PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17172471-8 2007 Iron increases interactions of TAK1 and PI3K with p21ras as demonstrated by co-immunoprecipitation and co-localization of these proteins with caveolin-1 as shown by immunofluorescent microscopy. Iron 0-4 H3 histone pseudogene 16 Homo sapiens 50-53 17822515-6 2007 This article discusses three cellular regulators (p53, p21 and TRAIL) induced in synovial tissue that are important for iron metabolism. Iron 120-124 H3 histone pseudogene 16 Homo sapiens 55-58 34298093-7 2021 Heme-iron induced lipid peroxidation and DNA oxidation by interacting with Nox4-independent mechanisms, promoting p53/p21 activity and cellular senescence. Iron 5-9 H3 histone pseudogene 16 Homo sapiens 118-121 24568186-13 2014 In conclusion, upregulation of p53 and p21 via HO-1 induction and subsequent release of iron with accumulation of H-ferritin may confer resistance to oxidative damage in cancer cells frequently challenged by redox-cycling anticancer drugs. Iron 88-92 H3 histone pseudogene 16 Homo sapiens 39-42 9396728-4 1997 The results obtained indicate that His-13 of P21 co-ordinates to the sixth co-ordination position of the haem iron, thus leading to the formation of a complex characterized by an equilibrium between an "open" and a "closed" structure, as confirmed by molecular dynamics simulations. Iron 110-114 H3 histone pseudogene 16 Homo sapiens 45-48 9396728-5 1997 Under acidic pH conditions, where His-13 of P21 is loosely bound to the haem iron ("open" conformation), MKP displays appreciable, quasi-reversible electrochemical activity; in contrast, at neutral pH ("closed" conformation) electrochemical behaviour is negligible, indicating that P21 interferes with the electron-transfer properties typical of Mp. Iron 77-81 H3 histone pseudogene 16 Homo sapiens 44-47 29572098-0 2019 Ironing out the role of the cyclin-dependent kinase inhibitor, p21 in cancer: Novel iron chelating agents to target p21 expression and activity. Iron 84-88 H3 histone pseudogene 16 Homo sapiens 63-66 29572098-0 2019 Ironing out the role of the cyclin-dependent kinase inhibitor, p21 in cancer: Novel iron chelating agents to target p21 expression and activity. Iron 84-88 H3 histone pseudogene 16 Homo sapiens 116-119 30141807-10 2018 Our data indicate that lipin1 overexpression may cause reduction of intracellular iron content, which could activate the p53-p21-p27 signaling pathways, leading to cell cycle arrest at the G0/G1 phase in the hepatic carcinoma cells. Iron 82-86 H3 histone pseudogene 16 Homo sapiens 125-128 29872820-6 2018 Furthermore, the reduction of the cellular iron content induced alterations of p53-p27-p21 signaling to arrest the cell cycle at S phase in SMMC7721 cells treated by chemerin. Iron 43-47 H3 histone pseudogene 16 Homo sapiens 87-90 28203649-3 2016 We observed increased expression of heme and iron-regulated genes, previously shown to inhibit HIV-1, including ferroportin, IKBalpha, HO-1, p21, and SAM domain and HD domain-containing protein 1 (SAMHD1). Iron 45-49 H3 histone pseudogene 16 Homo sapiens 141-144