PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29872820-6	2018	Furthermore, the reduction of the cellular iron content induced alterations of p53-p27-p21 signaling to arrest the cell cycle at S phase in SMMC7721 cells treated by chemerin.	Iron	43-47	H3 histone pseudogene 16	Homo sapiens	87-90	
30141807-10	2018	Our data indicate that lipin1 overexpression may cause reduction of intracellular iron content, which could activate the p53-p21-p27 signaling pathways, leading to cell cycle arrest at the G0/G1 phase in the hepatic carcinoma cells.	Iron	82-86	H3 histone pseudogene 16	Homo sapiens	125-128	
29572098-0	2019	Ironing out the role of the cyclin-dependent kinase inhibitor, p21 in cancer: Novel iron chelating agents to target p21 expression and activity.	Iron	84-88	H3 histone pseudogene 16	Homo sapiens	63-66	
29572098-0	2019	Ironing out the role of the cyclin-dependent kinase inhibitor, p21 in cancer: Novel iron chelating agents to target p21 expression and activity.	Iron	84-88	H3 histone pseudogene 16	Homo sapiens	116-119	
24568186-13	2014	In conclusion, upregulation of p53 and p21 via HO-1 induction and subsequent release of iron with accumulation of H-ferritin may confer resistance to oxidative damage in cancer cells frequently challenged by redox-cycling anticancer drugs.	Iron	88-92	H3 histone pseudogene 16	Homo sapiens	39-42	
28203649-3	2016	We observed increased expression of heme and iron-regulated genes, previously shown to inhibit HIV-1, including ferroportin, IKBalpha, HO-1, p21, and SAM domain and HD domain-containing protein 1 (SAMHD1).	Iron	45-49	H3 histone pseudogene 16	Homo sapiens	141-144	
17172471-8	2007	Iron increases interactions of TAK1 and PI3K with p21ras as demonstrated by co-immunoprecipitation and co-localization of these proteins with caveolin-1 as shown by immunofluorescent microscopy.	Iron	0-4	H3 histone pseudogene 16	Homo sapiens	50-53	
17822515-6	2007	This article discusses three cellular regulators (p53, p21 and TRAIL) induced in synovial tissue that are important for iron metabolism.	Iron	120-124	H3 histone pseudogene 16	Homo sapiens	55-58	
9396728-4	1997	The results obtained indicate that His-13 of P21 co-ordinates to the sixth co-ordination position of the haem iron, thus leading to the formation of a complex characterized by an equilibrium between an "open" and a "closed" structure, as confirmed by molecular dynamics simulations.	Iron	110-114	H3 histone pseudogene 16	Homo sapiens	45-48	
9396728-5	1997	Under acidic pH conditions, where His-13 of P21 is loosely bound to the haem iron ("open" conformation), MKP displays appreciable, quasi-reversible electrochemical activity; in contrast, at neutral pH ("closed" conformation) electrochemical behaviour is negligible, indicating that P21 interferes with the electron-transfer properties typical of Mp.	Iron	77-81	H3 histone pseudogene 16	Homo sapiens	44-47	
34298093-7	2021	Heme-iron induced lipid peroxidation and DNA oxidation by interacting with Nox4-independent mechanisms, promoting p53/p21 activity and cellular senescence.	Iron	5-9	H3 histone pseudogene 16	Homo sapiens	118-121