by neurons, we examined the neuronal expression of transferrin receptor (TR) in rats during development and iron (Fe) deficiency by using immunohistochemistry, in vitro receptor autoradiography and in situ hybridization. Iron 48-52 transferrin receptor Rattus norvegicus 143-145 9714152-1 1998 In order to characterize the mechanism by which Iron (Fe) is taken up by neurons, we examined the neuronal expression of transferrin receptor (TR) in rats during development and iron (Fe) deficiency by using immunohistochemistry, in vitro receptor autoradiography and in situ hybridization. Iron 54-56 transferrin receptor Rattus norvegicus 121-141 9714152-1 1998 In order to characterize the mechanism by which Iron (Fe) is taken up by neurons, we examined the neuronal expression of transferrin receptor (TR) in rats during development and iron (Fe) deficiency by using immunohistochemistry, in vitro receptor autoradiography and in situ hybridization. Iron 54-56 transferrin receptor Rattus norvegicus 143-145 9714152-3 1998 Reducing the Fe stores potentiated the expression of TR immunoreactivity in neurons of both young and adult rats in several grey matter regions. Iron 13-15 transferrin receptor Rattus norvegicus 53-55 9316467-1 1997 Expression of transferrin receptor and ferritin genes has been shown previously to be under transcriptional and posttranscriptional regulation, the latter being reciprocally regulated according to cellular iron levels. Iron 206-210 transferrin receptor Rattus norvegicus 14-34 8915458-2 1996 These processes require iron for the synthesis of iron-dependent proteins, the supply of which is mediated through the transferrin receptor. Iron 24-28 transferrin receptor Rattus norvegicus 119-139 8915458-2 1996 These processes require iron for the synthesis of iron-dependent proteins, the supply of which is mediated through the transferrin receptor. Iron 50-54 transferrin receptor Rattus norvegicus 119-139 7788730-0 1995 [Transferrin receptor and iron deposition pattern in the hepatic lobules of the iron-deficient and iron-overloaded rats]. Iron 80-84 transferrin receptor Rattus norvegicus 1-21 8527044-1 1995 Transferrin receptor (TR) performs the major function of binding and internalizing its specific iron-loaded ligand, transferrin, and its expression is closely linked to the proliferation status of the cell. Iron 96-100 transferrin receptor Rattus norvegicus 0-20 8527044-1 1995 Transferrin receptor (TR) performs the major function of binding and internalizing its specific iron-loaded ligand, transferrin, and its expression is closely linked to the proliferation status of the cell. Iron 96-100 transferrin receptor Rattus norvegicus 22-24 8527044-6 1995 The liver of rats fed on high iron diet accumulated iron and the expression of TR was down regulated by intrahepatic iron accumulation. Iron 30-34 transferrin receptor Rattus norvegicus 79-81 8527044-8 1995 The strong membranous expression of TR is one of the characteristics of the resistant hepatocyte of hyperplastic lesion and it seems to be related to the inability to accumulate iron in spite of a high iron diet. Iron 178-182 transferrin receptor Rattus norvegicus 36-38 8527044-8 1995 The strong membranous expression of TR is one of the characteristics of the resistant hepatocyte of hyperplastic lesion and it seems to be related to the inability to accumulate iron in spite of a high iron diet. Iron 202-206 transferrin receptor Rattus norvegicus 36-38 7788730-0 1995 [Transferrin receptor and iron deposition pattern in the hepatic lobules of the iron-deficient and iron-overloaded rats]. Iron 80-84 transferrin receptor Rattus norvegicus 1-21 7788730-4 1995 TfR and Tf were mainly distributed in the peripheral part of the lobule (zone 1) in the normal, iron deficient and iron-overloaded rats. Iron 96-100 transferrin receptor Rattus norvegicus 0-3 7788730-4 1995 TfR and Tf were mainly distributed in the peripheral part of the lobule (zone 1) in the normal, iron deficient and iron-overloaded rats. Iron 115-119 transferrin receptor Rattus norvegicus 0-3 7788730-6 1995 The staining intensity of TfR was strongest in iron-deficiency rat hepatic cells, weakest in iron-overloaded rat hepatic cells when compared with controls. Iron 47-51 transferrin receptor Rattus norvegicus 26-29 7788730-8 1995 In the iron-overloaded rats, the staining intensity of iron was stronger in zone 1 than in zone 2 and 3, similar to the distribution pattern of TfR and Tf. Iron 7-11 transferrin receptor Rattus norvegicus 144-147 7788730-9 1995 These findings suggest that (1) iron uptake in hepatic cells in vivo is regulated and mediated by TfR and Tf, (2) the expression pattern of TfR and Tf in zone 1 to zone 3 liver cells may result in the progressive decrease of iron deposition in the hepatic lobules of the iron overloaded rats. Iron 32-36 transferrin receptor Rattus norvegicus 98-101 7788730-9 1995 These findings suggest that (1) iron uptake in hepatic cells in vivo is regulated and mediated by TfR and Tf, (2) the expression pattern of TfR and Tf in zone 1 to zone 3 liver cells may result in the progressive decrease of iron deposition in the hepatic lobules of the iron overloaded rats. Iron 32-36 transferrin receptor Rattus norvegicus 140-143 7788730-9 1995 These findings suggest that (1) iron uptake in hepatic cells in vivo is regulated and mediated by TfR and Tf, (2) the expression pattern of TfR and Tf in zone 1 to zone 3 liver cells may result in the progressive decrease of iron deposition in the hepatic lobules of the iron overloaded rats. Iron 225-229 transferrin receptor Rattus norvegicus 140-143 7788730-9 1995 These findings suggest that (1) iron uptake in hepatic cells in vivo is regulated and mediated by TfR and Tf, (2) the expression pattern of TfR and Tf in zone 1 to zone 3 liver cells may result in the progressive decrease of iron deposition in the hepatic lobules of the iron overloaded rats. Iron 225-229 transferrin receptor Rattus norvegicus 140-143 2004025-1 1991 The transferrin receptor is a major protein found on the basolateral membranes of intestinal epithelial cells, yet its possible role in intestinal iron metabolism and also in iron absorption is unclear. Iron 147-151 transferrin receptor Rattus norvegicus 4-24 7787990-8 1995 The staining intensity of TfR, Tf and Ft increased in hepatocytes of iron-deficient rats and decreased in that of the iron-overloaded in comparison with the control rats. Iron 69-73 transferrin receptor Rattus norvegicus 26-29 7787990-8 1995 The staining intensity of TfR, Tf and Ft increased in hepatocytes of iron-deficient rats and decreased in that of the iron-overloaded in comparison with the control rats. Iron 118-122 transferrin receptor Rattus norvegicus 26-29 8119990-2 1994 Transferrin receptor (TfR) expression is regulated by iron at the level of mRNA stability through a factor (IRF/IRE-BP) which binds to specific iron-responsive elements (IRE). Iron 54-58 transferrin receptor Rattus norvegicus 0-20 8119990-2 1994 Transferrin receptor (TfR) expression is regulated by iron at the level of mRNA stability through a factor (IRF/IRE-BP) which binds to specific iron-responsive elements (IRE). Iron 54-58 transferrin receptor Rattus norvegicus 22-25 8119990-2 1994 Transferrin receptor (TfR) expression is regulated by iron at the level of mRNA stability through a factor (IRF/IRE-BP) which binds to specific iron-responsive elements (IRE). Iron 144-148 transferrin receptor Rattus norvegicus 0-20 8119990-2 1994 Transferrin receptor (TfR) expression is regulated by iron at the level of mRNA stability through a factor (IRF/IRE-BP) which binds to specific iron-responsive elements (IRE). Iron 144-148 transferrin receptor Rattus norvegicus 22-25 8262977-1 1993 Phosphorylation by protein kinase C. The iron-responsive element-binding protein (IRE-BP) is a cytosolic RNA-binding protein that functions in the maintenance of iron homeostasis by post-transcriptionally regulating transferrin receptor and ferritin synthesis. Iron 41-45 transferrin receptor Rattus norvegicus 216-236 8262977-1 1993 Phosphorylation by protein kinase C. The iron-responsive element-binding protein (IRE-BP) is a cytosolic RNA-binding protein that functions in the maintenance of iron homeostasis by post-transcriptionally regulating transferrin receptor and ferritin synthesis. Iron 162-166 transferrin receptor Rattus norvegicus 216-236 1776464-5 1991 TfR staining of the islets was weaker in iron-overloaded rats than in the controls. Iron 41-45 transferrin receptor Rattus norvegicus 0-3 1776464-6 1991 These findings suggest that 1) iron uptake by islet cells in vivo is regulated and mediated by TfR, 2) intracytoplasmic Ft transforms into stainable iron in iron-overloaded rats, and 3) predominance of TfR expression in B cells may result in selective deposition of iron and predispose B cells to damage and diabetes mellitus in iron-overloaded rats. Iron 31-35 transferrin receptor Rattus norvegicus 95-98 2004025-1 1991 The transferrin receptor is a major protein found on the basolateral membranes of intestinal epithelial cells, yet its possible role in intestinal iron metabolism and also in iron absorption is unclear. Iron 175-179 transferrin receptor Rattus norvegicus 4-24