PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35038358-0 2022 Drosophila ZIP13 overexpression or transferrin1 RNAi influences the muscle degeneration of Pink1 RNAi by elevating iron levels in mitochondria. Iron 115-119 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 11-16 35038358-5 2022 Consistently, the rescue effects of dZIP13 OE or Tsf1 RNAi on Pink1 RNAi can be inhibited by decreasing the iron levels in mitochondria through mitoferrin (dmfrn) RNAi. Iron 108-112 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 36-42 35038358-2 2022 To investigate iron metabolism genes related to PTEN-induced kinase 1 (Pink1) and parkin (E3 ubiquitin ligase), two PD-associated proteins that function to coordinate mitochondrial turnover via induction of selective mitophagy, we conducted a genetic screen in Drosophila and found that altered expression of genes involved in iron metabolism, such as Drosophila ZIP13 (dZIP13) or transferrin1 (Tsf1), significantly influences the disease progression related to Pink1 but not parkin. Iron 15-19 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 363-368 35038358-6 2022 This study suggests that dZIP13, Tsf1 and dmfrn might act independently of parkin in a parallel pathway downstream of Pink1 by modulating respiration and indicates that manipulation of iron levels in mitochondria may provide a novel therapeutic strategy for PD associated with Pink1. Iron 185-189 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 25-31 35038358-2 2022 To investigate iron metabolism genes related to PTEN-induced kinase 1 (Pink1) and parkin (E3 ubiquitin ligase), two PD-associated proteins that function to coordinate mitochondrial turnover via induction of selective mitophagy, we conducted a genetic screen in Drosophila and found that altered expression of genes involved in iron metabolism, such as Drosophila ZIP13 (dZIP13) or transferrin1 (Tsf1), significantly influences the disease progression related to Pink1 but not parkin. Iron 15-19 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 370-376 35038358-4 2022 The rescue effects of dZIP13 OE or Tsf1 RNAi were not exerted through mitochondrial disruption or mitophagy, instead, the iron levels in mitochondira were significantly increased, resulting in enhanced activity of enzymes participating in respiration and increased ATP synthesis. Iron 122-126 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 22-28 31733261-0 2020 A distinctive sequence motif in the fourth transmembrane domain confers ZIP13 iron function in Drosophila melanogaster. Iron 78-82 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 72-77 31733261-4 2020 Specifically, we reported before that the Drosophila ZIP family member ZIP13 (dZIP13), functions as an iron exporter and was responsible for pumping iron into the secretory pathway. Iron 103-107 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 71-76 31733261-4 2020 Specifically, we reported before that the Drosophila ZIP family member ZIP13 (dZIP13), functions as an iron exporter and was responsible for pumping iron into the secretory pathway. Iron 103-107 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 78-84 31733261-4 2020 Specifically, we reported before that the Drosophila ZIP family member ZIP13 (dZIP13), functions as an iron exporter and was responsible for pumping iron into the secretory pathway. Iron 149-153 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 71-76 31733261-4 2020 Specifically, we reported before that the Drosophila ZIP family member ZIP13 (dZIP13), functions as an iron exporter and was responsible for pumping iron into the secretory pathway. Iron 149-153 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 78-84 31733261-8 2020 Swapping D/H position of this DNXXH sequence in dZIP13 resulted in loss of iron activity; normal dZIP13 could not complement dZIP7 loss, but swapping the two relative amino acid positions D and H in dZIP13 was sufficient to make it functionally analogous to its close homologue dZIP7. Iron 75-79 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 48-54 31229649-0 2019 Drosophila ZIP13 is posttranslationally regulated by iron-mediated stabilization. Iron 53-57 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 11-16 31229649-1 2019 Drosophila ZIP13 (dZIP13, CG7816/ZIP99C) belongs to the SLC39A family and is connected to iron homeostasis in the fruit fly. Iron 90-94 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 11-16 31229649-1 2019 Drosophila ZIP13 (dZIP13, CG7816/ZIP99C) belongs to the SLC39A family and is connected to iron homeostasis in the fruit fly. Iron 90-94 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 18-24 31229649-1 2019 Drosophila ZIP13 (dZIP13, CG7816/ZIP99C) belongs to the SLC39A family and is connected to iron homeostasis in the fruit fly. Iron 90-94 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 33-39 31229649-2 2019 In this study, we show that dZIP13 level is strongly regulated by iron. Iron 66-70 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 28-34 31229649-3 2019 In addition to a mild response to iron at the mRNA level, dZIP13 is strongly regulated at the protein level. Iron 34-38 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 58-64 31229649-4 2019 This posttranslational regulation by iron also happens when dZIP13 is expressed in the yeast Saccharomyces cerevisiae. Iron 37-41 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 60-66 31229649-5 2019 Iron functions to stabilize dZIP13. Iron 0-4 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 28-34 31229649-6 2019 Domain-swapping experiments between dZIP7 (CG10449/ Catsup) and dZIP13 suggest that the N-terminus of dZIP13 is necessary to mediate this iron regulatory process. Iron 138-142 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 64-70 31229649-6 2019 Domain-swapping experiments between dZIP7 (CG10449/ Catsup) and dZIP13 suggest that the N-terminus of dZIP13 is necessary to mediate this iron regulatory process. Iron 138-142 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 102-108 31229649-8 2019 Mutations of these potential iron binding sites at the N-terminus, as well as a likely iron binding site at the C-terminus of dZIP13, completely abolish the iron-dependent upregulation in the yeast and the fruit fly. Iron 87-91 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 126-132 31229649-8 2019 Mutations of these potential iron binding sites at the N-terminus, as well as a likely iron binding site at the C-terminus of dZIP13, completely abolish the iron-dependent upregulation in the yeast and the fruit fly. Iron 87-91 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 126-132 31229649-9 2019 Iron-responsiveness of dZIP13 is consistent with its key role in iron homeostasis. Iron 0-4 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 23-29 31229649-9 2019 Iron-responsiveness of dZIP13 is consistent with its key role in iron homeostasis. Iron 65-69 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 23-29 31229649-10 2019 We speculate that this process of dZIP13 regulation, and that of IRE/IRP-controlled ferritin production, work together to better cope with iron repletion in the fly. Iron 139-143 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 34-40 29445391-2 2017 Previously we identified dZIP13 (CG7816), a member of the ZIP transporter family (SLC39A) and presumably a zinc importer, is in fact physiologically primarily responsible to move iron from the cytosol into the secretory compartments in the fly. Iron 179-183 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 25-31 29684424-13 2018 However, its importance to fly iron homeostasis is greatly minimized, which is instead dominated by another iron efflux avenue mediated by the ZIP13-ferritin axis along the ER/Golgi secretion pathway. Iron 31-35 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 143-148 29684424-13 2018 However, its importance to fly iron homeostasis is greatly minimized, which is instead dominated by another iron efflux avenue mediated by the ZIP13-ferritin axis along the ER/Golgi secretion pathway. Iron 108-112 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 143-148 25006035-0 2014 The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster. Iron 37-41 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 22-27 25006035-2 2014 In this study, we show Drosophila ZIP13 (Slc39a13), a presumed zinc importer, fulfills the iron effluxing role. Iron 91-95 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 34-39 25006035-3 2014 Interfering with dZIP13 expression causes iron-rescuable iron absorption defect, simultaneous iron increase in the cytosol and decrease in the secretory compartments, failure of ferritin iron loading, and abnormal collagen secretion. Iron 42-46 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 17-23 25006035-3 2014 Interfering with dZIP13 expression causes iron-rescuable iron absorption defect, simultaneous iron increase in the cytosol and decrease in the secretory compartments, failure of ferritin iron loading, and abnormal collagen secretion. Iron 57-61 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 17-23 25006035-3 2014 Interfering with dZIP13 expression causes iron-rescuable iron absorption defect, simultaneous iron increase in the cytosol and decrease in the secretory compartments, failure of ferritin iron loading, and abnormal collagen secretion. Iron 57-61 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 17-23 25006035-3 2014 Interfering with dZIP13 expression causes iron-rescuable iron absorption defect, simultaneous iron increase in the cytosol and decrease in the secretory compartments, failure of ferritin iron loading, and abnormal collagen secretion. Iron 57-61 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 17-23 25006035-4 2014 dZIP13 expression in E. coli confers upon the host iron-dependent growth and iron resistance. Iron 51-55 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 0-6 25006035-4 2014 dZIP13 expression in E. coli confers upon the host iron-dependent growth and iron resistance. Iron 77-81 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 0-6 25006035-5 2014 Importantly, time-coursed transport assays using an iron isotope indicated a potent iron exporting activity of dZIP13. Iron 52-56 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 111-117 25006035-5 2014 Importantly, time-coursed transport assays using an iron isotope indicated a potent iron exporting activity of dZIP13. Iron 84-88 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 111-117 25006035-6 2014 The identification of dZIP13 as an iron transporter suggests that the spondylocheiro dysplastic form of Ehlers-Danlos syndrome, in which hZIP13 is defective, is likely due to a failure of iron delivery to the secretory compartments. Iron 35-39 Zinc/iron regulated transporter-related protein 99C Drosophila melanogaster 22-28