PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26605946-7	2015	The iron scores of DN-HCCs and overt HCCs were significantly lower than those of background livers [(0.091+-0.30) VS (2.18+-0.87), P = 0.000; (0.11+-0.41) VS (2.16+-0.97), P = 0.000; respectively].	Iron	4-8	holocytochrome c synthase	Homo sapiens	22-26	
28196881-1	2017	Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81).	Iron	211-215	holocytochrome c synthase	Homo sapiens	27-52	
28196881-1	2017	Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81).	Iron	211-215	holocytochrome c synthase	Homo sapiens	54-58	
28196881-1	2017	Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81).	Iron	211-215	holocytochrome c synthase	Homo sapiens	258-262	
26605946-7	2015	The iron scores of DN-HCCs and overt HCCs were significantly lower than those of background livers [(0.091+-0.30) VS (2.18+-0.87), P = 0.000; (0.11+-0.41) VS (2.16+-0.97), P = 0.000; respectively].	Iron	4-8	holocytochrome c synthase	Homo sapiens	37-41	
25170082-9	2014	Three roles for His-19 in HCCS-mediated assembly are suggested: (i) to provide the second axial ligand to the heme iron in preparation for covalent attachment; (ii) to spatially position the two cysteinyl sulfurs adjacent to the two heme vinyl groups for thioether formation; and (iii) to aid in release of the holocytochrome c from the HCCS active site.	Iron	115-119	holocytochrome c synthase	Homo sapiens	26-30	
25054239-6	2014	Previously, we proposed a four-step model describing HCCS-mediated cytochrome c assembly, identifying a conserved histidine residue (His154) as an axial ligand to the heme iron.	Iron	172-176	holocytochrome c synthase	Homo sapiens	53-57	
23150584-5	2013	A conserved histidine in HCCS (His154) provided the key ligand to the heme iron.	Iron	75-79	holocytochrome c synthase	Homo sapiens	25-29	
33549104-8	2021	In the semiquantitative methods, both peritumoral and background liver iron deposition grade were significantly higher in HCCs with a PTHR compared with HCCs without a PTHR (P < 0.001).	Iron	71-75	holocytochrome c synthase	Homo sapiens	122-126	
33549104-9	2021	The mean optical density in HCCs with a PTHR was significantly higher compared with HCCs without a PTHR, in the quantitative peritumoral (42,244.1 +- 20,854.9 vs. 18,739.1 +- 12,258.7, respectively; P < 0.001) and background liver iron deposition analyses (35,554.7 +- 19,854.8 vs. 17,292.4 +- 11,605.8, respectively; P < 0.001).	Iron	231-235	holocytochrome c synthase	Homo sapiens	28-32	
33549104-11	2021	CONCLUSIONS: A PTHR in HCCs on T2*WIs was strongly associated with peritumoral iron deposition in the iron-deposited background liver but not with the fibrous capsule.	Iron	79-83	holocytochrome c synthase	Homo sapiens	23-27	
33549104-11	2021	CONCLUSIONS: A PTHR in HCCs on T2*WIs was strongly associated with peritumoral iron deposition in the iron-deposited background liver but not with the fibrous capsule.	Iron	102-106	holocytochrome c synthase	Homo sapiens	23-27