PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31676164-0 2020 Knockdown of BTS may provide a new strategy to improve cadmium-phytoremediation efficiency by improving iron status in plants. Iron 104-108 zinc finger protein-like protein Arabidopsis thaliana 13-16 31676164-7 2020 These results demonstrated that BTS knockdown improved Cd tolerance and accumulation in plants by improving Fe nutrition; thus, the knockdown of BTS via biotechnological pathways may represent a valuable strategy for the improvement in the efficiency of Cd phytoremediation. Iron 108-110 zinc finger protein-like protein Arabidopsis thaliana 32-35 31676164-7 2020 These results demonstrated that BTS knockdown improved Cd tolerance and accumulation in plants by improving Fe nutrition; thus, the knockdown of BTS via biotechnological pathways may represent a valuable strategy for the improvement in the efficiency of Cd phytoremediation. Iron 108-110 zinc finger protein-like protein Arabidopsis thaliana 145-148 31676164-2 2020 Owing to the similarity between the ionic hydrated radius of Cd2+ and Fe2+, this study investigated how the Cd tolerance and accumulation of Arabidopsis plants was affected by the knockdown of BTS, a gene that negatively regulates Fe nutrition. Iron 70-74 zinc finger protein-like protein Arabidopsis thaliana 193-196 31676164-2 2020 Owing to the similarity between the ionic hydrated radius of Cd2+ and Fe2+, this study investigated how the Cd tolerance and accumulation of Arabidopsis plants was affected by the knockdown of BTS, a gene that negatively regulates Fe nutrition. Iron 70-72 zinc finger protein-like protein Arabidopsis thaliana 193-196 31676164-3 2020 After exposure to 40 muM Cd, the BTS-knockdown mutant, bts-1, exhibited greater Fe nutrition and better growth than wild-type plants. Iron 80-82 zinc finger protein-like protein Arabidopsis thaliana 33-36 31676164-3 2020 After exposure to 40 muM Cd, the BTS-knockdown mutant, bts-1, exhibited greater Fe nutrition and better growth than wild-type plants. Iron 80-82 zinc finger protein-like protein Arabidopsis thaliana 55-58 31676164-6 2020 Further study showed that Fe removal from the growth medium and inhibition of the Fe transporter gene, IRT1, removed the differences observed in the growth and Cd concentration of the bts-1 and wild-type plants, respectively. Iron 26-28 zinc finger protein-like protein Arabidopsis thaliana 184-187 31676164-6 2020 Further study showed that Fe removal from the growth medium and inhibition of the Fe transporter gene, IRT1, removed the differences observed in the growth and Cd concentration of the bts-1 and wild-type plants, respectively. Iron 82-84 zinc finger protein-like protein Arabidopsis thaliana 184-187 31776233-7 2020 bHLH121 acts as a direct transcriptional activator of key genes involved in the Fe regulatory network, including bHLH38, bHLH39, bHLH100, bHLH101, POPEYE, BRUTUS, and BRUTUS LIKE1, as well as IRONMAN1 and IRONMAN2 In addition, bHLH121 is necessary for activating the expression of transcription factor gene FIT in response to Fe deficiency via an indirect mechanism. Iron 80-82 zinc finger protein-like protein Arabidopsis thaliana 155-161 31776233-7 2020 bHLH121 acts as a direct transcriptional activator of key genes involved in the Fe regulatory network, including bHLH38, bHLH39, bHLH100, bHLH101, POPEYE, BRUTUS, and BRUTUS LIKE1, as well as IRONMAN1 and IRONMAN2 In addition, bHLH121 is necessary for activating the expression of transcription factor gene FIT in response to Fe deficiency via an indirect mechanism. Iron 80-82 zinc finger protein-like protein Arabidopsis thaliana 167-173 31413196-0 2019 Arabidopsis BRUTUS-LIKE E3 ligases negatively regulate iron uptake by targeting transcription factor FIT for recycling. Iron 55-59 zinc finger protein-like protein Arabidopsis thaliana 12-18 31413196-3 2019 Here we describe the function of 2 partially redundant E3 ubiquitin ligases, BRUTUS-LIKE1 (BTSL1) and BTSL2, in Arabidopsis thaliana and provide evidence that they target the transcription factor FIT, a key regulator of Fe uptake, for degradation. Iron 220-222 zinc finger protein-like protein Arabidopsis thaliana 77-89 29878379-1 2018 BRUTUS (BTS) is an iron binding E3 ligase that has been shown to bind to and influence the accumulation of target basic helix-loop-helix transcription factors through 26S proteasome-mediated degradation in Arabidopsis thaliana. Iron 19-23 zinc finger protein-like protein Arabidopsis thaliana 0-6 29878379-1 2018 BRUTUS (BTS) is an iron binding E3 ligase that has been shown to bind to and influence the accumulation of target basic helix-loop-helix transcription factors through 26S proteasome-mediated degradation in Arabidopsis thaliana. Iron 19-23 zinc finger protein-like protein Arabidopsis thaliana 8-11 23888164-7 2013 Comparing the responses to Fe deficiency in leaves to that in roots confirmed subgroup 1b bHLH transcription factors and POPEYE/BRUTUS as important regulators of Fe homeostasis in both leaf and root cells, and indicated six novel players with putative roles in Fe homeostasis that were highly expressed in leaves and roots and greatly induced by Fe deficiency. Iron 27-29 zinc finger protein-like protein Arabidopsis thaliana 128-134 34548401-0 2021 IRON MAN interacts with BRUTUS to maintain iron homeostasis in Arabidopsis. Iron 0-4 zinc finger protein-like protein Arabidopsis thaliana 24-30 34548401-0 2021 IRON MAN interacts with BRUTUS to maintain iron homeostasis in Arabidopsis. Iron 43-47 zinc finger protein-like protein Arabidopsis thaliana 24-30 34548401-2 2021 BRUTUS (BTS) is a potential Fe sensor that negatively regulates Fe homeostasis by promoting the ubiquitin-mediated degradation of bHLH105 and bHLH115, two positive regulators of the Fe deficiency response. Iron 28-30 zinc finger protein-like protein Arabidopsis thaliana 0-6 34548401-2 2021 BRUTUS (BTS) is a potential Fe sensor that negatively regulates Fe homeostasis by promoting the ubiquitin-mediated degradation of bHLH105 and bHLH115, two positive regulators of the Fe deficiency response. Iron 64-66 zinc finger protein-like protein Arabidopsis thaliana 0-6 34548401-2 2021 BRUTUS (BTS) is a potential Fe sensor that negatively regulates Fe homeostasis by promoting the ubiquitin-mediated degradation of bHLH105 and bHLH115, two positive regulators of the Fe deficiency response. Iron 182-184 zinc finger protein-like protein Arabidopsis thaliana 0-6 35422451-1 2022 E3 ligase BRUTUS (BTS), a putative iron sensor, is expressed in both root and shoot tissues in seedlings of Arabidopsis thaliana. Iron 35-39 zinc finger protein-like protein Arabidopsis thaliana 18-21 28620661-3 2017 The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response. Iron 94-96 zinc finger protein-like protein Arabidopsis thaliana 35-41 28620661-3 2017 The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response. Iron 94-96 zinc finger protein-like protein Arabidopsis thaliana 43-46 28620661-3 2017 The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response. Iron 94-96 zinc finger protein-like protein Arabidopsis thaliana 159-162 28620661-3 2017 The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response. Iron 94-96 zinc finger protein-like protein Arabidopsis thaliana 159-162 28620661-3 2017 The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response. Iron 94-96 zinc finger protein-like protein Arabidopsis thaliana 159-162 28620661-3 2017 The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response. Iron 280-282 zinc finger protein-like protein Arabidopsis thaliana 35-41 28620661-3 2017 The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response. Iron 280-282 zinc finger protein-like protein Arabidopsis thaliana 43-46 28620661-3 2017 The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response. Iron 280-282 zinc finger protein-like protein Arabidopsis thaliana 159-162 28620661-3 2017 The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response. Iron 280-282 zinc finger protein-like protein Arabidopsis thaliana 159-162 28620661-3 2017 The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response. Iron 280-282 zinc finger protein-like protein Arabidopsis thaliana 159-162 28620661-6 2017 Finally, we identified a mutant carrying a novel missense mutation of BTS that exhibits an Fe deficiency response in the root when grown under both Fe-deficient and Fe-sufficient conditions, leading to Fe toxicity when plants are grown under Fe-sufficient conditions. Iron 91-93 zinc finger protein-like protein Arabidopsis thaliana 70-73 28620661-6 2017 Finally, we identified a mutant carrying a novel missense mutation of BTS that exhibits an Fe deficiency response in the root when grown under both Fe-deficient and Fe-sufficient conditions, leading to Fe toxicity when plants are grown under Fe-sufficient conditions. Iron 148-150 zinc finger protein-like protein Arabidopsis thaliana 70-73 28620661-6 2017 Finally, we identified a mutant carrying a novel missense mutation of BTS that exhibits an Fe deficiency response in the root when grown under both Fe-deficient and Fe-sufficient conditions, leading to Fe toxicity when plants are grown under Fe-sufficient conditions. Iron 148-150 zinc finger protein-like protein Arabidopsis thaliana 70-73 28620661-6 2017 Finally, we identified a mutant carrying a novel missense mutation of BTS that exhibits an Fe deficiency response in the root when grown under both Fe-deficient and Fe-sufficient conditions, leading to Fe toxicity when plants are grown under Fe-sufficient conditions. Iron 148-150 zinc finger protein-like protein Arabidopsis thaliana 70-73 28620661-6 2017 Finally, we identified a mutant carrying a novel missense mutation of BTS that exhibits an Fe deficiency response in the root when grown under both Fe-deficient and Fe-sufficient conditions, leading to Fe toxicity when plants are grown under Fe-sufficient conditions. Iron 148-150 zinc finger protein-like protein Arabidopsis thaliana 70-73 20675571-6 2010 Moreover, ILR3 interacts with a third protein, BRUTUS (BTS), a putative E3 ligase protein, with metal ion binding and DNA binding domains, which negatively regulates the response to iron deficiency. Iron 182-186 zinc finger protein-like protein Arabidopsis thaliana 47-53