PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20105537-11 2010 As determined by real-time reverse transcription PCR, relative hepatic expression of the gene that encodes the Fe regulatory hormone hepcidin was 5-fold greater in calves fed high dietary Fe. Iron 111-113 hepcidin antimicrobial peptide Bos taurus 133-141 21161377-1 2011 Hepcidin, a novel gene encoded, 25 residue, 2-3 KDa cysteine rich cationic peptide synthesized in liver cells play an important role in iron metabolism in addition to its antimicrobial activity. Iron 136-140 hepcidin antimicrobial peptide Bos taurus 0-8 20105537-12 2010 Hepcidin is released in response to increased Fe status and binds to the Fe export protein ferroportin causing ferroportin to be degraded, thereby reducing dietary Fe absorption. Iron 46-48 hepcidin antimicrobial peptide Bos taurus 0-8 20105537-12 2010 Hepcidin is released in response to increased Fe status and binds to the Fe export protein ferroportin causing ferroportin to be degraded, thereby reducing dietary Fe absorption. Iron 73-75 hepcidin antimicrobial peptide Bos taurus 0-8 20105537-16 2010 In summary, feeding calves a diet high in Fe induced a signal cascade (hepcidin) designed to reduce absorption of Fe (via reduced protein expression of ferroportin and DMT1) in a manner similar to that reported in rodents. Iron 42-44 hepcidin antimicrobial peptide Bos taurus 71-79 20105537-16 2010 In summary, feeding calves a diet high in Fe induced a signal cascade (hepcidin) designed to reduce absorption of Fe (via reduced protein expression of ferroportin and DMT1) in a manner similar to that reported in rodents. Iron 114-116 hepcidin antimicrobial peptide Bos taurus 71-79 32182331-8 2020 Hepcidin downregulates ferroportin, its downstream target, increasing ferritin and iron-catalyzed ROS. Iron 83-87 hepcidin antimicrobial peptide Bos taurus 0-8 32397086-7 2020 Additionally, hepcidin protein expression decreased in control and anemic animals fed fermented goat milk with normal iron content. Iron 118-122 hepcidin antimicrobial peptide Bos taurus 14-22 32182331-12 2020 Conclusions: The above observations suggest that TGF-beta2 and hepcidin form a self-sustained feed-forward loop through iron-catalyzed ROS. Iron 120-124 hepcidin antimicrobial peptide Bos taurus 63-71 32182331-13 2020 This loop is partially disrupted by a hepcidin antagonist and an anti-oxidant, implicating iron and ROS in TGF-beta2-mediated POAG. Iron 91-95 hepcidin antimicrobial peptide Bos taurus 38-46 28780484-1 2017 Hepcidin (HEP) and ferroportin (FPN) play a central role in systemic iron homeostasis. Iron 69-73 hepcidin antimicrobial peptide Bos taurus 0-8 28780484-1 2017 Hepcidin (HEP) and ferroportin (FPN) play a central role in systemic iron homeostasis. Iron 69-73 hepcidin antimicrobial peptide Bos taurus 10-13 28780484-2 2017 The HEP/FPN axis controls both extracellular iron concentration and total body iron levels. Iron 45-49 hepcidin antimicrobial peptide Bos taurus 4-7 28780484-2 2017 The HEP/FPN axis controls both extracellular iron concentration and total body iron levels. Iron 79-83 hepcidin antimicrobial peptide Bos taurus 4-7 28780484-3 2017 HEP is synthesized mainly by hepatocytes and controls the absorption of dietary iron and the distribution of iron to the various cell types; its synthesis is regulated by both iron and innate immunity. Iron 80-84 hepcidin antimicrobial peptide Bos taurus 0-3 28780484-3 2017 HEP is synthesized mainly by hepatocytes and controls the absorption of dietary iron and the distribution of iron to the various cell types; its synthesis is regulated by both iron and innate immunity. Iron 109-113 hepcidin antimicrobial peptide Bos taurus 0-3 28780484-3 2017 HEP is synthesized mainly by hepatocytes and controls the absorption of dietary iron and the distribution of iron to the various cell types; its synthesis is regulated by both iron and innate immunity. Iron 109-113 hepcidin antimicrobial peptide Bos taurus 0-3 28780484-5 2017 HEP limits the pool of extracellular iron by binding FPN and mediating its degradation, thus preventing its release from intracellular sources. Iron 37-41 hepcidin antimicrobial peptide Bos taurus 0-3 28780484-15 2017 In addition, HEP may be responsible for iron flux regulation as a molecular bridge for iron trafficking and response to infection. Iron 40-44 hepcidin antimicrobial peptide Bos taurus 13-16 28780484-15 2017 In addition, HEP may be responsible for iron flux regulation as a molecular bridge for iron trafficking and response to infection. Iron 87-91 hepcidin antimicrobial peptide Bos taurus 13-16 27956775-9 2016 CONCLUSION: In light of the fact that hepcidin plays a role function in the regulation of Fe as well as the fact that Fe is a significant nutritional source for many microorganisms, it was concluded that hepcidin may play a significant role in nutritional immunity and the pathogenesis of diseases. Iron 90-92 hepcidin antimicrobial peptide Bos taurus 38-46 27956775-9 2016 CONCLUSION: In light of the fact that hepcidin plays a role function in the regulation of Fe as well as the fact that Fe is a significant nutritional source for many microorganisms, it was concluded that hepcidin may play a significant role in nutritional immunity and the pathogenesis of diseases. Iron 90-92 hepcidin antimicrobial peptide Bos taurus 204-212 27956775-9 2016 CONCLUSION: In light of the fact that hepcidin plays a role function in the regulation of Fe as well as the fact that Fe is a significant nutritional source for many microorganisms, it was concluded that hepcidin may play a significant role in nutritional immunity and the pathogenesis of diseases. Iron 118-120 hepcidin antimicrobial peptide Bos taurus 204-212