PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29959986-9 2018 Moreover, ferritin protein and CHOP mRNA expression were induced in combined iron and trigonelline incubated cells (p < 0.05). Iron 77-81 DNA damage inducible transcript 3 Homo sapiens 31-35 22046282-3 2011 Activated gadd153 can generate oxidative damage and reactive oxygen species (ROS), increase beta-amyloid (Abeta) levels, disturb iron homeostasis and induce inflammation as well as cell death, which are all pathological hallmarks of AD. Iron 129-133 DNA damage inducible transcript 3 Homo sapiens 10-17 23749468-0 2013 CHOP-mediated hepcidin suppression modulates hepatic iron load. Iron 53-57 DNA damage inducible transcript 3 Homo sapiens 0-4 20607588-7 2011 Moreover, pretreatment of HCT116 cells with the iron chelator deferoxamine mesylate salt (DFO) abrogated induction of GRP78 and GADD153 upon DHA treatment, indicating iron is required for DHA-induced ER stress. Iron 48-52 DNA damage inducible transcript 3 Homo sapiens 128-135 22046282-9 2011 Additionally, 27-OHC-induced tau phosphorylation, ROS generation, TNF-alpha activation, and iron and apoptosis-regulatory protein levels alteration were also markedly reduced by siRNA to gadd153. Iron 92-96 DNA damage inducible transcript 3 Homo sapiens 187-194 8670069-5 1996 o-Phenanthroline and mannitol blocked GADD153 induction by H2O2, indicating that iron-generated hydroxyl radical mediates this induction. Iron 81-85 DNA damage inducible transcript 3 Homo sapiens 38-45 15053923-0 2004 Increased GADD153 gene expression during iron chelation-induced apoptosis in Jurkat T-lymphocytes. Iron 41-45 DNA damage inducible transcript 3 Homo sapiens 10-17 15053923-10 2004 Because GADD153 is recognized as a pro-apoptotic gene, these findings generate the notion that GADD153 might help mediate apoptosis in iron-deficient cells. Iron 135-139 DNA damage inducible transcript 3 Homo sapiens 8-15 15053923-10 2004 Because GADD153 is recognized as a pro-apoptotic gene, these findings generate the notion that GADD153 might help mediate apoptosis in iron-deficient cells. Iron 135-139 DNA damage inducible transcript 3 Homo sapiens 95-102 2361941-10 1990 A region of homology with the cytochrome P-450s from various organisms was identified in the choP protein and may represent a region associated with a binding site for heme iron. Iron 173-177 DNA damage inducible transcript 3 Homo sapiens 93-97