PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33799121-4 2021 Assessment of these changes reveal increased expression of proteins critical for iron uptake, namely transferrin receptor 1 and the divalent metal transporter 1 (DMT1), and decreased expression of the iron exporter, ferroportin-1 (FPN1). Iron 201-205 solute carrier family 40 member 1 Homo sapiens 216-229 34675995-11 2021 These findings supported the hypothesis that downregulated HEPC could lose its function as a negative regulator of FPN1, resulting in iron overload in HbE/beta-thalassemia patients. Iron 134-138 solute carrier family 40 member 1 Homo sapiens 115-119 34675995-12 2021 Subsequently, assessing HEPC and FPN1 gene expression may be a useful tool to determine the risk of iron toxicity in patients with HbE/beta-thalassemia and their parents, and could therefore be considered as a therapeutic target in the management of iron burden in these patients. Iron 100-104 solute carrier family 40 member 1 Homo sapiens 33-37 34091657-9 2021 Drinking frequency was also related to decreased placental ferroportin-1:transferrin receptor-1 (beta = -0.57 for logged values; 95% CI: -1.03 to -0.10), indicating iron-restricted placental iron transport. Iron 165-169 solute carrier family 40 member 1 Homo sapiens 59-72 34091657-9 2021 Drinking frequency was also related to decreased placental ferroportin-1:transferrin receptor-1 (beta = -0.57 for logged values; 95% CI: -1.03 to -0.10), indicating iron-restricted placental iron transport. Iron 191-195 solute carrier family 40 member 1 Homo sapiens 59-72 35225679-0 2022 Estimates of West African Ancestry in African Americans Using Alleles of Iron-Related Genes HJV, SLC40A1, and TFR2. Iron 73-77 solute carrier family 40 member 1 Homo sapiens 97-104 35390708-4 2022 By consuming glutathione and oxidizing glucose to increase the H2O2 level in cancer cells and downregulating ferroportin 1 to accumulate intracellular iron ions, the homeostasis disruptor could effectively enhance the ferroptosis. Iron 151-155 solute carrier family 40 member 1 Homo sapiens 109-122 35624674-8 2022 We further elucidated that PPARdelta modulated cellular iron homeostasis by regulating expression of divalent metal transporter 1, ferroportin 1, and ferritin, but not transferrin receptor 1, through iron regulatory protein 1 in 6-OHDA-treated cells. Iron 56-60 solute carrier family 40 member 1 Homo sapiens 131-144 34204327-2 2021 In vertebrates, the stability of iron concentration in plasma and extracellular fluid, and the total body iron content are maintained by the interaction of the iron-regulatory peptide hormone hepcidin with its receptor and cellular iron exporter ferroportin (SLC40a1). Iron 33-37 solute carrier family 40 member 1 Homo sapiens 259-266 34204327-2 2021 In vertebrates, the stability of iron concentration in plasma and extracellular fluid, and the total body iron content are maintained by the interaction of the iron-regulatory peptide hormone hepcidin with its receptor and cellular iron exporter ferroportin (SLC40a1). Iron 106-110 solute carrier family 40 member 1 Homo sapiens 259-266 34204327-2 2021 In vertebrates, the stability of iron concentration in plasma and extracellular fluid, and the total body iron content are maintained by the interaction of the iron-regulatory peptide hormone hepcidin with its receptor and cellular iron exporter ferroportin (SLC40a1). Iron 160-164 solute carrier family 40 member 1 Homo sapiens 259-266 34204327-2 2021 In vertebrates, the stability of iron concentration in plasma and extracellular fluid, and the total body iron content are maintained by the interaction of the iron-regulatory peptide hormone hepcidin with its receptor and cellular iron exporter ferroportin (SLC40a1). Iron 232-236 solute carrier family 40 member 1 Homo sapiens 259-266 35562334-5 2022 Notably, suppression of FGFR4 dramatically diminishes glutathione synthesis and Fe2+ efflux efficiency via the beta-catenin/TCF4-SLC7A11/FPN1 axis, resulting in excessive ROS production and labile iron pool accumulation. Iron 197-201 solute carrier family 40 member 1 Homo sapiens 137-141 35404886-2 2022 Mounting clinical and experimental evidence also suggest that E2 modulates cellular iron metabolism by regulating the expression of several iron regulatory genes, including hepcidin (HAMP), hypoxia-inducible factor 1-alpha, ferroportin (SLC40A1), and lipocalin (LCN2). Iron 140-144 solute carrier family 40 member 1 Homo sapiens 237-244 35225679-2 2022 In sub-Saharan West African (WA) Blacks, some nonancestral alleles of iron-related genes HJV, SLC40A1, and TFR2 are common, whereas in European Americans (EA) the same alleles are rare. Iron 70-74 solute carrier family 40 member 1 Homo sapiens 94-101 35124772-3 2021 Ferroportin1 (FPN1) is the only mammalian protein associated with iron release and thus plays a vital role in iron homeostasis, while nuclear factor E2-related factor 2 (NRF2) controls the transcription of FPN1. Iron 110-114 solute carrier family 40 member 1 Homo sapiens 14-18 35204067-8 2022 As for iron-related proteins, an up-regulation of placental DMT1, ferroportin-1, and ferritin expression was recorded in infected women. Iron 7-11 solute carrier family 40 member 1 Homo sapiens 66-79 33714956-3 2021 FPN1 is the only known mammalian iron exporter. Iron 33-37 solute carrier family 40 member 1 Homo sapiens 0-4 35124772-3 2021 Ferroportin1 (FPN1) is the only mammalian protein associated with iron release and thus plays a vital role in iron homeostasis, while nuclear factor E2-related factor 2 (NRF2) controls the transcription of FPN1. Iron 66-70 solute carrier family 40 member 1 Homo sapiens 0-12 35124772-3 2021 Ferroportin1 (FPN1) is the only mammalian protein associated with iron release and thus plays a vital role in iron homeostasis, while nuclear factor E2-related factor 2 (NRF2) controls the transcription of FPN1. Iron 66-70 solute carrier family 40 member 1 Homo sapiens 14-18 35124772-3 2021 Ferroportin1 (FPN1) is the only mammalian protein associated with iron release and thus plays a vital role in iron homeostasis, while nuclear factor E2-related factor 2 (NRF2) controls the transcription of FPN1. Iron 110-114 solute carrier family 40 member 1 Homo sapiens 0-12 33398092-4 2021 Here, we report that ferroportin1 (Fpn), the only identified mammalian nonheme iron exporter, was downregulated in the brains of APPswe/PS1dE9 mice as an Alzheimer"s mouse model and Alzheimer"s patients. Iron 79-83 solute carrier family 40 member 1 Homo sapiens 21-33 33398092-4 2021 Here, we report that ferroportin1 (Fpn), the only identified mammalian nonheme iron exporter, was downregulated in the brains of APPswe/PS1dE9 mice as an Alzheimer"s mouse model and Alzheimer"s patients. Iron 79-83 solute carrier family 40 member 1 Homo sapiens 35-38 33787609-4 2021 Type 4B HH is a rare autosomal dominant disease that results from mutations in the Solute Carrier Family 40 member 1 (SLC40A1) gene, which encodes the iron transport protein ferroportin. Iron 151-155 solute carrier family 40 member 1 Homo sapiens 83-116 33787609-4 2021 Type 4B HH is a rare autosomal dominant disease that results from mutations in the Solute Carrier Family 40 member 1 (SLC40A1) gene, which encodes the iron transport protein ferroportin. Iron 151-155 solute carrier family 40 member 1 Homo sapiens 118-125 33722625-7 2021 Transcriptome analysis indicates that clusters of genes are up-or down-regulated in aged LECs, impacting cellular redox and iron homeostases, such as downregulation of both cystine/glutamate antiporter subunits SLC7A11 and SLC3A2 and iron exporter ferroportin (SLC40A1). Iron 124-128 solute carrier family 40 member 1 Homo sapiens 261-268 33683742-6 2021 Divalent metal transporter 1(DMT1) decreased significantly, ferroportin 1 and ferritin increased significantly in the liver of UL iron group (p < 0.05). Iron 130-134 solute carrier family 40 member 1 Homo sapiens 60-73 33673803-0 2021 Long-term phlebotomy successfully alleviated hepatic iron accumulation in a ferroportin disease patient with a mutation in SLC40A1: a case report. Iron 53-57 solute carrier family 40 member 1 Homo sapiens 123-130 33673803-2 2021 Hepcidin is a soluble regulator that acts to attenuate both intestinal iron absorption and iron release from reticuloendothelial macrophages through internalization of ferroportin-1, an iron exporter. Iron 91-95 solute carrier family 40 member 1 Homo sapiens 168-181 33673803-2 2021 Hepcidin is a soluble regulator that acts to attenuate both intestinal iron absorption and iron release from reticuloendothelial macrophages through internalization of ferroportin-1, an iron exporter. Iron 91-95 solute carrier family 40 member 1 Homo sapiens 168-181 33673803-12 2021 CONCLUSIONS: The present case demonstrated for the first time that there was a correlation between hepatic iron levels as measured by MRI and serum hepcidin levels through long-term phlebotomy in a patient with ferroportin disease with the p.H507R mutation of in SLC40A1. Iron 107-111 solute carrier family 40 member 1 Homo sapiens 263-270 33714956-10 2021 GO and KEGG analyses and GSEA suggested that FPN1 was remarkably related to iron homeostasis and immunity. Iron 76-80 solute carrier family 40 member 1 Homo sapiens 45-49 33490642-1 2021 Ferroportin (Fpn/IREG1/MTP1) is the only known transporter mediating iron efflux from epithelial cells and macrophages, and thus regulates how much iron is released into the circulation. Iron 69-73 solute carrier family 40 member 1 Homo sapiens 17-22 33385755-0 2021 Functional characterization of a novel SLC40A1 Arg88Ile mutation in a kindred with familial iron overload treated by phlebotomy. Iron 92-96 solute carrier family 40 member 1 Homo sapiens 39-46 32607777-3 2021 SLC40A1 encodes ferroportin, a macromolecule only known as iron exporter from mammalian cells. Iron 59-63 solute carrier family 40 member 1 Homo sapiens 0-7 33490642-1 2021 Ferroportin (Fpn/IREG1/MTP1) is the only known transporter mediating iron efflux from epithelial cells and macrophages, and thus regulates how much iron is released into the circulation. Iron 69-73 solute carrier family 40 member 1 Homo sapiens 23-27 33490642-1 2021 Ferroportin (Fpn/IREG1/MTP1) is the only known transporter mediating iron efflux from epithelial cells and macrophages, and thus regulates how much iron is released into the circulation. Iron 148-152 solute carrier family 40 member 1 Homo sapiens 17-22 33490642-1 2021 Ferroportin (Fpn/IREG1/MTP1) is the only known transporter mediating iron efflux from epithelial cells and macrophages, and thus regulates how much iron is released into the circulation. Iron 148-152 solute carrier family 40 member 1 Homo sapiens 23-27 33075721-9 2021 Placenta with fetal death (miscarriage) in the first and second trimester indicate significantly higher ratio of ho-1 gene for iron production to the fpn-1 gene for iron excretion than normal. Iron 165-169 solute carrier family 40 member 1 Homo sapiens 150-155 33419006-5 2021 Also present in the cerebrospinal fluid (CSF), hepcidin can reduce iron export from neurons and decreases iron entry through the blood-brain barrier (BBB) by binding to the iron exporter ferroportin 1 (Fpn1). Iron 106-110 solute carrier family 40 member 1 Homo sapiens 187-200 33419006-5 2021 Also present in the cerebrospinal fluid (CSF), hepcidin can reduce iron export from neurons and decreases iron entry through the blood-brain barrier (BBB) by binding to the iron exporter ferroportin 1 (Fpn1). Iron 106-110 solute carrier family 40 member 1 Homo sapiens 202-206 33419006-5 2021 Also present in the cerebrospinal fluid (CSF), hepcidin can reduce iron export from neurons and decreases iron entry through the blood-brain barrier (BBB) by binding to the iron exporter ferroportin 1 (Fpn1). Iron 106-110 solute carrier family 40 member 1 Homo sapiens 187-200 33419006-5 2021 Also present in the cerebrospinal fluid (CSF), hepcidin can reduce iron export from neurons and decreases iron entry through the blood-brain barrier (BBB) by binding to the iron exporter ferroportin 1 (Fpn1). Iron 106-110 solute carrier family 40 member 1 Homo sapiens 202-206 32038278-1 2019 The liver-derived hormone hepcidin plays a key role in iron metabolism by mediating the degradation of the iron export protein ferroportin 1 (FPN1). Iron 55-59 solute carrier family 40 member 1 Homo sapiens 127-140 31973819-5 2020 In addition, LY294002 also inhibited the basal expression of HEPH and FPN1 resulting in blockade of iron egress from cells. Iron 100-104 solute carrier family 40 member 1 Homo sapiens 70-74 31320750-13 2020 Together, we have identified an unexpected ATM-MTF1-Ferritin/FPN1 regulatory axis as novel determinants of ferroptosis through regulating labile iron levels. Iron 145-149 solute carrier family 40 member 1 Homo sapiens 61-65 32096669-1 2021 Background: During pregnancy, iron is transferred from mother to fetus with placental iron transport proteins (Transferrin receptor, Divalent metal transporter/DMT1, ferroportin/FPN1 and Zyklopen). Iron 30-34 solute carrier family 40 member 1 Homo sapiens 178-182 32258529-8 2020 Ferroportin disease is due to loss-of-function mutation of SLC40A1 that impairs the iron export efficiency of ferroportin, causes iron retention in reticuloendothelial cell and hyperferritinemia with normal transferrin saturation. Iron 84-88 solute carrier family 40 member 1 Homo sapiens 59-66 32258529-8 2020 Ferroportin disease is due to loss-of-function mutation of SLC40A1 that impairs the iron export efficiency of ferroportin, causes iron retention in reticuloendothelial cell and hyperferritinemia with normal transferrin saturation. Iron 130-134 solute carrier family 40 member 1 Homo sapiens 59-66 32023254-7 2020 Additionally, the LIP was raised along with an elevated mRNA expression of ferritin and HO-1, as also iron exporters NRAMP-1 and Fpn-1. Iron 102-106 solute carrier family 40 member 1 Homo sapiens 129-134 32023254-9 2020 However, enhancement of the iron exporters (NRAMP-1 and Fpn-1) defied the classical Ferritinlow/Ferroportinhigh phenotype of alternatively activated macrophages. Iron 28-32 solute carrier family 40 member 1 Homo sapiens 56-61 31721611-0 2020 Increased divalent metal ion transporter-1 (DMT1) and ferroportin-1 (FPN1) expression with enhanced iron absorption in ulcerative colitis human colon. Iron 100-104 solute carrier family 40 member 1 Homo sapiens 54-67 31721611-0 2020 Increased divalent metal ion transporter-1 (DMT1) and ferroportin-1 (FPN1) expression with enhanced iron absorption in ulcerative colitis human colon. Iron 100-104 solute carrier family 40 member 1 Homo sapiens 69-73 31721611-2 2020 Most iron absorption occurs in the duodenum via divalent metal transporter 1 (DMT1)-mediated uptake and ferroportin 1 (FPN1)-mediated export across the apical and basolateral membranes, respectively. Iron 5-9 solute carrier family 40 member 1 Homo sapiens 104-117 31721611-2 2020 Most iron absorption occurs in the duodenum via divalent metal transporter 1 (DMT1)-mediated uptake and ferroportin 1 (FPN1)-mediated export across the apical and basolateral membranes, respectively. Iron 5-9 solute carrier family 40 member 1 Homo sapiens 119-123 32038278-1 2019 The liver-derived hormone hepcidin plays a key role in iron metabolism by mediating the degradation of the iron export protein ferroportin 1 (FPN1). Iron 55-59 solute carrier family 40 member 1 Homo sapiens 142-146 32038278-1 2019 The liver-derived hormone hepcidin plays a key role in iron metabolism by mediating the degradation of the iron export protein ferroportin 1 (FPN1). Iron 107-111 solute carrier family 40 member 1 Homo sapiens 127-140 32038278-1 2019 The liver-derived hormone hepcidin plays a key role in iron metabolism by mediating the degradation of the iron export protein ferroportin 1 (FPN1). Iron 107-111 solute carrier family 40 member 1 Homo sapiens 142-146 31423010-6 2019 The cellular iron concentration regulated the expression of the iron-regulatory protein (IRP) via the 5"-untranslated region of IRP messenger RNA and modulated the post-transcriptional stability of FPN1. Iron 13-17 solute carrier family 40 member 1 Homo sapiens 198-202 31690120-1 2019 Ferroportin 1 (FPN1) is a major facilitator superfamily transporter that is essential for proper maintenance of human iron homeostasis at the systemic and cellular level. Iron 118-122 solute carrier family 40 member 1 Homo sapiens 0-13 31690120-1 2019 Ferroportin 1 (FPN1) is a major facilitator superfamily transporter that is essential for proper maintenance of human iron homeostasis at the systemic and cellular level. Iron 118-122 solute carrier family 40 member 1 Homo sapiens 15-19 31690120-2 2019 FPN1 dysfunction leads to the progressive accumulation of iron in reticuloendothelial cells, causing hemochromatosis type 4A (or ferroportin disease), an autosomal dominant disorder that displays large phenotypic heterogeneity. Iron 58-62 solute carrier family 40 member 1 Homo sapiens 0-4 31423010-8 2019 Nrf2-mediated FPN1 downregulation promoted intracellular iron accumulation and reactive oxygen species. Iron 57-61 solute carrier family 40 member 1 Homo sapiens 14-18 30776900-0 2019 Iron Dyshomeostasis Induces Binding of APP to BACE1 for Amyloid Pathology, and Impairs APP/Fpn1 Complex in Microglia: Implication in Pathogenesis of Cerebral Microbleeds. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 91-95 31412634-7 2019 Studies in intestinal cell culture models demonstrate that zinc induces iron uptake and transcellular transport via induction of divalent metal iron transporter-1 (DMT1) and ferroportin (FPN1) expression, respectively. Iron 72-76 solute carrier family 40 member 1 Homo sapiens 187-191 31412634-9 2019 Therefore, zinc appears to be modulating the iron metabolism possibly via regulating the DMT1 and FPN1 levels. Iron 45-49 solute carrier family 40 member 1 Homo sapiens 98-102 31412634-10 2019 Herein we critically reviewed the available evidence to hypothesize novel mechanism of Zinc-DMT1/FPN1 axis in regulating intestinal iron absorption and tissue iron accumulation to facilitate future research aimed at understanding the yet elusive mechanisms of iron and zinc interactions. Iron 132-136 solute carrier family 40 member 1 Homo sapiens 97-101 31412634-10 2019 Herein we critically reviewed the available evidence to hypothesize novel mechanism of Zinc-DMT1/FPN1 axis in regulating intestinal iron absorption and tissue iron accumulation to facilitate future research aimed at understanding the yet elusive mechanisms of iron and zinc interactions. Iron 159-163 solute carrier family 40 member 1 Homo sapiens 97-101 31412634-10 2019 Herein we critically reviewed the available evidence to hypothesize novel mechanism of Zinc-DMT1/FPN1 axis in regulating intestinal iron absorption and tissue iron accumulation to facilitate future research aimed at understanding the yet elusive mechanisms of iron and zinc interactions. Iron 159-163 solute carrier family 40 member 1 Homo sapiens 97-101 30776900-3 2019 In this study, we found a profound increase of amyloid formation with increasing FeCl3 treatment, and a distinct change in APP metabolism and expression of iron homeostasis proteins (ferritin, Fpn1, iron regulatory protein) was observed at the 300 uM concentration of FeCl3. Iron 156-160 solute carrier family 40 member 1 Homo sapiens 193-197 30776900-4 2019 Further results revealed that extracellular iron accumulation might potentially induce binding of APP to BACE1 for amyloid formation and decrease the capability of APP/Fpn1 in mediating iron export. Iron 44-48 solute carrier family 40 member 1 Homo sapiens 168-172 30776900-4 2019 Further results revealed that extracellular iron accumulation might potentially induce binding of APP to BACE1 for amyloid formation and decrease the capability of APP/Fpn1 in mediating iron export. Iron 186-190 solute carrier family 40 member 1 Homo sapiens 168-172 30132882-4 2019 We demonstrated that the iron exporter ferroportin 1 (FPN1) and iron importer divalent metal transporter 1 (DMT1) were upregulated and iron content was decreased after estrogen treatment for 12 hr in primary cultured astrocytes. Iron 25-29 solute carrier family 40 member 1 Homo sapiens 39-52 30500107-5 2019 To analyse iron export capacity of the SLC40A1 p.Y333H mutant, the 293T cells were transfected with the SLC40A1 p.Y333H construct and then treated with hepcidin after exposure to ferric ammonium citrate. Iron 11-15 solute carrier family 40 member 1 Homo sapiens 39-46 30500107-7 2019 RESULTS: Of 22 unrelated cases with primary iron overload, three cases (3/22, 13.6%) harboured the SLC40A1 p.Y333H, with no missense mutations identified in any other classical haemochromatosis-related genes including HFE, HJV, HAMP and TFR2. Iron 44-48 solute carrier family 40 member 1 Homo sapiens 99-108 30852438-2 2019 Here we show that SLC40A1, the gene encoding the iron exporter ferroportin (FPN), is variably expressed among primary AMLs and that low levels are associated with good prognosis and improved outcomes. Iron 49-53 solute carrier family 40 member 1 Homo sapiens 18-25 30811632-5 2019 METHODS AND RESULTS: We first investigated the mRNA level of iron metabolism-related genes, including hepcidin, ferroportin 1 (FPN-1) and transferrin receptor (TFR)-1/2. Iron 61-65 solute carrier family 40 member 1 Homo sapiens 112-125 30811632-5 2019 METHODS AND RESULTS: We first investigated the mRNA level of iron metabolism-related genes, including hepcidin, ferroportin 1 (FPN-1) and transferrin receptor (TFR)-1/2. Iron 61-65 solute carrier family 40 member 1 Homo sapiens 127-132 30132882-4 2019 We demonstrated that the iron exporter ferroportin 1 (FPN1) and iron importer divalent metal transporter 1 (DMT1) were upregulated and iron content was decreased after estrogen treatment for 12 hr in primary cultured astrocytes. Iron 25-29 solute carrier family 40 member 1 Homo sapiens 54-58 31456203-4 2019 Divalent metal transporter 1 (DMT1) at the apical membrane of intestinal enterocyte brings in non-heme iron from the diet, whereas ferroportin 1 (FPN1) at the basal membrane exports iron into the circulation. Iron 182-186 solute carrier family 40 member 1 Homo sapiens 131-144 30260393-9 2019 In parallel to increased expression of lipid storage-related genes (mitoNEET, SCD, DGAT2, SREBF1), SAT Tf, SLC40A1 (encoding ferroportin 1, a membrane iron export channel) and hephaestin mRNA levels increased, whereas SAT FTL mRNA decreased, suggesting increased AT iron requirement. Iron 151-155 solute carrier family 40 member 1 Homo sapiens 107-114 30260393-9 2019 In parallel to increased expression of lipid storage-related genes (mitoNEET, SCD, DGAT2, SREBF1), SAT Tf, SLC40A1 (encoding ferroportin 1, a membrane iron export channel) and hephaestin mRNA levels increased, whereas SAT FTL mRNA decreased, suggesting increased AT iron requirement. Iron 151-155 solute carrier family 40 member 1 Homo sapiens 125-138 30855106-4 2019 Hepcidin switches off cellular iron export via ferroportin-1 and sequesters the metal mainly within macrophages, which limits the transfer of iron to the serum to restrict its availability for extracellular microbes. Iron 31-35 solute carrier family 40 member 1 Homo sapiens 47-60 30855106-5 2019 When intracellular microbes are present within macrophages though, the opposite regulation is initiated because infected cells respond with increased ferroportin-1 expression and enhanced iron export as a strategy of iron withdrawal from engulfed bacteria. Iron 217-221 solute carrier family 40 member 1 Homo sapiens 150-163 30247984-2 2019 Mutations in the FPN1 gene, encoding a cell surface iron exporter [ferroportin (Fpn)], are responsible for hemochromatosis type 4, also known as ferroportin disease. Iron 52-56 solute carrier family 40 member 1 Homo sapiens 17-21 31456203-4 2019 Divalent metal transporter 1 (DMT1) at the apical membrane of intestinal enterocyte brings in non-heme iron from the diet, whereas ferroportin 1 (FPN1) at the basal membrane exports iron into the circulation. Iron 182-186 solute carrier family 40 member 1 Homo sapiens 146-150 31456203-8 2019 Excess iron can be exported from the cell via FPN1. Iron 7-11 solute carrier family 40 member 1 Homo sapiens 46-50 31456203-10 2019 Inside the cells, iron regulatory proteins (IRPs) modulate the expressions of DMT1, TfR1, ferritin, and FPN1 via binding to the iron-responsive element (IRE) in their mRNAs. Iron 18-22 solute carrier family 40 member 1 Homo sapiens 104-108 31456203-10 2019 Inside the cells, iron regulatory proteins (IRPs) modulate the expressions of DMT1, TfR1, ferritin, and FPN1 via binding to the iron-responsive element (IRE) in their mRNAs. Iron 128-132 solute carrier family 40 member 1 Homo sapiens 104-108 30186818-0 2018 Increased Duodenal Iron Absorption through Upregulation of Ferroportin 1 due to the Decrement in Serum Hepcidin in Patients with Chronic Hepatitis C. Hepatic iron accumulation is generally increased in the chronic hepatitis C (CHC) liver; however, the precise mechanism of such accumulation remains unclear. Iron 19-23 solute carrier family 40 member 1 Homo sapiens 59-72 30002125-2 2018 It is an autosomal dominant disorder, primarily due to missense mutations in SLC40A1 This gene encodes ferroportin 1 (FPN1), which is the sole iron export protein reported in mammals. Iron 143-147 solute carrier family 40 member 1 Homo sapiens 77-84 30002125-2 2018 It is an autosomal dominant disorder, primarily due to missense mutations in SLC40A1 This gene encodes ferroportin 1 (FPN1), which is the sole iron export protein reported in mammals. Iron 143-147 solute carrier family 40 member 1 Homo sapiens 103-116 30002125-2 2018 It is an autosomal dominant disorder, primarily due to missense mutations in SLC40A1 This gene encodes ferroportin 1 (FPN1), which is the sole iron export protein reported in mammals. Iron 143-147 solute carrier family 40 member 1 Homo sapiens 118-122 30002125-10 2018 In vitro experiments demonstrated that the p.Arg178Gln mutant reduces the ability of FPN1 to export iron without causing protein mislocalization. Iron 100-104 solute carrier family 40 member 1 Homo sapiens 85-89 30002125-11 2018 Based on a comparative model of the 3D structure of human FPN1 in an outward facing conformation, we argue that p.Arg178 is part of an interaction network modulating the conformational changes required for iron transport. Iron 206-210 solute carrier family 40 member 1 Homo sapiens 58-62 30186818-0 2018 Increased Duodenal Iron Absorption through Upregulation of Ferroportin 1 due to the Decrement in Serum Hepcidin in Patients with Chronic Hepatitis C. Hepatic iron accumulation is generally increased in the chronic hepatitis C (CHC) liver; however, the precise mechanism of such accumulation remains unclear. Iron 158-162 solute carrier family 40 member 1 Homo sapiens 59-72 29070551-3 2017 Although the absorption of heme iron is poorly understood, nonheme iron is transported across the apical membrane of the intestinal enterocyte by divalent metal-ion transporter 1 (DMT1) and is exported into the circulation via ferroportin 1 (FPN1). Iron 67-71 solute carrier family 40 member 1 Homo sapiens 227-240 29154924-1 2018 Mutations of SLC40A1 encoding ferroportin (Fpn), the unique cellular iron exporter, severely affect iron homeostasis causing type 4 hereditary hemochromatosis, an autosomal dominant iron overload condition with variable phenotypic manifestations. Iron 69-73 solute carrier family 40 member 1 Homo sapiens 13-20 29154924-1 2018 Mutations of SLC40A1 encoding ferroportin (Fpn), the unique cellular iron exporter, severely affect iron homeostasis causing type 4 hereditary hemochromatosis, an autosomal dominant iron overload condition with variable phenotypic manifestations. Iron 100-104 solute carrier family 40 member 1 Homo sapiens 13-20 29154924-1 2018 Mutations of SLC40A1 encoding ferroportin (Fpn), the unique cellular iron exporter, severely affect iron homeostasis causing type 4 hereditary hemochromatosis, an autosomal dominant iron overload condition with variable phenotypic manifestations. Iron 100-104 solute carrier family 40 member 1 Homo sapiens 13-20 29871715-9 2018 Intestinal expression of ferroportin 1, a mediator of iron absorption, was increased, indicating that despite high dietary iron, intestinal iron absorption did not compensate for iron losses. Iron 54-58 solute carrier family 40 member 1 Homo sapiens 25-38 29871715-9 2018 Intestinal expression of ferroportin 1, a mediator of iron absorption, was increased, indicating that despite high dietary iron, intestinal iron absorption did not compensate for iron losses. Iron 123-127 solute carrier family 40 member 1 Homo sapiens 25-38 29871715-9 2018 Intestinal expression of ferroportin 1, a mediator of iron absorption, was increased, indicating that despite high dietary iron, intestinal iron absorption did not compensate for iron losses. Iron 123-127 solute carrier family 40 member 1 Homo sapiens 25-38 29871715-9 2018 Intestinal expression of ferroportin 1, a mediator of iron absorption, was increased, indicating that despite high dietary iron, intestinal iron absorption did not compensate for iron losses. Iron 123-127 solute carrier family 40 member 1 Homo sapiens 25-38 29134618-5 2018 Mutations of SLC40A1 that encodes ferroportin, the only cellular iron exporter, causes either HH type 4A (loss-of-function mutations) or HH type 4B (gain-of-function mutations). Iron 65-69 solute carrier family 40 member 1 Homo sapiens 13-20 29070551-3 2017 Although the absorption of heme iron is poorly understood, nonheme iron is transported across the apical membrane of the intestinal enterocyte by divalent metal-ion transporter 1 (DMT1) and is exported into the circulation via ferroportin 1 (FPN1). Iron 67-71 solute carrier family 40 member 1 Homo sapiens 242-246 29070551-6 2017 This iron can be used for metabolic functions, stored within cytosolic ferritin, or exported from the cell via FPN1. Iron 5-9 solute carrier family 40 member 1 Homo sapiens 111-115 28027576-1 2017 Ferroportin (FPN1) is the sole iron exporter in mammals, but its cell-specific function and regulation are still elusive. Iron 31-35 solute carrier family 40 member 1 Homo sapiens 13-17 29101207-3 2017 FPN1 transfers iron from the intestine, macrophages and placenta into the bloodstream. Iron 15-19 solute carrier family 40 member 1 Homo sapiens 0-4 29101207-4 2017 In FD, loss-of-function mutations of FPN1 limit but do not impair iron export in enterocytes, but they do severely affect iron transfer in macrophages. Iron 122-126 solute carrier family 40 member 1 Homo sapiens 37-41 27729173-2 2017 Hepcidin, in fact, promotes the degradation of ferroportin (Fpn1), the iron exporter molecule expressed on the membrane of hepatocytes and macrophages, thus preventing iron release from cells to plasma. Iron 71-75 solute carrier family 40 member 1 Homo sapiens 60-64 27729173-2 2017 Hepcidin, in fact, promotes the degradation of ferroportin (Fpn1), the iron exporter molecule expressed on the membrane of hepatocytes and macrophages, thus preventing iron release from cells to plasma. Iron 168-172 solute carrier family 40 member 1 Homo sapiens 60-64 27729173-7 2017 RESULTS: In samples that had not been exposed to hepcidin, correlations were found between the expression of genes involved in iron absorption: DMT1, Fpn1, Dcytb and HCP1. Iron 127-131 solute carrier family 40 member 1 Homo sapiens 150-154 28655775-3 2017 Recently, we demonstrated that the iron chaperone poly(rC)-binding protein 2 (PCBP2) can directly receive ferrous iron from DMT1 or transfer iron to the iron exporter, ferroportin 1. Iron 35-39 solute carrier family 40 member 1 Homo sapiens 168-181 28655775-3 2017 Recently, we demonstrated that the iron chaperone poly(rC)-binding protein 2 (PCBP2) can directly receive ferrous iron from DMT1 or transfer iron to the iron exporter, ferroportin 1. Iron 114-118 solute carrier family 40 member 1 Homo sapiens 168-181 28655775-3 2017 Recently, we demonstrated that the iron chaperone poly(rC)-binding protein 2 (PCBP2) can directly receive ferrous iron from DMT1 or transfer iron to the iron exporter, ferroportin 1. Iron 114-118 solute carrier family 40 member 1 Homo sapiens 168-181 29075067-1 2017 In this study, the potential effect of three HFE gene polymorphisms (C282Y, H63D and S65C) and the SLC40A1 A77D polymorphism on iron balance was investigated in 234 subjects (91 Arab beta-thalassemia major (BTM) patients, 34 beta-thalassemia trait (BTT) individuals and 109 health controls). Iron 128-132 solute carrier family 40 member 1 Homo sapiens 99-106 29063108-4 2017 HIFs play a key role in iron metabolism by regulating the expression of iron-related proteins, such as divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), duodenal cytochrome b (Dcytb), and transferrin receptor (TfR). Iron 72-76 solute carrier family 40 member 1 Homo sapiens 140-153 28827515-7 2017 RESULTS Statistical analysis of the miRNAs expressions selected for further study the miR-31, miR-133a, miR-141, miR-145, miR-149, and miR-182, which are involved in the posttranscriptional expression of iron-related genes: TF, TFRI, DMT1, FTL, and FPN1. Iron 204-208 solute carrier family 40 member 1 Homo sapiens 249-253 29212168-0 2017 Nrf2 induces cisplatin resistance via suppressing the iron export related gene SLC40A1 in ovarian cancer cells. Iron 54-58 solute carrier family 40 member 1 Homo sapiens 79-86 29212168-2 2017 Solute carrier family 40 member 1 (SLC40A1) is an iron exporter, which possesses many putative Nrf2 binding sites. Iron 50-54 solute carrier family 40 member 1 Homo sapiens 0-33 29212168-2 2017 Solute carrier family 40 member 1 (SLC40A1) is an iron exporter, which possesses many putative Nrf2 binding sites. Iron 50-54 solute carrier family 40 member 1 Homo sapiens 35-42 29212168-8 2017 Overexpression of SLC40A1 was able to reverse cisplatin resistance induced by Nrf2, while knockdown of SLC40A1 restored cisplatin resistance and increased iron concentration. Iron 155-159 solute carrier family 40 member 1 Homo sapiens 103-110 29212168-12 2017 Iron overload induced by SLC40A1 resulted in cisplatin resistance in ovarian cancer. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 25-32 28027576-2 2017 This study examined FPN1 expression in human macrophages, the cells that are primarily responsible on a daily basis for plasma iron turnover and are central in the pathogenesis of ferroportin disease (FD), the disease attributed to lack-of-function FPN1 mutations. Iron 127-131 solute carrier family 40 member 1 Homo sapiens 20-24 28027576-7 2017 However, when FD macrophages were exposed to large amounts of heme iron, in contrast to donor and p.A69T macrophages, FPN1 could no longer reach the cell surface, leading to intracellular iron retention. Iron 67-71 solute carrier family 40 member 1 Homo sapiens 118-122 28027576-7 2017 However, when FD macrophages were exposed to large amounts of heme iron, in contrast to donor and p.A69T macrophages, FPN1 could no longer reach the cell surface, leading to intracellular iron retention. Iron 188-192 solute carrier family 40 member 1 Homo sapiens 118-122 28027576-9 2017 However, in FD, FPN1 fails to reach the cell surface when cells undergo high iron turnover. Iron 77-81 solute carrier family 40 member 1 Homo sapiens 16-20 28118841-4 2017 RESULTS: We show that copper deficiency and the inflammatory cytokine interleukin-6 have different effects on the expression of proteins involved in iron and copper metabolism such as the soluble and glycosylphosphtidylinositol anchored forms of ceruloplasmin, hepcidin, ferroportin1, transferrin receptor1, divalent metal transporter1 and H-ferritin subunit. Iron 149-153 solute carrier family 40 member 1 Homo sapiens 271-283 28464091-7 2017 These results indicated that organic Fe sources with greater Q values showed higher Fe absorption; however, all Fe sources followed the same saturated carrier-dependent transport process in the duodenum, and DMT1 and FPN1 might participate in Fe absorption in the duodenum of broilers regardless of Fe source. Iron 37-39 solute carrier family 40 member 1 Homo sapiens 217-221 28046154-1 2016 Two experiments were conducted with 28-d-old commercial male broilers to study the kinetics of iron (Fe) absorption and the effect of Fe treatment on divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) mRNA levels in in situ ligated segments from different small intestinal regions of broilers. Iron 134-136 solute carrier family 40 member 1 Homo sapiens 190-203 27445333-5 2016 Non-mutagenic chemical ribosomal inactivation disrupted iron homeostasis by regulating expression of the iron exporter FPN-1, leading to intracellular accumulation in enterocytes. Iron 56-60 solute carrier family 40 member 1 Homo sapiens 119-124 27445333-5 2016 Non-mutagenic chemical ribosomal inactivation disrupted iron homeostasis by regulating expression of the iron exporter FPN-1, leading to intracellular accumulation in enterocytes. Iron 105-109 solute carrier family 40 member 1 Homo sapiens 119-124 27298749-14 2016 Our results demonstrate that hepcidin knockdown protected N27 cells from 6-OHDA induced apoptosis and that hepcidin plays a major role in reducing cellular iron burden and oxidative damage by possibly regulating cellular iron export mediated by ferroportin 1. Iron 221-225 solute carrier family 40 member 1 Homo sapiens 245-258 27302059-0 2016 Iron Export through the Transporter Ferroportin 1 Is Modulated by the Iron Chaperone PCBP2. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 36-49 27302059-1 2016 Ferroportin 1 (FPN1) is an iron export protein found in mammals. Iron 27-31 solute carrier family 40 member 1 Homo sapiens 0-13 27302059-1 2016 Ferroportin 1 (FPN1) is an iron export protein found in mammals. Iron 27-31 solute carrier family 40 member 1 Homo sapiens 15-19 27302059-2 2016 FPN1 is important for the export of iron across the basolateral membrane of absorptive enterocytes and across the plasma membrane of macrophages. Iron 36-40 solute carrier family 40 member 1 Homo sapiens 0-4 27302059-9 2016 Importantly, iron-loaded, but not iron-depleted, PCBP2 interacts with FPN1. Iron 13-17 solute carrier family 40 member 1 Homo sapiens 70-74 27302059-11 2016 The silencing of PCBP2 expression suppressed FPN1-dependent iron export from cells. Iron 60-64 solute carrier family 40 member 1 Homo sapiens 45-49 27302059-12 2016 These results suggest that FPN1 exports iron received from the iron chaperone PCBP2. Iron 40-44 solute carrier family 40 member 1 Homo sapiens 27-31 27441659-9 2016 In addition, ferroportin-1 (FPN) is an iron transport protein, responsible for removal of iron from cells. Iron 39-43 solute carrier family 40 member 1 Homo sapiens 13-26 27441659-9 2016 In addition, ferroportin-1 (FPN) is an iron transport protein, responsible for removal of iron from cells. Iron 90-94 solute carrier family 40 member 1 Homo sapiens 13-26 26944411-4 2016 RESULTS: We confirm previous results by showing that breast cancer epithelial cells present an "iron-utilization phenotype" with an increased expression of hepcidin and TFR1, and decreased expression of FT. On the other hand, lymphocytes and macrophages infiltrating primary tumors and from metastized lymph nodes display an "iron-donor" phenotype, with increased expression of FPN1 and FT, concomitant with an activation profile reflected by a higher expression of TFR1 and hepcidin. Iron 96-100 solute carrier family 40 member 1 Homo sapiens 378-382 26743084-2 2016 Although cellular Fe import is well understood, its export is thought to be limited to transmembrane extrusion through ferroportin (also known as Slc40a1), the only known mammalian Fe exporter. Iron 18-20 solute carrier family 40 member 1 Homo sapiens 146-153 26617777-3 2015 Ferroportin 1 (FPN1) is the unique exporter of ferrous iron from mammalian cells. Iron 47-59 solute carrier family 40 member 1 Homo sapiens 0-13 26617777-3 2015 Ferroportin 1 (FPN1) is the unique exporter of ferrous iron from mammalian cells. Iron 47-59 solute carrier family 40 member 1 Homo sapiens 15-19 26756421-6 2015 Expression of the iron-related proteins ferritin, DMT1, and FPN1 was elevated in lung tissue from the six asbestosis patients relative to controls. Iron 18-22 solute carrier family 40 member 1 Homo sapiens 60-64 26185605-5 2015 Some of the suggested pathways are via transcription modulator of hepcidin (STAT3); ferroportin 1 expression on the cells involved in iron transport; transmembrane protease 6 enzyme; and pro-inflammatory cytokines, interleukin (IL)-1, IL-6, tumor necrosis factor-alpha and IL-10. Iron 134-138 solute carrier family 40 member 1 Homo sapiens 84-97 25855377-2 2015 Here, we systematically analyzed iron gene expression signature and demonstrated that mRNA expression of iron exporter ferroportin (FPN1) is significantly downregulated in myeloma cells and correlates negatively with clinic outcome. Iron 33-37 solute carrier family 40 member 1 Homo sapiens 132-136 25855377-2 2015 Here, we systematically analyzed iron gene expression signature and demonstrated that mRNA expression of iron exporter ferroportin (FPN1) is significantly downregulated in myeloma cells and correlates negatively with clinic outcome. Iron 105-109 solute carrier family 40 member 1 Homo sapiens 132-136 25855377-3 2015 Restoring expression of FPN1 reduces intracellular liable iron pool, inhibits STAT3-MCL-1 signaling, and suppresses myeloma cells growth. Iron 58-62 solute carrier family 40 member 1 Homo sapiens 24-28 25916292-0 2015 [The role of serum hepcidin and ferroportin1 in placenta on iron transfer from mother to fetus]. Iron 60-64 solute carrier family 40 member 1 Homo sapiens 32-44 25916292-1 2015 OBJECTIVE: To detect the concentration of serum hepcidin and the mRNA expression level of ferroportin1 (FPN1) in the placenta membrane from full term pregnant women with different degree of iron deficiency, and explore their roles for iron transport in placental. Iron 190-194 solute carrier family 40 member 1 Homo sapiens 90-102 25916292-1 2015 OBJECTIVE: To detect the concentration of serum hepcidin and the mRNA expression level of ferroportin1 (FPN1) in the placenta membrane from full term pregnant women with different degree of iron deficiency, and explore their roles for iron transport in placental. Iron 190-194 solute carrier family 40 member 1 Homo sapiens 104-108 25318588-12 2015 The increased duodenal DcytB, DMT1, and FPN1 expression can enhance intestinal iron absorption to meet the high iron requirements in infants. Iron 79-83 solute carrier family 40 member 1 Homo sapiens 40-44 25318588-12 2015 The increased duodenal DcytB, DMT1, and FPN1 expression can enhance intestinal iron absorption to meet the high iron requirements in infants. Iron 112-116 solute carrier family 40 member 1 Homo sapiens 40-44 25352340-3 2014 We find 11 genome-wide-significant (P<5 x 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14). Iron 80-84 solute carrier family 40 member 1 Homo sapiens 105-112 25330009-5 2014 The expression of duodenal Fpn1 is negatively correlated with mRNA levels of hepcidin, and positively correlated with serum iron parameters. Iron 124-128 solute carrier family 40 member 1 Homo sapiens 27-31 25162662-6 2014 Moreover, this marker was about 200 kb away from the candidate gene SLC40A1 which is responsible for iron export. Iron 101-105 solute carrier family 40 member 1 Homo sapiens 68-75 25120608-0 2014 Iron regulates the expression of ferroportin 1 in the cultured hFOB 1.19 osteoblast cell line. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 33-46 25120608-1 2014 Iron metabolism is tightly regulated in osteoblasts, and ferroportin 1 (FPN1) is the only identified iron exporter in mammals to date. Iron 101-105 solute carrier family 40 member 1 Homo sapiens 57-70 25120608-1 2014 Iron metabolism is tightly regulated in osteoblasts, and ferroportin 1 (FPN1) is the only identified iron exporter in mammals to date. Iron 101-105 solute carrier family 40 member 1 Homo sapiens 72-76 25120608-6 2014 The results demonstrated that increasing iron concentrations via FAC treatment increased the expression of FPN1. Iron 41-45 solute carrier family 40 member 1 Homo sapiens 107-111 25120608-8 2014 In addition to demonstrating that the FNP1 expression changed according to the iron concentration, the observations indicated that changes in FPN1 expression may contribute to the maintenance of the intracellular iron balance in osteoblasts. Iron 213-217 solute carrier family 40 member 1 Homo sapiens 142-146 24714983-1 2014 Hemochromatosis type 4 is a rare form of primary iron overload transmitted as an autosomal dominant trait caused by mutations in the gene encoding the iron transport protein ferroportin 1 (SLC40A1). Iron 49-53 solute carrier family 40 member 1 Homo sapiens 174-187 24714983-1 2014 Hemochromatosis type 4 is a rare form of primary iron overload transmitted as an autosomal dominant trait caused by mutations in the gene encoding the iron transport protein ferroportin 1 (SLC40A1). Iron 49-53 solute carrier family 40 member 1 Homo sapiens 189-196 24714983-1 2014 Hemochromatosis type 4 is a rare form of primary iron overload transmitted as an autosomal dominant trait caused by mutations in the gene encoding the iron transport protein ferroportin 1 (SLC40A1). Iron 151-155 solute carrier family 40 member 1 Homo sapiens 174-187 24714983-1 2014 Hemochromatosis type 4 is a rare form of primary iron overload transmitted as an autosomal dominant trait caused by mutations in the gene encoding the iron transport protein ferroportin 1 (SLC40A1). Iron 151-155 solute carrier family 40 member 1 Homo sapiens 189-196 23784628-1 2013 Ferroportin (SLC40A1) is the only known iron exporter in mammals and is considered a key coordinator of the iron balance between intracellular and systemic iron homeostasis. Iron 40-44 solute carrier family 40 member 1 Homo sapiens 13-20 24132807-6 2014 Iron is released from cells by the iron export protein ferroportin1, which requires the ferroxidase activity of ceruloplasmin or hephestin to load iron safely onto transferrin. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 55-67 24132807-6 2014 Iron is released from cells by the iron export protein ferroportin1, which requires the ferroxidase activity of ceruloplasmin or hephestin to load iron safely onto transferrin. Iron 35-39 solute carrier family 40 member 1 Homo sapiens 55-67 24132807-6 2014 Iron is released from cells by the iron export protein ferroportin1, which requires the ferroxidase activity of ceruloplasmin or hephestin to load iron safely onto transferrin. Iron 147-151 solute carrier family 40 member 1 Homo sapiens 55-67 23943237-2 2013 Mutations in the FPN gene (SLC40A1) lead to autosomal dominant iron overload diseases related either to loss or to gain of function, and usually characterized by normal or low transferrin saturation versus elevated transferrin saturation, respectively. Iron 63-67 solute carrier family 40 member 1 Homo sapiens 27-34 24994858-6 2014 Hepcidin decreases intestinal iron absorption by binding to the iron exporter ferroportin 1 on the basolateral surface of duodenal enterocytes, causing its internalization and degradation. Iron 30-34 solute carrier family 40 member 1 Homo sapiens 78-91 24994858-6 2014 Hepcidin decreases intestinal iron absorption by binding to the iron exporter ferroportin 1 on the basolateral surface of duodenal enterocytes, causing its internalization and degradation. Iron 64-68 solute carrier family 40 member 1 Homo sapiens 78-91 24644245-0 2014 A novel mutation in the SLC40A1 gene associated with reduced iron export in vitro. Iron 61-65 solute carrier family 40 member 1 Homo sapiens 24-31 24644245-7 2014 These findings and the iron overload phenotype of the patient suggest that the novel mutation c.386T>C (p.L129P) in the SLC40A1 gene has incomplete penetrance and causes the classical form of ferroportin disease. Iron 23-27 solute carrier family 40 member 1 Homo sapiens 123-130 24921009-2 2014 While many proteins involved in iron uptake by cells are known, only one cellular iron export protein has been identified in mammals: ferroportin (SLC40A1). Iron 82-86 solute carrier family 40 member 1 Homo sapiens 147-154 23771608-6 2013 In accordance with these iron traffic modulations, both mRNA and protein levels of iron importer divalent metal transporter 1 with iron responsive element (DMT1+IRE) and exporter ferroportin 1 (FPN1) were up-regulated in these cells. Iron 25-29 solute carrier family 40 member 1 Homo sapiens 194-198 23784628-1 2013 Ferroportin (SLC40A1) is the only known iron exporter in mammals and is considered a key coordinator of the iron balance between intracellular and systemic iron homeostasis. Iron 108-112 solute carrier family 40 member 1 Homo sapiens 13-20 23784628-1 2013 Ferroportin (SLC40A1) is the only known iron exporter in mammals and is considered a key coordinator of the iron balance between intracellular and systemic iron homeostasis. Iron 108-112 solute carrier family 40 member 1 Homo sapiens 13-20 22424293-2 2013 There is evidence that tumors possess altered iron homeostasis, which is mediated by the perturbed expression of iron-related proteins, for example, transferrin receptor 1, ferritin and ferroportin 1. Iron 46-50 solute carrier family 40 member 1 Homo sapiens 186-199 23506870-5 2013 Intestinal iron absorption is mediated by SLC11A2 at the apical membrane of enterocytes, followed by basolateral exit via SLC40A1. Iron 11-15 solute carrier family 40 member 1 Homo sapiens 122-129 23506870-9 2013 SLC40A1 is the sole member of the SLC40 family and is involved in the only cellular iron efflux mechanism described. Iron 84-88 solute carrier family 40 member 1 Homo sapiens 0-7 23506870-10 2013 SLC40A1 is highly expressed in several tissues and cells that play a critical role in body iron homeostasis. Iron 91-95 solute carrier family 40 member 1 Homo sapiens 0-7 23506870-12 2013 The roles of SLC11A2 and/or SLC40A1 in iron-associated disorders such as hemochromatosis, neurodegenerative diseases, and breast cancer are also summarized. Iron 39-43 solute carrier family 40 member 1 Homo sapiens 28-35 23991927-3 2013 Many iron-related proteins are expressed in the MPS, including heme oxygenase (HO) for heme degradation, the iron importer transferrin receptor 1 (TfR1) and divalent metal transport 1 (DMT1), the iron exporter ferroportin 1 (FPN1) and the iron regulatory hormone hepcidin. Iron 5-9 solute carrier family 40 member 1 Homo sapiens 210-223 23991927-3 2013 Many iron-related proteins are expressed in the MPS, including heme oxygenase (HO) for heme degradation, the iron importer transferrin receptor 1 (TfR1) and divalent metal transport 1 (DMT1), the iron exporter ferroportin 1 (FPN1) and the iron regulatory hormone hepcidin. Iron 5-9 solute carrier family 40 member 1 Homo sapiens 225-229 22424293-2 2013 There is evidence that tumors possess altered iron homeostasis, which is mediated by the perturbed expression of iron-related proteins, for example, transferrin receptor 1, ferritin and ferroportin 1. Iron 113-117 solute carrier family 40 member 1 Homo sapiens 186-199 23012398-0 2013 Iron homeostasis in porphyria cutanea tarda: mutation analysis of promoter regions of CP, CYBRD1, HAMP and SLC40A1. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 107-114 22137264-6 2012 FPN-1 expression increases upon zinc supplementation and decreases with iron or zinc depletion, effluxing the excess sequestered iron and thus maintaining cellular iron homeostasis. Iron 72-76 solute carrier family 40 member 1 Homo sapiens 0-5 24175256-3 2012 Homozygosity for the common C282Y and H63D HFE polymorphisms influence iron metabolism by hampering hepcidin release by hepatocytes in response to increased iron stores, thereby resulting in inadequate inhibition of the activity of Ferroportin-1, inappropriately high iron absorption and recycling, and iron overload. Iron 71-75 solute carrier family 40 member 1 Homo sapiens 232-245 22137264-6 2012 FPN-1 expression increases upon zinc supplementation and decreases with iron or zinc depletion, effluxing the excess sequestered iron and thus maintaining cellular iron homeostasis. Iron 129-133 solute carrier family 40 member 1 Homo sapiens 0-5 22137264-6 2012 FPN-1 expression increases upon zinc supplementation and decreases with iron or zinc depletion, effluxing the excess sequestered iron and thus maintaining cellular iron homeostasis. Iron 129-133 solute carrier family 40 member 1 Homo sapiens 0-5 22249207-1 2012 The Q248H mutation in the gene SLC40A1 which encodes for the cellular iron exporter ferroportin is relatively common in Africa. Iron 70-74 solute carrier family 40 member 1 Homo sapiens 31-38 22211782-4 2012 Cellular iron export is mediated by the membrane iron transporter ferroportin 1, in conjunction with an iron oxidase. Iron 9-13 solute carrier family 40 member 1 Homo sapiens 66-79 22211782-6 2012 The liver-derived peptide hepcidin binds to ferroportin 1 and removes it from the cell surface, thus reducing iron donation to the plasma. Iron 110-114 solute carrier family 40 member 1 Homo sapiens 44-57 22211782-8 2012 At the cellular level, ferroportin 1 can also be regulated independently of hepcidin by hypoxia-inducible factors and the iron regulatory proteins. Iron 122-126 solute carrier family 40 member 1 Homo sapiens 23-36 22924847-7 2012 Patients with the SLC40A1 genotype were affected by mild iron overload (ferroportin A) or severe iron overload (ferroportin B). Iron 57-61 solute carrier family 40 member 1 Homo sapiens 18-25 22924847-7 2012 Patients with the SLC40A1 genotype were affected by mild iron overload (ferroportin A) or severe iron overload (ferroportin B). Iron 97-101 solute carrier family 40 member 1 Homo sapiens 18-25 22575541-4 2012 Enterocyte iron is exported to the blood via ferroportin 1 on the basolateral membrane. Iron 11-15 solute carrier family 40 member 1 Homo sapiens 45-58 22170436-10 2012 It indicates that FPN1 may participate in placental iron transport, and placental FPN1 expression is obviously not dependent on the iron regular element/iron regular protein regulation. Iron 52-56 solute carrier family 40 member 1 Homo sapiens 18-22 22170436-0 2012 Ferroportin 1 and hephaestin expression in BeWo cell line with different iron treatment. Iron 73-77 solute carrier family 40 member 1 Homo sapiens 0-13 22198321-9 2012 We also demonstrated that ferroportin1 expression was significantly affected by HIF-1alpha in astrocytes, implying that the gene encoding this iron efflux protein might be a hypoxia-inducible one. Iron 143-147 solute carrier family 40 member 1 Homo sapiens 26-38 22170436-11 2012 An alternatively spliced FPN1 isoform that lacks an iron regular element may be the predominant expression in BeWo cells. Iron 52-56 solute carrier family 40 member 1 Homo sapiens 25-29 22170436-3 2012 Ferroportin 1 (FPN1) and hephaestin (Heph) have been identified as the important molecules involved in duodenal iron export. Iron 112-116 solute carrier family 40 member 1 Homo sapiens 0-13 22170436-3 2012 Ferroportin 1 (FPN1) and hephaestin (Heph) have been identified as the important molecules involved in duodenal iron export. Iron 112-116 solute carrier family 40 member 1 Homo sapiens 15-19 22357659-1 2012 BACKGROUND: We studied the association between iron intake and polymorphisms in the iron transporter gene SLC40A1 and the risk of tuberculosis. Iron 47-51 solute carrier family 40 member 1 Homo sapiens 106-113 22357659-5 2012 CONCLUSIONS: This pilot study demonstrated an association between polymorphisms in SLC40A1 and tuberculosis and provided evidence of an interaction between dietary iron and SLC40A1. Iron 164-168 solute carrier family 40 member 1 Homo sapiens 173-180 21901657-2 2011 Mutations in FPN1, the gene that encodes ferroportin, result in iron-overload disease that shows dominant inheritance and variation in phenotype. Iron 64-68 solute carrier family 40 member 1 Homo sapiens 13-17 22178646-1 2012 The present study examined the hypothesis that the iron exporter ferroportin (FPN1/SLC40A1) can also mediate cellular export of the essential trace element manganese, using Xenopus laevis oocytes expressing human FPN1. Iron 51-55 solute carrier family 40 member 1 Homo sapiens 213-217 22178646-4 2012 FPN1-mediated Mn export was concentration dependent and could be partially cis-inhibited by 100muM Fe, Co, and Ni, but not by Rb. Iron 99-101 solute carrier family 40 member 1 Homo sapiens 0-4 22717199-6 2012 Hepcidin controls movement of iron into plasma by regulating the activity of the sole known iron exporter ferroportin-1. Iron 30-34 solute carrier family 40 member 1 Homo sapiens 106-119 22717199-6 2012 Hepcidin controls movement of iron into plasma by regulating the activity of the sole known iron exporter ferroportin-1. Iron 92-96 solute carrier family 40 member 1 Homo sapiens 106-119 22717199-7 2012 Downregulation of the ferroportin-1 exporter results in sequestration of iron within intestinal enterocytes, hepatocytes, and iron-storing macrophages reducing iron bioavailability. Iron 73-77 solute carrier family 40 member 1 Homo sapiens 22-35 22717199-7 2012 Downregulation of the ferroportin-1 exporter results in sequestration of iron within intestinal enterocytes, hepatocytes, and iron-storing macrophages reducing iron bioavailability. Iron 126-130 solute carrier family 40 member 1 Homo sapiens 22-35 22717199-7 2012 Downregulation of the ferroportin-1 exporter results in sequestration of iron within intestinal enterocytes, hepatocytes, and iron-storing macrophages reducing iron bioavailability. Iron 126-130 solute carrier family 40 member 1 Homo sapiens 22-35 22281055-5 2012 We also demonstrated that Fpn1 expression was significantly affected by HIF-1alpha, implying that the gene encoding this iron efflux protein is hypoxia-inducible. Iron 121-125 solute carrier family 40 member 1 Homo sapiens 26-30 22408404-4 2012 In addition to HFE gene, mutations in the genes that encode hemojuvelin (HJV), hepcidin (HAMP), transferrin receptor 2 (TFR2) and ferroportin (SLC40A1) have been associated with regulation of iron homeostasis and development of HH. Iron 192-196 solute carrier family 40 member 1 Homo sapiens 143-150 21700773-1 2011 The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes. Iron 4-8 solute carrier family 40 member 1 Homo sapiens 132-136 21700773-1 2011 The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes. Iron 58-62 solute carrier family 40 member 1 Homo sapiens 132-136 21700773-1 2011 The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes. Iron 58-62 solute carrier family 40 member 1 Homo sapiens 132-136 21700773-1 2011 The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes. Iron 58-62 solute carrier family 40 member 1 Homo sapiens 132-136 21700773-1 2011 The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release from storage in hepatocytes. Iron 58-62 solute carrier family 40 member 1 Homo sapiens 132-136 21700773-2 2011 We previously demonstrated that FPN1 was highly expressed in erythroblasts, a cell type that consumes most of the serum iron for use in hemoglobin synthesis. Iron 120-124 solute carrier family 40 member 1 Homo sapiens 32-36 21700773-3 2011 Herein, we have demonstrated that FPN1 localizes to the plasma membrane of erythroblasts, and hepcidin treatment leads to decreased expression of FPN1 and a subsequent increase in intracellular iron concentrations in both erythroblast cell lines and primary erythroblasts. Iron 194-198 solute carrier family 40 member 1 Homo sapiens 34-38 21700773-4 2011 Moreover, injection of exogenous hepcidin decreased FPN1 expression in BM erythroblasts in vivo, whereas iron depletion and associated hepcidin reduction led to increased FPN1 expression in erythroblasts. Iron 105-109 solute carrier family 40 member 1 Homo sapiens 171-175 21700773-6 2011 We hypothesize that FPN1 expression in erythroblasts allows fine-tuning of systemic iron utilization to ensure that erythropoiesis is partially suppressed when nonerythropoietic tissues risk developing iron deficiency. Iron 84-88 solute carrier family 40 member 1 Homo sapiens 20-24 22178646-1 2012 The present study examined the hypothesis that the iron exporter ferroportin (FPN1/SLC40A1) can also mediate cellular export of the essential trace element manganese, using Xenopus laevis oocytes expressing human FPN1. Iron 51-55 solute carrier family 40 member 1 Homo sapiens 78-82 22584997-0 2012 Mild iron overload in an African American man with SLC40A1 D270V. Iron 5-9 solute carrier family 40 member 1 Homo sapiens 51-58 22584997-2 2012 Exome sequencing revealed heterozygosity for SLC40A1 D270V (exon 7, c.809A T), a mutation previously reported only in 1 black patient with iron overload who resided in the Republic of South Africa. Iron 139-143 solute carrier family 40 member 1 Homo sapiens 45-52 21199650-2 2011 It has an autosomal-dominant pattern of inheritance and has been associated with mutations in the SLC40A1 gene, which encodes the cellular iron exporter ferroportin. Iron 139-143 solute carrier family 40 member 1 Homo sapiens 98-105 21396368-0 2011 Identification of mutations in SLC40A1 that affect ferroportin function and phenotype of human ferroportin iron overload. Iron 107-111 solute carrier family 40 member 1 Homo sapiens 31-38 21396368-1 2011 BACKGROUND & AIMS: Patients with ferroportin iron overload due to loss-of-function mutations in SLC40A1 have macrophage iron overload, hyperferritinemia, and normal transferrin saturation. Iron 49-53 solute carrier family 40 member 1 Homo sapiens 100-107 21396368-1 2011 BACKGROUND & AIMS: Patients with ferroportin iron overload due to loss-of-function mutations in SLC40A1 have macrophage iron overload, hyperferritinemia, and normal transferrin saturation. Iron 124-128 solute carrier family 40 member 1 Homo sapiens 100-107 21396368-2 2011 In contrast, hepatocellular iron storage, hyperferritinemia, and increased saturation of transferrin are a distinct clinical presentation of ferroportin iron overload that results from SLC40A1 mutations that confer resistance of ferroportin to hepcidin-mediated inactivation. Iron 28-32 solute carrier family 40 member 1 Homo sapiens 185-192 21396368-2 2011 In contrast, hepatocellular iron storage, hyperferritinemia, and increased saturation of transferrin are a distinct clinical presentation of ferroportin iron overload that results from SLC40A1 mutations that confer resistance of ferroportin to hepcidin-mediated inactivation. Iron 153-157 solute carrier family 40 member 1 Homo sapiens 185-192 21396368-3 2011 METHODS: SLC40A1 was sequenced in patients from 2 independent pedigrees affected by hepatic iron overload unrelated to HFE. Iron 92-96 solute carrier family 40 member 1 Homo sapiens 9-16 21396368-5 2011 RESULTS: A patient heterozygous for the variant p.W158C in SLC40A1 presented with macrophage iron overload, hyperferritinemia, and normal transferrin saturation. Iron 93-97 solute carrier family 40 member 1 Homo sapiens 59-66 21396368-10 2011 CONCLUSIONS: The variant p.W158C in SLC40A1 impairs intracellular trafficking of ferroportin, resulting in reduced iron export. Iron 115-119 solute carrier family 40 member 1 Homo sapiens 36-43 21682768-4 2011 HP, via its effect on ferroportin 1 (FP-1), keeps intracellular iron from being carried even if the iron storage is adequate; it also decreases iron absorption from the intestine. Iron 64-68 solute carrier family 40 member 1 Homo sapiens 22-35 21682768-4 2011 HP, via its effect on ferroportin 1 (FP-1), keeps intracellular iron from being carried even if the iron storage is adequate; it also decreases iron absorption from the intestine. Iron 64-68 solute carrier family 40 member 1 Homo sapiens 37-41 21682768-4 2011 HP, via its effect on ferroportin 1 (FP-1), keeps intracellular iron from being carried even if the iron storage is adequate; it also decreases iron absorption from the intestine. Iron 100-104 solute carrier family 40 member 1 Homo sapiens 22-35 21682768-4 2011 HP, via its effect on ferroportin 1 (FP-1), keeps intracellular iron from being carried even if the iron storage is adequate; it also decreases iron absorption from the intestine. Iron 100-104 solute carrier family 40 member 1 Homo sapiens 37-41 21682768-4 2011 HP, via its effect on ferroportin 1 (FP-1), keeps intracellular iron from being carried even if the iron storage is adequate; it also decreases iron absorption from the intestine. Iron 100-104 solute carrier family 40 member 1 Homo sapiens 22-35 21682768-4 2011 HP, via its effect on ferroportin 1 (FP-1), keeps intracellular iron from being carried even if the iron storage is adequate; it also decreases iron absorption from the intestine. Iron 100-104 solute carrier family 40 member 1 Homo sapiens 37-41 21411349-14 2011 The HJV p.E302K and HAMP p.R59G variants, and the novel SLC40A1 p.G204S mutation may also be linked to primary iron overload but their role in the pathophysiology of HH remain to be elucidated. Iron 111-115 solute carrier family 40 member 1 Homo sapiens 56-63 21438013-5 2011 Our results demonstrated that astrocytes, when treated with hepcidin peptide or infected with hepcidin expression adenovirus (ad-hepcidin), showed a significant ability in reducing iron uptake (both Tf-Fe and NTBI), and iron release, which were accompanied by decreased expressions of TfR1, DMT1, and Fpn1. Iron 181-185 solute carrier family 40 member 1 Homo sapiens 301-305 21177266-5 2011 Iron is exported by ferroportin 1 (the only putative iron exporter) across the basolateral membrane of the enterocyte into the circulation (absorbed iron), where it binds to transferrin and is transported to sites of use and storage. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 20-33 21177266-5 2011 Iron is exported by ferroportin 1 (the only putative iron exporter) across the basolateral membrane of the enterocyte into the circulation (absorbed iron), where it binds to transferrin and is transported to sites of use and storage. Iron 53-57 solute carrier family 40 member 1 Homo sapiens 20-33 21177266-5 2011 Iron is exported by ferroportin 1 (the only putative iron exporter) across the basolateral membrane of the enterocyte into the circulation (absorbed iron), where it binds to transferrin and is transported to sites of use and storage. Iron 149-153 solute carrier family 40 member 1 Homo sapiens 20-33 21175851-0 2011 Two novel mutations in the SLC40A1 and HFE genes implicated in iron overload in a Spanish man. Iron 63-67 solute carrier family 40 member 1 Homo sapiens 27-34 21175851-8 2011 The patient presented a mild iron overload phenotype probably because of the two novel mutations in the HFE and SLC40A1 genes. Iron 29-33 solute carrier family 40 member 1 Homo sapiens 112-119 20525315-15 2010 These localization studies support a model in which cytosolic heme can be degraded by HOs, and the resulting iron is exported into tissue fluids via the iron transporter ferroportin 1, which is expressed in the basolateral membrane in enterocytes or in the plasma membrane in macrophages. Iron 109-113 solute carrier family 40 member 1 Homo sapiens 170-183 20691492-4 2010 SLC40A1 encodes a cellular iron exporter expressed in macrophages, enterocytes, and hepatocytes. Iron 27-31 solute carrier family 40 member 1 Homo sapiens 0-7 20727382-1 2010 Previously, we demonstrated that IL-1beta was able to increase iron efflux from glial cells through a coordinate induction of both ferroportin-1 (Fpn) and ceruloplasmin (Cp) synthesis. Iron 63-67 solute carrier family 40 member 1 Homo sapiens 131-144 20727382-1 2010 Previously, we demonstrated that IL-1beta was able to increase iron efflux from glial cells through a coordinate induction of both ferroportin-1 (Fpn) and ceruloplasmin (Cp) synthesis. Iron 63-67 solute carrier family 40 member 1 Homo sapiens 146-149 21135991-0 2010 Increased intracellular iron and mineralization of cultured hFOB 1.19 cells following hepcidin activation through ferroportin-1. Iron 24-28 solute carrier family 40 member 1 Homo sapiens 114-127 20460119-1 2010 BACKGROUND: Iron deficiency and the Q248H mutation in the gene, SLC40A1, that encodes for the cellular iron exporter, ferroportin, are both common in African children. Iron 103-107 solute carrier family 40 member 1 Homo sapiens 64-71 19937651-3 2010 We describe a large pedigree with a novel SLC40A1 mutation and, through in vitro analysis, elucidate the associated molecular mechanism of iron overload. Iron 139-143 solute carrier family 40 member 1 Homo sapiens 42-49 20007457-0 2010 Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 105-118 19937651-7 2010 A novel SLC40A1 mutation p.R489K segregated with iron overload in a family with clinical and histopathological signs of macrophage-type ferroportin disease. Iron 49-53 solute carrier family 40 member 1 Homo sapiens 8-15 20039160-9 2009 Type 4 hemochromatosis follows an autosomal dominant trait; the corresponding mutation affects the basolateral iron carrier ferroportin 1. Iron 111-115 solute carrier family 40 member 1 Homo sapiens 124-137 20392994-1 2010 Since malignant cells often have a high demand for iron, we hypothesize that breast cancer cells may alter the expression of iron transporter genes including iron importers [transferrin receptor (TFRC) and solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2)] and the iron exporter SLC40A1 (ferroportin), and additionally that the growth of breast cancer can be inhibited by manipulating iron transporter gene expression. Iron 125-129 solute carrier family 40 member 1 Homo sapiens 323-330 20392994-1 2010 Since malignant cells often have a high demand for iron, we hypothesize that breast cancer cells may alter the expression of iron transporter genes including iron importers [transferrin receptor (TFRC) and solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2)] and the iron exporter SLC40A1 (ferroportin), and additionally that the growth of breast cancer can be inhibited by manipulating iron transporter gene expression. Iron 125-129 solute carrier family 40 member 1 Homo sapiens 323-330 20392994-5 2010 In conclusion, breast cancer cells up-regulate the expression of iron importer genes and down-regulate the expression of iron exporter SLC40A1 to satisfy their increased demand for iron. Iron 121-125 solute carrier family 40 member 1 Homo sapiens 135-142 20392994-5 2010 In conclusion, breast cancer cells up-regulate the expression of iron importer genes and down-regulate the expression of iron exporter SLC40A1 to satisfy their increased demand for iron. Iron 121-125 solute carrier family 40 member 1 Homo sapiens 135-142 19709084-0 2009 A novel missense mutation in SLC40A1 results in resistance to hepcidin and confirms the existence of two ferroportin-associated iron overload diseases. Iron 128-132 solute carrier family 40 member 1 Homo sapiens 29-36 19027283-0 2009 The iron regulatory hormone hepcidin reduces ferroportin 1 content and iron release in H9C2 cardiomyocytes. Iron 4-8 solute carrier family 40 member 1 Homo sapiens 45-58 19027283-4 2009 We provided evidence for the existence of iron exporter ferroportin 1 (Fpn1) in the heart in a recent study. Iron 42-46 solute carrier family 40 member 1 Homo sapiens 56-69 19027283-4 2009 We provided evidence for the existence of iron exporter ferroportin 1 (Fpn1) in the heart in a recent study. Iron 42-46 solute carrier family 40 member 1 Homo sapiens 71-75 19027283-9 2009 The similar regulation patterns of hepcidin on the Fpn1 and iron release suggested that the decreased iron release resulted from the decreased content of Fpn1 induced by hepcidin. Iron 60-64 solute carrier family 40 member 1 Homo sapiens 154-158 19027283-9 2009 The similar regulation patterns of hepcidin on the Fpn1 and iron release suggested that the decreased iron release resulted from the decreased content of Fpn1 induced by hepcidin. Iron 102-106 solute carrier family 40 member 1 Homo sapiens 154-158 19027283-11 2009 The data imply that Fpn1, rather than Heph and CP, is the limited factor in the regulation of iron release from heart cells under physiological conditions. Iron 94-98 solute carrier family 40 member 1 Homo sapiens 20-24 19907151-5 2009 The second subgroup of hemochromatosis is caused by autosomal dominant mutations in the SLC40A1 gene encoding the iron exporter ferroportin with distinctive features. Iron 114-118 solute carrier family 40 member 1 Homo sapiens 88-95 19444865-4 2009 In NAFLD, a moderate liver iron accumulation has been observed and molecular mechanisms, including the downregulation of the liver iron exporter ferroportin-1, have been described. Iron 131-135 solute carrier family 40 member 1 Homo sapiens 145-158 19307463-7 2009 On the other hand, expression of hepcidin, TfR2, ferroportin 1 and DMT1 were significantly up-regulated in iron-loaded non-cirrhotic non-tumorous liver tissues as compared with normal liver controls. Iron 107-111 solute carrier family 40 member 1 Homo sapiens 49-62 19416716-1 2009 Ferroportin (FPN1), the sole characterized mammalian iron exporter, has an iron-responsive element (IRE) in its 5" untranslated region, which ensures that its translation is repressed by iron regulatory proteins (IRPs) in iron-deficient conditions to maintain cellular iron content. Iron 53-57 solute carrier family 40 member 1 Homo sapiens 13-17 19416716-1 2009 Ferroportin (FPN1), the sole characterized mammalian iron exporter, has an iron-responsive element (IRE) in its 5" untranslated region, which ensures that its translation is repressed by iron regulatory proteins (IRPs) in iron-deficient conditions to maintain cellular iron content. Iron 75-79 solute carrier family 40 member 1 Homo sapiens 13-17 19416716-1 2009 Ferroportin (FPN1), the sole characterized mammalian iron exporter, has an iron-responsive element (IRE) in its 5" untranslated region, which ensures that its translation is repressed by iron regulatory proteins (IRPs) in iron-deficient conditions to maintain cellular iron content. Iron 75-79 solute carrier family 40 member 1 Homo sapiens 13-17 19416716-1 2009 Ferroportin (FPN1), the sole characterized mammalian iron exporter, has an iron-responsive element (IRE) in its 5" untranslated region, which ensures that its translation is repressed by iron regulatory proteins (IRPs) in iron-deficient conditions to maintain cellular iron content. Iron 75-79 solute carrier family 40 member 1 Homo sapiens 13-17 19416716-1 2009 Ferroportin (FPN1), the sole characterized mammalian iron exporter, has an iron-responsive element (IRE) in its 5" untranslated region, which ensures that its translation is repressed by iron regulatory proteins (IRPs) in iron-deficient conditions to maintain cellular iron content. Iron 75-79 solute carrier family 40 member 1 Homo sapiens 13-17 19416716-4 2009 The identification of FPN1B reveals how FPN1 expression can bypass IRP-dependent repression in intestinal iron uptake, even when cells throughout the body are iron deficient. Iron 106-110 solute carrier family 40 member 1 Homo sapiens 22-26 19416716-4 2009 The identification of FPN1B reveals how FPN1 expression can bypass IRP-dependent repression in intestinal iron uptake, even when cells throughout the body are iron deficient. Iron 159-163 solute carrier family 40 member 1 Homo sapiens 22-26 18820912-3 2009 The main objective of this work was to study the role of variants in the SLC40A1 gene in the severity of iron overload and his clinical consequences in 100 Spanish probands homozygous for the C282Y mutation of the HFE gene. Iron 105-109 solute carrier family 40 member 1 Homo sapiens 73-80 18820912-5 2009 We studied the association between polymorphisms in the SLC40A1 gene and median values of iron removed, taking into account statistical corrections for multiple comparisons. Iron 90-94 solute carrier family 40 member 1 Homo sapiens 56-63 18337195-0 2009 Ferroportin-1 in the recurrence of hepatic iron overload after liver transplantation. Iron 43-47 solute carrier family 40 member 1 Homo sapiens 0-13 18337195-2 2009 Here, we document the early recurrence of hepatic iron overload starting from host Kupffer cells and later involving hepatocytes in an Italian male submitted to liver transplantation for HCV-related cirrhosis, whose hemosiderosis was interpreted as related to a primary defect of iron handling by monocytic cells due to decreased Ferroportin-1 expression. Iron 50-54 solute carrier family 40 member 1 Homo sapiens 330-343 19452451-3 2009 However, iron egress from the basolateral side of enterocytes converges on a single export pathway requiring the iron transporter, ferroportin1, and hephaestin, a ferroxidase. Iron 9-13 solute carrier family 40 member 1 Homo sapiens 131-143 18727423-1 2008 The review summarizes the results of the state-of-the-art studies of hemochromatosis (HC): iron-regulatory genes (HFE, HJV, HAMP, TFR2, SLC40A1) have been discovered; the HC types caused by mutations in these genes (types 1, 2, 3, and 4 in the OMIM register) have been identified; the inflammation anemia (IA) mediator - the polypeptide hepatic hormone hepcidin that is an important constituent of the natural immunity system - has been found. Iron 91-95 solute carrier family 40 member 1 Homo sapiens 136-143 18586980-2 2008 Ferroportin 1 (FPN1; SLC40A1) is the sole iron exporter from mammalian cells and is expressed in the duodenum and macrophages. Iron 42-46 solute carrier family 40 member 1 Homo sapiens 0-13 18586980-2 2008 Ferroportin 1 (FPN1; SLC40A1) is the sole iron exporter from mammalian cells and is expressed in the duodenum and macrophages. Iron 42-46 solute carrier family 40 member 1 Homo sapiens 15-19 18586980-2 2008 Ferroportin 1 (FPN1; SLC40A1) is the sole iron exporter from mammalian cells and is expressed in the duodenum and macrophages. Iron 42-46 solute carrier family 40 member 1 Homo sapiens 21-28 18469261-5 2008 RESULTS: The hepatic expressions of the iron-export protein ferroportin-1 (FP-1) and of the iron-sensing molecule hemojuvelin (HJV) were significantly lower in NAFLD patients. Iron 40-44 solute carrier family 40 member 1 Homo sapiens 60-73 18469261-5 2008 RESULTS: The hepatic expressions of the iron-export protein ferroportin-1 (FP-1) and of the iron-sensing molecule hemojuvelin (HJV) were significantly lower in NAFLD patients. Iron 40-44 solute carrier family 40 member 1 Homo sapiens 75-79 18469261-6 2008 The mRNA expression of the iron-regulatory peptide hepcidin was increased in NAFLD patients with iron overload, which was paralleled by low duodenal FP-1 expression. Iron 27-31 solute carrier family 40 member 1 Homo sapiens 149-153 18469261-12 2008 Increased hepcidin formation in iron-overloaded NAFLD patients, however, results in decreased duodenal FP-1 expression, whereas a reduction in liver FP-1 may perpetuate hepatic iron retention. Iron 32-36 solute carrier family 40 member 1 Homo sapiens 103-107 18469261-12 2008 Increased hepcidin formation in iron-overloaded NAFLD patients, however, results in decreased duodenal FP-1 expression, whereas a reduction in liver FP-1 may perpetuate hepatic iron retention. Iron 177-181 solute carrier family 40 member 1 Homo sapiens 149-153 19759876-2 2009 Other mutations have been described in the HFE gene as well as in genes involved in iron metabolism, such as transferrin receptor 2 (TfR2) and ferroportin 1 (SCL40A1). Iron 84-88 solute carrier family 40 member 1 Homo sapiens 143-156 18586377-10 2008 CONCLUSION: The expression of TfR1, ferritin and FP1 in the human term placenta tissues showed different trend of change with different maternal iron status. Iron 145-149 solute carrier family 40 member 1 Homo sapiens 49-52 18586377-13 2008 In addition to FP1, other proteins may be involved in the placental iron efflux either directly or indirectly. Iron 68-72 solute carrier family 40 member 1 Homo sapiens 15-18 17997113-1 2008 Mutations in the SLC40A1 gene result in a dominant genetic disorder [ferroportin disease; hereditary hemochromatosis type (HH) IV], characterized by iron overload with two different clinical manifestations, normal transferrin saturation with macrophage iron accumulation (the most prevalent type) or high transferrin saturation with hepatocyte iron accumulation (classical hemochromatosis phenotype). Iron 149-153 solute carrier family 40 member 1 Homo sapiens 17-24 17997113-1 2008 Mutations in the SLC40A1 gene result in a dominant genetic disorder [ferroportin disease; hereditary hemochromatosis type (HH) IV], characterized by iron overload with two different clinical manifestations, normal transferrin saturation with macrophage iron accumulation (the most prevalent type) or high transferrin saturation with hepatocyte iron accumulation (classical hemochromatosis phenotype). Iron 253-257 solute carrier family 40 member 1 Homo sapiens 17-24 17997113-1 2008 Mutations in the SLC40A1 gene result in a dominant genetic disorder [ferroportin disease; hereditary hemochromatosis type (HH) IV], characterized by iron overload with two different clinical manifestations, normal transferrin saturation with macrophage iron accumulation (the most prevalent type) or high transferrin saturation with hepatocyte iron accumulation (classical hemochromatosis phenotype). Iron 253-257 solute carrier family 40 member 1 Homo sapiens 17-24 17997113-4 2008 This protocol turned out to be rapid, sensitive and reliable, facilitating the detection of the SLC40A1 gene mutations in two patients with hyperferritinemia, normal transferrin saturation and iron accumulation predominantly in macrophages and Kupffer cells. Iron 193-197 solute carrier family 40 member 1 Homo sapiens 96-103 18177470-0 2008 Novel mutations of the ferroportin gene (SLC40A1): analysis of 56 consecutive patients with unexplained iron overload. Iron 104-108 solute carrier family 40 member 1 Homo sapiens 41-48 18646536-0 2008 [Effect of iron status of pregnant women on ferroportin 1 expression in third-trimester placenta]. Iron 11-15 solute carrier family 40 member 1 Homo sapiens 44-57 18326322-4 2008 However, recent analyses have clearly shown that hepcidin, of which expression is induced by inflammatory cytokines such as IL-1beta and IL-6, suppresses the expression of the iron transporter, ferroportin-1, thereby inhibiting the absorption of iron from the duodenum, the release of iron from the reticulo-endothelial system. Iron 176-180 solute carrier family 40 member 1 Homo sapiens 194-207 18326322-4 2008 However, recent analyses have clearly shown that hepcidin, of which expression is induced by inflammatory cytokines such as IL-1beta and IL-6, suppresses the expression of the iron transporter, ferroportin-1, thereby inhibiting the absorption of iron from the duodenum, the release of iron from the reticulo-endothelial system. Iron 246-250 solute carrier family 40 member 1 Homo sapiens 194-207 18177470-1 2008 The aim of this study was to search for SLC40A1 mutations in iron overloaded patients, which tested negative for HFE mutations and other iron-related genes. Iron 61-65 solute carrier family 40 member 1 Homo sapiens 40-47 17540536-7 2007 Ferroportin disease is a special dominantly inherited clinical form of iron overload due to mutations of the SLC40A1 gene. Iron 71-75 solute carrier family 40 member 1 Homo sapiens 109-116 17490902-1 2007 The ferroportin polymorphism SLC40A1 Q248H (exon 6, cDNA 744G-->T; Gln248His) occurs in persons of sub-Saharan African descent with and without iron overload, and is associated with elevated serum ferritin concentrations (SF). Iron 147-151 solute carrier family 40 member 1 Homo sapiens 29-36 19066423-0 2008 Multi-organ iron overload in an African-American man with ALAS2 R452S and SLC40A1 R561G. Iron 12-16 solute carrier family 40 member 1 Homo sapiens 74-81 19066423-11 2008 SLC40A1 R561G may have increased his iron absorption and overload further. Iron 37-41 solute carrier family 40 member 1 Homo sapiens 0-7 17719162-1 2007 Low iron status is known to increase the uptake of dietary cadmium in both adolescents and adults and there are indications that cadmium is absorbed from the intestine by the two major iron transporters divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1). Iron 4-8 solute carrier family 40 member 1 Homo sapiens 243-256 17719162-1 2007 Low iron status is known to increase the uptake of dietary cadmium in both adolescents and adults and there are indications that cadmium is absorbed from the intestine by the two major iron transporters divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1). Iron 4-8 solute carrier family 40 member 1 Homo sapiens 258-262 17273818-4 2007 Following its synthesis and secretion from the liver, circulating hepcidin reduces iron export into the plasma by binding to the iron efflux protein ferroportin1 on the surface of enterocytes, macrophages and other cell types and causing its internalization. Iron 83-87 solute carrier family 40 member 1 Homo sapiens 149-161 17486601-1 2007 An iron exporter ferroportin-1 (FPN-1) and a multi-copper oxidase hephaestin (Heph) are predicted to be expressed on the basolateral membrane of the enterocyte and involved in the processes of iron export across the basolateral membrane of the enterocyte. Iron 3-7 solute carrier family 40 member 1 Homo sapiens 17-30 17486601-1 2007 An iron exporter ferroportin-1 (FPN-1) and a multi-copper oxidase hephaestin (Heph) are predicted to be expressed on the basolateral membrane of the enterocyte and involved in the processes of iron export across the basolateral membrane of the enterocyte. Iron 3-7 solute carrier family 40 member 1 Homo sapiens 32-37 17486601-1 2007 An iron exporter ferroportin-1 (FPN-1) and a multi-copper oxidase hephaestin (Heph) are predicted to be expressed on the basolateral membrane of the enterocyte and involved in the processes of iron export across the basolateral membrane of the enterocyte. Iron 193-197 solute carrier family 40 member 1 Homo sapiens 17-30 17486601-1 2007 An iron exporter ferroportin-1 (FPN-1) and a multi-copper oxidase hephaestin (Heph) are predicted to be expressed on the basolateral membrane of the enterocyte and involved in the processes of iron export across the basolateral membrane of the enterocyte. Iron 193-197 solute carrier family 40 member 1 Homo sapiens 32-37 17486601-6 2007 In stably transfected human intestinal absorptive cells expressing human FPN-1 modified by the addition of GFP at the C-terminus, we show that FPN-1-GFP is located on the basolateral membrane and it is associated with Heph suggesting the possibility that FPN-1 might associate and interact with Heph in the process of iron exit across the basolateral membrane of intestinal absorptive cell. Iron 318-322 solute carrier family 40 member 1 Homo sapiens 143-148 17486601-6 2007 In stably transfected human intestinal absorptive cells expressing human FPN-1 modified by the addition of GFP at the C-terminus, we show that FPN-1-GFP is located on the basolateral membrane and it is associated with Heph suggesting the possibility that FPN-1 might associate and interact with Heph in the process of iron exit across the basolateral membrane of intestinal absorptive cell. Iron 318-322 solute carrier family 40 member 1 Homo sapiens 143-148 17273818-4 2007 Following its synthesis and secretion from the liver, circulating hepcidin reduces iron export into the plasma by binding to the iron efflux protein ferroportin1 on the surface of enterocytes, macrophages and other cell types and causing its internalization. Iron 129-133 solute carrier family 40 member 1 Homo sapiens 149-161 16927405-7 2007 The expression of DMT1 and HFE barely varies upon endotoxin-induced maturation but TfR is up-regulated and the iron export molecule Ferroportin-1 is down-regulated. Iron 111-115 solute carrier family 40 member 1 Homo sapiens 132-145 16927405-9 2007 Our results indicate that the uptake of iron during DCs development and maturation is mediated by a strong expression of iron-uptake molecules such as DMT1 and TfR as well as a down-regulation of iron export molecules such as Ferroportin-1. Iron 40-44 solute carrier family 40 member 1 Homo sapiens 226-239 17194590-4 2007 The past decade has seen the identification of new molecules involved in iron metabolism, such as divalent metal transporter-1, ferroportin-1, hepcidin, hemojuvelin and heme carrier protein-1. Iron 73-77 solute carrier family 40 member 1 Homo sapiens 128-141 17181986-1 2006 The discovery of the HFE, HJV, HAMP, TfR2, and SLC40A1 genes and preliminary understanding of their roles in iron homeostasis have contributed tremendously to our understanding of the pathogenesis of genetic hemochromatosis. Iron 109-113 solute carrier family 40 member 1 Homo sapiens 47-54 16257244-3 2006 This report describes the clinical and laboratory findings of two Spanish families with autosomal dominant iron overload associated with previously unrecognized Ferroportin 1 mutations (p.R88T and p.I180T). Iron 107-111 solute carrier family 40 member 1 Homo sapiens 161-174 16457665-1 2006 Ferroportin [FPN; Slc40a1 (solute carrier family 40, member 1)] is a transmembrane iron export protein expressed in macrophages and duodenal enterocytes. Iron 83-87 solute carrier family 40 member 1 Homo sapiens 18-25 16457665-1 2006 Ferroportin [FPN; Slc40a1 (solute carrier family 40, member 1)] is a transmembrane iron export protein expressed in macrophages and duodenal enterocytes. Iron 83-87 solute carrier family 40 member 1 Homo sapiens 27-61 16546437-12 2006 Meanwhile, the possible involvement of ferroportin 1 in down-regulation of intracellular iron level by overexpression of hsp27 was checked. Iron 89-93 solute carrier family 40 member 1 Homo sapiens 39-52 16351644-1 2005 Ferroportin is encoded by the SLC40A1 gene and mediates iron export from cells by interacting with hepcidin. Iron 56-60 solute carrier family 40 member 1 Homo sapiens 30-37 16351644-2 2005 SLC40A1 gene mutations are associated with an autosomal type of genetic iron overload described as haemochromatosis type 4, or HFE4 (Online Mendelian Inheritance in Man number 606069), or ferroportin disease. Iron 72-76 solute carrier family 40 member 1 Homo sapiens 0-7 16298746-7 2005 Increased expression of DMT-1 and IREG-1 was associated with iron accumulation and oxidative stress. Iron 61-65 solute carrier family 40 member 1 Homo sapiens 34-40 16330432-1 2005 BACKGROUND AND OBJECTIVES: Ferroportin-1 (FPN1) is expressed in various types of cells that play critical roles in mammalian iron metabolism and appears to act as an iron exporter in these tissues. Iron 125-129 solute carrier family 40 member 1 Homo sapiens 27-40 16330432-1 2005 BACKGROUND AND OBJECTIVES: Ferroportin-1 (FPN1) is expressed in various types of cells that play critical roles in mammalian iron metabolism and appears to act as an iron exporter in these tissues. Iron 125-129 solute carrier family 40 member 1 Homo sapiens 42-46 16330432-1 2005 BACKGROUND AND OBJECTIVES: Ferroportin-1 (FPN1) is expressed in various types of cells that play critical roles in mammalian iron metabolism and appears to act as an iron exporter in these tissues. Iron 166-170 solute carrier family 40 member 1 Homo sapiens 27-40 16330432-1 2005 BACKGROUND AND OBJECTIVES: Ferroportin-1 (FPN1) is expressed in various types of cells that play critical roles in mammalian iron metabolism and appears to act as an iron exporter in these tissues. Iron 166-170 solute carrier family 40 member 1 Homo sapiens 42-46 16330432-5 2005 The iron-responsive element (IRE) in the 5"- untranslated region (UTR) of FPN1 mRNA is functional but, in spite of that, FPN1 protein expression, as well as mRNA level and half-life, seem not to be affected by iron. Iron 4-8 solute carrier family 40 member 1 Homo sapiens 74-78 16330432-5 2005 The iron-responsive element (IRE) in the 5"- untranslated region (UTR) of FPN1 mRNA is functional but, in spite of that, FPN1 protein expression, as well as mRNA level and half-life, seem not to be affected by iron. Iron 210-214 solute carrier family 40 member 1 Homo sapiens 74-78 16330432-10 2005 INTERPRETATION AND CONCLUSIONS: This is the first report describing the presence of FPN1 in erythroid cells at all stages of differentiation, providing evidence that erythroid cells possess specific mechanisms of iron export. Iron 213-217 solute carrier family 40 member 1 Homo sapiens 84-88 16315136-6 2005 The liver can divest itself of iron through the plasma membrane iron exporter ferroportin 1, a process that also requires ceruloplasmin. Iron 31-35 solute carrier family 40 member 1 Homo sapiens 78-91 16315136-6 2005 The liver can divest itself of iron through the plasma membrane iron exporter ferroportin 1, a process that also requires ceruloplasmin. Iron 64-68 solute carrier family 40 member 1 Homo sapiens 78-91 15880641-4 2005 Several iron transporters and regulators were recently characterized, including DMT1 and ferroportin/Ireg1 that transport iron through membranes, and HFE that regulates TfR-mediated iron uptake. Iron 8-12 solute carrier family 40 member 1 Homo sapiens 101-106 16168234-3 2005 The subsequent movement of iron across the basolateral membrane and into the circulation is mediated by ferroportin1 in conjunction with the iron oxidase hephaestin. Iron 27-31 solute carrier family 40 member 1 Homo sapiens 104-116 15901240-6 2005 TNFalpha mediated an early induction in both iron import and iron export, which were associated with increased DMT-1 and IREG-1 mRNA and protein expression (P<0.05). Iron 45-49 solute carrier family 40 member 1 Homo sapiens 121-127 16234038-4 2005 Heterozygosity for mutations in the gene encoding ferroportin 1 (FPN1) is probably the second most common genetic cause of hereditary iron storage in adults; here the primarily affected cell is the macrophage. Iron 134-138 solute carrier family 40 member 1 Homo sapiens 50-63 16234038-4 2005 Heterozygosity for mutations in the gene encoding ferroportin 1 (FPN1) is probably the second most common genetic cause of hereditary iron storage in adults; here the primarily affected cell is the macrophage. Iron 134-138 solute carrier family 40 member 1 Homo sapiens 65-69 15880641-4 2005 Several iron transporters and regulators were recently characterized, including DMT1 and ferroportin/Ireg1 that transport iron through membranes, and HFE that regulates TfR-mediated iron uptake. Iron 122-126 solute carrier family 40 member 1 Homo sapiens 101-106 16158226-2 2005 Mutations in DMT1 and Ireg1 have revealed that these molecules are major mediators of iron transport across the brush border and basolateral membranes of the enterocyte, respectively. Iron 86-90 solute carrier family 40 member 1 Homo sapiens 22-27 15749737-0 2005 Apical location of ferroportin 1 in airway epithelia and its role in iron detoxification in the lung. Iron 69-73 solute carrier family 40 member 1 Homo sapiens 19-32 15986403-2 2005 Mutations in the gene encoding ferroportin 1, a cellular iron exporter, are responsible for this iron storage disease, inherited as an autosomal dominant trait. Iron 57-61 solute carrier family 40 member 1 Homo sapiens 31-44 15986403-2 2005 Mutations in the gene encoding ferroportin 1, a cellular iron exporter, are responsible for this iron storage disease, inherited as an autosomal dominant trait. Iron 97-101 solute carrier family 40 member 1 Homo sapiens 31-44 15749737-1 2005 Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron. Iron 101-105 solute carrier family 40 member 1 Homo sapiens 0-13 15749737-1 2005 Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron. Iron 101-105 solute carrier family 40 member 1 Homo sapiens 15-19 15749737-1 2005 Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron. Iron 101-105 solute carrier family 40 member 1 Homo sapiens 25-29 15749737-1 2005 Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron. Iron 101-105 solute carrier family 40 member 1 Homo sapiens 42-49 15749737-1 2005 Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron. Iron 142-146 solute carrier family 40 member 1 Homo sapiens 0-13 15749737-1 2005 Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron. Iron 142-146 solute carrier family 40 member 1 Homo sapiens 15-19 15749737-1 2005 Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron. Iron 142-146 solute carrier family 40 member 1 Homo sapiens 25-29 15749737-1 2005 Ferroportin 1 (FPN1; aka MTP1, IREG1, and SLC40A1), which was originally identified as a basolateral iron transporter crucial for nutritional iron absorption in the intestine, is expressed in airway epithelia and upregulated when these cells are exposed to iron. Iron 142-146 solute carrier family 40 member 1 Homo sapiens 42-49 15749737-8 2005 Our findings indicate that FPN1, depending on its subcellular location, could have distinct functions in iron homeostasis in different cells and tissues. Iron 105-109 solute carrier family 40 member 1 Homo sapiens 27-31 15935710-1 2005 The cellular iron exporter ferroportin 1 is expressed in both the duodenum and in cells of the mononuclear phagocyte system. Iron 13-17 solute carrier family 40 member 1 Homo sapiens 27-40 15935710-5 2005 HFE4 differs from classical hemochromatosis in that there is a greater amount of macrophage iron sequestration. Iron 92-96 solute carrier family 40 member 1 Homo sapiens 0-4 15935710-8 2005 Others are indistinguishable from native ferroportin 1 and have a similar ability to deplete transfected cells of iron as evidenced by activation of the iron-response proteins and cellular ferritin depletion. Iron 114-118 solute carrier family 40 member 1 Homo sapiens 41-54 16305465-3 2005 We review our current understanding of the intestinal absorption of iron in the light of recently identified membrane proteins, namely the ferrric reductase, Dcytb, the two iron(II) transport proteins, DMT1 and ferroportin/Ireg1, and hephaestin, the membrane-bound homologue of the ferroxidase ceruloplasmin. Iron 68-72 solute carrier family 40 member 1 Homo sapiens 223-228 15737888-8 2005 In this latter condition, reticuloendothelial iron overload and hyperferritinaemia are caused by loss-of-function mutations in the SLC11A3 gene that mainly impair macrophage iron recycling. Iron 46-50 solute carrier family 40 member 1 Homo sapiens 131-138 15737888-8 2005 In this latter condition, reticuloendothelial iron overload and hyperferritinaemia are caused by loss-of-function mutations in the SLC11A3 gene that mainly impair macrophage iron recycling. Iron 174-178 solute carrier family 40 member 1 Homo sapiens 131-138 15818145-7 2005 Hereditary hemochromatosis is now a complex entity with various clinicopathological forms based on mutations in the HFE gene and other iron-homeostatic genes such as transferrin receptor 2 and ferroportin 1. Iron 135-139 solute carrier family 40 member 1 Homo sapiens 193-206 15897636-3 2005 It was located in the noncoding region of the ferroportin 1; nucleotide 117 adenine was changed to guanine, 7 nucleotides downstream the iron responsive element (IRE) region. Iron 137-141 solute carrier family 40 member 1 Homo sapiens 46-59 15836704-0 2005 Upregulation of transferrin receptor 2 and ferroportin 1 mRNA in the liver of patients with chronic hepatitis C. BACKGROUND: Iron accumulation has been reported to be associated with progression of liver injury. Iron 125-129 solute carrier family 40 member 1 Homo sapiens 43-56 16054062-0 2005 The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Iron 4-8 solute carrier family 40 member 1 Homo sapiens 30-37 16054062-0 2005 The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Iron 55-59 solute carrier family 40 member 1 Homo sapiens 30-37 16054062-1 2005 Ferroportin (SLC40A1) is an iron transporter postulated to play roles in intestinal iron absorption and cellular iron release. Iron 28-32 solute carrier family 40 member 1 Homo sapiens 13-20 16054062-1 2005 Ferroportin (SLC40A1) is an iron transporter postulated to play roles in intestinal iron absorption and cellular iron release. Iron 84-88 solute carrier family 40 member 1 Homo sapiens 13-20 15667655-0 2005 Iron homeostasis in neuronal cells: a role for IREG1. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 47-52 15667655-6 2005 Increased expression of IREG1 was further substantiated by immunocytochemistry and iron efflux experiments. Iron 83-87 solute carrier family 40 member 1 Homo sapiens 24-29 15667655-7 2005 IREG1 expression directly correlated with iron content in SH-SY5Y and hippocampal cells. Iron 42-46 solute carrier family 40 member 1 Homo sapiens 0-5 15667655-8 2005 Similarly, a high correlation was found between IREG1 expression and the rate of iron efflux from SH-SY5Y cells. Iron 81-85 solute carrier family 40 member 1 Homo sapiens 48-53 15667655-9 2005 CONCLUSIONS: Neuronal survival of iron accumulation associates with increased expression of the efflux transporter IREG1. Iron 34-38 solute carrier family 40 member 1 Homo sapiens 115-120 15667655-10 2005 Thus, the capacity of neurons to express IREG1 may be one of the clues to iron accumulation survival. Iron 74-78 solute carrier family 40 member 1 Homo sapiens 41-46 15956209-1 2005 Mutations in the iron exporter ferroportin (Fpn) (IREG1, SLC40A1, and MTP1) result in hemochromatosis type IV, a disorder with a dominant genetic pattern of inheritance and heterogeneous clinical presentation. Iron 17-21 solute carrier family 40 member 1 Homo sapiens 50-55 15956209-1 2005 Mutations in the iron exporter ferroportin (Fpn) (IREG1, SLC40A1, and MTP1) result in hemochromatosis type IV, a disorder with a dominant genetic pattern of inheritance and heterogeneous clinical presentation. Iron 17-21 solute carrier family 40 member 1 Homo sapiens 57-64 15956209-1 2005 Mutations in the iron exporter ferroportin (Fpn) (IREG1, SLC40A1, and MTP1) result in hemochromatosis type IV, a disorder with a dominant genetic pattern of inheritance and heterogeneous clinical presentation. Iron 17-21 solute carrier family 40 member 1 Homo sapiens 70-74 15896335-3 2005 The iron transporter divalent metal transporter-1 (DMT-1) of enterocytes is responsible for iron uptake from the intestinal lumen; iron is further extruded into the blood by the basolateral transporter ferroportin-1. Iron 4-8 solute carrier family 40 member 1 Homo sapiens 202-215 15896335-3 2005 The iron transporter divalent metal transporter-1 (DMT-1) of enterocytes is responsible for iron uptake from the intestinal lumen; iron is further extruded into the blood by the basolateral transporter ferroportin-1. Iron 92-96 solute carrier family 40 member 1 Homo sapiens 202-215 15725899-3 2005 RECENT FINDINGS: Hepcidin antimicrobial peptide likely modulates iron transport from macrophages and enterocytes to red blood cell precursors as a consequence of its interaction with SLC40A1/ferroportin, the only known transporter that facilitates iron egress. Iron 65-69 solute carrier family 40 member 1 Homo sapiens 183-190 15725899-3 2005 RECENT FINDINGS: Hepcidin antimicrobial peptide likely modulates iron transport from macrophages and enterocytes to red blood cell precursors as a consequence of its interaction with SLC40A1/ferroportin, the only known transporter that facilitates iron egress. Iron 248-252 solute carrier family 40 member 1 Homo sapiens 183-190 15338274-5 2004 We identified a novel D270V mutation in the SLC40A1 gene in a Black South African female with iron overload. Iron 94-98 solute carrier family 40 member 1 Homo sapiens 44-51 16240664-3 2005 Iron absorption is regulated by divalent metal ion transporter 1 (DMT1) and ferroportin 1 (FPN1). Iron 0-4 solute carrier family 40 member 1 Homo sapiens 76-89 16240664-3 2005 Iron absorption is regulated by divalent metal ion transporter 1 (DMT1) and ferroportin 1 (FPN1). Iron 0-4 solute carrier family 40 member 1 Homo sapiens 91-95 15566364-1 2004 Missense mutations in the ferroportin gene (SLC11A3) result in haemochromatosis type 4 [HFE4, Online Mendelian Inheritance in Man (OMIM) reference 606069] or ferroportin disease, an autosomal dominant disorder characterized by predominantly reticuloendothelial iron accumulation. Iron 261-265 solute carrier family 40 member 1 Homo sapiens 44-51 15566364-7 2004 First, this indicates that ferroportin levels must be finely regulated in order to maintain cellular iron homeostasis, and that both copies of SLC11A3 must function efficiently to prevent iron accumulation. Iron 188-192 solute carrier family 40 member 1 Homo sapiens 143-150 15178542-2 2004 Iron transport is a function of the major iron transport proteins: transferrin receptor-1 (TfR-1) and ferroportin-1 (FPN-1). Iron 0-4 solute carrier family 40 member 1 Homo sapiens 102-115 15178542-2 2004 Iron transport is a function of the major iron transport proteins: transferrin receptor-1 (TfR-1) and ferroportin-1 (FPN-1). Iron 0-4 solute carrier family 40 member 1 Homo sapiens 117-122 15178542-2 2004 Iron transport is a function of the major iron transport proteins: transferrin receptor-1 (TfR-1) and ferroportin-1 (FPN-1). Iron 42-46 solute carrier family 40 member 1 Homo sapiens 102-115 15178542-2 2004 Iron transport is a function of the major iron transport proteins: transferrin receptor-1 (TfR-1) and ferroportin-1 (FPN-1). Iron 42-46 solute carrier family 40 member 1 Homo sapiens 117-122 15178542-12 2004 We conclude that, toward the end of the third trimester of iron-sufficient human pregnancy, the placenta accumulates ferritin and potentially increases placental-fetal iron delivery through increased FPN-1 expression. Iron 59-63 solute carrier family 40 member 1 Homo sapiens 200-205 15566364-8 2004 Second, this observation supports the hypothesis that reticuloendothelial iron overload in patients with ferroportin disease is caused by loss-of-function mutations in the SLC11A3 gene that mainly impair macrophage iron recycling. Iron 74-78 solute carrier family 40 member 1 Homo sapiens 172-179 15566364-8 2004 Second, this observation supports the hypothesis that reticuloendothelial iron overload in patients with ferroportin disease is caused by loss-of-function mutations in the SLC11A3 gene that mainly impair macrophage iron recycling. Iron 215-219 solute carrier family 40 member 1 Homo sapiens 172-179 15831128-5 2004 Hephaestin, a caeruloplasmin homologue, works in concert with the IREG1 transporter to permit Fe efflux from enterocytes for loading onto transferrin. Iron 94-96 solute carrier family 40 member 1 Homo sapiens 66-71 15831128-9 2004 Furthermore, expression of both DMT1 and the basolateral Fe-efflux transporter IREG1 can be regulated by Cu, suggesting that the Fe-Cu relationship may be more complex than first thought. Iron 57-59 solute carrier family 40 member 1 Homo sapiens 79-84 15338274-7 2004 In Africans with iron overload not related to the HFE gene, the possible involvement of the SLC40A1 and CYBRD1 genes was demonstrated for the first time. Iron 17-21 solute carrier family 40 member 1 Homo sapiens 92-99 15054143-8 2004 FP1 expression was localized on the basolateral membrane of enterocytes and increased with low iron stores. Iron 95-99 solute carrier family 40 member 1 Homo sapiens 0-3 15529941-4 2004 Recently, other forms of HH that are not related to HFE, but are due to mutations in genes coding iron transport proteins (ferroportin-1, TfR2, hepcidin) have been described. Iron 98-102 solute carrier family 40 member 1 Homo sapiens 123-136 15168383-13 2004 CONCLUSION: We show for the first time that increased iron levels in PMNLs of HD patients were associated with downregulation of ferroportin 1 and upregulation of TfR, which might be linked to hypercytokinemia. Iron 54-58 solute carrier family 40 member 1 Homo sapiens 129-142 15703643-7 2004 A mutation in ferroportin 1 produced a form of hemochromatosis with excessive iron in hepatocytes and also in Kupffer cells and macrophages. Iron 78-82 solute carrier family 40 member 1 Homo sapiens 14-27 15081108-4 2004 With regard to iron metabolism, we showed that HEPH, SLC11A2, SLC11A3, and TF are significantly up-regulated, while ATP7B and SLC39A1 (and SFT) are down-regulated and ACO1, dCYTb, FECH, and FTH1 show constant expression. Iron 15-19 solute carrier family 40 member 1 Homo sapiens 62-69 14757427-2 2004 The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene. Iron 84-88 solute carrier family 40 member 1 Homo sapiens 51-58 15084469-1 2004 Coding region mutations in the principal basolateral iron transporter of the duodenal enterocyte, ferroportin 1 (FPN1), lead to autosomal dominant reticuloendothelial iron overload in humans. Iron 53-57 solute carrier family 40 member 1 Homo sapiens 98-111 15084469-1 2004 Coding region mutations in the principal basolateral iron transporter of the duodenal enterocyte, ferroportin 1 (FPN1), lead to autosomal dominant reticuloendothelial iron overload in humans. Iron 53-57 solute carrier family 40 member 1 Homo sapiens 113-117 15075083-0 2004 The impact of the mutations of the HFE gene and of the SLC11A3 gene on iron overload in Greek thalassemia intermedia and beta(s)/beta(thal) anemia patients. Iron 71-75 solute carrier family 40 member 1 Homo sapiens 55-62 14972659-3 2004 In recent years, several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized. Iron 25-29 solute carrier family 40 member 1 Homo sapiens 78-83 14972659-3 2004 In recent years, several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized. Iron 25-29 solute carrier family 40 member 1 Homo sapiens 131-138 14972659-3 2004 In recent years, several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized. Iron 25-29 solute carrier family 40 member 1 Homo sapiens 146-150 14972659-3 2004 In recent years, several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized. Iron 58-62 solute carrier family 40 member 1 Homo sapiens 78-83 14768003-5 2004 Expression of DMT1 and Ireg1 was increased 1.5 to 3-fold in subjects with cirrhosis compared with iron-replete control subjects. Iron 98-102 solute carrier family 40 member 1 Homo sapiens 23-28 15030991-0 2004 Autosomal dominant iron overload due to a novel mutation of ferroportin1 associated with parenchymal iron loading and cirrhosis. Iron 19-23 solute carrier family 40 member 1 Homo sapiens 60-72 15030991-0 2004 Autosomal dominant iron overload due to a novel mutation of ferroportin1 associated with parenchymal iron loading and cirrhosis. Iron 101-105 solute carrier family 40 member 1 Homo sapiens 60-72 15030991-1 2004 We report the identification of a novel mutation in ferroportin1 in an Australian family with autosomal dominant iron overload. Iron 113-117 solute carrier family 40 member 1 Homo sapiens 52-64 14757427-2 2004 The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene. Iron 84-88 solute carrier family 40 member 1 Homo sapiens 116-128 14757427-2 2004 The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene. Iron 84-88 solute carrier family 40 member 1 Homo sapiens 129-134 14757427-2 2004 The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene. Iron 84-88 solute carrier family 40 member 1 Homo sapiens 135-139 14757427-2 2004 The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene. Iron 207-211 solute carrier family 40 member 1 Homo sapiens 51-58 14757427-2 2004 The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene. Iron 207-211 solute carrier family 40 member 1 Homo sapiens 116-128 14757427-2 2004 The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene. Iron 207-211 solute carrier family 40 member 1 Homo sapiens 129-134 14757427-2 2004 The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene. Iron 207-211 solute carrier family 40 member 1 Homo sapiens 135-139 12907459-0 2003 Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 46-59 12907459-0 2003 Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 61-65 12907459-1 2003 The expression of ferroportin1 (FPN1) in reticuloendothelial macrophages supports the hypothesis that this iron-export protein participates in iron recycling from senescent erythrocytes. Iron 107-111 solute carrier family 40 member 1 Homo sapiens 18-30 12907459-1 2003 The expression of ferroportin1 (FPN1) in reticuloendothelial macrophages supports the hypothesis that this iron-export protein participates in iron recycling from senescent erythrocytes. Iron 107-111 solute carrier family 40 member 1 Homo sapiens 32-36 12907459-1 2003 The expression of ferroportin1 (FPN1) in reticuloendothelial macrophages supports the hypothesis that this iron-export protein participates in iron recycling from senescent erythrocytes. Iron 143-147 solute carrier family 40 member 1 Homo sapiens 18-30 12907459-1 2003 The expression of ferroportin1 (FPN1) in reticuloendothelial macrophages supports the hypothesis that this iron-export protein participates in iron recycling from senescent erythrocytes. Iron 143-147 solute carrier family 40 member 1 Homo sapiens 32-36 12907459-2 2003 To gain insight into FPN1"s role in macrophage iron metabolism, we examined the effect of iron status and erythrophagocytosis on FPN1 expression in J774 macrophages. Iron 47-51 solute carrier family 40 member 1 Homo sapiens 21-25 12907459-3 2003 Northern analysis indicated that FPN1 mRNA levels decreased with iron depletion and increased on iron loading. Iron 65-69 solute carrier family 40 member 1 Homo sapiens 33-37 12907459-3 2003 Northern analysis indicated that FPN1 mRNA levels decreased with iron depletion and increased on iron loading. Iron 97-101 solute carrier family 40 member 1 Homo sapiens 33-37 12907459-4 2003 The iron-induced induction of FPN1 mRNA was blocked by actinomycin D, suggesting that transcriptional control was responsible for this effect. Iron 4-8 solute carrier family 40 member 1 Homo sapiens 30-34 12907459-7 2003 Iron chelation suppressed FPN1 mRNA and protein induction after erythrophagocytosis, suggesting that FPN1 induction results from erythrocyte-derived iron. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 26-30 12907459-7 2003 Iron chelation suppressed FPN1 mRNA and protein induction after erythrophagocytosis, suggesting that FPN1 induction results from erythrocyte-derived iron. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 101-105 12907459-7 2003 Iron chelation suppressed FPN1 mRNA and protein induction after erythrophagocytosis, suggesting that FPN1 induction results from erythrocyte-derived iron. Iron 149-153 solute carrier family 40 member 1 Homo sapiens 26-30 12907459-7 2003 Iron chelation suppressed FPN1 mRNA and protein induction after erythrophagocytosis, suggesting that FPN1 induction results from erythrocyte-derived iron. Iron 149-153 solute carrier family 40 member 1 Homo sapiens 101-105 12907459-8 2003 Comparative Northern analyses of iron-related genes after erythrophagocytosis revealed a 16-fold increase in FPN1 levels after 3 hours, a 10-fold increase in heme oxygenase-1 (HO-1) after 3 hours, a 2-fold increase in natural resistance macrophage-associated protein 1 (Nramp1) levels after 6 hours, but no change in divalent metal ion transporter 1 (DMT1) levels. Iron 33-37 solute carrier family 40 member 1 Homo sapiens 109-113 12907459-9 2003 The rapid and strong induction of FPN1 expression after erythrophagocytosis suggests that FPN1 plays a role in iron recycling. Iron 111-115 solute carrier family 40 member 1 Homo sapiens 34-38 12907459-9 2003 The rapid and strong induction of FPN1 expression after erythrophagocytosis suggests that FPN1 plays a role in iron recycling. Iron 111-115 solute carrier family 40 member 1 Homo sapiens 90-94 14636642-0 2003 Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 86-99 14636642-1 2003 The product of the SLC40A1 gene, ferroportin 1, is a main iron export protein. Iron 58-62 solute carrier family 40 member 1 Homo sapiens 19-26 14636642-1 2003 The product of the SLC40A1 gene, ferroportin 1, is a main iron export protein. Iron 58-62 solute carrier family 40 member 1 Homo sapiens 33-46 14636642-2 2003 Pathogenic mutations in ferroportin 1 lead to an autosomal dominant hereditary iron overload syndrome characterized by high serum ferritin concentration, normal transferrin saturation, iron accumulation predominantly in macrophages, and marginal anemia. Iron 79-83 solute carrier family 40 member 1 Homo sapiens 24-37 14636642-4 2003 We analyzed the ferroportin 1 gene in 19 unrelated patients from southern Africa (N = 15) and the United States (N = 4) presenting with primary iron overload. Iron 144-148 solute carrier family 40 member 1 Homo sapiens 16-29 14636642-10 2003 We conclude that the Q248H mutation is a common polymorphism in the ferroportin 1 gene in African populations that may be associated with mild anemia and a tendency to iron loading. Iron 168-172 solute carrier family 40 member 1 Homo sapiens 68-81 14636643-0 2003 Ferroportin 1 (SCL40A1) variant associated with iron overload in African-Americans. Iron 48-52 solute carrier family 40 member 1 Homo sapiens 0-13 12737947-6 2003 Circulating hepcidin then directly influences the expression of Ireg1 in the mature villus enterocytes of the duodenum, thereby regulating iron absorption in response to body iron requirements. Iron 139-143 solute carrier family 40 member 1 Homo sapiens 64-69 12730114-0 2003 Molecular analyses of patients with hyperferritinemia and normal serum iron values reveal both L ferritin IRE and 3 new ferroportin (slc11A3) mutations. Iron 71-75 solute carrier family 40 member 1 Homo sapiens 133-140 12873829-0 2003 Novel mutation in ferroportin 1 gene is associated with autosomal dominant iron overload. Iron 75-79 solute carrier family 40 member 1 Homo sapiens 18-31 12873829-1 2003 We report a family affected with dominant autosomal iron overload related to a new mutation in ferroportin 1, a transmembrane protein involved in the export of iron from duodenal enterocytes and likely from macrophages. Iron 52-56 solute carrier family 40 member 1 Homo sapiens 95-108 12873829-1 2003 We report a family affected with dominant autosomal iron overload related to a new mutation in ferroportin 1, a transmembrane protein involved in the export of iron from duodenal enterocytes and likely from macrophages. Iron 160-164 solute carrier family 40 member 1 Homo sapiens 95-108 12857562-0 2003 Autosomal dominant reticuloendothelial iron overload (HFE type 4) due to a new missense mutation in the FERROPORTIN 1 gene (SLC11A3) in a large French-Canadian family. Iron 39-43 solute carrier family 40 member 1 Homo sapiens 104-117 12857562-0 2003 Autosomal dominant reticuloendothelial iron overload (HFE type 4) due to a new missense mutation in the FERROPORTIN 1 gene (SLC11A3) in a large French-Canadian family. Iron 39-43 solute carrier family 40 member 1 Homo sapiens 124-131 14568251-0 2003 The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression. Iron 16-20 solute carrier family 40 member 1 Homo sapiens 58-70 14568251-0 2003 The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression. Iron 16-20 solute carrier family 40 member 1 Homo sapiens 71-76 14568251-0 2003 The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression. Iron 16-20 solute carrier family 40 member 1 Homo sapiens 77-81 14568251-1 2003 BACKGROUND/AIMS: MTP1/Ferroportin1/IREG1, the product of the SLC40A1 gene, is a main iron export protein in mammals. Iron 85-89 solute carrier family 40 member 1 Homo sapiens 17-21 14568251-1 2003 BACKGROUND/AIMS: MTP1/Ferroportin1/IREG1, the product of the SLC40A1 gene, is a main iron export protein in mammals. Iron 85-89 solute carrier family 40 member 1 Homo sapiens 22-34 14568251-1 2003 BACKGROUND/AIMS: MTP1/Ferroportin1/IREG1, the product of the SLC40A1 gene, is a main iron export protein in mammals. Iron 85-89 solute carrier family 40 member 1 Homo sapiens 35-40 14568251-1 2003 BACKGROUND/AIMS: MTP1/Ferroportin1/IREG1, the product of the SLC40A1 gene, is a main iron export protein in mammals. Iron 85-89 solute carrier family 40 member 1 Homo sapiens 61-68 14568251-3 2003 The aim of this study was to investigate the functional role of genomic SLC40A1 elements in response to iron. Iron 104-108 solute carrier family 40 member 1 Homo sapiens 72-79 14568251-8 2003 Then, in cells transfected with SLC40A1-DeltaIRE-Luc, we found that, in spite of iron regulatory protein activation, the response to iron manipulation was lost. Iron 81-85 solute carrier family 40 member 1 Homo sapiens 32-39 14568251-9 2003 CONCLUSIONS: We demonstrate that the iron responsive element in the SLC40A1 gene is functional and that it controls gene expression through the cytoplasmic iron regulatory protein system. Iron 37-41 solute carrier family 40 member 1 Homo sapiens 68-75 14568251-9 2003 CONCLUSIONS: We demonstrate that the iron responsive element in the SLC40A1 gene is functional and that it controls gene expression through the cytoplasmic iron regulatory protein system. Iron 156-160 solute carrier family 40 member 1 Homo sapiens 68-75 12949720-2 2003 Two oxidoreductases, termed duodenal cytochrome b and hephaestin, are proposed to co-operate with divalent-metal-transporter-1 and FPN1, respectively, to transfer iron from the duodenal lumen to the circulation. Iron 163-167 solute carrier family 40 member 1 Homo sapiens 131-135 12949720-6 2003 Spearman rank correlations showed that Dcytb, hephaestin, FPN1, and DMT1 mRNA expression are positively related to each other independently of the underlying disease, which ensures an efficient transepithelial transport of absorbed iron. Iron 232-236 solute carrier family 40 member 1 Homo sapiens 58-62 12743117-8 2003 The coordinated actions of GPI-Cp and IREG1 may be required for iron efflux from neural cells, and disruption of this balance could lead to iron accumulation in the central nervous system and neurodegeneration. Iron 64-68 solute carrier family 40 member 1 Homo sapiens 38-43 12743117-8 2003 The coordinated actions of GPI-Cp and IREG1 may be required for iron efflux from neural cells, and disruption of this balance could lead to iron accumulation in the central nervous system and neurodegeneration. Iron 140-144 solute carrier family 40 member 1 Homo sapiens 38-43 12801950-5 2003 RESULTS: Expression of DMT1 (IRE) and Ireg1 was increased 3-5-fold in iron deficient subjects compared with iron replete subjects. Iron 70-74 solute carrier family 40 member 1 Homo sapiens 38-43 12801950-5 2003 RESULTS: Expression of DMT1 (IRE) and Ireg1 was increased 3-5-fold in iron deficient subjects compared with iron replete subjects. Iron 108-112 solute carrier family 40 member 1 Homo sapiens 38-43 12801950-6 2003 Duodenal expression of DMT1 (IRE) and Ireg1 was similar in haemochromatosis patients and iron replete subjects but in haemochromatosis patients with elevated serum ferritin concentrations, both DMT1 (IRE) and Ireg1 expression were inappropriately increased relative to serum ferritin concentration. Iron 89-93 solute carrier family 40 member 1 Homo sapiens 38-43 12801950-9 2003 CONCLUSIONS: These findings are consistent with DMT1 (IRE) and Ireg1 playing primary roles in the adaptive response to iron deficiency. Iron 119-123 solute carrier family 40 member 1 Homo sapiens 63-68 12737947-6 2003 Circulating hepcidin then directly influences the expression of Ireg1 in the mature villus enterocytes of the duodenum, thereby regulating iron absorption in response to body iron requirements. Iron 175-179 solute carrier family 40 member 1 Homo sapiens 64-69 12606179-3 2003 To investigate this possible association, we studied the hepatic expression of the gene for hepcidin (HAMP) and a gene important in iron transport (IREG1) in patients with haemochromatosis, in normal controls, and in Hfe-knockout mice. Iron 132-136 solute carrier family 40 member 1 Homo sapiens 148-153 12572662-18 2003 The recent identification of other proteins of iron and copper metabolism, for example, copper ATPases and the membrane iron transporters DCT1/DMT1/Nramp2 and IREG1/MTP1/ferroportinl, are likely to fill crucial pathway gaps. Iron 47-51 solute carrier family 40 member 1 Homo sapiens 159-164 12572662-18 2003 The recent identification of other proteins of iron and copper metabolism, for example, copper ATPases and the membrane iron transporters DCT1/DMT1/Nramp2 and IREG1/MTP1/ferroportinl, are likely to fill crucial pathway gaps. Iron 47-51 solute carrier family 40 member 1 Homo sapiens 165-169 12606179-9 2003 There was a significant correlation between hepatic iron concentration and expression of HAMP (r=0.59, p=0.02) and IREG1 (r=0.67, p=0.007) in untreated patients. Iron 52-56 solute carrier family 40 member 1 Homo sapiens 115-120 12606179-12 2003 Furthermore, the increase in hepatic IREG1 expression in haemochromatosis suggests that IREG1 could function to facilitate the removal of excess iron from the liver. Iron 145-149 solute carrier family 40 member 1 Homo sapiens 37-42 12606179-12 2003 Furthermore, the increase in hepatic IREG1 expression in haemochromatosis suggests that IREG1 could function to facilitate the removal of excess iron from the liver. Iron 145-149 solute carrier family 40 member 1 Homo sapiens 88-93 12674739-6 2003 The autosomal-dominant type 4 is located on chromosome 2q32 and affects the basolateral iron carrier ferroportin 1. Iron 88-92 solute carrier family 40 member 1 Homo sapiens 101-114 12457803-5 2002 Progress in our understanding of how HFE regulates the absorption of dietary iron has been slow, but much can be learnt from the study of the rare instances of haemochromatosis that involve mutations in newly-identified iron-metabolism genes, such as TFR2--a transferrin receptor isoform--and ferroportin1/Ireg1/mtp1--an intestinal iron transporter. Iron 220-224 solute carrier family 40 member 1 Homo sapiens 293-305 12457803-5 2002 Progress in our understanding of how HFE regulates the absorption of dietary iron has been slow, but much can be learnt from the study of the rare instances of haemochromatosis that involve mutations in newly-identified iron-metabolism genes, such as TFR2--a transferrin receptor isoform--and ferroportin1/Ireg1/mtp1--an intestinal iron transporter. Iron 220-224 solute carrier family 40 member 1 Homo sapiens 306-311 12457803-5 2002 Progress in our understanding of how HFE regulates the absorption of dietary iron has been slow, but much can be learnt from the study of the rare instances of haemochromatosis that involve mutations in newly-identified iron-metabolism genes, such as TFR2--a transferrin receptor isoform--and ferroportin1/Ireg1/mtp1--an intestinal iron transporter. Iron 220-224 solute carrier family 40 member 1 Homo sapiens 312-316 11809412-0 2002 Ferroportin1: a new iron export molecule? Iron 20-24 solute carrier family 40 member 1 Homo sapiens 0-12 12547233-3 2002 We describe here the clinical and biological characteristics of autosomal dominant form of iron overload due to the N144H mutation of the SLC11A3 gene. Iron 91-95 solute carrier family 40 member 1 Homo sapiens 138-145 12547233-10 2002 The disease in this family represents a non-classical form of iron overload caused by the N144H mutation in the SLC11A3 gene. Iron 62-66 solute carrier family 40 member 1 Homo sapiens 112-119 12547239-0 2002 Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1. Iron 14-18 solute carrier family 40 member 1 Homo sapiens 106-119 12547239-2 2002 Identification of divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) has improved our understanding of iron transport across the intestinal epithelium. Iron 113-117 solute carrier family 40 member 1 Homo sapiens 58-71 12547239-2 2002 Identification of divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) has improved our understanding of iron transport across the intestinal epithelium. Iron 113-117 solute carrier family 40 member 1 Homo sapiens 73-77 12547239-3 2002 Although DMT1 and FPN1 mRNA bear an iron responsive element (IRE) within its untranslated regions which should cause susceptibility to iron mediated posttranscriptional regulation the latter has not been shown so far. Iron 36-40 solute carrier family 40 member 1 Homo sapiens 18-22 11897618-11 2002 Our data show that expression levels of human DCT1 mRNA, and to a lesser extent IREG1 mRNA, are regulated in an iron-dependent manner, whereas mRNA of hephaestin is not affected. Iron 112-116 solute carrier family 40 member 1 Homo sapiens 80-85 11925462-3 2002 Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation. Iron 75-79 solute carrier family 40 member 1 Homo sapiens 154-166 11925462-3 2002 Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation. Iron 75-79 solute carrier family 40 member 1 Homo sapiens 148-153 11925462-3 2002 Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation. Iron 75-79 solute carrier family 40 member 1 Homo sapiens 154-166 11925462-4 2002 The aim of this study was to investigate the effects of iron treatment on DMT1 and IREG1 mRNA expression in Caco-2 cells, a human intestinal cell line. Iron 56-60 solute carrier family 40 member 1 Homo sapiens 83-88 11925462-5 2002 Exposure of the cells to iron (200 micromol/L ferric nitrilotriacetic acid for 72 h) significantly decreased transferrin receptor mRNA (80%), DMT1 mRNA (57%) and IREG1 mRNA (52%). Iron 25-29 solute carrier family 40 member 1 Homo sapiens 162-167 11842003-6 2002 These results suggest that DMT1, Fpn1, and Heph are involved in the iron uptake process modulated by copper status. Iron 68-72 solute carrier family 40 member 1 Homo sapiens 33-37 12376346-0 2002 Iron increases expression of iron-export protein MTP1 in lung cells. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 49-53 12376346-0 2002 Iron increases expression of iron-export protein MTP1 in lung cells. Iron 29-33 solute carrier family 40 member 1 Homo sapiens 49-53 12376346-3 2002 We provide evidence for the expression and iron-induced upregulation of the metal transporter protein-1 (MTP1) genes in human and rodent lung cells at both the protein and mRNA levels. Iron 43-47 solute carrier family 40 member 1 Homo sapiens 76-103 12376346-3 2002 We provide evidence for the expression and iron-induced upregulation of the metal transporter protein-1 (MTP1) genes in human and rodent lung cells at both the protein and mRNA levels. Iron 43-47 solute carrier family 40 member 1 Homo sapiens 105-109 12376346-4 2002 In human bronchial epithelial cells, a 3.8-fold increase in mRNA level and a 2.4-fold increase in protein level of MTP1 were observed after iron exposure. Iron 140-144 solute carrier family 40 member 1 Homo sapiens 115-119 12376346-5 2002 In freshly isolated human macrophages, as much as an 18-fold increase in the MTP1 protein level was detected after incubation with an iron compound. Iron 134-138 solute carrier family 40 member 1 Homo sapiens 77-81 12376346-6 2002 The elevation in expression of MTP1 gene was also demonstrated in iron-instilled rat lungs and in hypotransferrinemic mouse lungs. Iron 66-70 solute carrier family 40 member 1 Homo sapiens 31-35 12406098-0 2002 Genetic hyperferritinaemia and reticuloendothelial iron overload associated with a three base pair deletion in the coding region of the ferroportin gene (SLC11A3). Iron 51-55 solute carrier family 40 member 1 Homo sapiens 154-161 12547239-3 2002 Although DMT1 and FPN1 mRNA bear an iron responsive element (IRE) within its untranslated regions which should cause susceptibility to iron mediated posttranscriptional regulation the latter has not been shown so far. Iron 135-139 solute carrier family 40 member 1 Homo sapiens 18-22 12547239-8 2002 Nuclear run-off analysis then demonstrated that the effects of iron and desferrioxamine on DMT1 and FPN1 mRNA expression are rather due to modulation of transcription of these genes. Iron 63-67 solute carrier family 40 member 1 Homo sapiens 100-104 12547239-9 2002 Our results demonstrate that iron unidirectionally regulates the expression of the two ferrous ion transporters DMT1 and FPN1 by affecting their transcription. Iron 29-33 solute carrier family 40 member 1 Homo sapiens 121-125 12382200-10 2002 Mutations in the gene encoding the iron exporter, ferroportin 1, cause iron overload characterized by iron accumulation in macrophages yet normal plasma iron levels. Iron 35-39 solute carrier family 40 member 1 Homo sapiens 50-63 12382200-10 2002 Mutations in the gene encoding the iron exporter, ferroportin 1, cause iron overload characterized by iron accumulation in macrophages yet normal plasma iron levels. Iron 71-75 solute carrier family 40 member 1 Homo sapiens 50-63 12382200-10 2002 Mutations in the gene encoding the iron exporter, ferroportin 1, cause iron overload characterized by iron accumulation in macrophages yet normal plasma iron levels. Iron 71-75 solute carrier family 40 member 1 Homo sapiens 50-63 12382200-10 2002 Mutations in the gene encoding the iron exporter, ferroportin 1, cause iron overload characterized by iron accumulation in macrophages yet normal plasma iron levels. Iron 71-75 solute carrier family 40 member 1 Homo sapiens 50-63 12091366-7 2002 We propose that this mutation disrupts the function of the ferroportin1 protein, leading to impaired iron homeostasis and iron overload. Iron 101-105 solute carrier family 40 member 1 Homo sapiens 59-71 12091367-0 2002 Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3). Iron 39-43 solute carrier family 40 member 1 Homo sapiens 99-112 12091367-0 2002 Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3). Iron 39-43 solute carrier family 40 member 1 Homo sapiens 119-126 11925462-0 2002 Iron treatment downregulates DMT1 and IREG1 mRNA expression in Caco-2 cells. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 38-43 11925462-3 2002 Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation. Iron 46-50 solute carrier family 40 member 1 Homo sapiens 148-153 11925462-3 2002 Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation. Iron 46-50 solute carrier family 40 member 1 Homo sapiens 154-166 11925462-3 2002 Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation. Iron 46-50 solute carrier family 40 member 1 Homo sapiens 167-171 11925462-3 2002 Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation. Iron 75-79 solute carrier family 40 member 1 Homo sapiens 148-153 11925462-3 2002 Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation. Iron 75-79 solute carrier family 40 member 1 Homo sapiens 154-166 11925462-3 2002 Recently, a number of novel genes involved in iron metabolism, such as the iron uptake transporter DMT1/DCT1/Nramp2 and the iron export transporter IREG1/ferroportin1/MTP1, have been identified, providing important insights about molecular aspects of intestinal iron absorption and its regulation. Iron 75-79 solute carrier family 40 member 1 Homo sapiens 148-153 11809412-1 2002 Ferroportin1 is a newly discovered molecule that may play a role in iron export. Iron 68-72 solute carrier family 40 member 1 Homo sapiens 0-12 11809412-5 2002 In addition, the ferroportin1 mRNA transcript contains an iron response element in its 5" untranslated region. Iron 58-62 solute carrier family 40 member 1 Homo sapiens 17-29 12139399-0 2002 The expression and regulation of the iron transport molecules hephaestin and IREG1: implications for the control of iron export from the small intestine. Iron 37-41 solute carrier family 40 member 1 Homo sapiens 77-82 12139399-0 2002 The expression and regulation of the iron transport molecules hephaestin and IREG1: implications for the control of iron export from the small intestine. Iron 116-120 solute carrier family 40 member 1 Homo sapiens 77-82 12139399-3 2002 The basolateral transfer of iron requires two components: a copper-containing iron oxidase known as hephaestin and a membrane transport protein IREG1. Iron 28-32 solute carrier family 40 member 1 Homo sapiens 144-149 11313311-0 2001 Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload. Iron 27-31 solute carrier family 40 member 1 Homo sapiens 78-91 11673399-4 2001 In parallel, our understanding of iron transport has expanded through identification of Fpn1/Ireg1/MTP1, Sfxn1 and DCYTB: Ongoing studies of Friedreich"s ataxia, sideroblastic anemia, aceruloplasminemia and neurodegeneration with brain-iron accumulation are clarifying the role for iron in the nervous system. Iron 34-38 solute carrier family 40 member 1 Homo sapiens 88-92 11673399-4 2001 In parallel, our understanding of iron transport has expanded through identification of Fpn1/Ireg1/MTP1, Sfxn1 and DCYTB: Ongoing studies of Friedreich"s ataxia, sideroblastic anemia, aceruloplasminemia and neurodegeneration with brain-iron accumulation are clarifying the role for iron in the nervous system. Iron 34-38 solute carrier family 40 member 1 Homo sapiens 93-98 11684086-5 2001 Transepithelial flux of iron was also increased and was associated with a rise in IREG1 mRNA expression. Iron 24-28 solute carrier family 40 member 1 Homo sapiens 82-87 11389698-8 2001 Iron efflux is thought to be mediated by the metal transporter protein, IREG1/ferroportin1/MTP1, and oxidation of Fe(II) to Fe(III) prior to incorporation into fetal transferrin is carried out by the placental copper oxidase. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 72-77 11389698-8 2001 Iron efflux is thought to be mediated by the metal transporter protein, IREG1/ferroportin1/MTP1, and oxidation of Fe(II) to Fe(III) prior to incorporation into fetal transferrin is carried out by the placental copper oxidase. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 78-90 11389698-8 2001 Iron efflux is thought to be mediated by the metal transporter protein, IREG1/ferroportin1/MTP1, and oxidation of Fe(II) to Fe(III) prior to incorporation into fetal transferrin is carried out by the placental copper oxidase. Iron 0-4 solute carrier family 40 member 1 Homo sapiens 91-95 11313311-2 2001 The identification of divalent-metal transporter 1 (DMT1) and ferroportin 1 (FP1) has improved our understanding of transmembrane iron trafficking. Iron 130-134 solute carrier family 40 member 1 Homo sapiens 62-75 11313311-2 2001 The identification of divalent-metal transporter 1 (DMT1) and ferroportin 1 (FP1) has improved our understanding of transmembrane iron trafficking. Iron 130-134 solute carrier family 40 member 1 Homo sapiens 77-80 11313311-6 2001 Moreover, DMT1 and FP1 mRNA levels were significantly increased in patients with iron deficiency, HFE and non-HFE hemochromatosis, whereas they were unchanged in patients with secondary iron overload. Iron 81-85 solute carrier family 40 member 1 Homo sapiens 19-22 11313311-8 2001 In patients with normal iron status or iron deficiency, significant negative correlations between DMT1, FP1 mRNA, and serum iron parameters were found, which were absent in subjects with primary hemochromatosis. Iron 39-43 solute carrier family 40 member 1 Homo sapiens 104-107 11313311-9 2001 CONCLUSIONS: DMT1 and FP1 are centrally involved in iron uptake/transfer in the duodenum and in the adaptive changes of iron homeostasis to iron deficiency and overload. Iron 52-56 solute carrier family 40 member 1 Homo sapiens 22-25 11313311-9 2001 CONCLUSIONS: DMT1 and FP1 are centrally involved in iron uptake/transfer in the duodenum and in the adaptive changes of iron homeostasis to iron deficiency and overload. Iron 120-124 solute carrier family 40 member 1 Homo sapiens 22-25 10693807-8 2000 Human Ferroportin1 is found at the basal surface of placental syncytiotrophoblasts, suggesting that it also transports iron from mother to embryo. Iron 119-123 solute carrier family 40 member 1 Homo sapiens 6-18 27420126-5 2001 Based on these observations, it is possible to propose a general model for the regulation of iron absorption whereby the basolateral transfer step involving Ireg1 and Hp controls the rate of absorption. Iron 93-97 solute carrier family 40 member 1 Homo sapiens 157-162 11207374-7 2001 Recent identification and characterization of the hemochromatosis protein HFE, the iron importer Nramp2, the iron exporter ferroportin1, and the second transferrin-binding and -transport protein transferrin receptor 2, have demonstrated their important roles in maintaining body"s iron homeostasis. Iron 109-113 solute carrier family 40 member 1 Homo sapiens 123-135 10747949-2 2000 This gene, termed metal transporter protein (mtp1), is expressed in tissues involved in body iron homeostasis including the developing and mature reticuloendothelial system, the duodenum, and the pregnant uterus. Iron 93-97 solute carrier family 40 member 1 Homo sapiens 45-49 10747949-5 2000 Overexpression of MTP1 in tissue culture cells results in intracellular iron depletion. Iron 72-76 solute carrier family 40 member 1 Homo sapiens 18-22 10747949-8 2000 These data indicate that MTP1 is an iron-regulated membrane-spanning protein that is involved in intracellular iron metabolism. Iron 36-40 solute carrier family 40 member 1 Homo sapiens 25-29 10747949-8 2000 These data indicate that MTP1 is an iron-regulated membrane-spanning protein that is involved in intracellular iron metabolism. Iron 111-115 solute carrier family 40 member 1 Homo sapiens 25-29 10693807-9 2000 Mammalian Ferroportin1 is expressed at the basolateral surface of duodenal enterocytes and could export cellular iron into the circulation. Iron 113-117 solute carrier family 40 member 1 Homo sapiens 10-22 10905536-0 2000 Another jigsaw piece towards solving the iron metabolism puzzle: the cloning of the iron exporter, ferroportin1. Iron 41-45 solute carrier family 40 member 1 Homo sapiens 99-111 10905536-0 2000 Another jigsaw piece towards solving the iron metabolism puzzle: the cloning of the iron exporter, ferroportin1. Iron 84-88 solute carrier family 40 member 1 Homo sapiens 99-111