PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21540277-6 2011 Iron concentrations in the liver, kidney, and spleen were increased, derived from internally released iron from hemolyzed red blood cells, increased duodenal iron absorption, insufficient erythropoiesis, and hepatic ferritin overproduced by cadmium-induced interleukin-6. Iron 0-4 interleukin 6 Rattus norvegicus 257-270 22364558-2 2012 Interleukin-6 (IL-6) induces the iron hormone hepcidin, which blocks iron uptake and may compromise iron uptake in the growing liver. Iron 33-37 interleukin 6 Rattus norvegicus 0-13 22364558-2 2012 Interleukin-6 (IL-6) induces the iron hormone hepcidin, which blocks iron uptake and may compromise iron uptake in the growing liver. Iron 33-37 interleukin 6 Rattus norvegicus 15-19 22364558-2 2012 Interleukin-6 (IL-6) induces the iron hormone hepcidin, which blocks iron uptake and may compromise iron uptake in the growing liver. Iron 69-73 interleukin 6 Rattus norvegicus 0-13 22364558-2 2012 Interleukin-6 (IL-6) induces the iron hormone hepcidin, which blocks iron uptake and may compromise iron uptake in the growing liver. Iron 69-73 interleukin 6 Rattus norvegicus 15-19 22364558-2 2012 Interleukin-6 (IL-6) induces the iron hormone hepcidin, which blocks iron uptake and may compromise iron uptake in the growing liver. Iron 69-73 interleukin 6 Rattus norvegicus 0-13 22364558-2 2012 Interleukin-6 (IL-6) induces the iron hormone hepcidin, which blocks iron uptake and may compromise iron uptake in the growing liver. Iron 69-73 interleukin 6 Rattus norvegicus 15-19 19167990-3 2009 The aim of this study was to investigate the effect of iron polyisomaltosate, an iron (Fe(3+)) compound, on serum iron, interleukin-6 (IL-6) and serotonin (5-HT) concentration, neutrophil activity, and NF-kappaB activation in peritoneal macrophages and spleen cells in rats. Iron 55-59 interleukin 6 Rattus norvegicus 120-133 20626630-10 2010 However, pioglitazone inhibited iron-induced alpha-synuclein aggregation, elevations in interleukin-1beta and interleukin-6 mRNA levels as well as increases in oxygenase-1, cyclo-oxygenase II, nitric oxide synthase and ED-1 protein levels, an indicator of activated microglia. Iron 32-36 interleukin 6 Rattus norvegicus 110-123 16133010-7 2006 The addition of vitamin E to iron (DSS+iron+vitamin E group) significantly reduced the inflammatory scores, TNF-alpha and IL-6. Iron 29-33 interleukin 6 Rattus norvegicus 122-126 18541141-7 2008 In conclusion, the IL-6-hepcidin axis is up-regulated by psychological stress in rats, resulting in hypoferremia and increase of hepatic iron storage. Iron 137-141 interleukin 6 Rattus norvegicus 19-23 16133010-7 2006 The addition of vitamin E to iron (DSS+iron+vitamin E group) significantly reduced the inflammatory scores, TNF-alpha and IL-6. Iron 39-43 interleukin 6 Rattus norvegicus 122-126 11354283-7 2001 Interleukin-6 mRNA levels in iron-loaded Kupffer cells were also reduced. Iron 29-33 interleukin 6 Rattus norvegicus 0-13 12757853-6 2003 LPS-induced plasma levels of IL-6, IL-1beta, and TNF-alpha were also significantly higher in iron-preloaded rats as shown by ELISA, but IFN-gamma levels were unchanged. Iron 93-97 interleukin 6 Rattus norvegicus 29-33 12757853-7 2003 We conclude that colloidal-iron phagocytosed by liver Kupffer cells enhanced LPS-induced NO production in vivo, iNOS induction in the liver, and release of IL-6, IL-1beta, and TNF-alpha. Iron 27-31 interleukin 6 Rattus norvegicus 156-160 16221503-0 2006 Regulatory effects of tumor necrosis factor-alpha and interleukin-6 on HAMP expression in iron loaded rat hepatocytes. Iron 90-94 interleukin 6 Rattus norvegicus 54-67 16221503-6 2006 In the presence of serum, tumor necrosis factor-alpha, lipopolysaccharide and interleukin-6 increased HAMP expression in hepatocytes from both control and iron-loaded rats. Iron 155-159 interleukin 6 Rattus norvegicus 78-91 12363398-7 2002 Significant higher levels of glutamate, IL-6 and TNF-alpha were observed in the group with iron intake (peak values were obtained at 6, 8 and 4 h, respectively). Iron 91-95 interleukin 6 Rattus norvegicus 40-44 33580994-4 2021 The results showed that ergothioneine inhibited iron-evoked inflammation and apoptosis as demonstrated by a significant reduction in tumor necrosis factor-alpha and interleukin-6 levels and in caspase-3 activity. Iron 48-52 interleukin 6 Rattus norvegicus 165-178 8188178-1 1994 To explore a mechanism of interleukin (IL)-6-induced hypoferremia in rats, iron metabolism was investigated both in vivo and in vitro. Iron 75-79 interleukin 6 Rattus norvegicus 26-44 8188178-2 1994 Recombinant IL-6 was intraperitoneally administered to male Wistar rats and the serial change of parameters related to iron metabolism was examined. Iron 119-123 interleukin 6 Rattus norvegicus 12-16 8188178-8 1994 By ferrokinetic study with plasma that contained iron 59-labeled transferrin, the plasma iron disappearance half time, calculated from the disappearance curve, was significantly shortened from 55 min to 22 min by IL-6 treatment (p < 0.01). Iron 49-53 interleukin 6 Rattus norvegicus 213-217 8188178-8 1994 By ferrokinetic study with plasma that contained iron 59-labeled transferrin, the plasma iron disappearance half time, calculated from the disappearance curve, was significantly shortened from 55 min to 22 min by IL-6 treatment (p < 0.01). Iron 89-93 interleukin 6 Rattus norvegicus 213-217 9227470-11 1997 These results demonstrate that the iron chelator effectively blocks NF-kappa B activation and coordinate TNF-alpha and IL-6 gene upregulation by HM in cholestatic liver injury or under in vitro lipopolysaccharide stimulation. Iron 35-39 interleukin 6 Rattus norvegicus 119-123 34873429-9 2021 In CFA-saline rats, activities of the IL-6/STAT and BMP/SMAD pathways were enhanced in the liver compared with those in control rats and their levels were further increased in CFA-iron rats, whereas IL-6 expression remained unaffected after IV iron administration. Iron 180-184 interleukin 6 Rattus norvegicus 38-42 34873429-9 2021 In CFA-saline rats, activities of the IL-6/STAT and BMP/SMAD pathways were enhanced in the liver compared with those in control rats and their levels were further increased in CFA-iron rats, whereas IL-6 expression remained unaffected after IV iron administration. Iron 244-248 interleukin 6 Rattus norvegicus 38-42 29382887-5 2018 The FE group decreased the retroperitoneal adipose tissue relative weight and SOD activity, but increased adiponectin, LPS, IL-10 and IL-6 content and IL-10/TNF-alpha ratio in retroperitoneal, IL-10 and TNF-alpha content in gonadal, and IL-6 content in mesenteric adipose tissues. Iron 4-6 interleukin 6 Rattus norvegicus 237-241 32077535-2 2020 NTBI can be taken up by cells expressing Zrt-, Irt-like protein-14 (ZIP14), which is regulated by iron overload and pro-inflammatory cytokines, for example, interleukin-1beta (IL-1beta) and IL-6. Iron 98-102 interleukin 6 Rattus norvegicus 190-194 30584425-6 2018 On the other hand, iron overload increased IL6 and reduced IL10 in small intestinal tissues reflecting inflammatory condition and increased caspase 3 reactivity indicating apoptosis and increased iNOs expressing cell indicting oxidative stress especially in ileum. Iron 19-23 interleukin 6 Rattus norvegicus 43-46 31931255-1 2020 The aim of the study was to evaluate the effect of dietary supplementation with chosen minerals (Zn, Se, Fe) on expression of selected cytokines (IL-1, IL-6, TNFalpha) in spleen of rats and on their concentrations in rat serum under inflammatory and pathological conditions obtained by implantation of prostate cancer cells (LnCaP). Iron 105-107 interleukin 6 Rattus norvegicus 152-156 31524964-0 2019 Alcohol"s dysregulation of maternal-fetal IL-6 and p-STAT3 is a function of maternal iron status. Iron 85-89 interleukin 6 Rattus norvegicus 42-46 31524964-4 2019 Here, we hypothesize that iron status and PAE dysregulate the major upstream pathways that govern hepcidin production - EPO/BMP6/SMAD and IL-6/JAK2/STAT3. Iron 26-30 interleukin 6 Rattus norvegicus 138-142 31524964-11 2019 Dietary iron fortification sharply attenuated Il-6 expression in response to PAE, with IF driving a 150-fold decrease (P<0.001) in maternal liver and a 10-fold decrease (P<0.01) in fetal liver. Iron 8-12 interleukin 6 Rattus norvegicus 46-50 30910397-9 2019 Iron-overload caused a graded increase (p < 0.05) in serum iron, ferritin, transferrin, creatinine, urea, IL-6, TNF-alpha, TAC, MDA and NO levels as well as a reduction in albumin levels, renal SOD and GSH in groups 2 (iron 15 mg/kg) and 3 (iron 30 mg/kg) respectively compared to control. Iron 0-4 interleukin 6 Rattus norvegicus 109-113 29909454-11 2019 OGDR and iron reduced the cell viability and increased the expression of TLR-4 associated proteins (RIP3, MyD88, phospho-NF-kB, and release of IL-6) in BMVECs from diabetic animals. Iron 9-13 interleukin 6 Rattus norvegicus 143-147 29382887-5 2018 The FE group decreased the retroperitoneal adipose tissue relative weight and SOD activity, but increased adiponectin, LPS, IL-10 and IL-6 content and IL-10/TNF-alpha ratio in retroperitoneal, IL-10 and TNF-alpha content in gonadal, and IL-6 content in mesenteric adipose tissues. Iron 4-6 interleukin 6 Rattus norvegicus 134-138 25516512-2 2014 The mechanism involves not only hepcidin, the key hormone in iron metabolism, but also iron-related proteins and signaling-transduction molecules, such as IL-6 and signal transducer and activator of transcription 3 (Stat3). Iron 87-91 interleukin 6 Rattus norvegicus 155-159 29122540-10 2018 At the same time, with iron intervention, the concentrations of serum SOD decreased but MDA increased; the mRNA expression of osteocalcin and osteoprotegerin (OPG) decreased, whereas that of receptor activator of nuclear factor kappa B ligand (RANKL) and IL-6 increased significantly. Iron 23-27 interleukin 6 Rattus norvegicus 255-259 25907691-2 2015 BMP and IL-6 signaling act via Smad and Stat3 transcription factors, respectively, to increase expression of hepcidin, the master regulator of iron metabolism. Iron 143-147 interleukin 6 Rattus norvegicus 8-12 24365882-8 2014 This uptake was further enhanced in the presence of AP cytokines with a maximum iron uptake (481 +- 25.81 microg/g of protein) after concomitant administration of IL-6 + iron to cultured hepatocytes. Iron 80-84 interleukin 6 Rattus norvegicus 163-167 24365882-10 2014 In contrast, a decreased TfR1 level was detected by IL-6 and iron alone, whereas combination of iron and AP cytokines (mainly IL-6) abrogated the downregulation of TfR1. Iron 96-100 interleukin 6 Rattus norvegicus 126-130 24373749-11 2014 Our results suggest that IL6 released by portal macrophages may regulate hepatocyte hepcidin expression via STAT3 activation during transient iron overload in TAA-induced acute liver injury. Iron 142-146 interleukin 6 Rattus norvegicus 25-28