PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34563663-0 2022 Vitamin D decreases pancreatic iron overload in type 2 diabetes through the NF-kappaB-DMT1 pathway. Iron 31-35 RoBo-1 Rattus norvegicus 86-90 34563663-9 2022 Our study showed that iron overload in pancreas may contribute to T2D pathogenesis and uncovered a potentially protective role for vitamin D on iron deposition of diabetic pancreas through NF-kappaB- DMT1 signaling. Iron 22-26 RoBo-1 Rattus norvegicus 200-204 34987706-9 2021 Our results showed that inhibition of DMT1 by ebselen could suppress iron accumulation and lipid peroxidation, and thereby alleviate ferroptosis and EBI in SAH rats. Iron 69-73 RoBo-1 Rattus norvegicus 38-42 35487763-1 2022 Belgrade rats have a defect in divalent metal transport 1 (DMT1) with a reduced heart iron, indicating that DMT1 plays a physiological role in non-transferrin-bound iron (NTBI) uptake by cardiomyocytes. Iron 86-90 RoBo-1 Rattus norvegicus 59-63 35487763-1 2022 Belgrade rats have a defect in divalent metal transport 1 (DMT1) with a reduced heart iron, indicating that DMT1 plays a physiological role in non-transferrin-bound iron (NTBI) uptake by cardiomyocytes. Iron 86-90 RoBo-1 Rattus norvegicus 108-112 35487763-1 2022 Belgrade rats have a defect in divalent metal transport 1 (DMT1) with a reduced heart iron, indicating that DMT1 plays a physiological role in non-transferrin-bound iron (NTBI) uptake by cardiomyocytes. Iron 165-169 RoBo-1 Rattus norvegicus 108-112 35487763-1 2022 Belgrade rats have a defect in divalent metal transport 1 (DMT1) with a reduced heart iron, indicating that DMT1 plays a physiological role in non-transferrin-bound iron (NTBI) uptake by cardiomyocytes. Iron 165-169 RoBo-1 Rattus norvegicus 59-63 34997531-3 2022 In this study, we investigated how the nonheme iron transporters divalent metal transporter 1 (DMT1) and ferroportin (FPN) are involved in the transient suppression of iron uptake in SAMB. Iron 168-172 RoBo-1 Rattus norvegicus 65-93 35487763-6 2022 Our findings imply that the verapamil-induced reduction in NTBI uptake by H9C2 cells is not associated with DMT1 and also indicate that verapamil stimulates rather than inhibits DMT1 expression and DMT1-mediated iron uptake by heart cells. Iron 212-216 RoBo-1 Rattus norvegicus 198-202 34997531-3 2022 In this study, we investigated how the nonheme iron transporters divalent metal transporter 1 (DMT1) and ferroportin (FPN) are involved in the transient suppression of iron uptake in SAMB. Iron 168-172 RoBo-1 Rattus norvegicus 95-99 34997531-6 2022 After 15 min of 1 mg iron loading, the fluorescence intensity of duodenal DMT1 in iron-deficient rats was decreased and was comparable to that in iron-sufficient rats. Iron 21-25 RoBo-1 Rattus norvegicus 74-78 34997531-6 2022 After 15 min of 1 mg iron loading, the fluorescence intensity of duodenal DMT1 in iron-deficient rats was decreased and was comparable to that in iron-sufficient rats. Iron 82-86 RoBo-1 Rattus norvegicus 74-78 34997531-7 2022 Internalized DMT1-IRE as puncta was observed at 15 and 60 min after 1 mg iron loading, and the number of punctas was significantly increased after 60 min compared with control. Iron 73-77 RoBo-1 Rattus norvegicus 13-17 34997531-9 2022 Our results suggest that the decrease and internalization of DMT1-IRE protein may be related, at least in part, to iron uptake suppression in SAMB. Iron 115-119 RoBo-1 Rattus norvegicus 61-65 32574785-13 2021 DMT1(-)IRE knockdown attenuated iron accumulation but did not influence Ca2+ influx. Iron 32-36 RoBo-1 Rattus norvegicus 0-4 34997531-0 2022 Internalization and Decrease of Duodenal DMT1 Involved in Transient Suppression of Iron Uptake in Short-Acting Mucosal Block. Iron 83-87 RoBo-1 Rattus norvegicus 41-45 34997531-3 2022 In this study, we investigated how the nonheme iron transporters divalent metal transporter 1 (DMT1) and ferroportin (FPN) are involved in the transient suppression of iron uptake in SAMB. Iron 47-51 RoBo-1 Rattus norvegicus 65-93 34997531-3 2022 In this study, we investigated how the nonheme iron transporters divalent metal transporter 1 (DMT1) and ferroportin (FPN) are involved in the transient suppression of iron uptake in SAMB. Iron 47-51 RoBo-1 Rattus norvegicus 95-99 32574785-0 2021 NMDA receptor modulates spinal iron accumulation via activating DMT1(-)IRE in remifentanil-induced hyperalgesia. Iron 31-35 RoBo-1 Rattus norvegicus 64-68 32574785-14 2021 This study suggests that DMT1(-)IRE-mediated iron accumulation is likely to be the downstream event following NMDA receptor activation and Ca2+ influx, contributing to remifentanil-induced hyperalgesia. Iron 45-49 RoBo-1 Rattus norvegicus 25-29 31848921-7 2020 Meanwhile, the increased divalent metal transporter 1 (DMT1) expression enhanced iron import and the decreased ferroportin 1 (Fpn1) expression reduced iron export in AlCl3-exposed groups. Iron 81-85 RoBo-1 Rattus norvegicus 25-53 31848921-7 2020 Meanwhile, the increased divalent metal transporter 1 (DMT1) expression enhanced iron import and the decreased ferroportin 1 (Fpn1) expression reduced iron export in AlCl3-exposed groups. Iron 81-85 RoBo-1 Rattus norvegicus 55-59 30521948-2 2019 Iron overload mediated by divalent metal transporter 1 (DMT1) in the central nervous system has participated in various neuroinflammatory diseases. Iron 0-4 RoBo-1 Rattus norvegicus 56-60 32670009-8 2020 Interestingly, ALA attenuated 6-OHDA-induced iron accumulation both in vivo and in vitro by antagonizing the 6-OHDA-induced upregulation of iron regulatory protein 2 and divalent metal transporter 1. Iron 45-49 RoBo-1 Rattus norvegicus 170-198 32260496-10 2020 The correlations of serum hepcidin and erythroferrone with liver DMT1 and TfR represent significant mechanisms of Fe homeostasis. Iron 114-116 RoBo-1 Rattus norvegicus 65-69 31889778-10 2019 Conclusions: Acupuncture can reduce iron accumulation in the SN and protect the loss of dopamine neurons by promoting balanced expression of the iron importer DMT1 and the iron exporter Fpn1. Iron 145-149 RoBo-1 Rattus norvegicus 159-163 31889778-10 2019 Conclusions: Acupuncture can reduce iron accumulation in the SN and protect the loss of dopamine neurons by promoting balanced expression of the iron importer DMT1 and the iron exporter Fpn1. Iron 145-149 RoBo-1 Rattus norvegicus 159-163 31518742-7 2020 RESULTS: Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload. Iron 9-13 RoBo-1 Rattus norvegicus 100-127 31518742-7 2020 RESULTS: Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload. Iron 9-13 RoBo-1 Rattus norvegicus 129-133 31518742-7 2020 RESULTS: Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload. Iron 172-176 RoBo-1 Rattus norvegicus 100-127 31518742-7 2020 RESULTS: Iron accumulation after SCI resulted in the upregulation of transferrin receptor (TfR) and divalent metal transporter1 (DMT1), which exacerbated the intracellular iron overload. Iron 172-176 RoBo-1 Rattus norvegicus 129-133 32276637-9 2020 Moreover, we found that GA-induced iron overload was activated by NMDAR-RASD1 signalling via DMT1 action in the brain. Iron 35-39 RoBo-1 Rattus norvegicus 93-97 31787896-4 2019 Here, we used a PAE rat model to analyze messenger RNA (mRNA) and protein expression of iron homeostasis genes such as transferrin receptor (TfR), divalent metal transporter (DMT1), ferroportin (FPN1), and ferritin (FT) in brain areas associated with memory formation such as the prefrontal cortex (PFC), ventral tegmental area, and hippocampus. Iron 88-92 RoBo-1 Rattus norvegicus 175-179 30027360-10 2018 Tfr1, Dmt1, ferritin and ferroportin1 exist in bone tissue of rats, and they may be involved in the pathological process of iron overload-induced bone lesion. Iron 124-128 RoBo-1 Rattus norvegicus 6-10 30521948-0 2019 The involvement of iron responsive element (-) divalent metal transporter 1-mediated the spinal iron overload via CXCL10/CXCR3 pathway in neuropathic pain in rats. Iron 19-23 RoBo-1 Rattus norvegicus 47-75 30521948-0 2019 The involvement of iron responsive element (-) divalent metal transporter 1-mediated the spinal iron overload via CXCL10/CXCR3 pathway in neuropathic pain in rats. Iron 96-100 RoBo-1 Rattus norvegicus 47-75 30521948-2 2019 Iron overload mediated by divalent metal transporter 1 (DMT1) in the central nervous system has participated in various neuroinflammatory diseases. Iron 0-4 RoBo-1 Rattus norvegicus 26-54 30027360-8 2018 In addition, significantly up-regulated expression of FtH and FtL mRNA, and markedly down-regulated expression of Tfr1, Dmt1 + IRE and Ireg1 mRNA, were observed in the iron overload group compared with the control group. Iron 168-172 RoBo-1 Rattus norvegicus 120-124 29897813-5 2018 In vitro studies demonstrated that NMDA treatment increased the expression of iron importer divalent metal transporter 1 (DMT1) and decreased the expression of iron exporter ferropotin 1 (Fpn1), which were dependent on iron regulatory protein 1 (IRP1). Iron 78-82 RoBo-1 Rattus norvegicus 92-120 29897813-5 2018 In vitro studies demonstrated that NMDA treatment increased the expression of iron importer divalent metal transporter 1 (DMT1) and decreased the expression of iron exporter ferropotin 1 (Fpn1), which were dependent on iron regulatory protein 1 (IRP1). Iron 78-82 RoBo-1 Rattus norvegicus 122-126 29897813-8 2018 This suggested that 6-OHDA-induced activation of NRs might modulate the expression of DMT1 and Fpn1 via the neuronal nitric oxide synthase-IRP1 pathway.-Xu, H., Liu, X., Xia, J., Yu, T., Qu, Y., Jiang, H., Xie, J., Activation of NMDA receptors mediated iron accumulation via modulating iron transporters in Parkinson"s disease. Iron 253-257 RoBo-1 Rattus norvegicus 86-90 29317744-0 2018 A role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese. Iron 72-76 RoBo-1 Rattus norvegicus 39-43 29899851-3 2018 mRNA levels of divalent metal transporter 1 and transferrin receptor 1, which stimulate iron absorption and excretion, were enhanced in small intestine. Iron 88-92 RoBo-1 Rattus norvegicus 15-70 27578012-6 2017 Our findings suggest that the age-dependent increase in brain iron may be partly due to the age-induced increase in DMT1 expression, rather than TfR1 and Fpn1 expression, and also imply that the increased brain iron is associated with expression of the pathological hallmarks of AD and PD. Iron 62-66 RoBo-1 Rattus norvegicus 116-120 28669019-12 2017 These results suggest that impaired intestinal expression of Dcyt-b and DMT-1 might be associated with the reduction of an iron uptake in CKD. Iron 123-127 RoBo-1 Rattus norvegicus 72-77 28243203-7 2017 These findings suggest that the nifedipine-induced increase in cell iron may mainly be due to the corresponding increase in TfR1 and DMT1 expression and also imply that the effects of nifedipine on iron transport in proximal tubule cells can not explain the increase in urinary iron excretion. Iron 68-72 RoBo-1 Rattus norvegicus 133-137 28243203-3 2017 We speculated that nifedipine might inhibit the TfR1/ DMT1 (transferrin receptor 1/divalent metal transporter1)-mediated iron uptake by proximal tubule cells in addition to blocking L-type Ca2+ channels, leading to an increase in iron in lumen-fluid and then urinary iron excretion. Iron 121-125 RoBo-1 Rattus norvegicus 54-58 28243203-3 2017 We speculated that nifedipine might inhibit the TfR1/ DMT1 (transferrin receptor 1/divalent metal transporter1)-mediated iron uptake by proximal tubule cells in addition to blocking L-type Ca2+ channels, leading to an increase in iron in lumen-fluid and then urinary iron excretion. Iron 230-234 RoBo-1 Rattus norvegicus 54-58 28243203-3 2017 We speculated that nifedipine might inhibit the TfR1/ DMT1 (transferrin receptor 1/divalent metal transporter1)-mediated iron uptake by proximal tubule cells in addition to blocking L-type Ca2+ channels, leading to an increase in iron in lumen-fluid and then urinary iron excretion. Iron 230-234 RoBo-1 Rattus norvegicus 54-58 26687231-9 2016 Ferric iron can then undergo reduction to ferrous iron by ferrireductases inside endosomes followed by DMT1-mediated pumping into the cytosol and subsequently cellular export by ferroportin. Iron 7-11 RoBo-1 Rattus norvegicus 103-107 27331785-1 2016 The divalent metal transporter 1 (DMT1) is a major iron transporter required for iron absorption and erythropoiesis. Iron 51-55 RoBo-1 Rattus norvegicus 4-32 27331785-1 2016 The divalent metal transporter 1 (DMT1) is a major iron transporter required for iron absorption and erythropoiesis. Iron 51-55 RoBo-1 Rattus norvegicus 34-38 27331785-14 2016 Iron-copper model: Mutations in the divalent metal transporter 1 (DMT1) decrease body iron status and up-regulate copper absorption, which leads to copper loading in the brain and consequently increases metal-induced oxidative stress. Iron 0-4 RoBo-1 Rattus norvegicus 36-64 27331785-14 2016 Iron-copper model: Mutations in the divalent metal transporter 1 (DMT1) decrease body iron status and up-regulate copper absorption, which leads to copper loading in the brain and consequently increases metal-induced oxidative stress. Iron 0-4 RoBo-1 Rattus norvegicus 66-70 27331785-14 2016 Iron-copper model: Mutations in the divalent metal transporter 1 (DMT1) decrease body iron status and up-regulate copper absorption, which leads to copper loading in the brain and consequently increases metal-induced oxidative stress. Iron 86-90 RoBo-1 Rattus norvegicus 36-64 27331785-14 2016 Iron-copper model: Mutations in the divalent metal transporter 1 (DMT1) decrease body iron status and up-regulate copper absorption, which leads to copper loading in the brain and consequently increases metal-induced oxidative stress. Iron 86-90 RoBo-1 Rattus norvegicus 66-70 24833704-10 2014 The rapid induction of short-acting mucosal block only in iron-deficient rats suggests DMT1 internalization. Iron 58-62 RoBo-1 Rattus norvegicus 87-91 26824729-5 2016 Liver DMT1 mRNA abundance was greater (P<0 05) in MnSO4 than in the MnLys group for H-Fe rats. Iron 89-91 RoBo-1 Rattus norvegicus 6-10 26824729-6 2016 The DMT1 protein in duodenum and liver and ferroportin 1 (FPN1) protein in liver was greater (P<0 05) in the MnSO4 group than in the MnLys group, and in L-Fe rats than in H-Fe rats. Iron 158-160 RoBo-1 Rattus norvegicus 4-8 26475181-7 2015 Dietary Pi regulated the messenger RNA expression of iron-regulated genes, including divalent metal transporter 1, duodenal cytochrome B, and hepcidin. Iron 53-57 RoBo-1 Rattus norvegicus 85-113 26617777-2 2015 Divalent metal transporter1 (DMT1) is the important and well-known plasma membrane transport protein which was proved to be involved in the transport of free ferrous iron in mammals. Iron 166-170 RoBo-1 Rattus norvegicus 0-27 26617777-2 2015 Divalent metal transporter1 (DMT1) is the important and well-known plasma membrane transport protein which was proved to be involved in the transport of free ferrous iron in mammals. Iron 166-170 RoBo-1 Rattus norvegicus 29-33 26617777-13 2015 Expression levels of DMT1 and FPN1 were in parallel with ferrous iron deposition. Iron 57-69 RoBo-1 Rattus norvegicus 21-25 26617777-18 2015 CONCLUSIONS: DMT1 and FPN1 are positively influenced by ferrous iron status in brain after ICH. Iron 56-68 RoBo-1 Rattus norvegicus 13-17 26617777-19 2015 DMT1 and FPN1 attenuate iron overload after ICH via increasing transmembrane iron export. Iron 24-28 RoBo-1 Rattus norvegicus 0-4 26617777-19 2015 DMT1 and FPN1 attenuate iron overload after ICH via increasing transmembrane iron export. Iron 77-81 RoBo-1 Rattus norvegicus 0-4 25649872-4 2015 Zip8, DMT1, and Steap2 co-localize with the transferrin receptor/transferrin complex, suggesting they may be involved in transferrin receptor/transferrin-mediated iron assimilation. Iron 163-167 RoBo-1 Rattus norvegicus 6-10 26078704-9 2015 The loss of DMT1 can reduce the content of iron in bone. Iron 43-47 RoBo-1 Rattus norvegicus 12-16 25332470-6 2014 RESULTS: High iron loading increased hepatic hepcidin by 3-fold and reduced duodenal expression of divalent metal transporter 1 (DMT1) by 76%. Iron 14-18 RoBo-1 Rattus norvegicus 99-127 25332470-6 2014 RESULTS: High iron loading increased hepatic hepcidin by 3-fold and reduced duodenal expression of divalent metal transporter 1 (DMT1) by 76%. Iron 14-18 RoBo-1 Rattus norvegicus 129-133 26464252-0 2015 Influence of Iron Supplementation on DMT1 (IRE)-induced Transport of Lead by Brain Barrier Systems in vivo. Iron 13-17 RoBo-1 Rattus norvegicus 37-41 25501899-4 2015 Iron accumulation mediated by divalent metal transporter 1 (DMT1) plays a key role in N-methyl-D-aspartate neurotoxicity. Iron 0-4 RoBo-1 Rattus norvegicus 30-58 25501899-4 2015 Iron accumulation mediated by divalent metal transporter 1 (DMT1) plays a key role in N-methyl-D-aspartate neurotoxicity. Iron 0-4 RoBo-1 Rattus norvegicus 60-64 25501899-5 2015 This study aims to determine whether peroxynitrite contributes to remifentanil-induced postoperative hyperalgesia via DMT1-mediated iron accumulation. Iron 132-136 RoBo-1 Rattus norvegicus 118-122 25501899-13 2015 CONCLUSIONS: Our study identifies that spinal peroxynitrite activates DMT1(-)IRE, leading to abnormal iron accumulation in remifentanil-induced postoperative hyperalgesia, while providing the rationale for the development of molecular hydrogen and "iron-targeted" therapies. Iron 102-106 RoBo-1 Rattus norvegicus 70-74 25501899-13 2015 CONCLUSIONS: Our study identifies that spinal peroxynitrite activates DMT1(-)IRE, leading to abnormal iron accumulation in remifentanil-induced postoperative hyperalgesia, while providing the rationale for the development of molecular hydrogen and "iron-targeted" therapies. Iron 249-253 RoBo-1 Rattus norvegicus 70-74 25318588-13 2015 Hepcidin or enterocyte iron levels may be involved in the regulation of age-dependent FPN1, DMT1, and DcytB expression in the duodenum. Iron 23-27 RoBo-1 Rattus norvegicus 92-96 24795636-5 2014 We describe how studies of the Belgrade rat have revealed key roles for DMT1 in iron distribution to red blood cells as well as duodenal iron absorption. Iron 80-84 RoBo-1 Rattus norvegicus 72-76 24850829-2 2014 Therefore the expression of the different divalent metal transporter 1 (Dmt1) isoforms and ferritin (Ft) subunits, responsible for iron import and chelation, was analyzed under pro-inflammatory conditions (IL1beta alone or together with TNFalpha+IFNgamma). Iron 131-135 RoBo-1 Rattus norvegicus 42-70 24795636-7 2014 For example, relationships between iron and manganese metabolism have been discerned since both are essential metals transported by DMT1. Iron 35-39 RoBo-1 Rattus norvegicus 132-136 23814049-1 2013 Genes with G/C-rich promoters were up-regulated in the duodenal epithelium of iron-deficient rats including those encoding iron (e.g. Dmt1 and Dcytb) and copper (e.g. Atp7a and Mt1) metabolism-related proteins. Iron 78-82 RoBo-1 Rattus norvegicus 134-138 25206866-4 2014 Results showed that iron content decreased 41% after blocking divalent metal transporter 1 and ferroportin 1 proteins. Iron 20-24 RoBo-1 Rattus norvegicus 62-90 25206866-7 2014 These results indicate that baicalin down-regulated iron concentration, which positively regulated divalent metal transporter 1 expression and negatively regulated ferroportin 1 expression, and decreased iron accumulation in the substantia nigra. Iron 52-56 RoBo-1 Rattus norvegicus 99-127 24089420-0 2013 Divalent metal transporter 1 (Dmt1) mediates copper transport in the duodenum of iron-deficient rats and when overexpressed in iron-deprived HEK-293 cells. Iron 81-85 RoBo-1 Rattus norvegicus 0-28 24089420-0 2013 Divalent metal transporter 1 (Dmt1) mediates copper transport in the duodenum of iron-deficient rats and when overexpressed in iron-deprived HEK-293 cells. Iron 81-85 RoBo-1 Rattus norvegicus 30-34 24089420-0 2013 Divalent metal transporter 1 (Dmt1) mediates copper transport in the duodenum of iron-deficient rats and when overexpressed in iron-deprived HEK-293 cells. Iron 127-131 RoBo-1 Rattus norvegicus 0-28 24089420-0 2013 Divalent metal transporter 1 (Dmt1) mediates copper transport in the duodenum of iron-deficient rats and when overexpressed in iron-deprived HEK-293 cells. Iron 127-131 RoBo-1 Rattus norvegicus 30-34 24089420-4 2013 Given this possibility and that Dmt1 expression is upregulated by iron deprivation, we sought to test the hypothesis that Dmt1 transports copper during iron deficiency. Iron 66-70 RoBo-1 Rattus norvegicus 32-36 24089420-8 2013 The control diet-fed +/b rats had normal hematological parameters, whereas iron-deprived +/b and b/b rats were iron deficient and Dmt1 mRNA and protein levels increased. Iron 75-79 RoBo-1 Rattus norvegicus 130-134 24089420-11 2013 Dmt1 transcript stabilization due to a 3" iron-responsive element was also documented, likely contributing to increased transport activity. Iron 42-46 RoBo-1 Rattus norvegicus 0-4 24089420-12 2013 In summary, these studies suggest that Dmt1 enhances copper uptake into duodenal enterocytes during iron deprivation. Iron 100-104 RoBo-1 Rattus norvegicus 39-43 24226520-2 2014 Although DMT1 plays a major role in intestinal iron absorption, the transporter is also highly expressed in the kidney, where its function remains unknown. Iron 47-51 RoBo-1 Rattus norvegicus 9-13 23814049-1 2013 Genes with G/C-rich promoters were up-regulated in the duodenal epithelium of iron-deficient rats including those encoding iron (e.g. Dmt1 and Dcytb) and copper (e.g. Atp7a and Mt1) metabolism-related proteins. Iron 123-127 RoBo-1 Rattus norvegicus 134-138 23814049-4 2013 Initial studies in IEC-6 cells showed that mithramycin, an Sp1 inhibitor, reduced expression of Atp7a and iron transport-related genes (Dmt1, Dcytb, and Fpn1) and blocked their induction by CoCl2, a hypoxia mimetic. Iron 106-110 RoBo-1 Rattus norvegicus 136-140 23597830-2 2013 The iron transport protein, divalent metal transporter 1 (DMT1) is found in reactive astrocytes of the lesioned hippocampal CA fields after excitotoxicity induced by the glutamate analog kainate (KA), but in order for iron to be transported by DMT1, it must be converted from the ferric to the ferrous form. Iron 4-8 RoBo-1 Rattus norvegicus 28-56 23597830-2 2013 The iron transport protein, divalent metal transporter 1 (DMT1) is found in reactive astrocytes of the lesioned hippocampal CA fields after excitotoxicity induced by the glutamate analog kainate (KA), but in order for iron to be transported by DMT1, it must be converted from the ferric to the ferrous form. Iron 4-8 RoBo-1 Rattus norvegicus 58-62 23597830-2 2013 The iron transport protein, divalent metal transporter 1 (DMT1) is found in reactive astrocytes of the lesioned hippocampal CA fields after excitotoxicity induced by the glutamate analog kainate (KA), but in order for iron to be transported by DMT1, it must be converted from the ferric to the ferrous form. Iron 4-8 RoBo-1 Rattus norvegicus 244-248 23361852-4 2013 Divalent metal transporter 1(DMT1) has been widely described in literature as a key player in iron metabolism, but never before in the PNS context. Iron 94-98 RoBo-1 Rattus norvegicus 0-28 23506423-9 2013 The data presented here establish for the first time a causal association between inflammation and iron accumulation in brain cells, probably promoted by changes in DMT1 and FPN1 expression and mediated in part by hepcidin. Iron 99-103 RoBo-1 Rattus norvegicus 165-169 23361852-0 2013 DMT1 as a candidate for non-transferrin-bound iron uptake in the peripheral nervous system. Iron 46-50 RoBo-1 Rattus norvegicus 0-4 23349308-0 2013 ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders. Iron 81-85 RoBo-1 Rattus norvegicus 10-14 23349308-0 2013 ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders. Iron 135-139 RoBo-1 Rattus norvegicus 10-14 23361852-4 2013 Divalent metal transporter 1(DMT1) has been widely described in literature as a key player in iron metabolism, but never before in the PNS context. Iron 94-98 RoBo-1 Rattus norvegicus 29-33 23361852-8 2013 These data allow us to suggest the participation of DMT1 as part of a Tf independent iron uptake mechanism in SC and lead us to postulate a crucial role for iron in SC maturation and, as a consequence, in PNS myelination. Iron 85-89 RoBo-1 Rattus norvegicus 52-56 23361852-8 2013 These data allow us to suggest the participation of DMT1 as part of a Tf independent iron uptake mechanism in SC and lead us to postulate a crucial role for iron in SC maturation and, as a consequence, in PNS myelination. Iron 157-161 RoBo-1 Rattus norvegicus 52-56 23635304-8 2013 Placental expression of transferrin and DMT1+IRE were also upregulated, indicating adaptive responses to ensure availability of iron to the fetus. Iron 128-132 RoBo-1 Rattus norvegicus 40-44 23599042-3 2013 The Belgrade rat carries a mutation in the iron transporter divalent metal transporter 1 (DMT1) resulting in iron-loading anemia. Iron 43-47 RoBo-1 Rattus norvegicus 60-88 23599042-3 2013 The Belgrade rat carries a mutation in the iron transporter divalent metal transporter 1 (DMT1) resulting in iron-loading anemia. Iron 43-47 RoBo-1 Rattus norvegicus 90-94 23599042-7 2013 These findings suggest that loss of DMT1 protects against oxidative damage to the pancreas and helps to maintain insulin sensitivity despite iron overload. Iron 141-145 RoBo-1 Rattus norvegicus 36-40 22749870-1 2012 Inhibition of intestinal brush border DMT1 offers a novel therapeutic approach to the prevention and treatment of disorders of iron overload. Iron 127-131 RoBo-1 Rattus norvegicus 38-42 21278260-1 2011 Divalent metal transporter 1 (DMT1) is the major iron transporter responsible for duodenal dietary iron absorption and is required for erythropoiesis. Iron 49-53 RoBo-1 Rattus norvegicus 0-28 21274654-8 2011 Since alterations in iron levels in the brain are causally linked to degenerative conditions such as Alzheimer"s disease, an improved understanding of the regulation of iron transport protein expression such as FPN1, DMT1, and CP could lead to novel strategies for treatments. Iron 169-173 RoBo-1 Rattus norvegicus 217-221 22492739-6 2012 These results indicate that olfactory uptake of ferric iron by iron-deficient rats involves DMT1. Iron 55-59 RoBo-1 Rattus norvegicus 92-96 22492739-7 2012 Western blot experiments confirmed that DMT1 levels are significantly higher in iron-deficient rats compared with iron-sufficient controls in olfactory tissue. Iron 80-84 RoBo-1 Rattus norvegicus 40-44 22492739-7 2012 Western blot experiments confirmed that DMT1 levels are significantly higher in iron-deficient rats compared with iron-sufficient controls in olfactory tissue. Iron 114-118 RoBo-1 Rattus norvegicus 40-44 22492739-8 2012 Thus the molecular mechanism of olfactory iron absorption is regulated by body iron status and involves DMT1. Iron 42-46 RoBo-1 Rattus norvegicus 104-108 22383495-1 2012 The divalent metal transporter 1 (DMT1) is essential for cellular uptake of iron, mediating iron absorption across the duodenal brush border membrane. Iron 76-80 RoBo-1 Rattus norvegicus 4-32 22383495-1 2012 The divalent metal transporter 1 (DMT1) is essential for cellular uptake of iron, mediating iron absorption across the duodenal brush border membrane. Iron 76-80 RoBo-1 Rattus norvegicus 34-38 22383495-1 2012 The divalent metal transporter 1 (DMT1) is essential for cellular uptake of iron, mediating iron absorption across the duodenal brush border membrane. Iron 92-96 RoBo-1 Rattus norvegicus 4-32 22383495-1 2012 The divalent metal transporter 1 (DMT1) is essential for cellular uptake of iron, mediating iron absorption across the duodenal brush border membrane. Iron 92-96 RoBo-1 Rattus norvegicus 34-38 22383495-2 2012 We have previously shown that with iron feeding DMT1 in the brush border membrane undergoes endocytosis into the subapical compartment of enterocytes. Iron 35-39 RoBo-1 Rattus norvegicus 48-52 21278260-1 2011 Divalent metal transporter 1 (DMT1) is the major iron transporter responsible for duodenal dietary iron absorption and is required for erythropoiesis. Iron 49-53 RoBo-1 Rattus norvegicus 30-34 21325818-5 2011 Expression levels of iron transport proteins including DMT1, TfR, Fpn1 and Heph were assessed by Western blot technique. Iron 21-25 RoBo-1 Rattus norvegicus 55-59 20015204-3 2011 We suggested that following receptor mediated endocytosis of transferrin filtered by the glomerulus, DMT1 exports iron liberated from transferrin into the cytosol. Iron 114-118 RoBo-1 Rattus norvegicus 101-105 21191310-9 2011 Duodenal cytochrome b (Dcyt-b), divalent metal transporter 1 (DMT-1), and ferroportin are the crucial regulators of intestinal iron transport and absorption. Iron 127-131 RoBo-1 Rattus norvegicus 32-60 21191310-9 2011 Duodenal cytochrome b (Dcyt-b), divalent metal transporter 1 (DMT-1), and ferroportin are the crucial regulators of intestinal iron transport and absorption. Iron 127-131 RoBo-1 Rattus norvegicus 62-67 20411304-9 2010 The data suggested that the induced elevation of NO level by exercise lead to the up-regulation of both TfR1 and DMT1 (IRE), which in turn increasing the iron absorption in skeletal muscle. Iron 154-158 RoBo-1 Rattus norvegicus 113-117 20511703-10 2010 Meanwhile, down-regulation of DMT1 and up-regulation of MTP1 were induced to alleviate the excessive iron in the myocardium. Iron 101-105 RoBo-1 Rattus norvegicus 30-34 20007457-3 2010 In rat duodenum, iron gavage resulted in the relocation of DMT1 to basal domains and the internalization of basolateral FPN. Iron 17-21 RoBo-1 Rattus norvegicus 59-63 20125122-8 2010 Increased DMT1+IRE expression resulted in increased iron influx by MES23.5 cells. Iron 52-56 RoBo-1 Rattus norvegicus 10-14 20125122-9 2010 Our data provide direct evidence that DMT1+IRE up-regulation can account for IRE/IRP-dependent 6-OHDA-induced iron accumulation initiated by 6-OHDA-induced intracellular oxidative stress and that increased levels of intracellular iron result in aggravated oxidative stress. Iron 110-114 RoBo-1 Rattus norvegicus 38-42 20125122-9 2010 Our data provide direct evidence that DMT1+IRE up-regulation can account for IRE/IRP-dependent 6-OHDA-induced iron accumulation initiated by 6-OHDA-induced intracellular oxidative stress and that increased levels of intracellular iron result in aggravated oxidative stress. Iron 230-234 RoBo-1 Rattus norvegicus 38-42 20125122-10 2010 The results of this study provide novel evidence supporting the use of anti-oxidants in the treatment of PD, with the goal of inhibiting iron accumulation by regulation of DMT1 expression. Iron 137-141 RoBo-1 Rattus norvegicus 172-176 19746426-7 2010 These data indicate that, in addition to the DMT1-mediated uptake of ferrous iron, astrocytes can accumulate ferric and ferrous iron by mechanisms that are independent of DMT1 or transferrin. Iron 77-81 RoBo-1 Rattus norvegicus 45-49 19655216-2 2010 Neurons acquire iron through transferrin receptor-mediated endocytosis and via the divalent metal transporter 1 (DMT1). Iron 16-20 RoBo-1 Rattus norvegicus 83-111 19655216-2 2010 Neurons acquire iron through transferrin receptor-mediated endocytosis and via the divalent metal transporter 1 (DMT1). Iron 16-20 RoBo-1 Rattus norvegicus 113-117 19655216-3 2010 The N-terminus (1A, 1B) and C-terminus (+IRE, -IRE) splice variants of DMT1 originate four protein isoforms, all of which supply iron to cells. Iron 129-133 RoBo-1 Rattus norvegicus 71-75 20125122-4 2010 In the present study, we observed that in the SN of 6-hydroxydopamine (6-OHDA)-induced PD rats, DMT1 with the iron responsive element (IRE, DMT1+IRE), but not DMT1 without IRE (DMT1-IRE), was up-regulated, suggesting that increased DMT1+IRE expression might account for nigral iron accumulation in PD rats. Iron 110-114 RoBo-1 Rattus norvegicus 96-100 20125122-4 2010 In the present study, we observed that in the SN of 6-hydroxydopamine (6-OHDA)-induced PD rats, DMT1 with the iron responsive element (IRE, DMT1+IRE), but not DMT1 without IRE (DMT1-IRE), was up-regulated, suggesting that increased DMT1+IRE expression might account for nigral iron accumulation in PD rats. Iron 277-281 RoBo-1 Rattus norvegicus 96-100 20208373-0 2010 Rapid regulation of intestinal divalent metal (cation) transporter 1 (DMT1/DCT1) and ferritin mRNA expression in response to excess iron loading in iron-deficient rats. Iron 132-136 RoBo-1 Rattus norvegicus 70-74 20208373-0 2010 Rapid regulation of intestinal divalent metal (cation) transporter 1 (DMT1/DCT1) and ferritin mRNA expression in response to excess iron loading in iron-deficient rats. Iron 148-152 RoBo-1 Rattus norvegicus 70-74 20208373-1 2010 We determined the effects of excess iron on the expression of duodenal divalent metal transporter 1 (DMT1) and ferritin (Ft) in iron-deficient rats which had increased iron absorption. Iron 36-40 RoBo-1 Rattus norvegicus 71-99 20208373-1 2010 We determined the effects of excess iron on the expression of duodenal divalent metal transporter 1 (DMT1) and ferritin (Ft) in iron-deficient rats which had increased iron absorption. Iron 36-40 RoBo-1 Rattus norvegicus 101-105 20208373-1 2010 We determined the effects of excess iron on the expression of duodenal divalent metal transporter 1 (DMT1) and ferritin (Ft) in iron-deficient rats which had increased iron absorption. Iron 128-132 RoBo-1 Rattus norvegicus 71-99 20208373-1 2010 We determined the effects of excess iron on the expression of duodenal divalent metal transporter 1 (DMT1) and ferritin (Ft) in iron-deficient rats which had increased iron absorption. Iron 128-132 RoBo-1 Rattus norvegicus 101-105 20208373-1 2010 We determined the effects of excess iron on the expression of duodenal divalent metal transporter 1 (DMT1) and ferritin (Ft) in iron-deficient rats which had increased iron absorption. Iron 128-132 RoBo-1 Rattus norvegicus 71-99 20208373-1 2010 We determined the effects of excess iron on the expression of duodenal divalent metal transporter 1 (DMT1) and ferritin (Ft) in iron-deficient rats which had increased iron absorption. Iron 128-132 RoBo-1 Rattus norvegicus 101-105 20208373-2 2010 DMT1 mRNA was down-regulated and Ft mRNA was up-regulated 2 h after administering the iron. Iron 86-90 RoBo-1 Rattus norvegicus 0-4 18849539-7 2008 Moreover, when the siRNA knocked down the cellular DMT1 expression, the elevated Fe uptake caused by Mn exposure in the choroidal epithelial Z310 cells was completely abolished, indicating that Mn may facilitate Fe efflux via a DMT1-mediated transport mechanism. Iron 81-83 RoBo-1 Rattus norvegicus 51-55 19051252-1 2009 The cellular localization of DMT1 and its functional characterization suggest that DMT1 may play an important role in the physiological brain iron transport. Iron 142-146 RoBo-1 Rattus norvegicus 29-33 19051252-1 2009 The cellular localization of DMT1 and its functional characterization suggest that DMT1 may play an important role in the physiological brain iron transport. Iron 142-146 RoBo-1 Rattus norvegicus 83-87 19051252-2 2009 But the regulation of DMT1 expression by iron in the brain is still not clearly understood. Iron 41-45 RoBo-1 Rattus norvegicus 22-26 19051252-6 2009 Whereas the expression of DMT1 (-IRE) decreased significantly after 7 days of ICV when ferrous iron was increased significantly. Iron 87-99 RoBo-1 Rattus norvegicus 26-30 19051252-8 2009 The results demonstrate that DMT1 (-IRE) expression was correlated probably with brain iron levels; especially, its regulation was correlated with ferrous iron (not ferric iron) in CPu and SN in adult rats, compared with those of saline-injected control rats. Iron 87-91 RoBo-1 Rattus norvegicus 29-33 19051252-8 2009 The results demonstrate that DMT1 (-IRE) expression was correlated probably with brain iron levels; especially, its regulation was correlated with ferrous iron (not ferric iron) in CPu and SN in adult rats, compared with those of saline-injected control rats. Iron 147-159 RoBo-1 Rattus norvegicus 29-33 19051252-9 2009 The effect of ferrous iron on the expression of DMT1 (-IRE) in the brain also suggests that it might play a major physiological role in brain iron uptake and transport, but further studies are needed to clarify these issues. Iron 22-26 RoBo-1 Rattus norvegicus 48-52 19051252-9 2009 The effect of ferrous iron on the expression of DMT1 (-IRE) in the brain also suggests that it might play a major physiological role in brain iron uptake and transport, but further studies are needed to clarify these issues. Iron 142-146 RoBo-1 Rattus norvegicus 48-52 18849539-7 2008 Moreover, when the siRNA knocked down the cellular DMT1 expression, the elevated Fe uptake caused by Mn exposure in the choroidal epithelial Z310 cells was completely abolished, indicating that Mn may facilitate Fe efflux via a DMT1-mediated transport mechanism. Iron 212-214 RoBo-1 Rattus norvegicus 51-55 18849539-9 2008 Taken together, these data suggest that free Fe appears to be favorably transported from the CSF toward the blood by DMT1 and this process can be facilitated by Mn exposure. Iron 45-47 RoBo-1 Rattus norvegicus 117-121 18420243-1 2008 Confocal microscopy was used to investigate the effects of manganese (Mn) and iron (Fe) exposure on the subcellular distribution of metal transporting proteins, i.e., divalent metal transporter 1 (DMT1), metal transporter protein 1 (MTP1), and transferrin receptor (TfR), in the rat intact choroid plexus which comprises the blood-cerebrospinal fluid barrier. Iron 78-82 RoBo-1 Rattus norvegicus 167-195 18420243-1 2008 Confocal microscopy was used to investigate the effects of manganese (Mn) and iron (Fe) exposure on the subcellular distribution of metal transporting proteins, i.e., divalent metal transporter 1 (DMT1), metal transporter protein 1 (MTP1), and transferrin receptor (TfR), in the rat intact choroid plexus which comprises the blood-cerebrospinal fluid barrier. Iron 84-86 RoBo-1 Rattus norvegicus 167-195 18375546-7 2008 Concerning messenger RNA (mRNA) and protein levels of spleen iron recycling markers from RBC degradation (DMT1 [divalent metal transporter 1], iron regulated protein 1, HO1, HO2 [heme oxygenase 1 and 2], cluster of differentiation 36), increase in HO2 and DMT1 mRNA level was induced after chronic exposure to DU. Iron 61-65 RoBo-1 Rattus norvegicus 106-110 18189270-0 2008 Decreased DMT1 and increased ferroportin 1 expression is the mechanisms of reduced iron retention in macrophages by erythropoietin in rats. Iron 83-87 RoBo-1 Rattus norvegicus 10-14 17614955-0 2008 Subcellular location of heme oxygenase 1 and 2 and divalent metal transporter 1 in relation to endocytotic markers during heme iron absorption. Iron 127-131 RoBo-1 Rattus norvegicus 51-79 17981932-11 2008 Importantly, the maintenance of divalent metal transporter-1 protein expression into old age could play a role in the accumulation of skeletal muscle iron. Iron 150-154 RoBo-1 Rattus norvegicus 32-60 17614955-3 2008 This would require the translocation of HO-1 or HO-2 to endosomes and/or lysosomes and the presence of a transporter, possibly divalent metal transporter 1 (DMT1), to transfer released iron to the cytoplasm. Iron 185-189 RoBo-1 Rattus norvegicus 127-155 17614955-3 2008 This would require the translocation of HO-1 or HO-2 to endosomes and/or lysosomes and the presence of a transporter, possibly divalent metal transporter 1 (DMT1), to transfer released iron to the cytoplasm. Iron 185-189 RoBo-1 Rattus norvegicus 157-161 17614955-9 2008 DMT1 staining was markedly reduced by ferrous iron, but not heme and did not exhibit colocalization with endocytotic markers. Iron 46-50 RoBo-1 Rattus norvegicus 0-4 17663481-0 2007 Divalent metal transporter 1 up-regulation is involved in the 6-hydroxydopamine-induced ferrous iron influx. Iron 96-100 RoBo-1 Rattus norvegicus 0-28 17663481-2 2007 We suppose, based on our previous studies, that the newly discovered iron transporter divalent metal transporter 1 (DMT1) might be involved in this SN iron accumulation process. Iron 69-73 RoBo-1 Rattus norvegicus 86-114 17663481-2 2007 We suppose, based on our previous studies, that the newly discovered iron transporter divalent metal transporter 1 (DMT1) might be involved in this SN iron accumulation process. Iron 69-73 RoBo-1 Rattus norvegicus 116-120 17663481-3 2007 To investigate this, we first observed the cellular expression of DMT1 in rat SN, both with the iron response element (+IRE) and without the IRE (-IRE) forms. Iron 96-100 RoBo-1 Rattus norvegicus 66-70 17663481-5 2007 We further observed the relationship between the increased iron influx and DMT1 expression in 6-hydroxydopamine (6-OHDA)-treated C6 cells. Iron 59-63 RoBo-1 Rattus norvegicus 75-79 17663481-10 2007 Increased DMT1+IRE expression is the mechanism behind ferrous iron influx induced by 6-OHDA treatment in C6 cells. Iron 62-66 RoBo-1 Rattus norvegicus 10-14 17663481-11 2007 This may give some evidence for the involvement of DMT1 in the iron accumulation in PD. Iron 63-67 RoBo-1 Rattus norvegicus 51-55 17298691-11 2007 Transferrin receptor 1 and the Fe-responsive element (IRE)-regulated divalent metal transporter 1 (DMT1) were up regulated; while ferroportin and non-IRE1-regulated DMT1 levels did not change. Iron 31-33 RoBo-1 Rattus norvegicus 99-103 17497534-4 2007 The divalent metal transporter 1 (DMT1) transports iron and other divalent metals, such as manganese, and the depletion of iron is known to upregulate DMT1 expression. Iron 51-55 RoBo-1 Rattus norvegicus 4-32 17497534-4 2007 The divalent metal transporter 1 (DMT1) transports iron and other divalent metals, such as manganese, and the depletion of iron is known to upregulate DMT1 expression. Iron 51-55 RoBo-1 Rattus norvegicus 34-38 17497534-4 2007 The divalent metal transporter 1 (DMT1) transports iron and other divalent metals, such as manganese, and the depletion of iron is known to upregulate DMT1 expression. Iron 123-127 RoBo-1 Rattus norvegicus 4-32 17497534-4 2007 The divalent metal transporter 1 (DMT1) transports iron and other divalent metals, such as manganese, and the depletion of iron is known to upregulate DMT1 expression. Iron 123-127 RoBo-1 Rattus norvegicus 34-38 17497534-4 2007 The divalent metal transporter 1 (DMT1) transports iron and other divalent metals, such as manganese, and the depletion of iron is known to upregulate DMT1 expression. Iron 123-127 RoBo-1 Rattus norvegicus 151-155 17497534-6 2007 The feeding of an iron-deficient diet for 4 wk produced a depletion of body iron, such as decreased iron levels in the serum and tissues, and upregulated the DMT1 expression in the rat duodenum. Iron 18-22 RoBo-1 Rattus norvegicus 158-162 17640977-1 2007 Divalent metal transporter-1 (DMT1) mediates dietary nonheme iron absorption. Iron 61-65 RoBo-1 Rattus norvegicus 0-28 17640977-1 2007 Divalent metal transporter-1 (DMT1) mediates dietary nonheme iron absorption. Iron 61-65 RoBo-1 Rattus norvegicus 30-34 17640977-2 2007 Belgrade (b) rats have defective iron metabolism due to a mutation in the DMT1 gene. Iron 33-37 RoBo-1 Rattus norvegicus 74-78 17640977-7 2007 Blood (59)Fe levels measured 5 min to 4 h postgavage were significantly lower in b/b rats, consistent with impaired DMT1 function in intestinal iron absorption. Iron 144-148 RoBo-1 Rattus norvegicus 116-120 17298691-11 2007 Transferrin receptor 1 and the Fe-responsive element (IRE)-regulated divalent metal transporter 1 (DMT1) were up regulated; while ferroportin and non-IRE1-regulated DMT1 levels did not change. Iron 31-33 RoBo-1 Rattus norvegicus 165-169 16879716-5 2006 (59)Fe occurred in significantly lower amounts in the postvascular compartment in Belgrade b/b rats, indicating impaired iron uptake by transferrin receptor and DMT1-expressing neurons. Iron 4-6 RoBo-1 Rattus norvegicus 161-165 17460390-7 2007 Real-time polymerase chain reaction (PCR) showed that the mRNA expression of TfR, iron-responsive element-negative DMT1, FPN, and hepcidin mRNA increased ~1.9-fold, ~1.7-fold, ~2.3-fold, and ~4.7-fold, respectively, after angiotensin II infusion as compared with that of untreated controls, and that these increases could be suppressed by the concomitant administration of losartan. Iron 82-86 RoBo-1 Rattus norvegicus 115-119 17116743-4 2007 Divalent metal transporter-1 (DMT1) is the major transporter responsible for intestinal iron absorption and its expression is regulated by body iron status. Iron 88-92 RoBo-1 Rattus norvegicus 0-28 17116743-4 2007 Divalent metal transporter-1 (DMT1) is the major transporter responsible for intestinal iron absorption and its expression is regulated by body iron status. Iron 88-92 RoBo-1 Rattus norvegicus 30-34 17116743-4 2007 Divalent metal transporter-1 (DMT1) is the major transporter responsible for intestinal iron absorption and its expression is regulated by body iron status. Iron 144-148 RoBo-1 Rattus norvegicus 0-28 17116743-4 2007 Divalent metal transporter-1 (DMT1) is the major transporter responsible for intestinal iron absorption and its expression is regulated by body iron status. Iron 144-148 RoBo-1 Rattus norvegicus 30-34 17116743-9 2007 The apparent function of DMT1 in olfactory manganese absorption suggests that the neurotoxicity of the metal can be modified by iron status due to the iron-responsive regulation of the transporter. Iron 128-132 RoBo-1 Rattus norvegicus 25-29 17116743-9 2007 The apparent function of DMT1 in olfactory manganese absorption suggests that the neurotoxicity of the metal can be modified by iron status due to the iron-responsive regulation of the transporter. Iron 151-155 RoBo-1 Rattus norvegicus 25-29 16552559-2 2006 This is accompanied by an increased expression of divalent metal transporter-1 (DMT1) in the lesioned hippocampus, suggesting that the transporter may be partially responsible for the iron accumulation. Iron 184-188 RoBo-1 Rattus norvegicus 50-78 16552559-2 2006 This is accompanied by an increased expression of divalent metal transporter-1 (DMT1) in the lesioned hippocampus, suggesting that the transporter may be partially responsible for the iron accumulation. Iron 184-188 RoBo-1 Rattus norvegicus 80-84 17116712-1 2006 Patients with mutations in divalent metal transporter-1 (DMT1), an intestinal nonheme iron transporter, suffer from microcytic anemia and hepatic iron loading. Iron 86-90 RoBo-1 Rattus norvegicus 27-55 17116712-1 2006 Patients with mutations in divalent metal transporter-1 (DMT1), an intestinal nonheme iron transporter, suffer from microcytic anemia and hepatic iron loading. Iron 86-90 RoBo-1 Rattus norvegicus 57-61 16208485-6 2006 Parallel studies were performed for the primary iron absorption protein, divalent metal transporter 1 (DMT1). Iron 48-52 RoBo-1 Rattus norvegicus 103-107 16340001-2 2006 Intestinal manganese and iron absorption is mediated by divalent metal transporter 1 (DMT1) and is upregulated in iron deficiency. Iron 25-29 RoBo-1 Rattus norvegicus 56-84 16340001-2 2006 Intestinal manganese and iron absorption is mediated by divalent metal transporter 1 (DMT1) and is upregulated in iron deficiency. Iron 25-29 RoBo-1 Rattus norvegicus 86-90 16208485-9 2006 DMT1 was localised primarily on the microvillus membrane, but did partially co-localise with HFE raising the possibility that the two proteins may interact to regulate iron absorption. Iron 168-172 RoBo-1 Rattus norvegicus 0-4 16075245-1 2005 Absorption of iron occurs by duodenal enterocytes, involving uptake by the divalent metal transporter-1 (DMT1) and release by ferroportin. Iron 14-18 RoBo-1 Rattus norvegicus 75-103 16221503-11 2006 Tumor necrosis factor-alpha regulates the mRNA levels of HAMP, IREG1, DMT1 and TfR2 in cultured hepatocytes from both iron-loaded and control animals. Iron 118-122 RoBo-1 Rattus norvegicus 70-74 16160008-2 2006 Both mk mice and Belgrade rats, which carry an identical DMT1 mutation, exhibit severe microcytic anemia at birth and defective intestinal iron use and erythroid iron use. Iron 139-143 RoBo-1 Rattus norvegicus 57-61 16160008-2 2006 Both mk mice and Belgrade rats, which carry an identical DMT1 mutation, exhibit severe microcytic anemia at birth and defective intestinal iron use and erythroid iron use. Iron 162-166 RoBo-1 Rattus norvegicus 57-61 16317519-5 2006 Western blot was performed to detect the expression of iron transport proteins: divalent metal transporter1 (DMT1) and ferroportin 1 (FPN1) in duodenal epithelium. Iron 55-59 RoBo-1 Rattus norvegicus 80-107 16317519-5 2006 Western blot was performed to detect the expression of iron transport proteins: divalent metal transporter1 (DMT1) and ferroportin 1 (FPN1) in duodenal epithelium. Iron 55-59 RoBo-1 Rattus norvegicus 109-113 16317519-7 2006 The results showed: (1) the body iron status in MG was kept at a high level compared to that of CG and SG, (2) Western blot showed DMT1 with iron responsive element (IRE) and FPN1 in duodenal epithelium which were higher in MG than that of CG and (3) the expression of hepatic hepcidin mRNA was down regulated in MG (p < 0.05). Iron 33-37 RoBo-1 Rattus norvegicus 131-135 16317519-7 2006 The results showed: (1) the body iron status in MG was kept at a high level compared to that of CG and SG, (2) Western blot showed DMT1 with iron responsive element (IRE) and FPN1 in duodenal epithelium which were higher in MG than that of CG and (3) the expression of hepatic hepcidin mRNA was down regulated in MG (p < 0.05). Iron 141-145 RoBo-1 Rattus norvegicus 131-135 16317519-8 2006 The data suggested that moderate exercise improved iron status and that was likely regulated by increased DMT1 with IRE and FPN1 expression. Iron 51-55 RoBo-1 Rattus norvegicus 106-110 16443171-14 2006 Both are compatible with the more marked expression of divalent metal transporter 1 (DMT-1) and IREG-1 at the brushborder and basolateral membrane of iron-deficient enterocytes. Iron 150-154 RoBo-1 Rattus norvegicus 55-83 16443171-14 2006 Both are compatible with the more marked expression of divalent metal transporter 1 (DMT-1) and IREG-1 at the brushborder and basolateral membrane of iron-deficient enterocytes. Iron 150-154 RoBo-1 Rattus norvegicus 85-90 16140386-9 2006 As expected, DMT-1 was increased due to Fe deprivation, but surprisingly, DMT-1 levels were also increased due to +Fe treatment, albeit not to the extent noted in ID. Iron 40-42 RoBo-1 Rattus norvegicus 13-18 16140386-9 2006 As expected, DMT-1 was increased due to Fe deprivation, but surprisingly, DMT-1 levels were also increased due to +Fe treatment, albeit not to the extent noted in ID. Iron 115-117 RoBo-1 Rattus norvegicus 74-79 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. Iron 114-118 RoBo-1 Rattus norvegicus 0-28 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. Iron 114-118 RoBo-1 Rattus norvegicus 30-34 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. Iron 148-152 RoBo-1 Rattus norvegicus 0-28 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. Iron 148-152 RoBo-1 Rattus norvegicus 30-34 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. Iron 157-159 RoBo-1 Rattus norvegicus 0-28 16137791-1 2005 Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) might play a key role in non-transferrin-bound iron (NTBI) and transferrin-bound iron (Tf-Fe) uptake by neuronal cells. Iron 157-159 RoBo-1 Rattus norvegicus 30-34 16137791-3 2005 We speculated the increased NTBI and Tf-Fe uptake induced by NGF treatment might be associated with the increased expression of DMT1 and TfR. Iron 40-42 RoBo-1 Rattus norvegicus 128-132 15908475-2 2005 Based on the fate of iron in airway epithelial cells, we postulated that divalent metal transporter-1 (DMT1) participates in detoxification of metal associated with air pollution particles. Iron 21-25 RoBo-1 Rattus norvegicus 73-101 15908475-2 2005 Based on the fate of iron in airway epithelial cells, we postulated that divalent metal transporter-1 (DMT1) participates in detoxification of metal associated with air pollution particles. Iron 21-25 RoBo-1 Rattus norvegicus 103-107 15908475-4 2005 Preexposure of normal rats to iron in vivo increased expression of the isoform of DMT1 protein that lacked an iron-response element (-IRE), accelerated metal transport out of the lung, and decreased injury after particle exposure. Iron 30-34 RoBo-1 Rattus norvegicus 82-86 15908475-4 2005 Preexposure of normal rats to iron in vivo increased expression of the isoform of DMT1 protein that lacked an iron-response element (-IRE), accelerated metal transport out of the lung, and decreased injury after particle exposure. Iron 110-114 RoBo-1 Rattus norvegicus 82-86 15908475-7 2005 Also, DMT1 mRNA and protein expression for the -IRE isoform increased or decreased in these cells when exposed to iron or vanadium, respectively. Iron 114-118 RoBo-1 Rattus norvegicus 6-10 15637178-4 2005 Genes encoding the apical iron transport-related proteins [divalent metal transporter 1 (DMT1) and duodenal cytochrome b] were strongly induced at all ages studied, whereas increases in mRNA encoding the basolateral proteins iron-regulated gene 1 and hephaestin were observed only by real-time PCR. Iron 26-30 RoBo-1 Rattus norvegicus 59-87 15637178-4 2005 Genes encoding the apical iron transport-related proteins [divalent metal transporter 1 (DMT1) and duodenal cytochrome b] were strongly induced at all ages studied, whereas increases in mRNA encoding the basolateral proteins iron-regulated gene 1 and hephaestin were observed only by real-time PCR. Iron 26-30 RoBo-1 Rattus norvegicus 89-93 15637178-11 2005 We speculate that dietary iron deprivation leads to increased intestinal copper absorption via DMT1 on the brush-border membrane and the Menkes copper ATPase on the basolateral membrane. Iron 26-30 RoBo-1 Rattus norvegicus 95-99 16075245-1 2005 Absorption of iron occurs by duodenal enterocytes, involving uptake by the divalent metal transporter-1 (DMT1) and release by ferroportin. Iron 14-18 RoBo-1 Rattus norvegicus 105-109 16075245-12 2005 Surface binding of Fe(II) and iron transport V(max) were reduced by 50%, indicating that the antibody removed membrane-bound DMT1. Iron 30-34 RoBo-1 Rattus norvegicus 125-129 15699234-2 2005 Whether intestinal iron transporters, divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1), are present in the mammary gland and are involved in iron transfer into milk are unknown. Iron 19-23 RoBo-1 Rattus norvegicus 38-66 15699234-2 2005 Whether intestinal iron transporters, divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1), are present in the mammary gland and are involved in iron transfer into milk are unknown. Iron 19-23 RoBo-1 Rattus norvegicus 68-72 15699234-10 2005 DMT1, FPN1, and transferrin receptor values were unchanged; however, a smaller-size DMT1 protein was observed in the low-iron rats. Iron 121-125 RoBo-1 Rattus norvegicus 84-88 15699234-12 2005 CONCLUSIONS: The results show that DMT1 and FPN1 concentrations are higher during early lactation and are possibly involved in iron transfer into milk. Iron 127-131 RoBo-1 Rattus norvegicus 35-39 15358806-10 2004 Iron-responsive element (IRE)-regulated divalent metal transporter 1 (DMT1) increased in maternal and neonatal liver. Iron 0-4 RoBo-1 Rattus norvegicus 70-74 25175614-3 2004 This study was performed to investigate the role of metal transporters (divalent metal transporter 1, DMT1, and metal transporter protein 1, MTP1) in the lung under the environments of Fe deficiency in the body and Fe over-exposure in the lung. Iron 185-187 RoBo-1 Rattus norvegicus 52-100 25175614-12 2004 Therefore, DMT1 and MTP1 mRNA was highly expressed in both FeD-diet and FeS-diet fed rats, after intratracheal instillation of Fe. Iron 59-61 RoBo-1 Rattus norvegicus 11-15 14675167-0 2004 The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain. Iron 69-73 RoBo-1 Rattus norvegicus 60-64 14688618-10 2004 In contrast, in Belgrade rats, whose brain is iron deficient, the expression of both divalent metal transporter 1 and transferrin receptor was increased compared with control in almost all brain regions examined, but not transferrin or ferritin. Iron 46-50 RoBo-1 Rattus norvegicus 85-113 15315826-6 2004 The positive regulation of iron responsive element (IRE)-DMT1 gene was found, with different extent, in both experimental groups. Iron 27-31 RoBo-1 Rattus norvegicus 57-61 15082582-5 2004 Duodenal expression of the iron transport molecules DMT1, Dcytb, and Ireg1 increased during pregnancy, and this corresponded with a reduction in hepcidin, HFE, and transferrin receptor 2 expression in the liver. Iron 27-31 RoBo-1 Rattus norvegicus 52-56 14736998-5 2004 Cells treated with the iron chelator deferoxamine displayed higher levels of the iron transporter divalent metal transporter 1 (DMT1) mRNA and protein, and consistent with increased DMT1 expression, the treated cells displayed greater uptake of Pb in the buffer at pH 5.5 but not at pH 7.4. Iron 23-27 RoBo-1 Rattus norvegicus 128-132 14736998-5 2004 Cells treated with the iron chelator deferoxamine displayed higher levels of the iron transporter divalent metal transporter 1 (DMT1) mRNA and protein, and consistent with increased DMT1 expression, the treated cells displayed greater uptake of Pb in the buffer at pH 5.5 but not at pH 7.4. Iron 23-27 RoBo-1 Rattus norvegicus 182-186 14684575-16 2004 CONCLUSIONS: In addition to release, ferroportin functions in the uptake of iron at the apical membrane, possibly by modulating the activity of DMT1. Iron 76-80 RoBo-1 Rattus norvegicus 144-148 14675167-9 2004 Neuronal expression of transferrin receptors and DMT1 in adult rats implies that neurones at this age acquire iron by receptor-mediated endocytosis of transferrin followed by iron transport out of endosomes mediated by DMT1. Iron 110-114 RoBo-1 Rattus norvegicus 49-53 14675167-10 2004 The existence of the mutated DMT1 molecule in neurones suggests that the low cerebral iron uptake in b/b rats derives from a reduced neuronal uptake rather than an impaired iron transport through the blood-brain barrier. Iron 86-90 RoBo-1 Rattus norvegicus 29-33 14675167-10 2004 The existence of the mutated DMT1 molecule in neurones suggests that the low cerebral iron uptake in b/b rats derives from a reduced neuronal uptake rather than an impaired iron transport through the blood-brain barrier. Iron 173-177 RoBo-1 Rattus norvegicus 29-33 14668284-10 2003 By day 20, DMT1 and FPN1 expression and iron absorption had decreased significantly with iron supplementation. Iron 89-93 RoBo-1 Rattus norvegicus 11-15 12767048-3 2003 The understanding of the role of DMT1 in heart iron metabolism is fundamental for elucidating the cause resulting in excessive iron in the heart. Iron 47-51 RoBo-1 Rattus norvegicus 33-37 12958019-0 2003 DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption. Iron 69-73 RoBo-1 Rattus norvegicus 0-4 14531808-1 2003 BACKGROUND: We have previously shown that the rat kidney reabsorbs metabolically significant amounts of iron and that it expresses the divalent metal transporter 1, DMT1. Iron 104-108 RoBo-1 Rattus norvegicus 165-169 14531808-2 2003 The Belgrade (b) rat carries a mutation in DMT1 gene, which causes hypochromic, microcytic anemia due to impaired intestinal iron absorption and transport of iron out of the transferrin cycle endosome. Iron 125-129 RoBo-1 Rattus norvegicus 43-47 14531808-3 2003 In the duodenum of b/b rats, expression of DMT1 mRNA and protein is increased, suggesting a feedback regulation by iron stores. Iron 115-119 RoBo-1 Rattus norvegicus 43-47 12767048-3 2003 The understanding of the role of DMT1 in heart iron metabolism is fundamental for elucidating the cause resulting in excessive iron in the heart. Iron 127-131 RoBo-1 Rattus norvegicus 33-37 12767048-4 2003 The study was to evaluate effects of age and dietary iron on DMT1 mRNA expression and protein synthesis in rat heart. Iron 53-57 RoBo-1 Rattus norvegicus 61-65 12767048-8 2003 During different ages, the levels of DMT1 (IRE) mRNA were higher than those of DMT1 (non-IRE) mRNA and were significantly correlated with the non-heme iron contents in the heart. Iron 151-155 RoBo-1 Rattus norvegicus 37-41 12767048-9 2003 After fed a high iron for 6 weeks, the rats had a sixfold elevation in heart iron and 22% (non-IRE from) and 40% (IRE from) reduction in DMT1 protein compared to the controls. Iron 17-21 RoBo-1 Rattus norvegicus 137-141 12767048-10 2003 A low iron diet for 6-weeks caused cardiac hypertrophy and heart iron deficiency and also an increase in levels of two forms of DMT1 proteins. Iron 6-10 RoBo-1 Rattus norvegicus 128-132 12767048-12 2003 The results demonstrated that DMT1 mRNAs expression in the heart is age-dependent and that two forms of DMT1 mRNAs both are regulated by iron on the post-transcriptional level only. Iron 137-141 RoBo-1 Rattus norvegicus 104-108 12734938-1 2003 OBJECTIVE: To investigate the expression of divalent metal transporter 1 (DMT1) mRNA in male Sprague-Dawley rat heart of different ages and the expression of DMT1 regulated by dietary iron. Iron 184-188 RoBo-1 Rattus norvegicus 158-162 12621119-2 2003 The membrane proteins that mediate iron transport [transferrin receptor (TfR) and divalent metal transporter 1 (DMT-1)] and the iron regulatory proteins (IRP-1 and IRP-2) that stabilize their mRNAs undergo regional developmental changes in the iron-sufficient rat brain between postnatal day (P) 5 and 15. Iron 35-39 RoBo-1 Rattus norvegicus 82-110 12621119-2 2003 The membrane proteins that mediate iron transport [transferrin receptor (TfR) and divalent metal transporter 1 (DMT-1)] and the iron regulatory proteins (IRP-1 and IRP-2) that stabilize their mRNAs undergo regional developmental changes in the iron-sufficient rat brain between postnatal day (P) 5 and 15. Iron 35-39 RoBo-1 Rattus norvegicus 112-117 12734938-3 2003 RESULTS: (1)Two isoforms of DMT1 mRNA [with and without iron-responsive element (IRE)] were both detected in rat heart, which were correlated with heart iron content. Iron 56-60 RoBo-1 Rattus norvegicus 28-32 12734938-3 2003 RESULTS: (1)Two isoforms of DMT1 mRNA [with and without iron-responsive element (IRE)] were both detected in rat heart, which were correlated with heart iron content. Iron 153-157 RoBo-1 Rattus norvegicus 28-32 12734938-7 2003 By using Western blot analysis, a 21% and 40% reduction in DMT1 protein non IRE form and IRE form respectively were found in iron overload rat (P<0.01, compared with control). Iron 125-129 RoBo-1 Rattus norvegicus 59-63 12734938-9 2003 CONCLUSION: The level of DMT1 mRNA expression in heart is age dependent;the two isoforms of DMT1 protein may be both regulated by iron on the posttranscriptional mechanism. Iron 130-134 RoBo-1 Rattus norvegicus 25-29 12734938-9 2003 CONCLUSION: The level of DMT1 mRNA expression in heart is age dependent;the two isoforms of DMT1 protein may be both regulated by iron on the posttranscriptional mechanism. Iron 130-134 RoBo-1 Rattus norvegicus 92-96 12584213-0 2003 A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption. Iron 122-126 RoBo-1 Rattus norvegicus 38-42 12584213-7 2003 Reduced absorption was also accompanied by a rapid decrease in expression of the mRNAs encoding the brush border iron transport molecules Dcytb and the iron responsive element (IRE) containing the splice variant of DMT1. Iron 152-156 RoBo-1 Rattus norvegicus 215-219 12460733-2 2002 Divalent metal transporter-1 (DMT-1) is primarily responsible for dietary iron uptake in the duodenum but also recognizes nonessential metals such as cadmium (Cd). Iron 74-78 RoBo-1 Rattus norvegicus 0-28 12849737-1 2003 The present investigation was carried out to elucidate the effect of the antimalarial drug quinacrine on levels of expression of the non-heme iron transporter, divalent metal transporter-1 (DMT1) and iron, in the hippocampus of rats after kainate treatment. Iron 142-146 RoBo-1 Rattus norvegicus 160-188 12849737-3 2003 The increased DMT1 immunoreactivity was correlated with increased levels of Fe3+ and Fe2+ staining in the CA fields, as demonstrated by iron histochemistry (Perl"s and Turnbull"s blue stain for Fe3+ and Fe2+). Iron 136-140 RoBo-1 Rattus norvegicus 14-18 12849737-7 2003 These results show that DMT1 expression is closely linked to iron levels, and provide further support for a crucial role that DMT1 plays in iron accumulation in the degenerating hippocampus. Iron 61-65 RoBo-1 Rattus norvegicus 24-28 12849737-7 2003 These results show that DMT1 expression is closely linked to iron levels, and provide further support for a crucial role that DMT1 plays in iron accumulation in the degenerating hippocampus. Iron 140-144 RoBo-1 Rattus norvegicus 24-28 12849737-7 2003 These results show that DMT1 expression is closely linked to iron levels, and provide further support for a crucial role that DMT1 plays in iron accumulation in the degenerating hippocampus. Iron 140-144 RoBo-1 Rattus norvegicus 126-130 12460733-2 2002 Divalent metal transporter-1 (DMT-1) is primarily responsible for dietary iron uptake in the duodenum but also recognizes nonessential metals such as cadmium (Cd). Iron 74-78 RoBo-1 Rattus norvegicus 30-35 12196177-2 2002 We have examined the relationship between the expression of hepcidin in the liver and the expression of the iron-transport molecules divalent-metal transporter 1, duodenal cytochrome b, hephaestin and Ireg1 in the duodenum of rats switched from an iron-replete to an iron-deficient diet or treated to induce an acute phase response. Iron 108-112 RoBo-1 Rattus norvegicus 133-161 12547229-17 2002 The results confirm the essential role of DMT1 in the uptake phase of non-heme iron absorption. Iron 79-83 RoBo-1 Rattus norvegicus 42-46 12547229-18 2002 When normal rats previously fed a low iron diet were given a bolus of iron by stomach tube, the subsequent absorption of iron from a test dose placed in the duodenum diminished in parallel with the expression of DMT1 mRNA and protein, commencing within 1hour and reaching low levels by 7 hours. Iron 38-42 RoBo-1 Rattus norvegicus 212-216 12547229-18 2002 When normal rats previously fed a low iron diet were given a bolus of iron by stomach tube, the subsequent absorption of iron from a test dose placed in the duodenum diminished in parallel with the expression of DMT1 mRNA and protein, commencing within 1hour and reaching low levels by 7 hours. Iron 70-74 RoBo-1 Rattus norvegicus 212-216 12547229-18 2002 When normal rats previously fed a low iron diet were given a bolus of iron by stomach tube, the subsequent absorption of iron from a test dose placed in the duodenum diminished in parallel with the expression of DMT1 mRNA and protein, commencing within 1hour and reaching low levels by 7 hours. Iron 70-74 RoBo-1 Rattus norvegicus 212-216 12547229-20 2002 These results show the level of expression and intracellular distribution and function of DMT1 respond very quickly to the iron content of the diet as well as being affected by storage iron levels. Iron 123-127 RoBo-1 Rattus norvegicus 90-94 12547229-20 2002 These results show the level of expression and intracellular distribution and function of DMT1 respond very quickly to the iron content of the diet as well as being affected by storage iron levels. Iron 185-189 RoBo-1 Rattus norvegicus 90-94 12547229-2 2002 It has been proposed that the efficiency of absorption is determined by the amount of iron acquired by developing enterocytes when they are in the crypts of Lieberkuhn and that this regulates expression of iron transporters such as DMT1 in mature enterocytes of the intestinal villi. Iron 86-90 RoBo-1 Rattus norvegicus 232-236 12429222-9 2002 The observation that DMT-1 is present on astrocytic end feet in contact with blood vessels suggests that these cells may be involved in uptake of iron from endothelial cells. Iron 146-150 RoBo-1 Rattus norvegicus 21-26 12198710-5 2002 RESULTS: Iron absorption increased 2.7-fold within 6 days of switching to an iron-deficient diet and was accompanied by an increase in the duodenal expression of Dcytb, divalent metal transporter 1, and Ireg1. Iron 9-13 RoBo-1 Rattus norvegicus 169-197 11292622-8 2001 The described distribution of DMT-1 protein is in agreement with our previous identification of nephron sites of iron reabsorption, suggesting that DMT-1 provides the molecular mechanism for apical iron entry in the distal nephron but not in the proximal tubule. Iron 198-202 RoBo-1 Rattus norvegicus 30-35 11925460-2 2002 Recent identification of proteins that are involved in iron absorption such as the uptake transporter-divalent metal transporter (DMT1), the basolateral transporter, IREG1, and the ferroxidase-hephaestin provide new opportunities to study this process. Iron 55-59 RoBo-1 Rattus norvegicus 130-134 11925460-6 2002 The uptake of 1 micromol/L ferrous iron [Fe(II)]:ascorbate and its efflux also was associated with the expression of DMT1 under different levels of iron loading. Iron 27-39 RoBo-1 Rattus norvegicus 117-121 11925460-6 2002 The uptake of 1 micromol/L ferrous iron [Fe(II)]:ascorbate and its efflux also was associated with the expression of DMT1 under different levels of iron loading. Iron 35-39 RoBo-1 Rattus norvegicus 117-121 11925460-7 2002 The expression of DMT1 changed inversely with iron levels as did the uptake of Fe(II). Iron 46-50 RoBo-1 Rattus norvegicus 18-22 11746453-3 2001 The Divalent Metal Transporter 1 (DMT1), is responsible for iron uptake from the gut and transport from endosomes. Iron 60-64 RoBo-1 Rattus norvegicus 4-32 11746453-3 2001 The Divalent Metal Transporter 1 (DMT1), is responsible for iron uptake from the gut and transport from endosomes. Iron 60-64 RoBo-1 Rattus norvegicus 34-38 11746453-6 2001 Belgrade rats have a defect in DMT1 that is associated with lower levels of iron in the brain. Iron 76-80 RoBo-1 Rattus norvegicus 31-35 11746453-8 2001 The staining in the ependymal cells and endothelial cells suggests that DMT1 has an important role in iron transport into the brain. Iron 102-106 RoBo-1 Rattus norvegicus 72-76 11746453-15 2001 These results indicate that DMT1 and MTP1 are involved in brain iron transport and this involvement is regionally and cellularly specific. Iron 64-68 RoBo-1 Rattus norvegicus 28-32 12151624-2 2002 The depletion of Fe upregulates the expression of divalent metal transporter 1 (DMT1), which is located at the apical membrane of enterocytes lining the small intestine. Iron 17-19 RoBo-1 Rattus norvegicus 50-78 12151624-2 2002 The depletion of Fe upregulates the expression of divalent metal transporter 1 (DMT1), which is located at the apical membrane of enterocytes lining the small intestine. Iron 17-19 RoBo-1 Rattus norvegicus 80-84 12151624-3 2002 DMT1 has been shown to transport Fe and other divalent metal ions in vitro. Iron 33-35 RoBo-1 Rattus norvegicus 0-4 12151624-12 2002 The levels of DMT1 mRNA were significantly lower in kidney and liver than in duodenum, but were 30 and 40% higher, respectively, in rats fed the FeD diet than in rats fed the FeS diet. Iron 175-178 RoBo-1 Rattus norvegicus 14-18 12151624-13 2002 These findings suggest that functional DMT1 protein is likely upregulated in the small intestine at the mRNA level by body iron depletion and increases Cd uptake from the gastrointestinal tract with subsequent transfer of Cd to the circulation and body tissues. Iron 123-127 RoBo-1 Rattus norvegicus 39-43 12151624-14 2002 Furthermore, the data from this study may indicate that DMT1 is a nonspecific metal transporter, which can transport not only Fe, but probably the toxic metal as well. Iron 126-128 RoBo-1 Rattus norvegicus 56-60 12224755-9 2002 DMT1 exists in two isoforms resulting from alternate splicing of a single gene product with one of the two mRNA species containing an iron response element (IRE) motif downstream from the stop codon. Iron 134-138 RoBo-1 Rattus norvegicus 0-4 12224755-10 2002 The presence of the IRE provides a binding site for the iron response proteins (IRP1 and 2); binding of either of these proteins could stabilize DMT1 mRNA and would increase expression of the +IRE form of the transporter. Iron 56-60 RoBo-1 Rattus norvegicus 145-149 12224755-11 2002 Iron and Mn compete for transport into PC12 cells via DMT1, so removal of iron from the culture media enhances Mn toxicity. Iron 0-4 RoBo-1 Rattus norvegicus 54-58 12224755-11 2002 Iron and Mn compete for transport into PC12 cells via DMT1, so removal of iron from the culture media enhances Mn toxicity. Iron 74-78 RoBo-1 Rattus norvegicus 54-58 11292622-8 2001 The described distribution of DMT-1 protein is in agreement with our previous identification of nephron sites of iron reabsorption, suggesting that DMT-1 provides the molecular mechanism for apical iron entry in the distal nephron but not in the proximal tubule. Iron 198-202 RoBo-1 Rattus norvegicus 148-153 10644324-9 2000 DMT1 protein staining was observed on hepatocyte plasma membranes, with highest values in the iron loaded state, lower values in control animals, and none after iron depletion. Iron 94-98 RoBo-1 Rattus norvegicus 0-4 11093950-1 2000 Recently, mutation of the DMT1 gene has been discovered to cause ineffective intestinal iron uptake and abnormal body iron metabolism in the anemic Belgrade rat and mk mouse. Iron 88-92 RoBo-1 Rattus norvegicus 26-30 11093950-1 2000 Recently, mutation of the DMT1 gene has been discovered to cause ineffective intestinal iron uptake and abnormal body iron metabolism in the anemic Belgrade rat and mk mouse. Iron 118-122 RoBo-1 Rattus norvegicus 26-30 10644324-0 2000 Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload. Iron 111-115 RoBo-1 Rattus norvegicus 16-44 10644324-0 2000 Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload. Iron 111-115 RoBo-1 Rattus norvegicus 46-50 10644324-2 2000 Recently an iron carrier was cloned and named DMT1 (divalent metal transporter 1). Iron 12-16 RoBo-1 Rattus norvegicus 46-50 10644324-2 2000 Recently an iron carrier was cloned and named DMT1 (divalent metal transporter 1). Iron 12-16 RoBo-1 Rattus norvegicus 52-80 11224665-7 2001 In rats, the divalent metal ion transporter, DMT1, appeared to be important for regulation of both absorption of iron and its movement into the liver. Iron 113-117 RoBo-1 Rattus norvegicus 45-49 10859223-1 2000 Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor (TfR)-transferrin cycle and the activity of the divalent metal transporter (DMT1), although DMT1 cannot be detected morphologically in crypt cells. Iron 14-18 RoBo-1 Rattus norvegicus 216-220 10859223-1 2000 Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor (TfR)-transferrin cycle and the activity of the divalent metal transporter (DMT1), although DMT1 cannot be detected morphologically in crypt cells. Iron 14-18 RoBo-1 Rattus norvegicus 232-236 10859223-3 2000 We showed that DMT1 in our colony of b/b rats contains the G185R mutation, which in enterocytes results in reduced cellular iron content and increased DMT1 gene expression similar to levels in iron deficiency of normal rats. Iron 124-128 RoBo-1 Rattus norvegicus 15-19 10859223-3 2000 We showed that DMT1 in our colony of b/b rats contains the G185R mutation, which in enterocytes results in reduced cellular iron content and increased DMT1 gene expression similar to levels in iron deficiency of normal rats. Iron 193-197 RoBo-1 Rattus norvegicus 15-19 10644324-5 2000 RESULTS: Duodenal DMT1 mRNA was low in crypts and increased at the crypt-villus junction in iron deficient and control rats; it fell in the iron loaded state. Iron 92-96 RoBo-1 Rattus norvegicus 18-22 10644324-9 2000 DMT1 protein staining was observed on hepatocyte plasma membranes, with highest values in the iron loaded state, lower values in control animals, and none after iron depletion. Iron 161-165 RoBo-1 Rattus norvegicus 0-4 10644324-10 2000 CONCLUSIONS: Results are consistent with a role for DMT1 in the transmembrane transport of non-transferrin bound iron from the intestinal lumen and from the portal blood. Iron 113-117 RoBo-1 Rattus norvegicus 52-56 10473284-2 1999 These rats have a mutation in Divalent Metal Transporter 1, which has been implicated in iron transport from endosomes. Iron 89-93 RoBo-1 Rattus norvegicus 30-58 10473284-8 1999 The results of this study indicate that Divalent Metal Transporter 1 is important to iron transport in the brain. Iron 85-89 RoBo-1 Rattus norvegicus 40-68