PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34826546-4 2022 We found that iron, manifesting as ferric ammonium citrate (FAC; 0.05-4.8 mM), significantly inhibited cell growth, induced oxidative stress through the Fenton reaction, and functionally activated autophagy in EuESCs, as measured by 5-ethynyl-2"-deoxyuridine incorporation assay, MitoSOX Red staining, LC3 turnover assay, and tandem mCherry-eGFP-LC3B fluorescence microscopy. Iron 14-18 microtubule associated protein 1 light chain 3 beta Homo sapiens 347-351 32793311-8 2020 Furthermore, erastin-induced breast cancer cell death was inhibited by an iron chelator, deferoxamine, which inhibited the increases of erastin-induced iron levels and inhibited the erastin-induced changes in the expression levels of the autophagy-related proteins beclin1, ATG5, ATG12, LC3B and P62. Iron 74-78 microtubule associated protein 1 light chain 3 beta Homo sapiens 287-291 31659150-5 2019 Furthermore, we show that autophagy leads to iron-dependent ferroptosis by degradation of ferritin and induction of transferrin receptor 1 (TfR1) expression, using wild-type and autophagy-deficient cells, BECN1+/- and LC3B-/-. Iron 45-49 microtubule associated protein 1 light chain 3 beta Homo sapiens 218-222