PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33955709-10 2021 From in vivo and ex vivo experiments, Tfr1 deletion in SCs results in an irreversible depletion of SCs (~60% reduction, P < 0.005) and cell-autonomous defect in SC proliferation and differentiation, leading to skeletal muscle regeneration impairment, followed by labile iron accumulation, lipogenesis, and decreased Gpx4 and Nrf2 protein levels leading to reactive oxygen species scavenger defects. Iron 270-274 transferrin receptor Mus musculus 38-42 33693820-11 2021 Proteins translated from iron-responsive element (IRE)-containing mRNA were altered in abundance; ferritin and ferroportin 1 decreased, while TFRC increased in ID placentas. Iron 25-29 transferrin receptor Mus musculus 142-146 6243376-0 1980 Common pathway for tumor cell uptake of gallium-67 and iron-59 via a transferrin receptor. Iron 55-59 transferrin receptor Mus musculus 69-89 34034544-9 2022 Likewise, decreased expression of Tfrc and Slc40a1, both of which are crucial proteins for iron transportation, was observed in Lif-/- mice and Lif-knockdown ameloblast lineage cell lines, according to quantitative reverse transcription polymerase chain reaction, immunohistochemistry, and Western blot. Iron 91-95 transferrin receptor Mus musculus 34-38 33955709-14 2021 However, intramuscular administration of lentivirus-expressing Tfr1 could partially reduce labile iron accumulation, decrease lipogenesis, and promote skeletal muscle regeneration. Iron 98-102 transferrin receptor Mus musculus 63-67 33493903-3 2021 Subsequent investigations showed that the increased iron in the liver and spleen was due to phosphorylated extracellular regulated protein kinases (pERK) mediated up-regulation of transferrin receptor 1 (TfR1), and nuclear factor erythroid 2-related factor-2 (Nrf2)-dependent down-regulation of ferroportin 1. Iron 52-56 transferrin receptor Mus musculus 180-202 33493903-3 2021 Subsequent investigations showed that the increased iron in the liver and spleen was due to phosphorylated extracellular regulated protein kinases (pERK) mediated up-regulation of transferrin receptor 1 (TfR1), and nuclear factor erythroid 2-related factor-2 (Nrf2)-dependent down-regulation of ferroportin 1. Iron 52-56 transferrin receptor Mus musculus 204-208 33937615-3 2021 The subcellular locations of transferrin receptor and ferroportin 1 in iron-transporting cells in the mouse placenta have not been directly assessed. Iron 71-75 transferrin receptor Mus musculus 29-49 33469535-8 2020 Pro-inflammatory cytokines could disturb cellular iron homeostasis via upregulating iron import proteins, TFR1 and DMT1, downregulating iron efflux protein FPN, thus result in cellular iron overload. Iron 50-54 transferrin receptor Mus musculus 106-110 33837742-8 2021 In neural retina of the mutant mice, reduced Tfrc mRNA was also an indicator of retinal iron overload. Iron 88-92 transferrin receptor Mus musculus 45-49 33402423-8 2021 In neural retina of the mutant mice, reduced Tfrc mRNA was also an indicator of retinal iron overload. Iron 88-92 transferrin receptor Mus musculus 45-49 32129080-6 2020 The reduced expression in TfR1 and Fpn1 is a secondary effect of CPX-induced iron accumulation in the liver and spleen and also partly associated with the suppressed IRP/iron-responsive element system, upregulation of hepcidin, and downregulation of Nrf2. Iron 170-174 transferrin receptor Mus musculus 26-30 33148716-7 2020 In the current study, we report that interaction of the ESAT-6 protein with beta2M causes downregulation of surface HFE, a protein regulating iron homeostasis via interacting with transferrin receptor 1 (TFR1). Iron 142-146 transferrin receptor Mus musculus 204-208 32129080-6 2020 The reduced expression in TfR1 and Fpn1 is a secondary effect of CPX-induced iron accumulation in the liver and spleen and also partly associated with the suppressed IRP/iron-responsive element system, upregulation of hepcidin, and downregulation of Nrf2. Iron 77-81 transferrin receptor Mus musculus 26-30 32763423-7 2020 We applied our new sorting strategy to demonstrate that CD71, which is the transferrin receptor mediating the uptake of transferrin-bound iron, is upregulated in beta-cells during early postnatal weeks. Iron 138-142 transferrin receptor Mus musculus 56-60 32763423-7 2020 We applied our new sorting strategy to demonstrate that CD71, which is the transferrin receptor mediating the uptake of transferrin-bound iron, is upregulated in beta-cells during early postnatal weeks. Iron 138-142 transferrin receptor Mus musculus 75-95 32763423-10 2020 CONCLUSIONS: This study provides a novel and efficient purification method for murine alpha-, beta-, and delta-cells, identifies for the first time CD71 as a post-natal beta-cell-specific marker, and points to a central role for iron metabolism in beta-cell function. Iron 229-233 transferrin receptor Mus musculus 148-152 32971969-5 2020 Mice supplemented with Fe or EPA/DHA had lower soluble transferrin receptor, ferritin and hepcidin than controls, but these effects were attenuated in Fe+EPA/DHA mice. Iron 23-25 transferrin receptor Mus musculus 55-75 32911688-8 2020 Chronic TfRMAb dosing did not alter plasma- and brain-iron measurements, nor brain TfR levels, however, it significantly increased splenic-TfR and -iron. Iron 148-152 transferrin receptor Mus musculus 8-11 31601687-0 2020 Transferrin receptor 1-mediated iron uptake plays an essential role in hematopoiesis. Iron 32-36 transferrin receptor Mus musculus 0-22 31601687-1 2020 Transferrin receptor 1 (Tfr1) mediates the endocytosis of diferric transferrin in order to transport iron, and Tfr1 has been suggested to play an important role in hematopoiesis. Iron 101-105 transferrin receptor Mus musculus 0-22 31601687-1 2020 Transferrin receptor 1 (Tfr1) mediates the endocytosis of diferric transferrin in order to transport iron, and Tfr1 has been suggested to play an important role in hematopoiesis. Iron 101-105 transferrin receptor Mus musculus 24-28 31601687-6 2020 Notably, hemin rescued the colony-forming capacity of Tfr1-deficient HSCs, whereas expressing a mutant Tfr1 that lack the protein"s iron-transporting capacity failed to rescue hematopoiesis. Iron 132-136 transferrin receptor Mus musculus 103-107 31601687-7 2020 These findings provide direct evidence that Tfr1 is essential for hematopoiesis through binding diferric transferrin to supply iron to cells. Iron 127-131 transferrin receptor Mus musculus 44-48 32209423-7 2020 There was an overload of iron, which was characterized by high levels of ferritin (FTL and FTH) and transferrin receptor 1 (TfR1) and low levels of ferroportin 1 (FPN1) in the hippocampus of CIH mice. Iron 25-29 transferrin receptor Mus musculus 100-122 32685019-7 2020 GLRX5 silencing activated iron-starvation response and boosted up intracellular free iron through the iron-responsive element-binding activity of increased iron regulatory protein (increased transferrin receptor and decreased ferritin). Iron 85-89 transferrin receptor Mus musculus 191-211 32685019-7 2020 GLRX5 silencing activated iron-starvation response and boosted up intracellular free iron through the iron-responsive element-binding activity of increased iron regulatory protein (increased transferrin receptor and decreased ferritin). Iron 85-89 transferrin receptor Mus musculus 191-211 32685019-7 2020 GLRX5 silencing activated iron-starvation response and boosted up intracellular free iron through the iron-responsive element-binding activity of increased iron regulatory protein (increased transferrin receptor and decreased ferritin). Iron 85-89 transferrin receptor Mus musculus 191-211 32304700-5 2020 Here, we describe the identification, maturation, characterization, and utilization of a CDP that binds to the transferrin receptor (TfR), a native receptor and BBB transporter for the iron chaperone transferrin. Iron 185-189 transferrin receptor Mus musculus 111-131 32304700-5 2020 Here, we describe the identification, maturation, characterization, and utilization of a CDP that binds to the transferrin receptor (TfR), a native receptor and BBB transporter for the iron chaperone transferrin. Iron 185-189 transferrin receptor Mus musculus 133-136 32209423-7 2020 There was an overload of iron, which was characterized by high levels of ferritin (FTL and FTH) and transferrin receptor 1 (TfR1) and low levels of ferroportin 1 (FPN1) in the hippocampus of CIH mice. Iron 25-29 transferrin receptor Mus musculus 124-128 32209423-8 2020 Decreased levels of TfR1 and FTL proteins observed in HuA treated CIH group, could reduce iron overload in hippocampus. Iron 90-94 transferrin receptor Mus musculus 20-24 32156022-8 2020 Treatment of murine RAW 264.7 macrophages with nanoencapsulated DFO promoted an increased expression of transferrin receptor 1 (TfR1) mRNA, a typical homeostatic response to iron deficiency. Iron 174-178 transferrin receptor Mus musculus 104-126 32346034-7 2020 Using RNA-seq analysis, we identified that an iron uptake-associated gene, transferrin receptor, was upregulated in obese ob/ob mice with LVH. Iron 46-50 transferrin receptor Mus musculus 75-95 32596110-6 2020 Notably, Tfr1 deficiency in interscapular brown adipose tissue (iBAT) leads to the transdifferentiation of brown preadipocytes into white adipocytes and muscle cells; in contrast, long-term exposure to a low-iron diet fails to phenocopy the transdifferentiation effect found in Tfr1-deficient mice. Iron 208-212 transferrin receptor Mus musculus 9-13 32596110-8 2020 Taken together, these findings indicate that Tfr1 plays an essential role in thermogenic adipocytes via both iron-dependent and iron-independent mechanisms. Iron 109-113 transferrin receptor Mus musculus 45-49 32596110-8 2020 Taken together, these findings indicate that Tfr1 plays an essential role in thermogenic adipocytes via both iron-dependent and iron-independent mechanisms. Iron 128-132 transferrin receptor Mus musculus 45-49 32156022-8 2020 Treatment of murine RAW 264.7 macrophages with nanoencapsulated DFO promoted an increased expression of transferrin receptor 1 (TfR1) mRNA, a typical homeostatic response to iron deficiency. Iron 174-178 transferrin receptor Mus musculus 128-132 31661462-6 2020 With maternal iron deficiency, critical transporters mediating placental iron uptake (transferrin receptor 1 [TFR1]) and export (ferroportin [FPN]) were strongly regulated. Iron 14-18 transferrin receptor Mus musculus 86-108 31661462-6 2020 With maternal iron deficiency, critical transporters mediating placental iron uptake (transferrin receptor 1 [TFR1]) and export (ferroportin [FPN]) were strongly regulated. Iron 14-18 transferrin receptor Mus musculus 110-114 31838906-3 2020 TfR1 (transferrin receptor 1) plays a crucial role in cellular iron transport. Iron 63-67 transferrin receptor Mus musculus 0-4 31838906-3 2020 TfR1 (transferrin receptor 1) plays a crucial role in cellular iron transport. Iron 63-67 transferrin receptor Mus musculus 6-28 31337415-9 2019 ATM also increased the expression of iron metabolism-related genes (FABP4, Hmox1, Ferroportin, CD163, TfR1, Ceruloplasmin, FtL1, FtH1) associated with a reduction in iron storage and increased turnover. Iron 37-41 transferrin receptor Mus musculus 102-106 31541184-3 2019 Intracellular iron transport is regulated by transferrin receptor 1 (TfR1). Iron 14-18 transferrin receptor Mus musculus 45-67 31541184-3 2019 Intracellular iron transport is regulated by transferrin receptor 1 (TfR1). Iron 14-18 transferrin receptor Mus musculus 69-73 31541184-9 2019 Level of intracellular iron transport protein, TfR1, was decreased in ischemic adductor muscles. Iron 23-27 transferrin receptor Mus musculus 47-51 31676601-10 2019 These results indicate that DMT1, Fth, and Tfr1 are critical proteins for early postnatal iron uptake and storage in SCs and, as a consequence, for the normal myelination of the PNS.SIGNIFICANCE STATEMENT To determine the function of the divalent metal transporter 1, the transferrin receptor 1, and the ferritin heavy chain in Schwann cell (SC) maturation and myelination, we created 3 conditional KO mice in which these proteins were postnatally deleted in Sox10-positive SCs. Iron 90-94 transferrin receptor Mus musculus 43-47 31676601-10 2019 These results indicate that DMT1, Fth, and Tfr1 are critical proteins for early postnatal iron uptake and storage in SCs and, as a consequence, for the normal myelination of the PNS.SIGNIFICANCE STATEMENT To determine the function of the divalent metal transporter 1, the transferrin receptor 1, and the ferritin heavy chain in Schwann cell (SC) maturation and myelination, we created 3 conditional KO mice in which these proteins were postnatally deleted in Sox10-positive SCs. Iron 90-94 transferrin receptor Mus musculus 272-294 30888858-9 2019 DOX reduced iron transport capacity through reduced transferrin receptor levels in heart and skeletal muscle. Iron 12-16 transferrin receptor Mus musculus 52-72 30692166-6 2019 At the cellular level, the major process redundantly regulated by EPS15 and EPS15L1 is the endocytosis of the transferrin receptor, a pathway that sustains the development of red blood cells and controls iron homeostasis. Iron 204-208 transferrin receptor Mus musculus 110-130 30370692-6 2019 We also provide evidence that under uninflamed conditions, the regulation of Fpn1 and TfR1 expression by H 2 S, both in vivo and in vitro, are mediated by the nitric oxide (NO)/Nrf2 and iron regulatory protein/iron responsive element pathways, respectively, which are independent of IL-6/pSTAT3/hepcidin signals. Iron 186-190 transferrin receptor Mus musculus 86-90 30370692-6 2019 We also provide evidence that under uninflamed conditions, the regulation of Fpn1 and TfR1 expression by H 2 S, both in vivo and in vitro, are mediated by the nitric oxide (NO)/Nrf2 and iron regulatory protein/iron responsive element pathways, respectively, which are independent of IL-6/pSTAT3/hepcidin signals. Iron 210-214 transferrin receptor Mus musculus 86-90 30776286-4 2019 Decreased hepcidin expression increased iron absorption by upregulating transferrin receptor 1 (TfR1) and divalent metal transporter 1 (DMT1) expression, resulting in iron accumulation within cells. Iron 40-44 transferrin receptor Mus musculus 96-100 30593976-6 2019 As expected, we also found that Lf suppressed MPTP-induced excessive iron accumulation and the upregulation of divalent metal transporter (DMT1) and transferrin receptor (TFR), which is the main intracellular iron regulation protein, and subsequently improved the activity of several antioxidant enzymes. Iron 209-213 transferrin receptor Mus musculus 149-169 30593976-6 2019 As expected, we also found that Lf suppressed MPTP-induced excessive iron accumulation and the upregulation of divalent metal transporter (DMT1) and transferrin receptor (TFR), which is the main intracellular iron regulation protein, and subsequently improved the activity of several antioxidant enzymes. Iron 209-213 transferrin receptor Mus musculus 171-174 30383537-1 2018 Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer"s disease (AD). Iron 33-37 transferrin receptor Mus musculus 120-131 30538134-0 2019 Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load. Iron 41-45 transferrin receptor Mus musculus 0-22 30538134-0 2019 Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load. Iron 111-115 transferrin receptor Mus musculus 0-22 30538134-1 2019 Transferrin receptor 1 (Tfr1) mediates uptake of circulating transferrin-bound iron to developing erythroid cells and other cell types. Iron 79-83 transferrin receptor Mus musculus 0-22 30538134-1 2019 Transferrin receptor 1 (Tfr1) mediates uptake of circulating transferrin-bound iron to developing erythroid cells and other cell types. Iron 79-83 transferrin receptor Mus musculus 24-28 30538134-11 2019 We conclude that Tfr1 is redundant for basal hepatocellular iron supply but essential for fine-tuning hepcidin responses according to the iron load of hepatocytes. Iron 60-64 transferrin receptor Mus musculus 17-21 30538134-11 2019 We conclude that Tfr1 is redundant for basal hepatocellular iron supply but essential for fine-tuning hepcidin responses according to the iron load of hepatocytes. Iron 138-142 transferrin receptor Mus musculus 17-21 30538134-12 2019 Our data are consistent with an inhibitory function of Tfr1 on iron signaling to hepcidin via its interaction with Hfe. Iron 63-67 transferrin receptor Mus musculus 55-59 30538134-13 2019 Moreover, they highlight hepatocellular Tfr1 as a link between cellular and systemic iron-regulatory pathways. Iron 85-89 transferrin receptor Mus musculus 40-44 30427936-7 2018 These findings were supported by the observed downregulation of bone metabolism markers and upregulation of ferritin heavy polypeptide 1 (Fth1) and transferrin receptor-1 (Tfrc), which are associated with iron toxicity and bone loss phenotype. Iron 205-209 transferrin receptor Mus musculus 148-170 30427936-7 2018 These findings were supported by the observed downregulation of bone metabolism markers and upregulation of ferritin heavy polypeptide 1 (Fth1) and transferrin receptor-1 (Tfrc), which are associated with iron toxicity and bone loss phenotype. Iron 205-209 transferrin receptor Mus musculus 172-176 30761254-5 2019 Although an antitransferrin receptor 1 (TfR1) monoclonal antibody inhibited both enucleation and hemoglobin synthesis promoted by holo-Tf, it inhibited only enucleation, but not hemoglobin synthesis, promoted by hinokitiol plus iron. Iron 228-232 transferrin receptor Mus musculus 40-44 30991414-11 2019 Thus, in CKD, decreased expression of TfR1 in erythroblasts as well as increased hepcidin levels in circulation may hamper erythroblast differentiation by decreasing the iron supply, as iron is an indispensable component of erythroblast differentiation. Iron 170-174 transferrin receptor Mus musculus 38-42 30383537-4 2018 Specifically, Fe stimulated the expression of mPGES-1 and the production of PGE2 and PGD2 via the Tf and TfR system. Iron 14-16 transferrin receptor Mus musculus 105-108 30383537-1 2018 Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer"s disease (AD). Iron 33-37 transferrin receptor Mus musculus 133-136 30383537-1 2018 Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer"s disease (AD). Iron 87-91 transferrin receptor Mus musculus 120-131 30383537-1 2018 Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer"s disease (AD). Iron 87-91 transferrin receptor Mus musculus 133-136 30383537-1 2018 Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer"s disease (AD). Iron 97-99 transferrin receptor Mus musculus 120-131 30383537-1 2018 Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer"s disease (AD). Iron 97-99 transferrin receptor Mus musculus 133-136 30169712-5 2018 Methods: Nonanemic, hippocampus-specific neuronal ID was generated by using a Tet-OFF dominant negative transferrin receptor (DN-TFR1) mouse model that impairs cellular iron uptake. Iron 169-173 transferrin receptor Mus musculus 104-124 28151426-3 2017 Transferrin-bound iron binding to transferrin receptor 1 (TfR1) is essential for cellular iron delivery during erythropoiesis. Iron 18-22 transferrin receptor Mus musculus 34-56 30002810-7 2018 Analysis of iron homeostatic proteins revealed increased expression of IRP1, Tf, ferritin and TfR in N171-82Q mice striatum and cortex. Iron 12-16 transferrin receptor Mus musculus 94-97 29406047-5 2018 RESULTS: HSC expressed the iron-uptake protein transferrin receptor 1 (TfR1) and the iron-export protein ferroportin. Iron 27-31 transferrin receptor Mus musculus 47-69 29406047-5 2018 RESULTS: HSC expressed the iron-uptake protein transferrin receptor 1 (TfR1) and the iron-export protein ferroportin. Iron 27-31 transferrin receptor Mus musculus 71-75 28538180-0 2017 Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs. Iron 20-24 transferrin receptor Mus musculus 60-82 28538180-2 2017 The mRNA of the iron-controlling gene, transferrin receptor 1 (TfR1), has long been believed to be negatively regulated by a yet-unidentified endonuclease. Iron 16-20 transferrin receptor Mus musculus 39-61 28538180-2 2017 The mRNA of the iron-controlling gene, transferrin receptor 1 (TfR1), has long been believed to be negatively regulated by a yet-unidentified endonuclease. Iron 16-20 transferrin receptor Mus musculus 63-67 30002810-5 2018 Iron homeostatic proteins including iron response protein 1 (IRP1), transferrin (Tf), ferritin and transferrin receptor (TfR) were determined by using western blotting and immunohistochemistry, and their relative expression levels of RNA were measured by RT-PCR in both N171-82Q HD transgenic mice and HEK293 cells expressing N-terminal of huntingtin. Iron 0-4 transferrin receptor Mus musculus 121-124 29296759-4 2017 However, mice lacking TfR1 or DMT1 demonstrate residual erythropoiesis, suggesting additional pathways for iron use. Iron 107-111 transferrin receptor Mus musculus 22-26 27736268-2 2017 Iron complexed to transferrin is delivered to the metabolism after endocytosis via the CD71 surface receptor. Iron 0-4 transferrin receptor Mus musculus 87-91 28151426-3 2017 Transferrin-bound iron binding to transferrin receptor 1 (TfR1) is essential for cellular iron delivery during erythropoiesis. Iron 18-22 transferrin receptor Mus musculus 58-62 28151426-3 2017 Transferrin-bound iron binding to transferrin receptor 1 (TfR1) is essential for cellular iron delivery during erythropoiesis. Iron 90-94 transferrin receptor Mus musculus 34-56 28151426-3 2017 Transferrin-bound iron binding to transferrin receptor 1 (TfR1) is essential for cellular iron delivery during erythropoiesis. Iron 90-94 transferrin receptor Mus musculus 58-62 28151426-7 2017 These findings strongly suggest that overexpressed TfR1 may play a regulatory role contributing to iron overload and anemia in beta-thalassemic mice. Iron 99-103 transferrin receptor Mus musculus 51-55 28151426-10 2017 Our data demonstrate for the first time that TfR1+/- haploinsufficiency reverses iron overload specifically in beta-thalassemic erythroid precursors. Iron 81-85 transferrin receptor Mus musculus 45-49 28151426-11 2017 Taken together, decreasing TfR1 expression during beta-thalassemic erythropoiesis, either directly via induced haploinsufficiency or via exogenous apotransferrin, decreases ineffective erythropoiesis and provides an endogenous mechanism to upregulate hepcidin, leading to sustained iron-restricted erythropoiesis and preventing systemic iron overload in beta-thalassemic mice. Iron 282-286 transferrin receptor Mus musculus 27-31 28151426-11 2017 Taken together, decreasing TfR1 expression during beta-thalassemic erythropoiesis, either directly via induced haploinsufficiency or via exogenous apotransferrin, decreases ineffective erythropoiesis and provides an endogenous mechanism to upregulate hepcidin, leading to sustained iron-restricted erythropoiesis and preventing systemic iron overload in beta-thalassemic mice. Iron 337-341 transferrin receptor Mus musculus 27-31 26870796-2 2015 We used a tissue-specific conditional knockout strategy to ask whether skeletal muscle required Tfr1 for iron uptake. Iron 105-109 transferrin receptor Mus musculus 96-100 27755990-8 2017 CONCLUSIONS: ALA could up-regulate TfR1, DMT1 and ferritin expression when iron is increased outside of the cell, promoting iron deposition into ferritin by increasing cell iron uptake, and then reducing free iron both inside and outside of the cell. Iron 75-79 transferrin receptor Mus musculus 35-39 27711215-7 2016 Interestingly, the clones showed also altered level of TfR1 and ferritin, indices of a modified iron homeostasis. Iron 96-100 transferrin receptor Mus musculus 55-59 26419445-3 2016 Transferrin receptor 1 (TfR1) plays a key role in cellular iron transport. Iron 59-63 transferrin receptor Mus musculus 0-22 26419445-3 2016 Transferrin receptor 1 (TfR1) plays a key role in cellular iron transport. Iron 59-63 transferrin receptor Mus musculus 24-28 26797126-5 2016 Our findings suggest that IRP2 regulates the 24-h rhythm of transferrin receptor 1 (Tfr1) mRNA expression post-transcriptionally, by binding to RNA stem-loop structures known as iron-response elements. Iron 178-182 transferrin receptor Mus musculus 60-82 26797126-5 2016 Our findings suggest that IRP2 regulates the 24-h rhythm of transferrin receptor 1 (Tfr1) mRNA expression post-transcriptionally, by binding to RNA stem-loop structures known as iron-response elements. Iron 178-182 transferrin receptor Mus musculus 84-88 26456827-2 2015 We hypothesized that the transferrin receptor (Tfr1) might play a role in cardiac iron uptake and used gene targeting to examine the role of Tfr1 in vivo. Iron 82-86 transferrin receptor Mus musculus 25-45 26456827-2 2015 We hypothesized that the transferrin receptor (Tfr1) might play a role in cardiac iron uptake and used gene targeting to examine the role of Tfr1 in vivo. Iron 82-86 transferrin receptor Mus musculus 47-51 26456827-3 2015 Surprisingly, we found that decreased iron, due to inactivation of Tfr1, was associated with severe cardiac consequences. Iron 38-42 transferrin receptor Mus musculus 67-71 27686598-7 2017 The increased iron content in bone was mainly a result of the upregulation of transferrin receptor 1 (TfR1) and divalent metal transporter 1 with iron response element (DMT1+IRE), rather than changes in the iron transporter ferroportin 1 (FPN1). Iron 14-18 transferrin receptor Mus musculus 78-100 27686598-7 2017 The increased iron content in bone was mainly a result of the upregulation of transferrin receptor 1 (TfR1) and divalent metal transporter 1 with iron response element (DMT1+IRE), rather than changes in the iron transporter ferroportin 1 (FPN1). Iron 14-18 transferrin receptor Mus musculus 102-106 27686598-7 2017 The increased iron content in bone was mainly a result of the upregulation of transferrin receptor 1 (TfR1) and divalent metal transporter 1 with iron response element (DMT1+IRE), rather than changes in the iron transporter ferroportin 1 (FPN1). Iron 146-150 transferrin receptor Mus musculus 78-100 26880306-1 2016 Transferrin receptor (TFR) is an important iron transporter regulating iron homeostasis and has long been used as a marker for clathrin mediated endocytosis. Iron 43-47 transferrin receptor Mus musculus 0-20 26880306-1 2016 Transferrin receptor (TFR) is an important iron transporter regulating iron homeostasis and has long been used as a marker for clathrin mediated endocytosis. Iron 43-47 transferrin receptor Mus musculus 22-25 26870796-3 2015 We found that iron assimilation via Tfr1 was critical for skeletal muscle metabolism, and that iron deficiency in muscle led to dramatic changes, not only in muscle, but also in adipose tissue and liver. Iron 14-18 transferrin receptor Mus musculus 36-40 25715406-8 2015 Systemic iron homeostasis is not compromised in Vk*MYC animals, but high expression of the iron importer CD71 by bone marrow plasma cells and iron accumulation in bone marrow macrophages suggest that iron competition takes place in the local multiple myeloma microenvironment, which might contribute to anemia. Iron 91-95 transferrin receptor Mus musculus 105-109 26324903-1 2015 Transferrin receptor 1 (Tfr1) facilitates cellular iron uptake through receptor-mediated endocytosis of iron-loaded transferrin. Iron 51-55 transferrin receptor Mus musculus 0-22 26324903-1 2015 Transferrin receptor 1 (Tfr1) facilitates cellular iron uptake through receptor-mediated endocytosis of iron-loaded transferrin. Iron 51-55 transferrin receptor Mus musculus 24-28 26324903-1 2015 Transferrin receptor 1 (Tfr1) facilitates cellular iron uptake through receptor-mediated endocytosis of iron-loaded transferrin. Iron 104-108 transferrin receptor Mus musculus 0-22 26324903-1 2015 Transferrin receptor 1 (Tfr1) facilitates cellular iron uptake through receptor-mediated endocytosis of iron-loaded transferrin. Iron 104-108 transferrin receptor Mus musculus 24-28 26324903-7 2015 Surprisingly, however, enforced expression of a mutant allele of Tfr1 that is unable to serve as a receptor for iron-loaded transferrin appeared to fully rescue most animals. Iron 112-116 transferrin receptor Mus musculus 65-69 26324903-8 2015 Our results implicate Tfr1 in homeostatic maintenance of the intestinal epithelium, acting through a role that is independent of its iron-uptake function. Iron 133-137 transferrin receptor Mus musculus 22-26 26047483-5 2015 We propose pathways for supplying iron to the lung in iron deficiency and for protecting the lung against iron excess in iron overload, mediated by the co-ordinated action of iron proteins, such as divalent metal transporter 1, ZRT-IRE-like-protein 14, transferrin receptor, ferritin, haemochromatosis-associated protein and ferroportin. Iron 34-38 transferrin receptor Mus musculus 253-273 26047483-13 2015 Divalent metal transporter 1 and TfR increased in iron deficiency, without changes in iron overload. Iron 50-54 transferrin receptor Mus musculus 33-36 26047483-20 2015 We propose the following two novel pathways in the lung: (i) for supplying iron in iron deficiency, mediated principally by DMT1 and TfR and regulated by the action of FPN and HFE; and (ii) for iron detoxification in order to protect the lung against iron overload, facilitated by the action of DMT1, ZIP14, FPN and ferritin. Iron 75-79 transferrin receptor Mus musculus 133-136 26047483-20 2015 We propose the following two novel pathways in the lung: (i) for supplying iron in iron deficiency, mediated principally by DMT1 and TfR and regulated by the action of FPN and HFE; and (ii) for iron detoxification in order to protect the lung against iron overload, facilitated by the action of DMT1, ZIP14, FPN and ferritin. Iron 83-87 transferrin receptor Mus musculus 133-136 26047483-20 2015 We propose the following two novel pathways in the lung: (i) for supplying iron in iron deficiency, mediated principally by DMT1 and TfR and regulated by the action of FPN and HFE; and (ii) for iron detoxification in order to protect the lung against iron overload, facilitated by the action of DMT1, ZIP14, FPN and ferritin. Iron 83-87 transferrin receptor Mus musculus 133-136 26149889-3 2015 Here we conjugated CRT peptide, an iron-mimicry moiety targeting the whole complex of Tf/TfR, to poly(ethylene glycol)-poly(l-lactic-co-glycolic acid) nanoparticles (CRT-NP), to open a new route to overcome such obstacle. Iron 35-39 transferrin receptor Mus musculus 89-92 25715406-8 2015 Systemic iron homeostasis is not compromised in Vk*MYC animals, but high expression of the iron importer CD71 by bone marrow plasma cells and iron accumulation in bone marrow macrophages suggest that iron competition takes place in the local multiple myeloma microenvironment, which might contribute to anemia. Iron 91-95 transferrin receptor Mus musculus 105-109 25715406-8 2015 Systemic iron homeostasis is not compromised in Vk*MYC animals, but high expression of the iron importer CD71 by bone marrow plasma cells and iron accumulation in bone marrow macrophages suggest that iron competition takes place in the local multiple myeloma microenvironment, which might contribute to anemia. Iron 91-95 transferrin receptor Mus musculus 105-109 24437279-1 2013 Transferrin receptor 1(TfR1) is a key cell surface molecule that regulates the uptake of iron-bound transferrin. Iron 89-93 transferrin receptor Mus musculus 23-27 25860887-5 2015 With manipulation of dietary iron in wild-type mice, Bmp6 and Tfr1 expression in both HCs and NPCs was inversely related, as expected. Iron 29-33 transferrin receptor Mus musculus 62-66 25447561-5 2014 Two genes related to iron metabolism, transferrin receptor 1 (TfR1) and H ferritin (HFt), were quantified by RT-PCR. Iron 21-25 transferrin receptor Mus musculus 38-60 25447561-5 2014 Two genes related to iron metabolism, transferrin receptor 1 (TfR1) and H ferritin (HFt), were quantified by RT-PCR. Iron 21-25 transferrin receptor Mus musculus 62-66 24569067-8 2014 The expressions of divalent metal transporter 1, zinc transporter member 14, mucolipin 1, transferrin receptor 1 (TfR1) and ferritin were up-regulated by ethanol and/or iron, which were partially normalized by quercetin. Iron 169-173 transferrin receptor Mus musculus 90-112 24569067-8 2014 The expressions of divalent metal transporter 1, zinc transporter member 14, mucolipin 1, transferrin receptor 1 (TfR1) and ferritin were up-regulated by ethanol and/or iron, which were partially normalized by quercetin. Iron 169-173 transferrin receptor Mus musculus 114-118 24847265-1 2014 Transferrin receptor 2 (TFR2), a protein homologous to the cell iron importer TFR1, is expressed in the liver and erythroid cells and is reported to bind diferric transferrin, although at lower affinity than TFR1. Iron 64-68 transferrin receptor Mus musculus 78-82 24359955-1 2014 The transferrin receptor (TfR) is responsible for iron uptake through its trafficking between the plasma membrane and recycling endosomes, and as a result it has become a well-known marker for recycling endosomes. Iron 50-54 transferrin receptor Mus musculus 4-24 24359955-1 2014 The transferrin receptor (TfR) is responsible for iron uptake through its trafficking between the plasma membrane and recycling endosomes, and as a result it has become a well-known marker for recycling endosomes. Iron 50-54 transferrin receptor Mus musculus 26-29 24437279-3 2013 Thus, intracellular targeting using iron-saturated Tf as a ligand for TfR-mediated endocytosis has attracted attention. Iron 36-40 transferrin receptor Mus musculus 70-73 23741765-3 2004 The TF receptor (TFRC) mediates the internalization of iron-loaded TF into cells (1, 2). Iron 55-59 transferrin receptor Mus musculus 4-15 24146952-7 2013 Analysis of iron homeostatic proteins in R6/2 HD mice revealed decreased levels of the iron response proteins (IRPs 1 and 2) and accordingly decreased expression of iron uptake transferrin receptor (TfR) and increased levels of neuronal iron export protein ferroportin (FPN). Iron 12-16 transferrin receptor Mus musculus 177-197 24146952-7 2013 Analysis of iron homeostatic proteins in R6/2 HD mice revealed decreased levels of the iron response proteins (IRPs 1 and 2) and accordingly decreased expression of iron uptake transferrin receptor (TfR) and increased levels of neuronal iron export protein ferroportin (FPN). Iron 12-16 transferrin receptor Mus musculus 199-202 23615502-1 2013 Hepcidin, the key regulatory hormone of iron homeostasis, and iron carriers such as transferrin receptor1 (TFR1), divalent metal transporter1 (DMT1), and ferroportin (FPN) are expressed in kidney. Iron 62-66 transferrin receptor Mus musculus 84-105 23741765-3 2004 The TF receptor (TFRC) mediates the internalization of iron-loaded TF into cells (1, 2). Iron 55-59 transferrin receptor Mus musculus 17-21 22560353-3 2012 Here, we demonstrated for the first time that hepcidin can significantly inhibit the expression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 in addition to Fpn1, and therefore reduce transferrin-bound iron and non-transferrin-bound iron uptake and also iron release in J774 macrophages. Iron 222-226 transferrin receptor Mus musculus 99-121 23303869-6 2013 This effect was shown to be iron-dependent, because iron repletion at postnatal d 21 normalized mTOR activity in the reversible DN TfR-1 model (62% reduction compared with unrepleted mice; P < 0.05). Iron 28-32 transferrin receptor Mus musculus 131-136 23303869-6 2013 This effect was shown to be iron-dependent, because iron repletion at postnatal d 21 normalized mTOR activity in the reversible DN TfR-1 model (62% reduction compared with unrepleted mice; P < 0.05). Iron 52-56 transferrin receptor Mus musculus 131-136 23086747-3 2013 To verify this speculation, we first confirmed the transcriptional changes of several key iron homeostasis- related genes, such as Tfrc, Trf, and Lcn2, using quantitative PCR, and found that an iron ion chelator, desferrioxamine, could alleviate the transcriptional alterations of two typical genes, Tfrc and Lcn2. Iron 90-94 transferrin receptor Mus musculus 131-135 23086747-3 2013 To verify this speculation, we first confirmed the transcriptional changes of several key iron homeostasis- related genes, such as Tfrc, Trf, and Lcn2, using quantitative PCR, and found that an iron ion chelator, desferrioxamine, could alleviate the transcriptional alterations of two typical genes, Tfrc and Lcn2. Iron 194-198 transferrin receptor Mus musculus 131-135 23086747-3 2013 To verify this speculation, we first confirmed the transcriptional changes of several key iron homeostasis- related genes, such as Tfrc, Trf, and Lcn2, using quantitative PCR, and found that an iron ion chelator, desferrioxamine, could alleviate the transcriptional alterations of two typical genes, Tfrc and Lcn2. Iron 194-198 transferrin receptor Mus musculus 300-304 22560353-3 2012 Here, we demonstrated for the first time that hepcidin can significantly inhibit the expression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 in addition to Fpn1, and therefore reduce transferrin-bound iron and non-transferrin-bound iron uptake and also iron release in J774 macrophages. Iron 253-257 transferrin receptor Mus musculus 123-127 22968581-3 2013 Well characterized examples are that of transferrin receptor (TfR) and intercellular adhesion molecule 1 (ICAM-1), involved in iron transport and leukocyte extravasation, respectively. Iron 127-131 transferrin receptor Mus musculus 40-60 22968581-3 2013 Well characterized examples are that of transferrin receptor (TfR) and intercellular adhesion molecule 1 (ICAM-1), involved in iron transport and leukocyte extravasation, respectively. Iron 127-131 transferrin receptor Mus musculus 62-65 23270517-10 2013 Of these, the transferrin receptor (Tfrc) was the only gene differentially regulated by the iron saturated and iron depleted (apo) rhLFs. Iron 92-96 transferrin receptor Mus musculus 14-34 23270517-10 2013 Of these, the transferrin receptor (Tfrc) was the only gene differentially regulated by the iron saturated and iron depleted (apo) rhLFs. Iron 92-96 transferrin receptor Mus musculus 36-40 23270517-10 2013 Of these, the transferrin receptor (Tfrc) was the only gene differentially regulated by the iron saturated and iron depleted (apo) rhLFs. Iron 111-115 transferrin receptor Mus musculus 14-34 23270517-10 2013 Of these, the transferrin receptor (Tfrc) was the only gene differentially regulated by the iron saturated and iron depleted (apo) rhLFs. Iron 111-115 transferrin receptor Mus musculus 36-40 23328867-1 2013 PURPOSE: Transferrin receptor (TfR) is a cell membrane-associated glycoprotein involved in the cellular uptake of iron and the regulation of cell growth. Iron 114-118 transferrin receptor Mus musculus 9-29 23328867-1 2013 PURPOSE: Transferrin receptor (TfR) is a cell membrane-associated glycoprotein involved in the cellular uptake of iron and the regulation of cell growth. Iron 114-118 transferrin receptor Mus musculus 31-34 22560353-3 2012 Here, we demonstrated for the first time that hepcidin can significantly inhibit the expression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 in addition to Fpn1, and therefore reduce transferrin-bound iron and non-transferrin-bound iron uptake and also iron release in J774 macrophages. Iron 222-226 transferrin receptor Mus musculus 123-127 22560353-3 2012 Here, we demonstrated for the first time that hepcidin can significantly inhibit the expression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 in addition to Fpn1, and therefore reduce transferrin-bound iron and non-transferrin-bound iron uptake and also iron release in J774 macrophages. Iron 253-257 transferrin receptor Mus musculus 99-121 22560353-3 2012 Here, we demonstrated for the first time that hepcidin can significantly inhibit the expression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 in addition to Fpn1, and therefore reduce transferrin-bound iron and non-transferrin-bound iron uptake and also iron release in J774 macrophages. Iron 253-257 transferrin receptor Mus musculus 123-127 22560353-3 2012 Here, we demonstrated for the first time that hepcidin can significantly inhibit the expression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 in addition to Fpn1, and therefore reduce transferrin-bound iron and non-transferrin-bound iron uptake and also iron release in J774 macrophages. Iron 253-257 transferrin receptor Mus musculus 99-121 22616905-1 2012 As the transport protein for iron, transferrin can trigger cellular endocytosis once binding to its receptor (TfR) on the cell membrane. Iron 29-33 transferrin receptor Mus musculus 110-113 22367974-5 2012 To circumvent these confounds, we developed transgenic mice that express tetracycline transactivator regulated, dominant negative transferrin receptor (DNTfR1) in hippocampal neurons, disrupting TfR1 mediated iron uptake specifically in CA1 pyramidal neurons. Iron 209-213 transferrin receptor Mus musculus 130-150 22367974-5 2012 To circumvent these confounds, we developed transgenic mice that express tetracycline transactivator regulated, dominant negative transferrin receptor (DNTfR1) in hippocampal neurons, disrupting TfR1 mediated iron uptake specifically in CA1 pyramidal neurons. Iron 209-213 transferrin receptor Mus musculus 154-158 22496346-6 2012 The localization and regulation of proteins involved in iron import, storage, and export such as transferrin, transferrin receptor, the divalent metal transporter-1, cytosolic ferritin, and ferroportin strongly support a model of a largely autonomous iron cycle within seminiferous tubules. Iron 56-60 transferrin receptor Mus musculus 110-130 22496346-6 2012 The localization and regulation of proteins involved in iron import, storage, and export such as transferrin, transferrin receptor, the divalent metal transporter-1, cytosolic ferritin, and ferroportin strongly support a model of a largely autonomous iron cycle within seminiferous tubules. Iron 251-255 transferrin receptor Mus musculus 110-130 22019886-6 2011 Expression of human IgA1 or treatment of wild-type mice with the TfR1 ligands pIgA1 or iron-loaded transferrin (Fe-Tf) accelerated recovery from acute anemia. Iron 87-91 transferrin receptor Mus musculus 65-69 22019713-1 2012 Transferrin receptor-1 (TfR1) is a cell membrane-associated glycoprotein responsible for incorporation of the iron bound to transferrin through an endocytotic process from the circulating blood. Iron 110-114 transferrin receptor Mus musculus 0-22 22019713-1 2012 Transferrin receptor-1 (TfR1) is a cell membrane-associated glycoprotein responsible for incorporation of the iron bound to transferrin through an endocytotic process from the circulating blood. Iron 110-114 transferrin receptor Mus musculus 24-28 22019713-4 2012 Marked mRNA expression was seen for various iron-related genes such as TfR1 in cultured mouse neocortical neurons, while TfR1 mRNA levels were more than doubled during culture from 3 to 6days. Iron 44-48 transferrin receptor Mus musculus 71-75 22019713-7 2012 Overexpression of TfR1 significantly decreased the length of neurite elongated, however, while significant promotion was invariably seen in the neurite elongation in Neuro2A cells transfected with TfR1 siRNA as well as in Neuro2A cells cultured with an iron chelator. Iron 253-257 transferrin receptor Mus musculus 18-22 21903580-0 2011 5-aza-2"-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of transferrin receptor 1 (TfR1) and ferrochelatase (Fech) genes. Iron 33-37 transferrin receptor Mus musculus 138-160 21903580-0 2011 5-aza-2"-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of transferrin receptor 1 (TfR1) and ferrochelatase (Fech) genes. Iron 33-37 transferrin receptor Mus musculus 162-166 21655188-6 2011 In irradiated recipients that received hmox(+/-) or hmox(+/+) bone marrow cells, we evaluated (i) the erythrocyte parameters in the peripheral blood; (ii) the staining intensity of CD71-, Ter119-, and CD49d-specific surface markers during erythroblast differentiation; (iii) the patterns of histological iron staining; and (iv) the number of Mac-1(+)-cells expressing TNF-alpha. Iron 304-308 transferrin receptor Mus musculus 181-185 21326867-6 2011 Despite iron accumulation within mitochondria, we found increased expression of transferrin receptor, Tfrc, at both the transcript and protein level in SOD2 deficient cells, suggesting deregulation of iron delivery. Iron 201-205 transferrin receptor Mus musculus 80-100 21326867-6 2011 Despite iron accumulation within mitochondria, we found increased expression of transferrin receptor, Tfrc, at both the transcript and protein level in SOD2 deficient cells, suggesting deregulation of iron delivery. Iron 201-205 transferrin receptor Mus musculus 102-106 21183793-3 2011 Specifically, we demonstrated that phage clones displaying an iron-mimic peptide were able to target a protein complex of transferrin and transferrin receptor (TfR) through a non-canonical allosteric binding mechanism and that this functional protein complex mediated transport of the corresponding viral particles into the normal mouse brain. Iron 62-66 transferrin receptor Mus musculus 138-158 21183793-3 2011 Specifically, we demonstrated that phage clones displaying an iron-mimic peptide were able to target a protein complex of transferrin and transferrin receptor (TfR) through a non-canonical allosteric binding mechanism and that this functional protein complex mediated transport of the corresponding viral particles into the normal mouse brain. Iron 62-66 transferrin receptor Mus musculus 160-163 21051716-4 2011 Transferrin receptor mRNA (Tfrc), an indicator of iron levels, was quantified by qPCR. Iron 50-54 transferrin receptor Mus musculus 0-20 21051716-4 2011 Transferrin receptor mRNA (Tfrc), an indicator of iron levels, was quantified by qPCR. Iron 50-54 transferrin receptor Mus musculus 27-31 21346313-5 2011 Furthermore, we documented that both iron chelators significantly attenuated the elevated iron level and transferrin receptor expression, decreased oxygen free radicals and suppressed microglial and astrocytic activation in the spinal cords of the SOD1(G93A) mice. Iron 37-41 transferrin receptor Mus musculus 105-125 19252502-6 2009 Owing to the heightened iron demand in osteoclast development, transferrin receptor 1 (TfR1) expression was induced post-transcriptionally via iron regulatory protein 2. Iron 24-28 transferrin receptor Mus musculus 63-85 19596281-6 2009 Upregulation of transferrin receptor 1 (TfR1) in brain microvasculature appears to mediate the compensatory iron uptake during postnatal development and iron content in Pcm brain is restored to wild-type levels by 7 weeks of age. Iron 108-112 transferrin receptor Mus musculus 16-38 19596281-6 2009 Upregulation of transferrin receptor 1 (TfR1) in brain microvasculature appears to mediate the compensatory iron uptake during postnatal development and iron content in Pcm brain is restored to wild-type levels by 7 weeks of age. Iron 108-112 transferrin receptor Mus musculus 40-44 19596281-6 2009 Upregulation of transferrin receptor 1 (TfR1) in brain microvasculature appears to mediate the compensatory iron uptake during postnatal development and iron content in Pcm brain is restored to wild-type levels by 7 weeks of age. Iron 153-157 transferrin receptor Mus musculus 16-38 19596281-6 2009 Upregulation of transferrin receptor 1 (TfR1) in brain microvasculature appears to mediate the compensatory iron uptake during postnatal development and iron content in Pcm brain is restored to wild-type levels by 7 weeks of age. Iron 153-157 transferrin receptor Mus musculus 40-44 20631077-1 2010 The abundance of cell surface levels of transferrin receptor 1 (TfR1), which regulates the uptake of iron-bound transferring, correlates with the rate of cell proliferation. Iron 101-105 transferrin receptor Mus musculus 40-62 20631077-1 2010 The abundance of cell surface levels of transferrin receptor 1 (TfR1), which regulates the uptake of iron-bound transferring, correlates with the rate of cell proliferation. Iron 101-105 transferrin receptor Mus musculus 64-68 20098432-2 2010 These complications are caused by labile plasma iron, which is taken up by parenchymal cells in a dysregulated manner; in contrast, erythropoiesis depends on transferrin-bound iron uptake via the transferrin receptor. Iron 176-180 transferrin receptor Mus musculus 196-216 19235734-4 2009 Flow cytometric analysis of developing Nme1(-/-)/Nme2(-/-) erythroid cells indicated that the major iron transport receptor molecule TfR1 is attenuated concomitant with a reduction of intracellular iron, suggesting that TfR1 is a downstream target of NDPKs and that reduced iron in Nme1(-/-)/Nme2(-/-) erythroblasts is inhibiting their development. Iron 100-104 transferrin receptor Mus musculus 133-137 19235734-4 2009 Flow cytometric analysis of developing Nme1(-/-)/Nme2(-/-) erythroid cells indicated that the major iron transport receptor molecule TfR1 is attenuated concomitant with a reduction of intracellular iron, suggesting that TfR1 is a downstream target of NDPKs and that reduced iron in Nme1(-/-)/Nme2(-/-) erythroblasts is inhibiting their development. Iron 198-202 transferrin receptor Mus musculus 133-137 19252502-7 2009 TfR1-mediated iron uptake promoted osteoclast differentiation and bone-resorbing activity, associated with the induction of mitochondrial respiration, production of reactive oxygen species and accelerated Ppargc1b transcription. Iron 14-18 transferrin receptor Mus musculus 0-4 19252502-9 2009 These data establish mitochondrial biogenesis orchestrated by PGC-1beta, coupled with iron uptake through TfR1 and iron supply to mitochondrial respiratory proteins, as a fundamental pathway linked to osteoclast activation and bone metabolism. Iron 86-90 transferrin receptor Mus musculus 106-110 19252502-6 2009 Owing to the heightened iron demand in osteoclast development, transferrin receptor 1 (TfR1) expression was induced post-transcriptionally via iron regulatory protein 2. Iron 24-28 transferrin receptor Mus musculus 87-91 18694996-0 2008 Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1. Iron 25-29 transferrin receptor Mus musculus 70-75 19013457-10 2009 A significant correlation (r(2)=0.79) was found between a primary marker of cellular iron status (transferrin receptor (TfR)) and A(2A)R protein density. Iron 85-89 transferrin receptor Mus musculus 98-118 19013457-10 2009 A significant correlation (r(2)=0.79) was found between a primary marker of cellular iron status (transferrin receptor (TfR)) and A(2A)R protein density. Iron 85-89 transferrin receptor Mus musculus 120-123 18685102-1 2008 In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts. Iron 58-62 transferrin receptor Mus musculus 272-294 18552213-2 2008 Serum iron is bound to transferrin and enters erythroid cells primarily via receptor-mediated endocytosis of the transferrin receptor (Tfr1). Iron 6-10 transferrin receptor Mus musculus 113-133 18552213-2 2008 Serum iron is bound to transferrin and enters erythroid cells primarily via receptor-mediated endocytosis of the transferrin receptor (Tfr1). Iron 6-10 transferrin receptor Mus musculus 135-139 18552213-11 2008 We conclude that STAT5A/B is an important regulator of iron update in erythroid progenitor cells via its control of Tfr1 transcription. Iron 55-59 transferrin receptor Mus musculus 116-120 18685102-1 2008 In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts. Iron 58-62 transferrin receptor Mus musculus 296-300 18685102-1 2008 In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts. Iron 118-122 transferrin receptor Mus musculus 272-294 18685102-1 2008 In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts. Iron 118-122 transferrin receptor Mus musculus 296-300 18685102-1 2008 In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts. Iron 118-122 transferrin receptor Mus musculus 272-294 18685102-1 2008 In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1) and ferritin H and L subunits, by binding to iron-responsive elements (IREs) within target transcripts. Iron 118-122 transferrin receptor Mus musculus 296-300 18685102-2 2008 Mice that lack IRP2 develop microcytic anemia and neurodegeneration associated with functional cellular iron depletion caused by low TfR1 and high ferritin expression. Iron 104-108 transferrin receptor Mus musculus 133-137 16418170-3 2006 Hepatic and/or duodenal response patterns of iron metabolism genes, such as Trfr, cybrd1, and Slc11a2, explained the transition from early postnatal iron deficiency to iron overload by 12 weeks of age. Iron 45-49 transferrin receptor Mus musculus 76-80 18393371-2 2008 Hepatocytes acquire transferrin-bound iron via transferrin receptor (Tfr) 1 and Tfr1-independent pathways (possibly Tfr2-mediated). Iron 38-42 transferrin receptor Mus musculus 47-75 18393371-2 2008 Hepatocytes acquire transferrin-bound iron via transferrin receptor (Tfr) 1 and Tfr1-independent pathways (possibly Tfr2-mediated). Iron 38-42 transferrin receptor Mus musculus 80-84 18393371-6 2008 Tfr1-mediated iron and transferrin uptake by Hfe knockout hepatocytes were increased by 40% to 70% compared with iron-loaded wild-type hepatocytes with similar iron levels and Tfr1 expression. Iron 14-18 transferrin receptor Mus musculus 0-4 18393371-6 2008 Tfr1-mediated iron and transferrin uptake by Hfe knockout hepatocytes were increased by 40% to 70% compared with iron-loaded wild-type hepatocytes with similar iron levels and Tfr1 expression. Iron 113-117 transferrin receptor Mus musculus 0-4 18393371-6 2008 Tfr1-mediated iron and transferrin uptake by Hfe knockout hepatocytes were increased by 40% to 70% compared with iron-loaded wild-type hepatocytes with similar iron levels and Tfr1 expression. Iron 113-117 transferrin receptor Mus musculus 0-4 18393371-7 2008 Iron and transferrin uptake by the Tfr1-independent pathway was approximately 100-fold greater than by the Tfr1 pathway and was not affected by the absence of Hfe. Iron 0-4 transferrin receptor Mus musculus 35-39 18393371-7 2008 Iron and transferrin uptake by the Tfr1-independent pathway was approximately 100-fold greater than by the Tfr1 pathway and was not affected by the absence of Hfe. Iron 0-4 transferrin receptor Mus musculus 107-111 18393371-9 2008 CONCLUSION: Tfr1-mediated iron uptake is regulated by Hfe in hepatocytes. Iron 26-30 transferrin receptor Mus musculus 12-16 18393371-10 2008 The Tfr1-independent pathway exhibited a much greater capacity for iron uptake than the Tfr1 pathway but it was not regulated by Hfe. Iron 67-71 transferrin receptor Mus musculus 4-8 17949489-10 2007 The expression of transferrin receptor, heat shock protein 1B and DnaJ homolog B1 were down-regulated by iron in both muscle types. Iron 105-109 transferrin receptor Mus musculus 18-38 17264297-2 2007 Identification of a direct interaction between Hfe and transferrin receptor 1 in duodenal cells led to the hypothesis that the lack of functional Hfe in the duodenum affects TfR1-mediated serosal uptake of iron and misprogramming of the iron absorptive cells. Iron 206-210 transferrin receptor Mus musculus 174-178 17241880-9 2007 Levels of the iron-related proteins TfR1, TfR2, ferritin, and prohepcidin were analyzed by immunoblotting. Iron 14-18 transferrin receptor Mus musculus 36-40 16424395-2 2006 Thus, erythroblasts must modify the "standard" post-transcriptional feedback regulation, balancing expression of ferritin (Fer; iron storage) versus transferrin receptor (TfR1; iron uptake) via specific mRNA binding of iron regulatory proteins (IRPs). Iron 177-181 transferrin receptor Mus musculus 171-175 16424395-2 2006 Thus, erythroblasts must modify the "standard" post-transcriptional feedback regulation, balancing expression of ferritin (Fer; iron storage) versus transferrin receptor (TfR1; iron uptake) via specific mRNA binding of iron regulatory proteins (IRPs). Iron 177-181 transferrin receptor Mus musculus 171-175 18519569-8 2008 The consequent changes in TfR1 expression may be involved in modulating iron retention in inflammatory macrophages, thus possibly contributing to the development of hypoferremia in the early phases preceding the down-regulation of macrophage ferroportin by hepcidin. Iron 72-76 transferrin receptor Mus musculus 26-30 18316026-2 2008 We developed mutant mouse strains to gain insight into the role of the Hfe/Tfr1 complex in regulating iron homeostasis. Iron 102-106 transferrin receptor Mus musculus 75-79 18316026-4 2008 Under conditions favoring a constitutive Hfe/Tfr1 interaction, mice developed iron overload attributable to inappropriately low expression of the hormone hepcidin. Iron 78-82 transferrin receptor Mus musculus 45-49 17264297-2 2007 Identification of a direct interaction between Hfe and transferrin receptor 1 in duodenal cells led to the hypothesis that the lack of functional Hfe in the duodenum affects TfR1-mediated serosal uptake of iron and misprogramming of the iron absorptive cells. Iron 237-241 transferrin receptor Mus musculus 174-178 16418170-3 2006 Hepatic and/or duodenal response patterns of iron metabolism genes, such as Trfr, cybrd1, and Slc11a2, explained the transition from early postnatal iron deficiency to iron overload by 12 weeks of age. Iron 149-153 transferrin receptor Mus musculus 76-80 15563524-7 2004 Overexpression of mouse Tfr1, mouse Tfr2, and zebrafish tfr1b partially rescued hypochromia in cia embryos, establishing that each of these transferrin receptors are capable of supporting iron uptake for hemoglobin production in vivo. Iron 188-192 transferrin receptor Mus musculus 24-28 16424878-10 2006 These data show that control of transferrin receptor expression is sufficient to regulate iron content in proliferating or differentiating keratinocytes in the epidermis. Iron 90-94 transferrin receptor Mus musculus 32-52 15710243-5 2005 We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin. Iron 66-70 transferrin receptor Mus musculus 285-307 15710243-5 2005 We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin. Iron 66-70 transferrin receptor Mus musculus 309-313 15710243-5 2005 We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin. Iron 153-157 transferrin receptor Mus musculus 285-307 15710243-5 2005 We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin. Iron 153-157 transferrin receptor Mus musculus 309-313 15710243-5 2005 We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin. Iron 153-157 transferrin receptor Mus musculus 285-307 15710243-5 2005 We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin. Iron 153-157 transferrin receptor Mus musculus 309-313 15710243-5 2005 We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin. Iron 153-157 transferrin receptor Mus musculus 285-307 15710243-5 2005 We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively), regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 (TfR1) and the iron sequestration protein ferritin. Iron 153-157 transferrin receptor Mus musculus 309-313 15710243-10 2005 However, the activities of IRP1 and IRP2, and protein levels of TfR1 and ferritin, were still significantly lower in iron-depleted ScN2a cells as compared to the N2a cells, suggesting lower need for iron in ScN2a cells. Iron 117-121 transferrin receptor Mus musculus 64-68 15956281-7 2005 This study links a classic regulator of cellular iron metabolism to systemic iron homeostasis and erythropoietic TfR1 expression. Iron 49-53 transferrin receptor Mus musculus 113-117 15744772-4 2005 In HFE -/- mice hepcidin formation was diminished upon iron challenge which was associated with decreased hepatic transferrin receptor (TfR)-2 levels. Iron 55-59 transferrin receptor Mus musculus 114-134 15744772-4 2005 In HFE -/- mice hepcidin formation was diminished upon iron challenge which was associated with decreased hepatic transferrin receptor (TfR)-2 levels. Iron 55-59 transferrin receptor Mus musculus 136-139 15389541-2 2005 A non-classical class I MHC molecule, the hemochromatosis factor (HFE), has been shown to regulate iron metabolism, potentially via its interaction with the transferrin receptor. Iron 99-103 transferrin receptor Mus musculus 157-177 15173932-1 2004 HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake. Iron 49-53 transferrin receptor Mus musculus 59-80 15173932-1 2004 HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake. Iron 106-110 transferrin receptor Mus musculus 59-80 15173932-1 2004 HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake. Iron 106-110 transferrin receptor Mus musculus 82-85 15173932-1 2004 HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake. Iron 49-53 transferrin receptor Mus musculus 82-85 10681454-12 2000 From these observations, we propose that TfR2 allows continued uptake of Tf-bound iron by hepatocytes even after TfR has been down-regulated by iron overload, and this uptake contributes to the susceptibility of liver to iron loading in HH. Iron 82-86 transferrin receptor Mus musculus 41-44 12572672-1 2003 Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) which are located in the 3" untranslated region (UTR) and the 5" UTR of their respective mRNAs. Iron 121-125 transferrin receptor Mus musculus 66-87 12572672-1 2003 Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) which are located in the 3" untranslated region (UTR) and the 5" UTR of their respective mRNAs. Iron 121-125 transferrin receptor Mus musculus 89-92 12572672-2 2003 Cellular iron levels affect binding of IRPs to IREs and consequently expression of TfR and ferritin. Iron 9-13 transferrin receptor Mus musculus 83-86 12572672-3 2003 Moreover, NO*, a redox species of nitric oxide that interacts primarily with iron, can activate IRP1 RNA-binding activity resulting in an increase in TfR mRNA levels. Iron 77-81 transferrin receptor Mus musculus 150-153 11535534-5 2001 In MEL cells, expression of TfR1 was induced by desferrioxamine, an iron chelator, and it was reduced by ferric nitrate. Iron 68-72 transferrin receptor Mus musculus 28-32 11445863-0 2001 CD71 antibody enhances iron uptake by mouse bone marrow cells and the survival potential of erythroid progenitor cells. Iron 23-27 transferrin receptor Mus musculus 0-4 11054110-12 2000 These results are of interest as the TfR and Nramp2 are thought to act together during Fe uptake from Tf. Iron 87-89 transferrin receptor Mus musculus 37-40 10864004-4 2000 Mice with haploinsufficiency for TfR are iron deficient and this is thought to be caused by reduced iron absorption. Iron 41-45 transferrin receptor Mus musculus 33-36 10864004-4 2000 Mice with haploinsufficiency for TfR are iron deficient and this is thought to be caused by reduced iron absorption. Iron 100-104 transferrin receptor Mus musculus 33-36 14981211-7 2004 Four genes involved in iron homeostasis were included in the 50 differentially expressed genes [hemochromatosis (Hfe), diaphorase 1, transferrin receptor (Trfr) 2, and protoporphyrinogen oxidase] and two additional iron-related genes did not quite meet the stringent criteria for differential expression (Trfr and lactotransferrin). Iron 23-27 transferrin receptor Mus musculus 133-153 14981211-7 2004 Four genes involved in iron homeostasis were included in the 50 differentially expressed genes [hemochromatosis (Hfe), diaphorase 1, transferrin receptor (Trfr) 2, and protoporphyrinogen oxidase] and two additional iron-related genes did not quite meet the stringent criteria for differential expression (Trfr and lactotransferrin). Iron 23-27 transferrin receptor Mus musculus 155-159 14981211-7 2004 Four genes involved in iron homeostasis were included in the 50 differentially expressed genes [hemochromatosis (Hfe), diaphorase 1, transferrin receptor (Trfr) 2, and protoporphyrinogen oxidase] and two additional iron-related genes did not quite meet the stringent criteria for differential expression (Trfr and lactotransferrin). Iron 23-27 transferrin receptor Mus musculus 305-309 12547230-1 2002 Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) that are located in the 3" untranslated region (UTR) and the 5" UTR of their respective mRNAs. Iron 121-125 transferrin receptor Mus musculus 66-87 12547230-1 2002 Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) that are located in the 3" untranslated region (UTR) and the 5" UTR of their respective mRNAs. Iron 121-125 transferrin receptor Mus musculus 89-92 12547230-2 2002 Cellular iron levels affect binding of IRPs to IREs and consequently expression of TfR and ferritin. Iron 9-13 transferrin receptor Mus musculus 83-86 12547230-4 2002 ), a redox species of nitric oxide that interacts primarily with iron, can activate IRP1 RNA-binding activity resulting in an increase in TfR mRNA levels and a decrease in ferritin synthesis. Iron 65-69 transferrin receptor Mus musculus 138-141 11264285-2 2001 Cellular iron uptake and storage are coordinately controlled by binding of iron-regulatory proteins (IRP), IRP1 and IRP2, to iron-responsive elements (IREs) within the mRNAs encoding transferrin receptor (TfR) and ferritin. Iron 9-13 transferrin receptor Mus musculus 183-203 11264285-2 2001 Cellular iron uptake and storage are coordinately controlled by binding of iron-regulatory proteins (IRP), IRP1 and IRP2, to iron-responsive elements (IREs) within the mRNAs encoding transferrin receptor (TfR) and ferritin. Iron 9-13 transferrin receptor Mus musculus 205-208 11264285-2 2001 Cellular iron uptake and storage are coordinately controlled by binding of iron-regulatory proteins (IRP), IRP1 and IRP2, to iron-responsive elements (IREs) within the mRNAs encoding transferrin receptor (TfR) and ferritin. Iron 75-79 transferrin receptor Mus musculus 183-203 11264285-2 2001 Cellular iron uptake and storage are coordinately controlled by binding of iron-regulatory proteins (IRP), IRP1 and IRP2, to iron-responsive elements (IREs) within the mRNAs encoding transferrin receptor (TfR) and ferritin. Iron 75-79 transferrin receptor Mus musculus 205-208 11264285-3 2001 Under conditions of iron starvation, both IRP1 and IRP2 bind with high affinity to cognate IREs, thus stabilizing TfR and inhibiting translation of ferritin mRNAs. Iron 20-24 transferrin receptor Mus musculus 114-117 11264285-7 2001 Second, treatment with H(2)O(2) induces a approximately 4-fold increase in TfR mRNA levels within 2-6 h, and subsequent accumulation of newly synthesized protein after 4 h. This is associated with a profound increase in the cell surface expression of TfR, enhanced binding to fluorescein-tagged transferrin, and stimulation of transferrin-mediated iron uptake into cells. Iron 348-352 transferrin receptor Mus musculus 251-254 11175792-2 2001 Two distinct but highly homologous proteins, IRP1 and IRP2, bind IREs with high affinity when cells are depleted of iron, inhibiting translation of some transcripts, such as ferritin, or turnover of others, such as the transferrin receptor (TFRC). Iron 116-120 transferrin receptor Mus musculus 219-239 11175792-2 2001 Two distinct but highly homologous proteins, IRP1 and IRP2, bind IREs with high affinity when cells are depleted of iron, inhibiting translation of some transcripts, such as ferritin, or turnover of others, such as the transferrin receptor (TFRC). Iron 116-120 transferrin receptor Mus musculus 241-245 10692416-2 2000 Cellular iron levels affect binding of IRPs to iron-responsive elements and consequently expression of TfR and ferritin. Iron 9-13 transferrin receptor Mus musculus 103-106 10692416-2 2000 Cellular iron levels affect binding of IRPs to iron-responsive elements and consequently expression of TfR and ferritin. Iron 47-51 transferrin receptor Mus musculus 103-106 10692416-3 2000 Moreover, NO(*), a redox species of nitric oxide that interacts primarily with iron, can activate IRP-1 RNA binding activity resulting in an increase in TfR mRNA levels. Iron 79-83 transferrin receptor Mus musculus 153-156 10681454-12 2000 From these observations, we propose that TfR2 allows continued uptake of Tf-bound iron by hepatocytes even after TfR has been down-regulated by iron overload, and this uptake contributes to the susceptibility of liver to iron loading in HH. Iron 144-148 transferrin receptor Mus musculus 41-44 10681454-12 2000 From these observations, we propose that TfR2 allows continued uptake of Tf-bound iron by hepatocytes even after TfR has been down-regulated by iron overload, and this uptake contributes to the susceptibility of liver to iron loading in HH. Iron 144-148 transferrin receptor Mus musculus 41-44 9046063-0 1997 Iron deprivation and cancer: a view beginning with studies of monoclonal antibodies against the transferrin receptor. Iron 0-4 transferrin receptor Mus musculus 96-116 10551872-2 1999 When iron in the intracellular transit pool is scarce, IRPs bind to iron-responsive elements (IREs) in the 5"-untranslated region of the ferritin mRNA and 3"-untranslated region of the transferrin receptor (TfR) mRNA. Iron 5-9 transferrin receptor Mus musculus 185-205 10551872-2 1999 When iron in the intracellular transit pool is scarce, IRPs bind to iron-responsive elements (IREs) in the 5"-untranslated region of the ferritin mRNA and 3"-untranslated region of the transferrin receptor (TfR) mRNA. Iron 5-9 transferrin receptor Mus musculus 207-210 10551872-2 1999 When iron in the intracellular transit pool is scarce, IRPs bind to iron-responsive elements (IREs) in the 5"-untranslated region of the ferritin mRNA and 3"-untranslated region of the transferrin receptor (TfR) mRNA. Iron 68-72 transferrin receptor Mus musculus 185-205 10551872-2 1999 When iron in the intracellular transit pool is scarce, IRPs bind to iron-responsive elements (IREs) in the 5"-untranslated region of the ferritin mRNA and 3"-untranslated region of the transferrin receptor (TfR) mRNA. Iron 68-72 transferrin receptor Mus musculus 207-210 10551872-3 1999 Such binding inhibits translation of ferritin mRNA and stabilizes the mRNA for TfR, whereas the opposite scenario develops when iron in the transit pool is plentiful. Iron 128-132 transferrin receptor Mus musculus 79-82 10077651-2 1999 We recently reported that HFE, the protein defective in HH, was physically associated with the transferrin receptor (TfR) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal crypt cells, leading to up-regulation of transporters for dietary iron. Iron 223-227 transferrin receptor Mus musculus 117-120 10077651-2 1999 We recently reported that HFE, the protein defective in HH, was physically associated with the transferrin receptor (TfR) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal crypt cells, leading to up-regulation of transporters for dietary iron. Iron 318-322 transferrin receptor Mus musculus 117-120 9506827-3 1998 Photofrin significantly increased spleen cell expression of the receptor (CD71) for the iron transport protein transferrin by 72 h post-injection but did not affect levels of a receptor (CD25) for the T-cell growth factor interleukin-2 (IL-2) or spleen cell responsiveness to rIL-2. Iron 88-92 transferrin receptor Mus musculus 74-78 9367630-3 1997 First, we examine the role of mRNA half-life, by studying the distribution of the mRNA for the transferrin receptor (TfR), whose half-life can be manipulated in culture by changing the availability of iron. Iron 201-205 transferrin receptor Mus musculus 95-115 9367630-3 1997 First, we examine the role of mRNA half-life, by studying the distribution of the mRNA for the transferrin receptor (TfR), whose half-life can be manipulated in culture by changing the availability of iron. Iron 201-205 transferrin receptor Mus musculus 117-120 9380695-2 1997 IRPs regulate iron metabolism by binding to iron responsive element(s) (IREs) in the 5" or 3" untranslated region of ferritin or transferrin receptor (TfR) mRNAs. Iron 14-18 transferrin receptor Mus musculus 129-149 9380695-2 1997 IRPs regulate iron metabolism by binding to iron responsive element(s) (IREs) in the 5" or 3" untranslated region of ferritin or transferrin receptor (TfR) mRNAs. Iron 14-18 transferrin receptor Mus musculus 151-154 9380695-2 1997 IRPs regulate iron metabolism by binding to iron responsive element(s) (IREs) in the 5" or 3" untranslated region of ferritin or transferrin receptor (TfR) mRNAs. Iron 44-48 transferrin receptor Mus musculus 129-149 9380695-2 1997 IRPs regulate iron metabolism by binding to iron responsive element(s) (IREs) in the 5" or 3" untranslated region of ferritin or transferrin receptor (TfR) mRNAs. Iron 44-48 transferrin receptor Mus musculus 151-154 9380695-9 1997 In the Ba/F3 family of cells, alterations in iron status modulated ferritin biosynthesis and TfR mRNA level over as much as a 20- and 14-fold range, respectively. Iron 45-49 transferrin receptor Mus musculus 93-96 9545264-2 1998 Both IRPs bind to specific sequences called iron-responsive elements (IREs) located in the 3" or 5" untranslated regions of several mRNAs, in particular mRNA encoding ferritin and transferrin receptor. Iron 44-48 transferrin receptor Mus musculus 180-200 7994765-1 1994 Dividing cells require iron and, therefore, express the transferrin receptor (CD71) on the cell surface to enable internalization of transferrin-bound iron. Iron 23-27 transferrin receptor Mus musculus 78-82 8977218-6 1997 The mRNA levels for the membrane receptor for iron uptake, transferrin receptor (TfR), decrease following stimulation with IFN-gamma/LPS, although IRP-mediated stabilization of the TfR mRNA would have been expected. Iron 46-50 transferrin receptor Mus musculus 59-79 8944690-5 1996 Iron overload produced a decrease in transferrin receptor (TfR) mRNA in the duodenum, with ferritin mRNA levels unaffected in both the duodenum and ileum. Iron 0-4 transferrin receptor Mus musculus 37-57 8944690-5 1996 Iron overload produced a decrease in transferrin receptor (TfR) mRNA in the duodenum, with ferritin mRNA levels unaffected in both the duodenum and ileum. Iron 0-4 transferrin receptor Mus musculus 59-62 7994765-1 1994 Dividing cells require iron and, therefore, express the transferrin receptor (CD71) on the cell surface to enable internalization of transferrin-bound iron. Iron 151-155 transferrin receptor Mus musculus 56-76 7994765-1 1994 Dividing cells require iron and, therefore, express the transferrin receptor (CD71) on the cell surface to enable internalization of transferrin-bound iron. Iron 151-155 transferrin receptor Mus musculus 78-82 8514748-2 1993 In addition, TfR mRNA is post-transcriptionally regulated by intracellular iron. Iron 75-79 transferrin receptor Mus musculus 13-16 8143723-2 1994 In proliferating non-erythroid cells, the expression of transferrin receptors (TfR) is negatively regulated by the amount of intracellular iron. Iron 139-143 transferrin receptor Mus musculus 56-77 8143723-2 1994 In proliferating non-erythroid cells, the expression of transferrin receptors (TfR) is negatively regulated by the amount of intracellular iron. Iron 139-143 transferrin receptor Mus musculus 79-82 8143723-3 1994 Fe-dependent regulation of TfR occurs post-transcriptionally and is mediated by iron-responsive elements (IRE) located in the 3" untranslated region of the TfR mRNA. Iron 0-2 transferrin receptor Mus musculus 27-30 8143723-3 1994 Fe-dependent regulation of TfR occurs post-transcriptionally and is mediated by iron-responsive elements (IRE) located in the 3" untranslated region of the TfR mRNA. Iron 0-2 transferrin receptor Mus musculus 156-159 8143723-3 1994 Fe-dependent regulation of TfR occurs post-transcriptionally and is mediated by iron-responsive elements (IRE) located in the 3" untranslated region of the TfR mRNA. Iron 80-84 transferrin receptor Mus musculus 27-30 8143723-3 1994 Fe-dependent regulation of TfR occurs post-transcriptionally and is mediated by iron-responsive elements (IRE) located in the 3" untranslated region of the TfR mRNA. Iron 80-84 transferrin receptor Mus musculus 156-159 8143723-9 1994 (c) Following induction of MEL cells, there is an increase in the stability of TfR mRNA, whose level is only slightly affected by iron excess. Iron 130-134 transferrin receptor Mus musculus 79-82 8514748-3 1993 Low iron levels activate a cytoplasmic RNA-binding protein, called iron regulatory factor (IRF) or iron-responsive element-binding protein, which coordinately stabilizes TfR mRNA and inhibits ferritin mRNA translation. Iron 4-8 transferrin receptor Mus musculus 170-173 8514748-3 1993 Low iron levels activate a cytoplasmic RNA-binding protein, called iron regulatory factor (IRF) or iron-responsive element-binding protein, which coordinately stabilizes TfR mRNA and inhibits ferritin mRNA translation. Iron 67-71 transferrin receptor Mus musculus 170-173 8514748-11 1993 Our results indicate that expression of TfR, like ferritin, is controlled by both iron and cytokines. Iron 82-86 transferrin receptor Mus musculus 40-43 1734036-11 1992 The results suggest that the depletion of cellular non-heme iron due to the increase in heme synthesis maintains a high level of transferrin receptor expression in differentiating erythroid cells even after the cessation of cell division. Iron 60-64 transferrin receptor Mus musculus 129-149 1915737-2 1991 Recent studies suggest that the transferrin receptor mediates the intracellular delivery and transport of iron bound to transferrin in the CNS. Iron 106-110 transferrin receptor Mus musculus 32-52 1915737-4 1991 Our hypothesis is that abnormal iron handling by the transferrin receptor may contribute to the formation of free radical species which catalyze the lipid peroxidation of nigral cell membranes. Iron 32-36 transferrin receptor Mus musculus 53-73 2290804-4 1990 In the definitive placenta (day 10), TR are expressed primarily on the differentiated labyrinthine trophoblast cells involved in the maternal-fetal transfer of iron. Iron 160-164 transferrin receptor Mus musculus 37-39 34716241-6 2021 The abnormalities also include increased expression of iron importers (TfR1, DMT1) and HO-1, which in turn result in high iron levels, low GSH and GPX4 activity, increased lipid peroxidation, and propensity to ferroptosis. Iron 122-126 transferrin receptor Mus musculus 71-75 34793849-7 2022 Moreover, MPs induced lipid peroxidation in the liver of mice could activate the expression of ferroptosis related proteins, including iron metabolism, such as transferrin receptor (TFRC) was active but ferritin heavy chain 1 (FTH1) was inhibited; amino acid metabolism, such as XCT system and glutathione peroxidase 4 (GPX4) were inhibited; lipid metabolism, such as acyl-CoA synthetase long-chain family member 4 (ACSL4) was inhibited. Iron 135-139 transferrin receptor Mus musculus 160-180 34793849-7 2022 Moreover, MPs induced lipid peroxidation in the liver of mice could activate the expression of ferroptosis related proteins, including iron metabolism, such as transferrin receptor (TFRC) was active but ferritin heavy chain 1 (FTH1) was inhibited; amino acid metabolism, such as XCT system and glutathione peroxidase 4 (GPX4) were inhibited; lipid metabolism, such as acyl-CoA synthetase long-chain family member 4 (ACSL4) was inhibited. Iron 135-139 transferrin receptor Mus musculus 182-186 34716241-6 2021 The abnormalities also include increased expression of iron importers (TfR1, DMT1) and HO-1, which in turn result in high iron levels, low GSH and GPX4 activity, increased lipid peroxidation, and propensity to ferroptosis. Iron 55-59 transferrin receptor Mus musculus 71-75 2393721-1 1990 Data are presented indicating that the growth of 5 out of 5 murine lymphoid tumors can be inhibited in a synergistic fashion in vitro by combined treatment with the iron chelator deferoxamine (DFO) and an immunoglobulin G (IgG) monoclonal anti-transferrin receptor antibody (ATRA). Iron 165-169 transferrin receptor Mus musculus 244-264 2386528-0 1990 The regulation of transferrin receptor and glutathione peroxidase mRNAs synthesis by changes in intracellular iron levels. Iron 110-114 transferrin receptor Mus musculus 18-38 2386528-2 1990 Raising the levels of intracellular iron by treatment of Friend 707 cells with either hemin, Fe-pyridoxal isonicotinoyl hydrazone (PIH) or diferric transferrin (Tf) resulted in decreased levels of the labeled TfR mRNA. Iron 36-40 transferrin receptor Mus musculus 209-212 34778662-4 2021 One such target could be the transferrin receptor, a glycoprotein receptor that is expressed many-folds on rapidly growing cells due to the greater demand of iron. Iron 158-162 transferrin receptor Mus musculus 29-49 35304229-9 2022 Upon SN iron chelation, transferrin receptor (Tfr) expression was found to be upregulated. Iron 8-12 transferrin receptor Mus musculus 24-44 34480710-8 2022 The decreased levels of TfR1 and the upregulation of FPN1 and FTH proteins observed in the LIRA-treated db/db group were shown to reduce iron overload in the hippocampus, whereas the increased expression of Mtft and decreased expression of Mfrn in the mitochondria indicated that mitochondrial iron overload was ameliorated. Iron 137-141 transferrin receptor Mus musculus 24-28 34238411-3 2021 Results The weight gain percentages of mice in the negative control, low-, medium-, and high-dose iron groups were 25.47%, 25.22%, 24.74%, and 21.36%, respectively, which was significantly lower in the high-dose group than in the negative control(F=17.235, P=0.027), low-dose(F=15.206, P=0.031), and medium-dose(F=11.061, P=0.036)groups.Liver had the highest iron content, followed by spleen, kidney, and small intestine.The iron content in heart and lung tissues of the low-dose group had no significant difference compared with those of the negative control group(F=19.023, P=0.715;F=23.193, P=0.902).Serum iron and ferritin in the iron-overloaded mice increased in a dose-dependent manner, while transferrin and transferrin receptor had no significant changes.HE and Prussian blue staining showed that the iron-overloaded mice had different degrees of iron deposition in tissues and high-dose iron caused liver and kidney damage.The lung(F=23.227, P=0.017), spleen(F=19.023, P=0.021), and liver(F=17.392, P=0.009)of the iron-overloaded mice with TB had a significantly shorter time of bacterial culture than those of the TB-infected mice without iron overload.The lung(F=21.012, P=0.007), spleen(F=20.173, P=0.002), and liver(F=19.091, P=0.005)of the iron-overloaded mice with TB had significantly higher bacterial loads than those of the TB-infected mice without iron overload. Iron 98-102 transferrin receptor Mus musculus 715-735 34646383-10 2021 The deletion of PDK1 in Treg cells destroyed the iron ion balance through regulating MEK-ERK signaling and CD71 expression, resulting in excessive production of intracellular ROS, which did not depend on the down-regulation of mTORC1 signaling. Iron 49-53 transferrin receptor Mus musculus 107-111 34272312-6 2021 Axons and SCs also express the iron importer transferrin receptor 1 (TfR1), indicating their ability for iron uptake. Iron 31-35 transferrin receptor Mus musculus 45-67 34272312-6 2021 Axons and SCs also express the iron importer transferrin receptor 1 (TfR1), indicating their ability for iron uptake. Iron 31-35 transferrin receptor Mus musculus 69-73 34272312-6 2021 Axons and SCs also express the iron importer transferrin receptor 1 (TfR1), indicating their ability for iron uptake. Iron 105-109 transferrin receptor Mus musculus 45-67 34272312-6 2021 Axons and SCs also express the iron importer transferrin receptor 1 (TfR1), indicating their ability for iron uptake. Iron 105-109 transferrin receptor Mus musculus 69-73 34272312-10 2021 We show that Schwann cells (SCs) are a likely source as they express the molecular machinery to import iron (transferrin receptor 1), and to export iron (ferroportin and ceruloplasmin (Cp)) to the axonal compartment at the nodes of Ranvier (NR) and Schmidt-Lanterman incisures (SLIs). Iron 103-107 transferrin receptor Mus musculus 109-131 34389031-12 2021 Further experiments showed that TFRC, the primary receptor for transferrin-mediated iron uptake, was overexpressed on HCC cells but not TAM. Iron 84-88 transferrin receptor Mus musculus 32-36 35304229-9 2022 Upon SN iron chelation, transferrin receptor (Tfr) expression was found to be upregulated. Iron 8-12 transferrin receptor Mus musculus 46-49 35118832-9 2022 RESULTS: In vitro, iron exposure caused dose-dependent increases of iron storage protein ferritin (P < 0.01) and dose-dependent decreases of mRNA TfR1 levels (P < 0.001), which support cellular adaptations to iron excess. Iron 19-23 transferrin receptor Mus musculus 146-150 35118832-9 2022 RESULTS: In vitro, iron exposure caused dose-dependent increases of iron storage protein ferritin (P < 0.01) and dose-dependent decreases of mRNA TfR1 levels (P < 0.001), which support cellular adaptations to iron excess. Iron 209-213 transferrin receptor Mus musculus 146-150 35118832-12 2022 In vivo, basal iron content and mRNA TfR1 levels were significantly higher in the soleus compared with the gastrocnemius (+130% and +127%; P < 0.001, respectively), supporting higher iron needs in oxidative skeletal muscle. Iron 183-187 transferrin receptor Mus musculus 37-41 35143157-2 2022 To further identify more potent ferroptosis inhibitors and effective targets for treating TBI, our study aims at investigating the effects of TfR1 on ferroptosis in a mouse TBI model using ferristatin II (an iron uptake and TfR1 inhibitor). Iron 208-212 transferrin receptor Mus musculus 142-146