PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10922376-8 2000 Elevated copper levels induced the expression of the metallothioneins CUP1 and CRS5 and two genes, FET3 and FTR1, in the iron uptake system. Iron 121-125 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 108-112 10922376-9 2000 Copper-induced FET3 and FTR1 expression arises from an indirect copper effect on cellular iron pools. Iron 90-94 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 24-28 11051552-4 2000 The PmrB protein bound iron via its periplasmic domain which harbors two copies of the sequence ExxE, a motif present in the Saccharomyces FTR1 iron transporter and in mammalian ferritin light chain. Iron 23-27 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 139-143 10713071-5 2000 CCC1 expression in wild type cells resulted in increased expression of the high affinity iron transport system composed of FET3 and FTR1, suggesting that intracellular iron is not sensed by the iron-dependent transcription factor Aft1p. Iron 89-93 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 132-136 9722559-2 1998 Fet3p is proposed to facilitate iron uptake by catalyzing the oxidation of Fe(II) to Fe(III) by O2; in this model, Fe(III) is the substrate for the iron permease, encoded by FTR1. Iron 32-36 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 174-178 10585494-1 1999 Fet3, the multicopper oxidase of yeast, oxidizes extracellular ferrous iron which is then transported into the cell through the permease Ftr1. Iron 71-75 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 137-141 9712864-1 1998 High affinity iron transport in yeast is mediated by two proteins, Fet3p and Ftr1p. Iron 14-18 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 77-82 9712864-2 1998 The multicopper oxidase Fet3p is thought to convert extracellular ferrous iron to ferric iron, which then crosses the plasma membrane through the permease Ftr1p. Iron 66-78 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 155-160 9611262-5 1998 YIpDCE1 has been used to create strains simultaneously overexpressing the permease (FTR1) and oxidase (FET3) components of the yeast high-affinity iron uptake system. Iron 147-151 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 84-88 9694900-6 1998 This transport protein also displays an REXXE motif resembling domains involved in iron binding by ferritin and in iron uptake mediated by the yeast transporter Ftr1. Iron 83-87 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 161-165 9694900-6 1998 This transport protein also displays an REXXE motif resembling domains involved in iron binding by ferritin and in iron uptake mediated by the yeast transporter Ftr1. Iron 115-119 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 161-165 34416697-6 2022 The analysis of various metal transport mutants revealed that mutant affected in calcium (mid1Delta and cch1Delta) and Fe(III) (ftr1Delta) transport, exhibited highly reduced U uptake rates and accumulation, demonstrating the implication of the calcium channel Mid1/Cch1 and the iron permease Ftr1 in U uptake. Iron 279-283 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 293-297 8599111-2 1996 Two proteins in the plasma membrane of yeast--a multicopper oxidase, encoded by the FET3 gene, and a permease, encoded by the FTR1 gene--were shown to mediate high-affinity iron uptake. Iron 173-177 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 126-130 8599111-5 1996 FTR1 protein also played a direct role in iron transport. Iron 42-46 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 0-4 8599111-6 1996 Mutations in a conserved sequence motif of FTR1 specifically blocked iron transport. Iron 69-73 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 43-47 35017613-6 2022 In response to the stress conditions (solids and inhibitors) imposed in ALE, cells induced the expression of genes related to cell wall integrity (SRL1, CWP2, WSC2 and WSC4) and general stress response (e.g., CDC5, DUN1, CTT1, GRE1), simultaneously repressing genes related to protein synthesis and iron transport and homeostasis (e.g., FTR1, ARN1, FRE1), ultimately leading to the improved phenotype. Iron 299-303 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 337-341 30381188-3 2018 Two genes were identified whose deletion resulted in sensitivity to EGCG: FET3 and FTR1, encoding the components of the Fet3/Ftr1 high-affinity iron uptake system, also involved in Cu(I)/Cu(II) balance on the surface of yeast cells. Iron 144-148 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 83-87 30381188-3 2018 Two genes were identified whose deletion resulted in sensitivity to EGCG: FET3 and FTR1, encoding the components of the Fet3/Ftr1 high-affinity iron uptake system, also involved in Cu(I)/Cu(II) balance on the surface of yeast cells. Iron 144-148 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 125-129 30425415-6 2018 Notable examples are Ftr1 iron permease and Fet3 ferro-O2-oxidoreductase, elements of the reductive iron assimilation pathway, in the S. cerevisiae-based model, as well as MpkC, a HogA-like mitogen activated protein kinase in the A. nidulans-based model. Iron 26-30 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 21-25 30425415-6 2018 Notable examples are Ftr1 iron permease and Fet3 ferro-O2-oxidoreductase, elements of the reductive iron assimilation pathway, in the S. cerevisiae-based model, as well as MpkC, a HogA-like mitogen activated protein kinase in the A. nidulans-based model. Iron 100-104 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 21-25 27376881-5 2017 In contrast to the upregulation of the nonreductive iron uptake genes ARN1 and FIT2 by ALA, the quantity of FET3 and FTR1 transcripts encoding the high-affinity iron uptake reductive pathway decreased. Iron 161-165 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 117-121 29452354-2 2018 In yeast, the membrane-bound heterodimer Fet3/Ftr1 is the high affinity iron importer. Iron 72-76 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 46-50 29452354-4 2018 When the concentration of external iron is low (<1 microM), Fet3/Ftr1 is maintained on the plasma membrane by retrograde endocytic-recycling; whereas, when the concentration of external iron is high (>10 microM), Fet3/Ftr1 is endocytosed and shunted to the vacuole for degradation. Iron 35-39 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 65-69 28357393-0 2017 Identification of Ftr1 and Zrt1 as iron and zinc micronutrient transceptors for activation of the PKA pathway in Saccharomyces cerevisiae. Iron 35-39 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 18-22 28357393-4 2017 We now show that the yeast high-affinity iron transporter Ftr1 and high-affinity zinc transporter Zrt1 function as transceptors for the micronutrients iron and zinc. Iron 41-45 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 58-62 28357393-6 2017 The activation with iron is dependent on Ftr1 and with zinc on Zrt1, and we show that it is independent of intracellular iron and zinc levels. Iron 20-24 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 41-45 28357393-7 2017 Similar to the transceptors for macronutrients, Ftr1 and Zrt1 are strongly induced upon iron and zinc starvation, respectively, and they are rapidly downregulated by substrate-induced endocytosis. Iron 88-92 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 48-52 18768754-2 2008 Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded. Iron 50-54 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 93-97 20348389-8 2010 Our analysis of FTR1 indicates its topology is similar to that of S. cerevisiae Ftr1p, with a potential exocytoplasmic iron channeling motif and two potential iron permeation motifs in membrane-spanning regions. Iron 119-123 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 16-20 20348389-8 2010 Our analysis of FTR1 indicates its topology is similar to that of S. cerevisiae Ftr1p, with a potential exocytoplasmic iron channeling motif and two potential iron permeation motifs in membrane-spanning regions. Iron 119-123 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 80-85 19469713-1 2009 Aft1 is a transcriptional activator in Saccharomyces cerevisiae that responds to iron availability and regulates the expression of genes in the iron regulon, such as FET3, FTR1 and the ARN family. Iron 144-148 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 172-176 27450384-8 2016 The function of cFTR1 in Synechocystis could be genetically complemented by the iron permease, Ftr1p, of Saccharomyces cerevisiae, that is known to transport Fe3+ produced by the oxidation of Fe2+ via a multicopper oxidase. Iron 80-84 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 95-100 23295455-3 2013 Here we report that arsenic activates the iron responsive transcription factor, Aft1, as a consequence of a defective high-affinity iron uptake mediated by Fet3 and Ftr1, whose mRNAs are drastically decreased upon arsenic exposure. Iron 42-46 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 165-169 21542867-1 2011 Saccharomyces cerevisiae can import iron through a high-affinity system consisting of the Ftr1/Fet3-mediated reductive pathway and the siderophore-mediated non-reductive one. Iron 36-40 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 90-94 21542867-9 2011 This reinforces the idea that upon oxidative stress S. cerevisiae cells redirect iron assimilation through the non-reductive pathway to minimize oxidative damage by the ferrous ions, which are formed during iron import through the Ftr1/Fet3 complexes. Iron 81-85 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 231-235 21542867-9 2011 This reinforces the idea that upon oxidative stress S. cerevisiae cells redirect iron assimilation through the non-reductive pathway to minimize oxidative damage by the ferrous ions, which are formed during iron import through the Ftr1/Fet3 complexes. Iron 207-211 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 231-235 18768754-2 2008 Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded. Iron 50-54 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 192-196 18768754-2 2008 Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded. Iron 50-54 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 192-196 18768754-2 2008 Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded. Iron 158-162 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 93-97 18768754-2 2008 Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded. Iron 158-162 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 192-196 18768754-2 2008 Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded. Iron 158-162 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 192-196 18768754-2 2008 Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded. Iron 158-162 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 93-97 18768754-2 2008 Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded. Iron 158-162 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 192-196 18768754-2 2008 Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iron-starved cells, Fet3-Ftr1 is sorted by Snx3/Grd19 and retromer into a recycling pathway that delivers it back to the plasma membrane, but when starved cells are exposed to iron, Fet3-Ftr1 is targeted to the lysosome-like vacuole and is degraded. Iron 158-162 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 192-196 18768754-3 2008 We report that iron-induced endocytosis of Fet3-Ftr1 is independent of Fet3-Ftr1 ubiquitylation, and after endocytosis, degradation of Fet3-Ftr1 is mediated by the multivesicular body (MVB) sorting pathway. Iron 15-19 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 48-52 18768754-5 2008 In the presence and absence of iron, Fet3-Ftr1 transits an endosomal compartment where a subunit of the MVB sorting receptor (Vps27), Snx3/Grd19, and retromer proteins colocalize. Iron 31-35 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 42-46 18282105-3 2008 In this study, we characterized the roles of the CFT1 and CFT2 genes that encode C. neoformans orthologs of the Saccharomyces cerevisiae high-affinity iron permease FTR1. Iron 151-155 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 165-169 18756096-1 2008 In our previous study, the expression of active H-ferritins in Saccharomyces cerevisiae was found to reduce cell growth and reactive oxygen species (ROS) generation upon exposure to oxidative stress; such expression enhanced that of high-affinity iron transport genes (FET3 and FTR1). Iron 247-251 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 278-282 16387364-3 2006 Fe(II) serves as substrate for Fe-uptake by being substrate for Fet3p; the resulting Fet3p-produced Fe(III) is then transported across the membrane via Ftr1p. Iron 0-2 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 152-157 17592720-1 2007 The ferroxidase Fet3 and the permease Ftr1 constitute a well-conserved high-affinity iron uptake system in yeast. Iron 85-89 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 38-42 17526834-0 2007 Cloning and characterization of the genes encoding the high-affinity iron-uptake protein complex Fet3/Ftr1 in the basidiomycete Phanerochaete chrysosporium. Iron 69-73 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 102-106 17526834-2 2007 This enzyme shows biochemical and structural similarities with the yeast Fet3p, a type I membrane glycoprotein that efficiently oxidizes Fe(II) to Fe(III) for its subsequent transport to the intracellular compartment by the iron permease Ftr1p. Iron 224-228 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 238-243 17526834-8 2007 Northern hybridization studies showed that the mRNA levels of both genes are reduced upon supplementation of the growth medium with iron, supporting the functional coupling of Fet3 and Ftr1 proteins in vivo. Iron 132-136 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 185-189 17042492-1 2006 Fet3p is a multicopper oxidase (MCO) that functions together with the iron permease, Ftr1p, to support high-affinity Fe uptake in yeast. Iron 0-2 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 85-90 17420293-2 2007 Endocytic sorting of the yeast reductive iron transporter, which is composed of the Fet3 and Ftr1 proteins, is regulated by available iron. Iron 41-45 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 93-97 17420293-3 2007 When iron is provided to iron-starved cells, Fet3p-Ftr1p is targeted to the lysosome-like vacuole and degraded. Iron 5-9 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 51-56 17420293-3 2007 When iron is provided to iron-starved cells, Fet3p-Ftr1p is targeted to the lysosome-like vacuole and degraded. Iron 25-29 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 51-56 17420293-4 2007 In contrast, when iron is not available, Fet3p-Ftr1p is maintained on the plasma membrane via an endocytic recycling pathway requiring the sorting nexin Grd19/Snx3p, the pentameric retromer complex, and the Ypt6p Golgi Rab GTPase module. Iron 18-22 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 47-52 17244486-4 2007 The modification of cellular iron metabolism, which involved the increased expression of high-affinity iron transport genes (FET3 and FTR1), was detected via Northern blot analysis. Iron 29-33 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 134-138 17244486-4 2007 The modification of cellular iron metabolism, which involved the increased expression of high-affinity iron transport genes (FET3 and FTR1), was detected via Northern blot analysis. Iron 103-107 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 134-138 16700543-0 2006 Evidence for iron channeling in the Fet3p-Ftr1p high-affinity iron uptake complex in the yeast plasma membrane. Iron 13-17 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 42-47 16700543-0 2006 Evidence for iron channeling in the Fet3p-Ftr1p high-affinity iron uptake complex in the yeast plasma membrane. Iron 62-66 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 42-47 16700543-1 2006 In high-affinity iron uptake in the yeast Saccharomyces cerevisiae, Fe(II) is oxidized to Fe(III) by the multicopper oxidase, Fet3p, and the Fe(III) produced is transported into the cell via the iron permease, Ftr1p. Iron 17-21 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 210-215 16700543-4 2006 We examine the (59)Fe uptake kinetics for a number of complexes containing mutant forms of both Fet3p and Ftr1p and demonstrate that a residue in one protein interacts with one in the other protein along the iron trafficking pathway as would be expected in a channeling process. Iron 19-21 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 106-111 16700543-4 2006 We examine the (59)Fe uptake kinetics for a number of complexes containing mutant forms of both Fet3p and Ftr1p and demonstrate that a residue in one protein interacts with one in the other protein along the iron trafficking pathway as would be expected in a channeling process. Iron 208-212 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 106-111 16522632-1 2006 The high affinity iron uptake complex in the yeast plasma membrane (PM) consists of the ferroxidase, Fet3p, and the ferric iron permease, Ftr1p. Iron 18-22 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 138-143 16522632-9 2006 The results are consistent with a (minimal) heterodimer model of the Fet3p.Ftr1p complex that supports the trafficking of iron from Fet3p to Ftr1p for iron permeation across the yeast PM. Iron 122-126 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 75-80 16522632-9 2006 The results are consistent with a (minimal) heterodimer model of the Fet3p.Ftr1p complex that supports the trafficking of iron from Fet3p to Ftr1p for iron permeation across the yeast PM. Iron 122-126 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 141-146 16522632-9 2006 The results are consistent with a (minimal) heterodimer model of the Fet3p.Ftr1p complex that supports the trafficking of iron from Fet3p to Ftr1p for iron permeation across the yeast PM. Iron 151-155 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 75-80 16522632-9 2006 The results are consistent with a (minimal) heterodimer model of the Fet3p.Ftr1p complex that supports the trafficking of iron from Fet3p to Ftr1p for iron permeation across the yeast PM. Iron 151-155 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 141-146 16387364-4 2006 A model of metabolite channeling of this Fe(III) is tested here by first constructing and kinetically characterizing in Fe-uptake two Fet3p-Ftr1p chimeras in which the multicopper oxidase/ferroxidase domain of Fet3p has been fused to the Ftr1p iron permease. Iron 41-43 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 140-145 16387364-4 2006 A model of metabolite channeling of this Fe(III) is tested here by first constructing and kinetically characterizing in Fe-uptake two Fet3p-Ftr1p chimeras in which the multicopper oxidase/ferroxidase domain of Fet3p has been fused to the Ftr1p iron permease. Iron 41-43 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 238-243 16387364-6 2006 Specifically, Fe-uptake through the Fet3p, Ftr1p complex is insensitive to a potential Fe(III) trapping agent - citrate - whereas Fe-uptake via the chimeric proteins is competitively inhibited by this Fe(III) chelator. Iron 14-16 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 43-48 16387364-6 2006 Specifically, Fe-uptake through the Fet3p, Ftr1p complex is insensitive to a potential Fe(III) trapping agent - citrate - whereas Fe-uptake via the chimeric proteins is competitively inhibited by this Fe(III) chelator. Iron 36-38 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 43-48 16387364-8 2006 The data are consistent with a channeling model of Fe-trafficking in the Fet3p, Ftr1p complex and suggest that in this system, Fet3p serves as a redox sieve that presents Fe(III) specifically for permeation through Ftr1p. Iron 51-53 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 80-85 16387364-8 2006 The data are consistent with a channeling model of Fe-trafficking in the Fet3p, Ftr1p complex and suggest that in this system, Fet3p serves as a redox sieve that presents Fe(III) specifically for permeation through Ftr1p. Iron 51-53 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 215-220 15817488-3 2005 We show that Fet3p and Ftr1p are post-translationally regulated by iron. Iron 67-71 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 23-28 16437160-1 2006 In the budding yeast Saccharomyces cerevisiae, transcription of genes encoding for the high-affinity iron (FET3, FTR1) and copper (CTR1) transporters does not occur in the absence of heme. Iron 101-105 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 113-117 15946650-1 2005 High affinity iron uptake in yeast is carried out by a multicomponent system formed by the ferroxidase Fet3p and the iron permease Ftr1p. Iron 14-18 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 131-136 15817488-4 2005 Incubation of cells in high iron leads to the internalization and degradation of both Fet3p and Ftr1p. Iron 28-32 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 96-101 15817488-5 2005 Yeast strains defective in endocytosis (Deltaend4) show a reduced iron-induced loss of Fet3p-Ftr1p. Iron 66-70 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 93-98 15817488-7 2005 Iron-induced degradation of Fet3p-Ftr1p is significantly reduced in strains containing a deletion of a gene, VTA1, which is involved in multivesicular body (MVB) sorting in yeast. Iron 0-4 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 34-39 15817488-10 2005 Iron-induced internalization and degradation of Fet3p-Ftr1p occurs in a mutant strain of the E3 ubiquitin ligase RSP5 (rsp5-1), suggesting that Rsp5p is not required. Iron 0-4 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 54-59 15817488-11 2005 Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex. Iron 47-51 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 25-30 15817488-11 2005 Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex. Iron 47-51 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 90-95 15817488-11 2005 Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex. Iron 47-51 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 90-95 15817488-11 2005 Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex. Iron 47-51 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 90-95 15817488-11 2005 Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex. Iron 136-140 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 25-30 15817488-11 2005 Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex. Iron 136-140 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 90-95 15817488-11 2005 Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex. Iron 136-140 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 90-95 15817488-11 2005 Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex. Iron 136-140 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 90-95 16566123-2 2005 It has been marked that iron uptake in the cells provides by high affinity system, it function is carried out by protein complex Fet3-Ftr1, and Fet4, protein with low affinity to iron ion. Iron 24-28 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 134-138 16566123-2 2005 It has been marked that iron uptake in the cells provides by high affinity system, it function is carried out by protein complex Fet3-Ftr1, and Fet4, protein with low affinity to iron ion. Iron 179-183 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 134-138 15347752-13 2004 It is hypothesized that ChpA, the iron permease and the iron(II) oxidase might have analogous functions for the three components of the S. cerevisiae copper-dependent high-affinity iron uptake system (Ctr1, Ftr1 and Fet3, respectively), and that strain MV-1 may have a similar iron uptake system. Iron 34-38 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 207-211 15347752-13 2004 It is hypothesized that ChpA, the iron permease and the iron(II) oxidase might have analogous functions for the three components of the S. cerevisiae copper-dependent high-affinity iron uptake system (Ctr1, Ftr1 and Fet3, respectively), and that strain MV-1 may have a similar iron uptake system. Iron 56-60 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 207-211 15123701-1 2004 Saccharomyces cerevisiae responds to iron deprivation by increased transcription of the iron regulon, including the high affinity cell-surface transport system encoded by FET3 and FTR1. Iron 37-41 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 180-184 15123701-1 2004 Saccharomyces cerevisiae responds to iron deprivation by increased transcription of the iron regulon, including the high affinity cell-surface transport system encoded by FET3 and FTR1. Iron 88-92 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 180-184 14992688-1 2004 Ftr1p is the permease component of the Fet3p-Ftr1p high affinity iron-uptake complex, in the plasma membrane of Saccharomyces cerevisiae, that transports the Fe3+ produced by the Fet3p ferroxidase into the cell. Iron 65-69 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 0-5 14992688-1 2004 Ftr1p is the permease component of the Fet3p-Ftr1p high affinity iron-uptake complex, in the plasma membrane of Saccharomyces cerevisiae, that transports the Fe3+ produced by the Fet3p ferroxidase into the cell. Iron 65-69 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 45-50 14992688-5 2004 Alanine substitutions at any one of these combined six arginine or glutamic acid residues inactivated Ftr1p in iron uptake, indicating that both motifs were essential to iron permeation. Iron 111-115 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 102-107 14992688-5 2004 Alanine substitutions at any one of these combined six arginine or glutamic acid residues inactivated Ftr1p in iron uptake, indicating that both motifs were essential to iron permeation. Iron 170-174 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 102-107 14992688-8 2004 The double substitution to AASA in the latter, inactivated Ftr1p in iron uptake while the Ftr1p(E89A) mutant had only 20% of wild-type activity. Iron 68-72 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 59-64 14992688-9 2004 The two REXLE and the EDLWE and DASE motifs are strongly conserved among fungal Ftr1p homologues, suggesting that these motifs are essential to iron permeation. Iron 144-148 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 80-85 14992688-12 2004 Ile369 was the only residue identified in this domain that made such a major contribution to iron uptake by the Fet3p-Ftr1p complex. Iron 93-97 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 118-123 15158278-8 2004 Finally, rFTR1 restored the ability of an ftr1 null mutant of S. cerevisiae to grow on iron-limited medium and to take up radiolabeled iron, whereas S. cerevisiae transformed with the empty vector did not. Iron 87-91 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 42-46 15158278-8 2004 Finally, rFTR1 restored the ability of an ftr1 null mutant of S. cerevisiae to grow on iron-limited medium and to take up radiolabeled iron, whereas S. cerevisiae transformed with the empty vector did not. Iron 135-139 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 42-46 12954629-6 2003 Production in the ftr1delta strain of an iron-uptake negative Ftr1p mutant, Ftr1p(RAGLA), suppressed this copper sensitivity. Iron 41-45 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 62-67 12954629-6 2003 Production in the ftr1delta strain of an iron-uptake negative Ftr1p mutant, Ftr1p(RAGLA), suppressed this copper sensitivity. Iron 41-45 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 76-81 14523005-8 2003 Supporting this is that the induction of an Aft1p target gene, FTR1, in response to iron starvation was greatly reduced in pse1-1 cells. Iron 84-88 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 63-67 11562378-2 2001 Siderophore-iron uptake can occur through the reduction of the complex and the subsequent uptake of iron by the high affinity iron transporter Fet3p/Ftr1p. Iron 12-16 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 149-154 11562378-2 2001 Siderophore-iron uptake can occur through the reduction of the complex and the subsequent uptake of iron by the high affinity iron transporter Fet3p/Ftr1p. Iron 100-104 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 149-154 12960168-3 2003 These genes, FET3, FTR1, TIS11, SIT1, and FIT2, are involved in the iron uptake pathway. Iron 68-72 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 19-23 12684851-2 2003 Fet3p catalyzes the oxidation of Fe(2+) to Fe(3+); this ferroxidation reaction is an obligatory first step in high-affinity iron uptake through the permease Ftr1p. Iron 124-128 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 157-162 11469807-1 2001 High-affinity iron uptake by yeast cells appears to require the presence of a complex formed on the plasma membrane by the multicopper oxidase Fet3 and the permease Ftr1 which work together to allow iron to enter safely inside the cell. Iron 14-18 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 165-169 11469807-1 2001 High-affinity iron uptake by yeast cells appears to require the presence of a complex formed on the plasma membrane by the multicopper oxidase Fet3 and the permease Ftr1 which work together to allow iron to enter safely inside the cell. Iron 199-203 high-affinity iron permease FTR1 Saccharomyces cerevisiae S288C 165-169