PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26492035-8 2015 Site-directed mutagenesis of ROS1 indicated that the conserved iron-sulfur motif is indispensable for ROS1 enzymatic activity. Iron 63-67 demeter-like 1 Arabidopsis thaliana 29-33 27193999-0 2016 The cytosolic Fe-S cluster assembly component MET18 is required for the full enzymatic activity of ROS1 in active DNA demethylation. Iron 14-18 demeter-like 1 Arabidopsis thaliana 99-103 27193999-7 2016 ROS1 activity was reduced in the met18 mutant plants and point mutation in the conserved Fe-S cluster binding motif of ROS1 disrupted its biological function. Iron 89-93 demeter-like 1 Arabidopsis thaliana 0-4 27193999-7 2016 ROS1 activity was reduced in the met18 mutant plants and point mutation in the conserved Fe-S cluster binding motif of ROS1 disrupted its biological function. Iron 89-93 demeter-like 1 Arabidopsis thaliana 119-123 26492035-8 2015 Site-directed mutagenesis of ROS1 indicated that the conserved iron-sulfur motif is indispensable for ROS1 enzymatic activity. Iron 63-67 demeter-like 1 Arabidopsis thaliana 102-106 26492035-9 2015 Our results suggest that ROS1-mediated active DNA demethylation requires MET18-dependent transfer of the iron-sulfur cluster, highlighting an important role of the CIA pathway in epigenetic regulation. Iron 105-109 demeter-like 1 Arabidopsis thaliana 25-29