PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12965205-0 2003 Iron chelation and a free radical scavenger suppress angiotensin II-induced downregulation of klotho, an anti-aging gene, in rat. Iron 0-4 angiotensinogen Rattus norvegicus 53-67 15627796-1 2004 BACKGROUND: Angiotensin II infusion into rats causes iron deposition in the kidney, which may augment the pro-proteinuric effects of this octapeptide. Iron 53-57 angiotensinogen Rattus norvegicus 12-26 15627796-2 2004 We have investigated whether administration of iron mimics the renal damage induced by angiotensin II. Iron 47-51 angiotensinogen Rattus norvegicus 87-101 15627796-6 2004 Prussian blue staining showed that iron deposition was observed mainly in the glomerular and medullar regions in the iron dextran-treated rats, but in the tubular epithelial cells in angiotensin II-infused rats. Iron 35-39 angiotensinogen Rattus norvegicus 183-197 12965205-1 2003 Administration of angiotensin II to rats decreases renal expression of klotho, an aging-related gene, and also causes abnormal iron deposition in renal cells. Iron 127-131 angiotensinogen Rattus norvegicus 18-32 12965205-3 2003 Administration of iron-dextran caused a downregulation of klotho expression, and iron chelation suppressed the angiotensin II-induced downregulation of this gene. Iron 18-22 angiotensinogen Rattus norvegicus 111-125 12965205-5 2003 Collectively, these findings suggest that abnormal iron metabolism and increased oxidative stress are involved in the mechanism of angiotensin II-mediated modulation of klotho expression. Iron 51-55 angiotensinogen Rattus norvegicus 131-145 31511561-6 2019 Knockdown of ABCB7 in H9C2 cells and stimulation with angiotensin II resulted in increased ROS levels, ferritin, and transferrin receptor expression and iron overload in both mitochondria and cytoplasm. Iron 153-157 angiotensinogen Rattus norvegicus 54-68 12356639-2 2002 We have previously reported that continuous administration of angiotensin II to rats results in an overt iron deposition in the renal tubular epithelial cells, which may have a role in angiotensin II-induced renal damage. Iron 105-109 angiotensinogen Rattus norvegicus 62-76 12356639-2 2002 We have previously reported that continuous administration of angiotensin II to rats results in an overt iron deposition in the renal tubular epithelial cells, which may have a role in angiotensin II-induced renal damage. Iron 105-109 angiotensinogen Rattus norvegicus 185-199 12356639-3 2002 In the present study, we investigated the role of iron in the development of cardiac injury induced by angiotensin II. Iron 50-54 angiotensinogen Rattus norvegicus 103-117 12356639-5 2002 No iron deposits were observed in the hearts of untreated rats, whereas iron deposition was seen in the cells in the subepicardial and granulation regions after angiotensin II infusion. Iron 72-76 angiotensinogen Rattus norvegicus 161-175 12356639-6 2002 Concomitant administration of deferoxamine, an iron chelator, significantly reduced the extent of cardiac fibrosis, which suggests that iron deposition aggravates the cardiac fibrosis induced by angiotensin II. Iron 47-51 angiotensinogen Rattus norvegicus 195-209 12356639-6 2002 Concomitant administration of deferoxamine, an iron chelator, significantly reduced the extent of cardiac fibrosis, which suggests that iron deposition aggravates the cardiac fibrosis induced by angiotensin II. Iron 136-140 angiotensinogen Rattus norvegicus 195-209 12356639-7 2002 Iron overload caused by the administration of iron-dextran resulted in an augmentation of cardiac fibrosis and the generation of neointimal cells in the coronary artery in angiotensin II-infused rats. Iron 0-4 angiotensinogen Rattus norvegicus 172-186 12356639-9 2002 CONCLUSIONS: Cardiac iron deposition may be involved in the development of cardiac fibrosis induced by angiotensin II. Iron 21-25 angiotensinogen Rattus norvegicus 103-117 12356639-10 2002 In addition, iron overload may enhance the formation of neointima under conditions of increased circulating angiotensin II but not catecholamines. Iron 13-17 angiotensinogen Rattus norvegicus 108-122 11796829-0 2002 Abnormal iron deposition in renal cells in the rat with chronic angiotensin II administration. Iron 9-13 angiotensinogen Rattus norvegicus 64-78 11796829-8 2002 Prussian blue staining revealed the distinct deposits of iron in the proximal tubular epithelial cells after angiotensin II administration. Iron 57-61 angiotensinogen Rattus norvegicus 109-123 11796829-11 2002 Treatment of angiotensin II-infused rats with an iron chelator, deferoxamine, blocked the abnormal iron deposition in kidneys and also the induced expression of HO-1 and ferritin expression. Iron 49-53 angiotensinogen Rattus norvegicus 13-27 11796829-11 2002 Treatment of angiotensin II-infused rats with an iron chelator, deferoxamine, blocked the abnormal iron deposition in kidneys and also the induced expression of HO-1 and ferritin expression. Iron 99-103 angiotensinogen Rattus norvegicus 13-27 11796829-13 2002 These results suggest that angiotensin II causes renal injury, in part, by inducing the deposition of iron in the kidney. Iron 102-106 angiotensinogen Rattus norvegicus 27-41 12356639-0 2002 Iron overload augments angiotensin II-induced cardiac fibrosis and promotes neointima formation. Iron 0-4 angiotensinogen Rattus norvegicus 23-37 17043664-6 2006 By contrast, in the kidneys of angiotensin II-infused rats, apoptosis occurred in tubular cells that contained deposits of iron but not lipids. Iron 123-127 angiotensinogen Rattus norvegicus 31-45 29266790-3 2018 This study aims to explore whether quercetin attenuates ethanol-induced iron uptake and myocardial injury by regulating angiotensin II-L-type voltage-dependent Ca2+ channel (Ang II-LTCC). Iron 72-76 angiotensinogen Rattus norvegicus 120-134 29266790-3 2018 This study aims to explore whether quercetin attenuates ethanol-induced iron uptake and myocardial injury by regulating angiotensin II-L-type voltage-dependent Ca2+ channel (Ang II-LTCC). Iron 72-76 angiotensinogen Rattus norvegicus 174-185 22277574-4 2013 Histological examination showed that pioglitazone reduced the area of cardiac fibrosis and iron deposition in the heart of angiotensin II-treated rats. Iron 91-95 angiotensinogen Rattus norvegicus 123-137 18619522-6 2009 In rats, infusion of angiotensin II increases ferritin levels and arterial thickness which are reversed by treatment with the iron chelator deferoxamine. Iron 126-130 angiotensinogen Rattus norvegicus 21-35 17460390-0 2007 Angiotensin II-induced regulation of the expression and localization of iron metabolism-related genes in the rat kidney. Iron 72-76 angiotensinogen Rattus norvegicus 0-14 17460390-2 2007 We have previously shown that the administration of angiotensin II alters iron homeostasis in the rat kidney, which may in turn aggravate angiotensin II-induced renal damage. Iron 74-78 angiotensinogen Rattus norvegicus 52-66 17460390-2 2007 We have previously shown that the administration of angiotensin II alters iron homeostasis in the rat kidney, which may in turn aggravate angiotensin II-induced renal damage. Iron 74-78 angiotensinogen Rattus norvegicus 138-152 17460390-6 2007 Staining of serial sections revealed that some, but not all, of the renal tubular cells positive for these genes contained iron deposits in the kidney of angiotensin II-infused animals. Iron 123-127 angiotensinogen Rattus norvegicus 154-168 17460390-7 2007 Real-time polymerase chain reaction (PCR) showed that the mRNA expression of TfR, iron-responsive element-negative DMT1, FPN, and hepcidin mRNA increased ~1.9-fold, ~1.7-fold, ~2.3-fold, and ~4.7-fold, respectively, after angiotensin II infusion as compared with that of untreated controls, and that these increases could be suppressed by the concomitant administration of losartan. Iron 82-86 angiotensinogen Rattus norvegicus 222-236 16100038-0 2005 Iron chelation suppresses ferritin upregulation and attenuates vascular dysfunction in the aorta of angiotensin II-infused rats. Iron 0-4 angiotensinogen Rattus norvegicus 100-114 16100038-1 2005 OBJECTIVE: We have investigated whether long-term administration of angiotensin (Ang) II causes ferritin induction and iron accumulation in the rat aorta, and their possible relation to regulatory effects on gene expression and vascular function in Ang II-infused animals. Iron 119-123 angiotensinogen Rattus norvegicus 68-88 16100038-5 2005 Prussian blue staining showed that stainable iron was observed in the adventitial layer of aorta from Ang II-infused animals, but not in the endothelial layer. Iron 45-49 angiotensinogen Rattus norvegicus 102-108 16100038-7 2005 In addition, iron chelation attenuated Ang II-induced impairment of aortic relaxations in response to acetylcholine and sodium nitroprusside and suppressed upregulation of mRNA levels of monocyte chemoattractant protein-1. Iron 13-17 angiotensinogen Rattus norvegicus 39-45 16100038-8 2005 Iron chelation also partially attenuated the medial thickening and perivascular fibrosis induced by Ang II infusion for 4 weeks. Iron 0-4 angiotensinogen Rattus norvegicus 100-106 16100038-9 2005 CONCLUSIONS: Ang II infusion caused ferritin induction and iron deposition in the aortas. Iron 59-63 angiotensinogen Rattus norvegicus 13-19 16203876-6 2005 Treatment of angiotensin II-infused animals with an iron chelator, deferoxamine, attenuated the angiotensin II-induced increases in renal expression of SREBP-1 and fatty acid synthase and normalized the lipid content in the renal cortical tissues. Iron 52-56 angiotensinogen Rattus norvegicus 13-27 16203876-6 2005 Treatment of angiotensin II-infused animals with an iron chelator, deferoxamine, attenuated the angiotensin II-induced increases in renal expression of SREBP-1 and fatty acid synthase and normalized the lipid content in the renal cortical tissues. Iron 52-56 angiotensinogen Rattus norvegicus 96-110 16203876-7 2005 Abnormal lipid metabolism may be associated with upregulation of TGF-beta1 expression and aberrant iron homeostasis in the kidneys of angiotensin II-infused animals. Iron 99-103 angiotensinogen Rattus norvegicus 134-148 15550525-0 2005 Iron chelation and a free radical scavenger suppress angiotensin II-induced upregulation of TGF-beta1 in the heart. Iron 0-4 angiotensinogen Rattus norvegicus 53-67 15550525-2 2005 We previously found iron deposition in the heart of the angiotensin II-infused rat, which may promote angiotensin II-induced cardiac damage. Iron 20-24 angiotensinogen Rattus norvegicus 56-70 15550525-2 2005 We previously found iron deposition in the heart of the angiotensin II-infused rat, which may promote angiotensin II-induced cardiac damage. Iron 20-24 angiotensinogen Rattus norvegicus 102-116 15550525-8 2005 These results collectively suggest that iron and the iron-mediated generation of reactive oxygen species may contribute to angiotensin II-induced upregulation of profibrotic and proinflammatory genes, such as TGF-beta1 and monocyte chemoattractant protein-1. Iron 40-44 angiotensinogen Rattus norvegicus 123-137 15550525-8 2005 These results collectively suggest that iron and the iron-mediated generation of reactive oxygen species may contribute to angiotensin II-induced upregulation of profibrotic and proinflammatory genes, such as TGF-beta1 and monocyte chemoattractant protein-1. Iron 53-57 angiotensinogen Rattus norvegicus 123-137 15604307-0 2005 Administration of ANG II induces iron deposition and upregulation of TGF-beta1 mRNA in the rat liver. Iron 33-37 angiotensinogen Rattus norvegicus 18-24 15604307-1 2005 We previously found that ANG II infusion into rats causes iron deposition in the kidney and heart, which may have a role in the regulation of profibrotic gene expression and tissue fibrosis. Iron 58-62 angiotensinogen Rattus norvegicus 25-31 15604307-2 2005 In the present study, we have investigated whether ANG II can also induce iron accumulation in the liver. Iron 74-78 angiotensinogen Rattus norvegicus 51-57 15604307-7 2005 Taken together, our data suggest that ANG II infusion induces aberrant iron homeostasis in the liver, which may have a role in the ANG II-induced upregulation of profibrotic gene expression in the liver. Iron 71-75 angiotensinogen Rattus norvegicus 38-44 15604307-7 2005 Taken together, our data suggest that ANG II infusion induces aberrant iron homeostasis in the liver, which may have a role in the ANG II-induced upregulation of profibrotic gene expression in the liver. Iron 71-75 angiotensinogen Rattus norvegicus 131-137 15492480-0 2004 Role of aberrant iron homeostasis in the upregulation of transforming growth factor-beta1 in the kidney of angiotensin II-induced hypertensive rats. Iron 17-21 angiotensinogen Rattus norvegicus 107-121 15492480-1 2004 We have previously shown that abnormal iron metabolism might be one underlying mechanism of the renal damage observed in the angiotensin II-infused rat. Iron 39-43 angiotensinogen Rattus norvegicus 125-139 15492480-3 2004 The purpose of the present study was to examine the effects of an iron chelator and a free radical scavenger on the angiotensin II-induced upregulation of TGF-beta1 in the kidney. Iron 66-70 angiotensinogen Rattus norvegicus 116-130 15492480-7 2004 Although tubular cells that overexpressed TGF-beta1 did not contain iron particles, angiotensin II-induced TGF-beta1 upregulation was suppressed by the iron chelator and the free radical scavenger. Iron 152-156 angiotensinogen Rattus norvegicus 84-98 15492480-10 2004 Collectively, these data suggest that the renal iron overload and presumed subsequent increase in oxidative stress play a role in angiotensin II-induced upregulation of the mRNAs of TGF-beta1 and collagen types I and IV in the kidney. Iron 48-52 angiotensinogen Rattus norvegicus 130-144