PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12848292-1	2003	Early experiments and molecular simulations of PUFA favored a rigid arrangement of double bonds in U-shaped or extended conformations such as angle-iron or helical.	Iron	148-152	pumilio RNA binding family member 3	Homo sapiens	47-51	
21549690-3	2011	RESULTS: Fe/As promoted the production of lipid peroxidation as reflected by the formation of malondialdehyde and H(2)O(2) along with reduced PUFA levels and elevated glutathione disulfide/total glutathione ratio, a reliable index of cellular redox status.	Iron	9-11	pumilio RNA binding family member 3	Homo sapiens	142-146	
21767448-8	2012	Mean n-3 PUFA intake represented 0 7-1 1 % FE.	Iron	43-45	pumilio RNA binding family member 3	Homo sapiens	9-13	
34284261-8	2021	One factor, comprised of vitamin E, lysine, DHA omega-3 and LA omega-6 PUFA, representing food groups such as nuts, healthy oils and fish, moderated the effects of age on both brain iron concentration and working memory performance, suggesting that these nutrients may slow the rate of brain iron accumulation and working memory declines in aging.	Iron	182-186	pumilio RNA binding family member 3	Homo sapiens	71-75	
34284261-8	2021	One factor, comprised of vitamin E, lysine, DHA omega-3 and LA omega-6 PUFA, representing food groups such as nuts, healthy oils and fish, moderated the effects of age on both brain iron concentration and working memory performance, suggesting that these nutrients may slow the rate of brain iron accumulation and working memory declines in aging.	Iron	292-296	pumilio RNA binding family member 3	Homo sapiens	71-75	
27506793-4	2016	We report here the mechanism of lipid peroxidation during ferroptosis, which involves phosphorylase kinase G2 (PHKG2) regulation of iron availability to lipoxygenase enzymes, which in turn drive ferroptosis through peroxidation of polyunsaturated fatty acids (PUFAs) at the bis-allylic position; indeed, pretreating cells with PUFAs containing the heavy hydrogen isotope deuterium at the site of peroxidation (D-PUFA) prevented PUFA oxidation and blocked ferroptosis.	Iron	132-136	pumilio RNA binding family member 3	Homo sapiens	260-264	
27506793-4	2016	We report here the mechanism of lipid peroxidation during ferroptosis, which involves phosphorylase kinase G2 (PHKG2) regulation of iron availability to lipoxygenase enzymes, which in turn drive ferroptosis through peroxidation of polyunsaturated fatty acids (PUFAs) at the bis-allylic position; indeed, pretreating cells with PUFAs containing the heavy hydrogen isotope deuterium at the site of peroxidation (D-PUFA) prevented PUFA oxidation and blocked ferroptosis.	Iron	132-136	pumilio RNA binding family member 3	Homo sapiens	327-331	
27506793-6	2016	In summary, we found that PUFA oxidation by lipoxygenases via a PHKG2-dependent iron pool is necessary for ferroptosis and that the covalent inhibition of the catalytic selenocysteine in Gpx4 prevents elimination of PUFA hydroperoxides; these findings suggest new strategies for controlling ferroptosis in diverse contexts.	Iron	80-84	pumilio RNA binding family member 3	Homo sapiens	26-30	
25471216-0	2015	Long-chain n-3 PUFA supplementation decreases physical activity during class time in iron-deficient South African school children.	Iron	85-89	pumilio RNA binding family member 3	Homo sapiens	15-19	
8386494-8	1993	These results suggest that the increased formation of conjugated dienes and/or hydroperoxyl (or peroxyl) groups in PUFA molecules is relevant to the cancer cell-killing effect of GLA+Fe.	Iron	183-185	pumilio RNA binding family member 3	Homo sapiens	115-119	
23547888-10	2013	Among food insecure women, higher long-chain (n-3) polyunsaturated fatty acid (LC-PUFA) status, which reflects a more traditional food pattern, was associated with reduced risk of iron depletion.	Iron	180-184	pumilio RNA binding family member 3	Homo sapiens	82-86	
23547888-13	2013	The anti-inflammatory properties of LC-PUFA may be important for iron status in this population.	Iron	65-69	pumilio RNA binding family member 3	Homo sapiens	39-43