PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26605946-7 2015 The iron scores of DN-HCCs and overt HCCs were significantly lower than those of background livers [(0.091+-0.30) VS (2.18+-0.87), P = 0.000; (0.11+-0.41) VS (2.16+-0.97), P = 0.000; respectively]. Iron 4-8 holocytochrome c synthase Homo sapiens 22-26 28196881-1 2017 Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81). Iron 211-215 holocytochrome c synthase Homo sapiens 27-52 28196881-1 2017 Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81). Iron 211-215 holocytochrome c synthase Homo sapiens 54-58 28196881-1 2017 Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81). Iron 211-215 holocytochrome c synthase Homo sapiens 258-262 26605946-7 2015 The iron scores of DN-HCCs and overt HCCs were significantly lower than those of background livers [(0.091+-0.30) VS (2.18+-0.87), P = 0.000; (0.11+-0.41) VS (2.16+-0.97), P = 0.000; respectively]. Iron 4-8 holocytochrome c synthase Homo sapiens 37-41 25170082-9 2014 Three roles for His-19 in HCCS-mediated assembly are suggested: (i) to provide the second axial ligand to the heme iron in preparation for covalent attachment; (ii) to spatially position the two cysteinyl sulfurs adjacent to the two heme vinyl groups for thioether formation; and (iii) to aid in release of the holocytochrome c from the HCCS active site. Iron 115-119 holocytochrome c synthase Homo sapiens 26-30 23150584-5 2013 A conserved histidine in HCCS (His154) provided the key ligand to the heme iron. Iron 75-79 holocytochrome c synthase Homo sapiens 25-29 25054239-6 2014 Previously, we proposed a four-step model describing HCCS-mediated cytochrome c assembly, identifying a conserved histidine residue (His154) as an axial ligand to the heme iron. Iron 172-176 holocytochrome c synthase Homo sapiens 53-57 33549104-8 2021 In the semiquantitative methods, both peritumoral and background liver iron deposition grade were significantly higher in HCCs with a PTHR compared with HCCs without a PTHR (P < 0.001). Iron 71-75 holocytochrome c synthase Homo sapiens 122-126 33549104-9 2021 The mean optical density in HCCs with a PTHR was significantly higher compared with HCCs without a PTHR, in the quantitative peritumoral (42,244.1 +- 20,854.9 vs. 18,739.1 +- 12,258.7, respectively; P < 0.001) and background liver iron deposition analyses (35,554.7 +- 19,854.8 vs. 17,292.4 +- 11,605.8, respectively; P < 0.001). Iron 231-235 holocytochrome c synthase Homo sapiens 28-32 33549104-11 2021 CONCLUSIONS: A PTHR in HCCs on T2*WIs was strongly associated with peritumoral iron deposition in the iron-deposited background liver but not with the fibrous capsule. Iron 79-83 holocytochrome c synthase Homo sapiens 23-27 33549104-11 2021 CONCLUSIONS: A PTHR in HCCs on T2*WIs was strongly associated with peritumoral iron deposition in the iron-deposited background liver but not with the fibrous capsule. Iron 102-106 holocytochrome c synthase Homo sapiens 23-27