PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20670216-5	2010	The decreased expression of CTR1 results in cellular copper deficiency and inhibition of Fet3 activity, which eventually impairs iron uptake.	Iron	129-133	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	28-32	
22304436-4	2012	This study sought to identify the molecular target in microbial cells by comparing the transcriptional profiles of key copper and iron homeostasis genes (CTR1, FRE1, FET3, CUP1, CRS5) in cells exposed to saxitoxin, excess copper, excess iron, an extracellular Cu(I) chelator, or an intracellular Cu(I) chelator.	Iron	237-241	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	154-158	
16437160-1	2006	In the budding yeast Saccharomyces cerevisiae, transcription of genes encoding for the high-affinity iron (FET3, FTR1) and copper (CTR1) transporters does not occur in the absence of heme.	Iron	101-105	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	131-135	
8293472-3	1994	CTR1 mutants and deletion strains have profound deficiency in ferrous iron uptake, thus revealing a requirement for copper in mediating ferrous transport into the cell.	Iron	62-74	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	0-4	
15347752-13	2004	It is hypothesized that ChpA, the iron permease and the iron(II) oxidase might have analogous functions for the three components of the S. cerevisiae copper-dependent high-affinity iron uptake system (Ctr1, Ftr1 and Fet3, respectively), and that strain MV-1 may have a similar iron uptake system.	Iron	34-38	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	201-205	
15347752-13	2004	It is hypothesized that ChpA, the iron permease and the iron(II) oxidase might have analogous functions for the three components of the S. cerevisiae copper-dependent high-affinity iron uptake system (Ctr1, Ftr1 and Fet3, respectively), and that strain MV-1 may have a similar iron uptake system.	Iron	56-60	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	201-205	
7982480-6	1994	High affinity copper uptake mediated by the copper transport protein encoded by CTR1 is required to provide the FET3 protein with copper, and thus copper uptake is indirectly required for ferrous iron uptake.	Iron	188-200	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	80-84	
14993228-3	2004	The list includes several key genes in copper and iron homeostasis, such as CCC2, RCS1, FET3, LYS7, and CTR1.	Iron	50-54	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	104-108	
14993228-5	2004	The beneficial effect of overexpression of CTR1 requires a functional high affinity iron transport system, as it was abolished by deletion of FET3, a component of the high affinity transport system, or CCC2, which is required for assembly of the transport system.	Iron	84-88	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	43-47	
12777486-11	2003	A C. albicans ctr1-null mutant displays phenotypes consistent with the lack of copper uptake including growth defects in low-copper and low-iron conditions, a respiratory deficiency and sensitivity to oxidative stress.	Iron	140-144	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	14-18	
34575794-6	2021	The protein level of Ctr1 was also decreased by nitrogen starvation, and addition of copper to the nitrogen starvation medium partially restored iron uptake activity.	Iron	145-149	high-affinity Cu transporter CTR1	Saccharomyces cerevisiae S288C	21-25